ÍNDICE
ÍNDICE ........................................................................................................ .............................................................................................................................................. ...................................... 1 Introducción al tejido conjuntivo ....................................................................................................... ....................................................................................................... 2 1.
FUNCIONES FUNCIONES DEL TEJIDO CONJUNTIVO ........................................................ ........................................................................ ................ 3
2.
MATRIZ EXTRACELULAR .......................................................... ................................................................................................ ...................................... 3 2.1.
Sustancia base .............................................................. ................................................................................................................ .................................................. 3
2.2.
Fibras .................................................................. .............................................................................................................................. ............................................................ 5
3.
COMPONENTES COMPONENTES CELULARES ............................................................... .......................................................................................... ........................... 8 3.1.
Fibroblastos y miofibroblastos ............................................................ ....................................................................................... ........................... 9
3.2.
Pericitos ............................................................. ........................................................................................................................ ........................................................... 10
3.3.
Macrófagos........................................................ ................................................................................................................... ........................................................... 11
3.4.
Adipocitos ......................................................... .................................................................................................................... ........................................................... 12
3.5.
Mastocitos (células cebadas) ............................................................... ........................................................................................ ......................... 13
3.6.
Linfocitos .......................................................... ..................................................................................................................... ........................................................... 14
3.7.
Células plasmáticas .................................................................. ...................................................................................................... .................................... 14
3.8.
Granulocitos eusinófilos ........................................................... ............................................................................................... .................................... 15
3.9.
Granulocitos neutrófilos ........................................................... ............................................................................................... .................................... 16
4.
TEJIDO CONJUNTIVO CONJUNTIVO PROPIO .............................................................. ....................................................................................... ......................... 16 4.1.
Tejido conjuntivo laxo ............................................................. ................................................................................................. .................................... 16
4.2.
Tejido conjuntivo denso ........................................................... ............................................................................................... .................................... 17
4.3.
Tejido conjuntivo elástico ................................................................... ............................................................................................ ......................... 20
4.4.
Tejido conjuntivo reticular .................................................................. ........................................................................................... ......................... 21
5.
DISCUSIÓN DEL TEMA ............................................................... ................................................................................................... .................................... 22
6.
CONCLUCION CONCLUCION ......................................................... .................................................................................................................... ........................................................... 22
7.
RECOMENDACIONES RECOMENDACIONES .................................................................. ...................................................................................................... .................................... 22
8.
ANEXOS.................................................................... .............................................................................................................................. .......................................................... 23 8.1.
ARTICULO POSTEADO ................................................................... ............................................................................................ ......................... 23
8.2.
RESUMEN POSTEADO ......................................................... ............................................................................................. .................................... 47
8.3.
PRESENTACION PRESENTACION DE POWERPOINT ......................................................... ....................................................................... .............. 48
9. 10.
RESUMENES DE LOS ARTICULOS ARTICULOS POSTEADOS........................................................ 62 REFERENCIAS REFERENCIAS BIBLIOGRAFICAS BIBLIOGRAFICAS Y WEBGRAFIA ................................................ 67
1
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Introducción al tejido conjuntivo
El tejido conjuntivo también denominado tejido de sostén, dado que representa el “esqueleto” que sostiene otros tejidos y órganos. Como el tejido conjuntivo conforma una
masa coherente entre el sistema vascular sanguíneo y todos los epitelios, todo intercambio de sustancias se debe realizar a través del tejido conjuntivo. El tejido conjuntivo se caracteriza por tener células y matriz extracelular, en su mayor parte secretadas por uno de los tipos celulares (los fibroblastos) y que, en condiciones normales representan una proporción del tejido mayor que las células. En conjunto, las sustancias extracelulares se denominas matriz extracelular, compuesta por fibras incluidas en una en una matriz a morfa que contiene liquido tisular. Las fibras del tejido conjuntivo se dividen en tres tipos, fibras de colágeno, reticulares y elásticas. La matriz amorfa está compuesta por glucosaminoglucanos glucosaminoglucanos y proteoglucanos que forman geles muy hidratados en los l os cuales están incluidos los demás componentes. En la matriz extracelular también hay glucoproteinas adhesivas, como por ejemplo fibronectinas y laminina. Los numerosos tipos celulares se clasifican en células fijas o migrantes. Los distintos tipos de células, las fibras y matriz amorfa aparecen en cantidades variables en cantidades variables en distintas partes del organismo, por los que confiere a los diferentes tejidos conjuntivos propiedades propiedades funcionales específicas. El tejido conjuntivo se desarrolla a partir del mesodermo embrionario, por la mayor parte del tejido conjuntivo de la zona cefálica tiene origen en la cresta neural.
