Errata Pathoma

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Pag e Se c t i o n 13

IV.E.1

31

II. B. 2.

43

IV. B. 2.

Li ne

Co m m e n t

…phagocytosis is enhanced by opsonins

CORRECTION – C3b (and not C3a) is the opsonin.

(IgG and C3a)

Should read “(IgG and C3b)”

Symptoms Symptoms of skin bleeding include petechiae, ecchymoses (> 3mm), purpura (> 1 cm)…  Aminolevulinic  Aminolevulinic acid dehydrogenase dehydrogenase (ALAD) (ALAD) converts ALA to porphobilinogen

Dat e A d d e d 06/21/2011

CORRECTION – Ecchymoses are >1cm and purpura are > 3mm. Should read “…include petechiae, purpura

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(>3mm), and ecchymoses (>1cm)” TYPO – The enzyme is ALA dehydratase (not dehydrogenase).

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CLARIFICATION – More recent studies show that hemolysis occurs throughout the day. Hence, the color  change (hemoglobinemia) seen in the first void upon

49

I. B

Intravascular Intravascular hemolysis hemolysis occurs e pisodically, pisodically, often at night during sleep

awakening is mostly due to urine production and concentration of hemoglobin overnight overnight (as o pposed to

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hemolysis occurring mostly at night). Of note, my explanation explanation in the t ext remains remains partly true and is a n excellent way to remember the pathophysiology of this disorder. CLARIFICATION – Nitrates do result in coronary artery vasodilation. However, a more significant effect is

74

G. 3.

Nitrates – vasodilate coronary arteries

vasodilation of veins. This r esults in decreased venous

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return to the heart, which in turn, decreases preload and, hence, stress on the myocardium. Table 9.5, Squamous 96

cell carcinoma (under  characteristic

Kertain pearls or intracellular bridges

TYPO – “intracellular” should read “ inter cellular” cellular”

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histology) CORRECTION – The gastroduodenal gastroduodenal artery lies posterior 

105

VI. B. 3.

May rupture leading to bleeding from the

to the duodenum. Hence, rupture of a posterior (and not

gastroduodenal gastroduodenal artery (anterior ulcer) or 

anterior) ulcer would lead to bleeding from the GDA.

acute pancreatitis (posterior ulcer)

Should read “…gastroduodenal artery (posterior ulcer) or 

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acute pancreatitis (posterior ulcer).” CLARIFICATION – ‘Tram-track’ appearance can be seen 128

V. A.

Thick glomerular basement membranes on

in both type I and type II MPGN. However, it is more

H&E, often with ‘tram-track’ appearance

commonly seen with type I (USMLE examiners do ask

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about this!). CORRECTION – The crystals in gout exhibit exhibit negative 199

Fig. 18 18.9

Gout. A, A, To Tophi. B, B, Po Postive bi bi refri ngence.

birefringence (and not, positive birefringence). This is correct in the text, but needs to be corrected in the image caption.

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