DRUG STUDY
BRAND
GENERIC
DOSAG
NAME
NAME
E
Omepron
Omeprazole
20mg BID
ACTION
INDICATION
CONTRA-
PRECAUTIONS
NURSING
INDICATION
Suppresses gastric secretion by inhibiting hydrogen/potass ium ATPase enzyme system in the gastric parietal cell: characterize as a gastric acid pump inhibitor, since it block the final step of acid production.
Short term treatment of active duodenal ulcer, gastroesophageal reflux disease (GERD), including erosive esophagitis and symptomatic GERD. Long term treatment of pathologic hypersecretory condition: to maintain healing of erosive esophagitis. Short term treatment of active benign gastric ulcer.
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hypersensitivity pregnancy lactation and children Combination therapy with clarithromicin should not be used in patients with hepatic impairment.
CONSIDERATION
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Presence of any alarms symptoms (significant unintentional weight loss, recurrent vomiting, dysphagia, hematemesis, or melena) should be taken before meals and should be swallowed whole. Hepatic impairment Pregnancy, lactation and children less than 12 years old
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Assess other medications patient maybe taking for effectiveness and interaction. Monitor therapeutic effectiveness and adverse reaction at the beginning of therapy and periodically throughout the therapy. Assess GI system: bowel sounds 8 hrly, abdomen for pain and swelling, appetite loss. Monitor hepatic enzymes. Assess knowledge/teach appropriate use of this medication, interventions to reduce side effects, and other symptoms to report.
BRAND
GENERIC
DOSAG
NAME
NAME
E
Afordel
simvastati n
25mg 1 tab OD
ACTION
INDICATION
CONTRA-
PRECAUTIONS
NURSING
INDICATION
Inhibits HMGCOA reductase enzyme which reduces cholesterol synthesis; this enzyme is needed for cholesterol production.
To reduce low-density lipoprotein (LDL) cholesterol, apolipoprotein apolipoprotein beta and triglycerides. To increase high density lipoprotein (HDL) cholesterol in the treatment of hyperlipidaemias, including hypercholesterolemias and combined hyperlipidaemia. Coronary heart disease
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Hypersensitivity to any components of this preparation. Active liver disease.
CONSIDERATION
- Temporarily stop therapy before major surgery. - Hypercholesterol emia must be monitored/ controlled. - Past history or an active liver disease. - Unexplained muscle pain, tenderness and weakness - History of hereditary muscular disorder. - Hypothyroidism.
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Assess nutrition: fat, protein, carbohydrates. Monitor creatinine phosphokinase levels due to possibility of myopathy. Monitor triglycerides, cholesterol baseline and throughout treatment; LDL, HDL, triglycerides, and cholesterol at 6-8 wks and every 6 mos should be monitored closely; if increases drug should be discontinue. Assess liver function test prior to therapy and periodically thereafter. Evaluate therapeutic response and adverse reaction on a regular basis. Assess knowledge or teach patient proper use, possible side effects/appropriate interventions, and adverse symptoms to report.
BRAND
GENERIC
DOSAG
NAME
NAME
E
Plavix
Clopidogrel
Tab OD
ACTION
INDICATION
CONTRA-
PRECAUTIONS
INDICATION
Blocks ADP receptors which prevent fibrinogen binding at the site and thereby reduce the possibility of platelet adhesion and aggregation.
Reduction of atherosclerotic events in patients with atherosclerosis documented by recent stoke, myocardial infarction, or established peripheral arterial disease.
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Hypersensitivi ty. ty. Severe liver impairment. Active pathological bleeding e.g. peptic ulcer and intracranial hemorrhage. Pregnancy and lactation.
NURSING CONSIDERATION
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Patients who may be at risk of increase bleeding from trauma, surgery, or other pathological conditions. Elective surgery. Patients who have lesions with a propensity to bleeding. Patients with moderate hepatic disease who may have bleeding diatheses.
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Assess for symptoms of stroke, MI during treatment. Monitor signs of bleeding; hemoglobin and hematocrit periodically. Monitor liver function studies: AST, ALT, bilirubin, creatinine if patient is on long term therapy; thrombocytopenia may occur.