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1. FUNCIONES DEL TEJIDO CONJUNTIVO
Proporciona soporte estructural, el tejido conjuntivo que forma capsulas y recubre a órganos y el estroma que integra el marco estructural y dentro de ellos ejercen funciones de sustento. Sirve como un medio de intercambio, el tejido t ejido conjuntivo es un medio de intercambio de desechos metabólicos, nutrientes y oxigeno entre la sangre y células del cuerpo. Contribuir a la defensa y protección de cuerpo: 1) Las células facociticas engloban y destruyen desechos celulares, partículas extrañas y microorganismos. 2) Las células del cuerpo con capacidad inmunitario, que producen anticuerpos para antígenos. 3) Las células que elaboran sustancias farmacológicas para controlar la inflamación.
2. MATRIZ EXTRACELULAR Es una red estructural compleja e intrincada que rodea y sustenta las células del tejido conjuntivo, compuesta de sustancia base y fibras, resistente a fuerzas de compresión y estiramiento.
2.1.
Sustancia base
La sustancia base también llamado sustancia fundamental es un materia amorfa que es parte de la matriz extracelular que ocupa el espacio que hay entre las células y las fibras, la sustancia fundamental consiste principalmente en tres grupos: proteoglucanos, macromoléculas muy grande que poseen una proteína central; glucosaminoglucanos, que están formados en forma covalente a los proteoglucanos y glucoproteinas de adhesivas. Los glucosaminoglucanos son las causas de las propiedades físicas de la sustancia fundamental.
Los GAG son los heteropolisacáridos más abundantes de la sustancia fundamental, los principales glucosaminogluca glucosaminoglucanos nos son: sulfatados (condroitinsulfatos, solo se encuentran en pequeñas cantidades en la matriz amorfa del tejido conjuntivo laxo, pero son muy abundantes en el cartílago, dermatansulfato es una sustancia muy relacionada con los condroitinsulfatos, queratansulfato se aísla de la córnea, del cartílago y del tejido óseo, heparansulfato se encuentra en la aorta, el hígado y los pulmones, heparina es producto de
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Los proteoglucanos están compuestos por AGA unidos forman covalente a proteínas centrales.
La mayoría de los AGA en el tejido conjuntivo están unidos a proteínas centrales para formar proteoglucanos. Los proteoglucanos están en la sustancia fundamental de todos los tejidos conjuntivos y también se hallan en la forma de molécula unidas a membranas en la superficie de muchos tipos celulares. El agrecano es un proteoglucano extracelular importante, sus moléculas están unidos de forma covalente a la molécula larga de hialuronano; esta unión es facilitada por las proteínas de enlace.
Las glucoproteinas adhesivas desempeñan un papel muy importante en la estabilización de la matriz extracelular y en su vinculación con las superficies celulares. Las glucoproteinas adhesivas son un grupo pequeño pero importante en la estabilización
de la MEC, regulan y modulan las funciones de la MEC relacionadas con el movimiento y con la migración de las células, y también estimula la proliferación y la diferenciación celular.
