PHAR3 LAB-Elixirs&Spirits.docx

ABHL|2DPH|PHAR3- Prelims Q3

ollo ollow wed

ELIXIR

addit dditon on o

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Hydr Hydroa oalc lcoh ohol olic ic or oral sol solut uton onss Clear, sweeened, and usually

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favored o improve ase Non-medicaed elixirs:

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vehicles Medi Medica caed Elixi lixirrs: Ha Hass A! A! Conains less su"ars han syrups-

used

ase Advana"e:

has

waer-solu%le

as

he volatle o elixir 8+ Admix Admixur ure e o 8 or more more li
ISO-ALCOHOLIC ELIXIR o

'

-

"lyc "lycol ol)) are are

o

added o manuacured elixirs rea rea solv solven en in er erms ms o o %ein %ein" " o a

o

.isadvan .isadvana" a"e: e: !ncreases !ncreases he o

sali salini niy y o he he as ase/ he he

vehicle: N12 34 NM2 564 alcoholic percena"e 0el 0el-p -pre rese serv rvin in": ": 764764-78 784 4

METHODS:

7+ 0!M1E 0!M1E 0912!9N 0912!9N ;!2H A!2A A!2A2!9N  0olues are simply dissolved in he he solv solven en, , and/ and/or or %y admi admix xur ure e o wo wo or more more li
alle"aton !n ma$in"/ ma$in"/pre prepar parin" in" he alcoho alcohol, l, =rs Add hi"h alcohol =rs o low alcohol

1ow Hi"h 0uia%le as vehicle or Alcohol Alcohol prep o he # solu%le Elixir Elixir sren"h ndilued None 6-764 5 volume 7 volume 76-864 ? volume 7 volume 86-?64 8 volume 7 volume ?6-564 7 volume 7 volume 56-364 7 volume 8 volume 36-@64 7 volume ? volume @6-64 None ndilued B64 o !n"rediens sed: Compound 9ran"e 0piri Alcohol lycerin 0ucrose 0accharin uri=ed ;aer

0yrup,

solu%iliy o he solue) 0ho 0hould uld hav have a lim limi wh when us used as as a

he

%y

ur%idiy in he soluton

ropylene lycol (help increase he

-

deermined

%eca %ecaus use e hi"h hi"h alco alcoho holl will will caus cause e

%i&er ase o he produc  Advana"e: has a wide ran"e

-

are

you add he non-alcoholic su%sance

vehicle

-

alcoholic sren"h+ >olume lumess need eed %y low low and hi"h i"h alcohols

comm common only ly

o solu%ilites Co-solvens: lycerine,

eneral vehicles or pharmaceutcal prepa prepara raton tonss re
is hydroalcoholic characer) Ad*u Ad*unc nctv tve e solv solven ens s (i+e (i+e++ "lyce "lyceri rine ne ' prop propyl ylen ene e

he spec speci= i=ed ed

concenraton  Hea is no used %ecause o 

alcohol-solu%le componens (since i -

su%s u%se
vehicle o a&ain he re
less e#ectve in mas$in" he %i&er -

%y

porton, ~1~

ABHL|2DPH|PHAR3- Prelims Q3

 1eaves are soa$ed in alcohol

TERPIN HYDRATE ORAL SOLUTION

o exrac he desired volatle o

Terpin Elixir, Terpin Hydrate Oral 

o

Soluon 5?4 o alcohol does he soluton

o o

conain se: expecoran !n"rediens: 2erpin Hydrae Alcohol 9ran"e peel tncure enDaldehydeused

su%sance ?+ CHEM!CA1 GEAC2!9N  Ex+ Ehyl Nirie 0piri 5+ .!02!11A2!9N  2a$es advana"e o

process o erme!"#$%! -B su"ar in he raw maerial is consumed as

yeas

a

o

he

meled

cereal

o

o

am%er %o&le Mehod se: 0imple 0oluton

o o

o 

"raer solu%iliy o he volatliy in"redien in alcohol raher in waer Actve in"redien: solid, li
Spiritus Auron Compositus Each 766 m1- N12 83 m1 ' NM2

?6 m1 o he mixed oils se: favourin" a"en !n"rediens sed: 9ran"e 9il 1emon 9il Coriander 9il Anise 9il Alcohol
spiris- usually @64 , due o he

-

o

COMPOUND ORAN+E SPIRIT

SPIRIT

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added

"rain

o

o aromatc or volatle maerial Clear, sauraed soluton Hi"h alcoholic concenraton

resultn"

ermened

7+ " o erpin hydrae

Also $nown as essences Alcoholic or hydroalcoholic solutons

he

ermened mashed o wholly

hic$enin" a"en 0yrup- (same w/ "lycerin) uri=ed ;aer Each 766 m1- N12 7+3? " NM2

-

%y

ormaton o alcohol  Ex+ Br#!&'- "rapes ()is*e'-

preservatve lycerin- humecan, co-solven,

o

he

o

oral ina$e reduces pun"en ase

PEPPERMINT SPIRIT METHODS

7+ 0!M1E 0912!9N  0olues are simply dissolved in he solven 8+ 0912!9N F MACEGA2!9N

~ 2~

o

Essence

of

Peppermint,

Spiritus

o o

Menthos Piperitas Medicaed 0piri se: Carminatve (or faulence),

o

nausea ' vomitn" Mehod se: 0oluton %y Maceraton

ABHL|2DPH|PHAR3- Prelims Q3

o

o

o o

Each 766 m1- N12 I+6 m1 ' NM2 77+6 m1 peppermin oil !n"rediens sed: eppermin 1eaves eppermin 9il Alcohol
AROMATIC AMMONIA SPIRIT o

Smelling Salts, Sal olale, Salt of 

o

hartshorn Hydroalcoholic

o

inended o %e inhaled Each 766 m1- N12 7+ " NM2 8+7 "

soluton

ha

is

oal NH? conen ' N12 ?+3 " NM2 o

o

o o

5+3 " (NH5)8C9? se: 0yncope (aintn"), o stmulae refexes !n"rediens sed: Ammonium icar%onae 0ron" Ammonia 0oluton 1emon 9il 1avender 9il Alcohol uri=ed ;aer
~ 3~