Friability Tester

Friability Tester

Function : Tablet friability test apparatus are used for determination of durability of tablets at the time of production. The apparatus is designed to provide the precise value of rate of abrasion and impact hardness of the tablets. Friability is important since it affects in particle size distribution of granules affecting compressibility into tablet, tablet weight variation, granule flowability. Friability is determined carrying out Tumbler Test Test or using Friability Friabilit y Tester Tester ( Roche Friabilator ) and  loss is determined. !utput : " #yarat : The Friability of the sample is given in terms of  weight loss (loss in weight e$pressed as a percentage of the original sample weight). % ma$imum weight loss of not more than & is considered acceptable for most tablets. 'rocess : The sample (normally & tablets) to be tested is first weighed and then placed into the drum. The drum is then rotated & times, any loose dust from the sample removed and the sample re"weighed. The friability drum features apertures behind the baffle, such that the tablets can be added and removed from the drum automatically at the beginning and end of the test. (hris, *+ )

Vernier Callipers

Function : To determine thicness of the tablet !utput : " ondition : %ccuracy refers to the ma$imum error encountered when a particular observation is made.-rror in measurement is normally one"half the magnitude of the smallest scale reading.ecause one has to align one end of the rule or device to the starting point of the measurement, the appropriate error is thus twice that of the smallest scale reading.

'rocess : To obtain the main scale reading.To obtain the vernier scale reading, loo at the image above and loo closely for an alignment of the scale lines of the main scale and vernier  scale/n order to obtain the final measurement reading, we will add the main scale reading and vernier scale reading together. (#teven, *0) Tablet disintegration testers

Function : 1isintegration testing determines whether tablets or capsules disintegrate within a defined period of time when placed in a li2uid medium. 1r. #chleuniger 'harmatron disintegration testers as re2uired by current 'harmacopeia provide a reproducible and standardized method of ensuring that disintegration has taen place. /n automatic tablet

disintegration testing, the disintegration time including disintegration characteristics is recorded automatically. !utput : To monitor 2uality of different dosage forms and their performance through evaluating the time a formulation (tablet or capsule) taes to completely disintegrate. /f disintegration time is found too high, it is considered that the tablet is highly compressed or the capsule shell gelatin is not adhering to pharmacopoeial 2uality. This test is also done to chec consistency and uniformity of batches3 if any ind of inconsistency is found and the samples fail to provide ade2uate results, appropriate actions can be taen on the basis of these results. ondition :The disintegration test for each dosage form is given in the pharmacopoeia. There are some general tests for typical types of dosage forms. 4owever, the disintegration test  prescribed in the individual monograph of a product is to be followed. /f the monograph does not specify any specific test, the general test for the specific dosage form may be employed. 'rocess : % single tablet is placed in a small wire mesh baset attached to the bottom of the shaft connected to a variable speed motor. The baset is immersed in a dissolution medium (as specified in monograph) contained in a & ml flas. The flas is cylindrical with a hemispherical bottom. The flas is maintained at 50 6 .7 by a constant temperature bath. The motor is ad8usted to turn at the specified speed and sample of the fluid are withdrawn at intervals to determine the amount of drug in solutions (%lbert, **) 1aftar 'ustaa #teven. *0.  Manufacturing of Tablets https:99dir.indiamart.com  'harmaceutical ;achinery < -2uipment %lbert, ** Tablet ;aing ;achines, www.riddhipharma.net9tablet"maing"machine.html hris, *+, ommon ;achineries =sed in 'harmaceutical Tablet ;anufacturing www.medical"reference.net9*&&9>9common"machineries"used"in.html