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Las principales tenemos: fifronectina la glucoproteina más abundante del tejido conjuntivo. Las fifronectinas son moléculas dimericas compuestas por dos péptidos semejantes unidos por enlace disulfuro en un extremo carboxiterminal para formar brazos. La fifronectina cumple una función importante en la adhesión de células a la MEC. Laminina que está en las láminas basales y en las láminas externas, posee sitios de unión para moléculas de colágeno tipo IV, heparansulfato, heparina, entactina, laminina y el receptor de laminina en la superficie celular. Tenascinas reaparece durante la curación de las heridas y también está en las uniones musculotendinosas y en los tumores malignos, participa en la adhesión de las células a la MEC. Osteonectina que está en la MEC del tejido óseo. La osteonectina desempeña un papel muy importante en el secuestro del calcio y en la promoción de la calcificación de la MEC.
2.2.
Fibras
Las fibras del tejido conjuntivo están presentes en cantidades variables, según las necesidades estructurales y la función del tejido en que se ubique. Cada tipo de fibra es producido por los fibroblastos y se compone compone de proteínas de cadenas cadenas peptídicas largas. largas. Los tipos de fibras son:
Fibras colágenas Fibras reticulares Fibras elásticas
Fibras colágenas Las fibras colágenas son de tipo más abundante de fibras de tejido conjuntivo. Son
flexibles y tienen una resistencia tensora notable. Con la microscopia electrónica de transmisión, las fibras colágenas aparecen como haces de subunidades filamentosas finas llamadas fibrillas colágena.
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Cada molécula de colágeno es una hélice triple compuesta por tres cadenas polipeptídicas entrelazadas. Cada tercer aminoácido de la cadena es una molécula de glicina, excepto en las cadenas α. Una hidroxiprolina o una hodroxilisina con frecuencia precede a cada glicina de la cadena; y una prolina a menudo sigue a cada glicina de la
cadena. Junto con la prolina y la hidroxiprolina, la glicina es indispensable para la conformación en hélice triple. En ocasiones con la hélice, hay grupos sacáridos que estan unidos a residuos hidroxilisilicos, es por estos grupos que el colágeno se clasifica con propiedad como como una glucoproteina. glucoproteina.
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Los seis principales de colágena TIPO UBICACIÓN I Tejido conjuntivo de la piel, huesos, tendones, ligamentos y cemento. II Cartílago (hialino y elástico), notocorda, y discos intervertebrales. III Fibras reticulares, tejido conjuntivo laxo, musculo liso y vasos sanguíneos. IV Lamina densa de la lámina basal, glomérulo renal y capsula de cristalino. V Distribución uniforme en toda la estroma del tejido conjuntivo, está relacionada con red reticular, placenta. VII Unión de la lámina basal con la lámina reticular, ojos, útero y esófago.
Fibras reticulares Las fibras reticulares proveen un armazón de sostén para los constituyentes celulares de diversos
reticulares es producido por un tipo celular especial la célula reticular.
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Fibras elásticas Las fibras elásticas permiten que los tejidos respondan al estiramiento y a la distención, las fibras estan entremezcladas con fibras colágeno para limitar la distendibilidad del tejido y para impedir el desgarro por el estiramiento exceso. Las propiedades elásticas de la molécula de elastina es consecuencia de su esqueleto polipeptico singular que causa el enrollamiento aleatorio, cuyos principales componentes aminoácidos son glisina y prolina. La elastina es rica en lisina, el aminoácido que tiene a su cargo la formación de los sumamente deformables residuos de desmosina que confiere gran elasticidad a las fibras. El material elástico es un componente extracelular importante en los ligamentos vertebrales, en la laringe y en las arterias elásticas, la elastina es sintetizada por los fibroblastos y por las células musculares lisas vasculares
.
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Macrófagos Adipocitos ( células adiposas) Mastocitos (células cebada)
La población celular transitoria, libre o errante consiste principalmente en células que han emigrado al tejido de la sangre en respuestas a estímulos específicos. Entre estas tenemos:
Linfocitos Plasmocitos (células plasmáticas) Neutrófilos Eusinofilos Basófilos Monocitos
3.1.
Fibroblastos y miofibroblastos miofibroblastos
Los fibroblastos es la célula principal del tejido conjuntivo.
