Levetiracetam Drug Study

DRUG STUDY

Drug Data Generic Name levetiracetam Trad e Name Keppra

!atient s Dose

Minimum Dose 10mg/day

Classification Therapeutic$ anticonvulsants !harmacologic pyrrolidines

!regnanc# Categor# C

Mechanism of Action  ppears to in!i"it "urst #iring $it!out a##ecting normal neuronal e%cita"ility and may selectively prevent !ypersync!roni&ation o# epilepti#orm "urst #iring and propagation o# sei&ure activity. !harmac o*ineti cs A$ 'apidly A$ 'apidly and completely a"sor"ed #ollo$ing oral administration.

Indication Genera l Indications Partial onset sei&ures -adunct. Primary generali&ed tonicclonic sei&ures -adunct -immediaterelease and inection only. yoclonic sei&ures in patients $it! uvenile myoclonic epilepsy -adunct-immediate release and inection only.

D$ (n)no$n D$ (n)no$n Ma"imu m Dose 3000mg/day Cont ents levetiracetam Availailit# and color  Talets$ 250 mg, 500 mg, 750 mg, 100 mg. %"tended&release talets$ 500 mg, 750mg. 'ral solution (grape&flavored)$ 100 mg/mL

M+%$ **+ e%creted unc!anged "y t!e )idneys some meta"olism "y t!e liver -meta"olites inactive. 'ns et rapid !ea* !e a* 11.5!rs. Dura tion 12 !rs. Drug ,a lf -i fe 7.1!rs.

.

Routes of administration PO

Source$ >eglin, C. et. l. 200D. >avis@s >rug :uide #or ;urses. 12 t! ed. E.. >avis. pp 762768

!atients Actual Indication

Contraindications ypersensitivity Lactation Lactation. !recau tion  ll patients -may increase ris) o# suicidal t!oug!ts/"e!aviors 'enal impairment -dose reduction recommended i# 44r 60 mL/min Pedi 4!ildren 8 yr -sa#ety not esta"lis!ed 1* yr -#or e%tended release and inection O9 (se only during pregnancy i# potential "ene#it usti#ies potential ris) to #etus :eridecreae renal elimination -dose reduction may "e necessary. Drug interaction &drug to drug

Adverse Reaction CNS$ <(=4=>L ?O(:?<, di&&iness, #atigue/somnolence, $ea)ness, "e!avioral a"normalities. Neuro$ coordination di##iculties -adults only.

Nursing Responsiilities .efo re 1. sses i#i# patient !ad any suicidal attempts "e#ore. 2. ssess ssess patient@s patient@s mental status. 3. ssess ssess duration, location location and c!aracteristics o# sei&ure activity/ activity/ 8. 4on#irm 4on#irm medication medication #rom doctor@s orders. 5. O"tain O"tain prescri"ed prescri"ed dose. Duri ng 1. 4on#irm 4on#irm patient@s ent@s identi identity. ty. 2. dminister ster medication medication $!ole. 3. >o not not crus!, crus!, "rea) "rea) or c!e$. 8. Practice Practice aseptic aseptic tec!ni tec!niAue. Aue. 5. ay administ administer er medicati medication on $it!out regard to meals.

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;one noted

After Aft er 1. O"serv O"serve e proper proper documentation o# administered medication. 2. Bnsure Bnsure t!at patient patient !as !as #ully s$allo$ed oral #orm o# medication. 3. O"serve O"serve patient@s patient@s "e!avior "e!avior closely #or atleast 1530 minutes a#ter administration. 8. =nstruct =nstruct patient patient to slo$ly slo$ly move to prevent di&&iness. 5. =nstruct =nstruct patient patient to rest to to decrease ris) o# #alls.