Los fibroblastos tienen a su cargo la síntesis de las fibras colágenas, reticulares y elásticas y de los hidratos de carbono complejos de las sustancias fundamental. Las investigaciones indican que un solo fibroblasto es capaz de producir todos los componentes de la MEC. El fibroblasto requiere entonces el aspecto de una célula granular activa, ocupada en la síntesis y la secreción de componentes extracelulares. La estimulación también puede incluir la proliferación de los fibroblastos, con diversiones mitóticas mi tóticas y es mediada por el factor de crecimiento denominado FGF. Por lo general, los fibroblastos activos se relacionan de modo estrecho con haces de colágena, en los que se encuentra paralelos al eje largo de la l a fibra, los fibroblastos inactivos son más pequeños y más ovoides y poseen un citoplasma cito plasma acidofilo. El miofibroblasto tiene propiedades tanto de fibroblasto como de células musculares
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3.2.
Pericitos
Los pericitos rodean a las células endoteliales de capilares y vénula pequeña y resistente fuerzas de compresión porque posee una lámina basal propia.
Los pericitos son derivados de células mesenquimatosas indiferenciadas, estas células se encuentran fuera del
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3.3.
Macrófagos
Los macrófagos son células fagociticas derivadas de monocitos.
Los macrófagos del tejido conjuntivo, también conocidos como histiocitos, derivan de las células sanguíneas llamadas monocitos, y estos migran del torrente t orrente sanguíneo hacia el tejido conjuntivo, en donde se diferencian en macrófagos. Los macrófagos desempeñan un papel muy importante en el sistema que preparan las defensas del organismo contra partículas extrañas invasoras, en especial microorganismos. A medida que maduran los los macrófagos jóvenes, aumentan de tamaño y hay incremento de RER, complejo de Golgi, microtúbulos, lisosomas, microfilamentos y síntesis de proteínas.
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3.4.
Adipocitos
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3.5.
Mastocitos (células cebadas)
Los mastocitos se originan en la medula ósea y se diferencian en el tejido conjuntivo.
Los mastocitos son capaces de diferenciarse a macrófagos, por lo l o que se verán ambos tipos
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3.6.
Linfocitos
Los linfocitos participan principalmente en las respuestas inmunitarias.
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conjuntivos contienen muy escasos células plasmáticas, pero la cantidad se incrementa notablemente en las inflamaciones crónicas. Las células plasmáticas se forman por diferenciación de linfocitos B, que se activan en presencia de una reacción inmune y sintetizan y secretan anticuerpos.
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3.9.
Granulocitos neutrófilos
En condiciones normales, los granulocitos neutrófilos son muy escasos en el tejido conjuntivo, pero frente a una reacción inflamatoria se agregan en grandes cantidades, dado que migran hacia la zona inflamada a través de los capilares y vénulas. A demás estos tienen movilidad activa y gran capacidad fagocitica. Estos se caracterizan porque su depósito de gránulos prefabricados es muy grande y son las primeras células reclutadas en gran número por una zona inflamada, donde ayudan a los macrófagos resistentes en la fase inicial de la inflamación.
4. TEJIDO 4. TEJIDO CONJUNTIVO CONJUNTIVO PROPIO
El tejido conjuntivo se clasifica en varios tipos, sobre la base de la cantidad relativa de componentes extracelulares extracelulares de la matriz y de los distintos tipos celulares.
4.1.
Tejido conjuntivo laxo
El tejido conectivo laxo es rico en células y cede a la presión (fig. 8-27). Presenta rica irrigación e inervación tiene amplia distribución y no está bien especializada, dado que se le
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4.2.
Tejido conjuntivo denso denso
En el tejido conectivo denso predominan las fibras respecto de la cantidad de las células y de matriz a morfa.
4.2.1. Tejido conjuntivo denso denso irregular Aquí se encuentran grandes cantidades de fibras de colágeno agrupados en grandes haces (fig. 8-27) entretejidos en una red tridimensional (fig. (fi g. 8-28). Las fibras de colágeno son más gruesos aquí que en tejido conjuntivo laxo
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En su mayor parte los tendones estan compuestos por haces de fibras de colágeno densamente empaquetadas, dispuestas en paralelo con el sentido longitudinal. En consecuencia, los tendones oponen gran resistencia contra las fuerzas de tracción longitudinales, entre los haces de fibras de colágeno se ubican células con núcleo condensados condensados alargados (fig. 8-28c y 8-29).
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4.3.
Tejido conjuntivo elástico
Se compone de haces paralelos agrupados de fibras elásticas, los haces se mantienen unidos mediante tejido conjuntivo laxo en el que se encuentran fibroblastos comunes, se encuentran en ligamento cervical posterior, ligamento amarillo de la columna vertebral, las cuerdas vocales.
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4.4.
Tejido conjuntivo reticular reticular
Es un tipo especial de tejido conjuntivo dado que se cree que las células denominadas reticulares, son distintas a los fibroblastos comunes, el tejido conjuntivo reticular se encuentra en la medula ósea y el tejido linfoide, y está compuesta por una red de fibras reticulares (fig. 830).
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5. DISCUSIÓN DEL TEMA Durante el estudio estudio del tema pude observar diferentes estructuras de tejido, note
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8. ANEXOS
8.1.
ARTICULO POSTEADO
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9. RESUMENES DE LOS ARTICULOS POSTEADOS
TEMA: TEJIDO CONJUNTIVO PRESENTADO POR: Yulisa Maily TITO HUACHALLA GRUPO: 17 TITULO DEL ARTICULO: EL MASTOCITO: UNA CÉLULA MULTIFUNCIONAL AUTORES: Carlos Alberto Navia Amézquita, Jairo Alfonso Vásquez-López. LINK: http://facultadsalud.unicauca.edu.co/.../Mastocito.pdf RESUMEN POSTEADO: El mastocito es una célula multifuncional que generalmente los textos clásicos de Histología y Fisiología abordan de manera superficial y breve br eve para hacer énfasis solo a los procesos inflamatorios inflamatorios y alérgicos. Gracias a los avances avances de la biología biología molecular y la inmunohistoquimica,, se puede hoy en día comprender aún más la variedad de funciones de inmunohistoquimica esta célula. El mastocito está presente en funciones que benefician la homeostasis o los fenómenos patológicos, relacionándose relacionándose con enfermedades como la artritis reumatoide, esclerosis múltiple y el asma. La finalidad del presente artículo es realizar una revisión de las funciones del mastocito, con el objetivo de recordar su multifuncionalidad e importancia para el entendimiento de numerosos procesos fisiopatológicos. f isiopatológicos. RESUMEN DEL EXPOSITOR
Los avances en biología molecular, biotecnología, e inmunohistoquimica, han permitido el entendimiento de su función. El mastocito desempeña diversos procesos, que favorecen la homeostasis o generan fenómenos patológicos. Dentro del papel en la homeostasis se mencionan: actividad inmunomoduladora, reparación de tejidos lesionados, crecimiento piloso, remodelación ósea, además intervienen en inmunorreacciones enfocadas a destrucción de parásitos y bacteriaspor activación del complemento. El mastocito está presente en funciones que favorecen la homeostasis o los fenómenos patológicos, relacionándose relacionándose con con enfermedades enfermedades como la artritis reumatoide, reumatoide, esclerosis múltiple y el asma. Al estudiarse la multifuncionalidad del Mastocito, se demostró su participación en muchos procesos que que ayudan al mantenimiento mantenimiento de la salud salud o la aparición aparición de la
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TEMA: TEJIDO CONJUNTIVO PRESENTADO POR : Jhony Cari Mamani GRUPO: 14 TITULO DEL ARTICULO: Efecto Potencial de la Simvastatina en la Regeneración Tisular AUTOR: Carlos Martín Ardila Medina LINK: http://scielo.isciii.es/pdf/peri/v25n1/original1.pdf RESUMEN POSTEADO La simvastatina (SIM) es una lactona que se utilizan para disminuir el colesterol. Estudios in vitro y en animales han demostrado que induce la actividad osteoblástica y conduce a la formación ósea incrementando la expresión de la proteína morfogenética ósea-2. La SIM además de promover la formación ósea, suprime la síntesis de mevalonatos y pirofosfatos que a su vez inhiben la formación y actividad de los osteoclastos. La SIM es un potencial agente terapéutico para los pacientes con osteoporosis y puede facilitar el desarrollo de estrategias terapéuticas locales diseñadas para reparar anormalidades óseas como lesiones periodontales, lesiones periapicales, defectos del reborde alveolar y defectos óseos asociados a implantes. También se ha indicado como ingrediente activo para acelerar la diferenciación celular en la pulpa dental humana. Sin embargo, se requieren más ensayos clínicos controlados que corroboren los resultados obtenidos por las investigacione investigacioness realizadas en modelos animales de experimentación.
RESUMEN DEL EXPOSITOR
La simvastatina (SIM) es una lactona inactiva que después de administrarse oralmente se convierte en su forma activa por acción de enzimas intracelulares . Desafortunadamente, Desafortunadamente, menos del 5% de las dosis orales de SIM alcanzan la circulación sistémica , sin embargo, las células óseas se pueden exponer a muy bajas concentraciones de estatinas con las dosificaciones existentes . La SIM S IM es un potencial agente terapéutico para los pacientes pacientes con osteoporosis osteoporosis y puede puede facilitar el desarrollo desarrollo de estrategias terapéuticas locales diseñadas para reparar anormalidades óseas como lesiones periodontales, lesiones lesiones periapicales, periapicales, defectos del del reborde alveolar y defectos óseos óseos asociados a implantes. Los estudios in vitro e in vivo demuestran que la SIM promueve la
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TEMA: TEJIDO CONJUNTIVO PRESENTADO POR: KELY YUDAN MACHACA HUANCOLLO GRUPO : 20 TITULO: RESPUESTA FISIOLÓGICA DEL TEJIDO CONJUNTIVO DE MÚSCULOS Y TENDONES TRAS LA APLICACIÓN DE AGENTES FISICOS AUTORES: C. Pedraza Mejıas y J. Martı´nez Canadas LINK: http://www.elsevier.es/es-revista-fisioterapia-146...
RESUMEN POSTEADO: Los tejidos conjuntivos (TC) son un grupo diverso de tejidos cuyo denominador común es su origen a partir del mesenquima embrionario. Presenta grandes variaciones en las distintas regiones del organismo, por lo que se han utilizado diferentes diferentes denominaciones denominaciones para facilitar su descripción . Las Las fibras de colágeno están presentes en todos los tipos t ipos de TC. El colágeno fue considerado inicialmente como una proteína única cuya cuya secuencia secuencia de aminoácidos aminoácidos se había mantenido mantenido constante constante en el curso de de la evolución. Los histologos y anatomologos se encuentran con mayor frecuencia con los colágenos intersticiales intersticiales de tipo I, II y III, que forman fibras visibles con el microscopio óptico. Entre las fibras de colágeno mas abundantes se pueden distinguir unas fibras muy delgadas denominadas fibras elásticas, que presentan un diámetro pequeño y uniforme. Las fibras elásticas están constituidas por una masa amorfa central de elastina rodeada por la glucoproteına . Las células del TC son de dos categorías:
células fijas y células libres. Las células fijas constituyen una población relativamente estable de elementos celulares de ciclo vital largo, en la que se incluyen los fibroblastos, que secretan y mantienen los componentes extra celulares . Hay diversas variedades de TC formadas por los elementos básicos (las fibras, fibras, células y sustancia sustancia amorfa) ya ya descritos: picas de esta clasificación. clasificación. El TC laxo es el mas abundante y sostiene estructuras normalmente sometidas a presión y pequen˜os traumatismos. Contiene todos los elementos estructurales tı´picos. Este tejido es
de consistencia delicada, flexible y poco resistente a la traccio´n. RESUMEN DEL EXPOSITOR
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TEMA: TEJIDO CONJUNTIVO PRESENTADO POR: ANGHYELA ANANHY CHAIÑA LOPE GRUPO: 11 TITULO DEL ARTICULO: Efectos inmunomoduladores de la célula cebada LINK: http://www.medigraphic.com/pdfs/alergia/al-2009/al092b.pdf RESUMEN POSTEADO: La célula cebada además de sus funciones efectoras, posee efectos inmunomoduladores positivos y negativos. negativos. La comprensión comprensión de cómo cómo estas funciones funciones pueden ser inducidas o suprimidas abre nuevos campos de interés para el desarrollo en un futuro cercano de tratamientos específicos. La localización de los mastocitos es crucial para el desencadenamiento desencade namiento de síntomas en la enfermedad alérgica. Normalmente se les encuentra adyacentes a los vasos sanguíneos y linfáticos, donde al liberar sus sustancias causan causan una respuesta inmediata y facilitan la afluencia celular al órgano blanco. Las células cebadas juegan un importante importante papel en la inmunidad innata y adquirida. RESUMEN DEL EXPOSITOR Las células cebadas juegan un importante papel en la inmunidad innata y adquirida. Además de sus funciones efectoras, poseen propiedades inmunomoduladoras inmunomoduladoras con respuestas estimuladoras estimuladoras y supresoras, lo que hace que jueguen un papel no sólo en la homeostasis del ser humano, humano, sino en algunas algunas patologías. Los mastocitos se originan originan en médula ósea, circulan en forma inmadura y se s e diferencian en el órgano blanco,la célula cebada puede tanto aumentar, como suprimir algunas facetas de una misma respuesta inmunológica. La respuesta que ejercerá la célula cebada dependerá de las bases biológicas individuales. La comprensión de cómo estas funciones pueden ser inducidas o suprimidas abre nuevos campos de interés para el desarrollo en un futuro cercano de tratamientos tr atamientos específicos.
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TEMA: TEJIDO CONJUNTIVO PRESENTADO POR: Jhunior Luque Delgado TITULO DEL ARTICULO: PLASMA RICO EN PLAQUETAS: APLICACIONES EN CIRUGIA MAXILOFACIAL Y ESTETICA FACIAL. LINK: http://scielo.isciii.es/scielo.php?script=sci_arttext... RESUMEN POSTEADO Esta revisión presenta el uso del preparado de plasma rico en plaquetas (PRP) como una herramienta potenciadora de ciertas características histológicas de los tejidos conformados por células con receptores para los factores de crecimiento plaquetarios.
RESUMEN DEL EXPOSITOR
En el contexto de investigaciones investigaciones bioquímicas para contrarrestar los procesos celulares del envejecimiento, se empezó a estudiar y a utilizar el plasma rico en plaquetas (y rico a su vez en factores de crecimiento derivados de las plaquetas) por sus propiedades moduladoras y estimuladoras de la proliferación de las células derivadas de células madre de origen mesenquimal (fibroblastos, osteoblastos, células endoteliales, células epiteliales, adipoblastos, miocitos, y condrocitos, principalmente), y como un útil elemento auxiliar para mejorar la regeneración regeneración tisular. En esta revista se describen describen los fundamentos fundamentos biológicos del PRP PRP a nivel celular, celular, la técnica de obtención, obtención, y sus sus usos clínicos en en la actualidad. El grado de reacción inflamatoria dismi nuye significativamente cuando se an˜
ade plasma rico en plaquetas al tejido t ejido mesenquimal en proceso de curación. El PRP promueve la biointegración biointegración y la supervivencia supervivencia de las células mesenquimales mesenquimales sobre las que actúa.
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10.
REFERENCIAS BIBLIOGRAFICAS Y WEBGRAFIA
Texto Atlas de Histologia/ GARTNER/ 3ed. Histología/ GENESER, Finn/ Madrid: Medica Panamericana (1994) Histologia/ MICHAEL H. ROSS/ Buenos Aires: Medica Panamericana (2012)
http://emecolombia.foroactivo.com/t800-tejido-conectivo https://www.google.com.pe/search?biw=1350&bih=502&tbm=isch&q=MASTOCITOS&chips=q:ma stocitos,g_3:tejido%20conectivo&sa=X&ved=0ahUKEwjSy-q2jr3UA