MCQs in Medical Microbiology

Series I-C Basic Medical Science Time:80mins

Model Paper

Microbiology

Author Email: [email protected] TotalMarks:100|PassMark:60

MEDICALMICROBIOLOGY Pleaseuseadarkpencil/pentocompl Pleaseuseadarkpencil/pentocompletethetest.Readtheinstruc etethetest.Readtheinstructionsatthe tionsatthe beginingcarefully.Thisisapracticetes beginingcarefully.ThisisapracticetestseriesinMedicalMic tseriesinMedicalMicrobiology. robiology. PleaseNote:ThereisaNegativeMarkingof(-1)foreachincorrectresponse. 1. Cas CaseSt eStud udy: y: A39-ye A39-yearar-oldm oldman anpre presen sents tswith withfe fever ver, ,fat fatigue, igue,he heada adache chean andb dblack lackdisc dischar harge ge fromhisnose.Onphysicalexamination,swellingisobservedinoneofhiseyes. Thepatientalsocomplaintsofpersistentheadachebehindtheaffectedeye.What couldbethemostprobablediagnosis? A Mucormycosis

C Coccidioidomycosis

B Blastomycosis

D Cryptococcosis

2. Considerthefo Considerthefollowingstatem llowingstatements entsabout aboutbact bacteria: eria: Statement1:MostbacteriahavessDNAbutlacksmitochondria Statement1: MostbacteriahavessDNAbutlacksmitochondria Statement2:Smallsubunitofribosomesarecomposedof16SrRNA Statement2:Smallsubunitofribosomesarecomposedof16SrRNA Statement3:Bacterialexoenzymesarepotenttoxinswhichcanaffecthumans Statement3:Bacterialexoenzymesarepotenttoxinswhichcanaffecthumans Whichofthestatementsgivenabovearecorrect? A 1,2,and3

C 2and3

B 1and3

D 1and2

3. Whichexot Whichexotoxinuse oxinusesam samechanism echanismsimilart similartodipht odiphtheriat heriatoxinto oxintoinhibitprot inhibitprotein ein synthesis? A tetanolysin

C thioredoxin

B toxinAofpseudomonas aeruginosa

D rImmunotoxinofP.pastoris

4. WaterChlorinat WaterChlorinationiseff ioniseffective ectiveagainst againstallofth allofthefollowingor efollowingorganism ganismsexc sexcept ept A Escherichiacoli

C Cryptosporidium

B Vibriocholerae

D Schistosomiasiscercariae

5. Apicomplexanpar Apicomplexanparasites asitesincludeallof includeallofthef thefollowingexcept ollowingexcept A Toxoplasmagondii

C plasmodiummalariae

B Cyclosporacayetensis

D Perkinsusmarinus

Basic Medical Sciences

-1-

Series I-C

Model Paper

Microbiology

6. Hypersensitivity Hypersensitivityvascu vasculitisisanexa litisisanexampleo mpleof f A Immunecomplexmediated reaction

Allergicreac eaction tion C Allergicr D antibody-dependent cell-mediatedcytotoxicity(ADCC)

B Tcellmediatedhypersensitivity reaction

7. Thetoxicgene Thetoxicgeneencod encodedinCor edinCornybact nybacterium eriumdiphth diphtheriae eriae A encodesapolypetidechainof 435aminoacids

D encodesapolypetidechainof 535aminoacids

B codesfortwosubunitsofthe polypetidechainknownasA-B toxin

E noneoftheabove

C codesfortwosubunitsofthe polypetidechainknownasC-D toxin 8. Caseousnecr Caseousnecrosisisse osisisseenm enmostlyinwh ostlyinwhichtyp ichtypeof eofCutane Cutaneoust oustubercu uberculosis(CTB)? losis(CTB)? A lupusvulgaris

C scrofuloderma

B Lichenscrofulosorum

D erythemanodosum

9. Granulom Granulomasar asarecollection ecollectionofallof ofallofthef thefollowingexcept ollowingexcept A Langhansgiantcell

D histiocytes

B tissuemacrophage

E Hofbauercell

C dendriticcell 10. Nottru Nottruea eabou boutG tGran ranulom ulomaing ainguinale uinale A diagnosisusuallymadebyFrie test

C characterizedbygentinalulcers

B causedbyCalymmatobacterium G.

D effectivetreatmentiswith amphotericinBandtetracycline

11. Whichoft Whichofthefo hefollowingfungus llowingfungusisacau isacausative sativeagent agentofs ofsubcut ubcutaneous aneousmy mycosis? cosis? A Histoplasmacapsulatum

C Cryptococcusneoformans

B Madurellamycetomatis

D Candidaalbicans

12. FungalmeningitisinAI FungalmeningitisinAIDSpatient DSpatientsiscau siscausedb sedby y A Exserohilumrostratum

C Cryptococcusneoformans

Aspergillusfu fumig migatu atus s B Aspergillus

D Coccidioidesimmitis


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Series I-C

Model Paper

Microbiology

13. Theconfirm Theconfirmatory atorytest testmo mosts stsensitivef ensitivefordiagn ordiagnosisof osisofcandidiasis candidiasis A complementfixation

D culturesofskinlesions

B sputumcultures

E quantitativeurineculture

C latexagglutinationtest 14. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsr tsregard egardingcoro ingcoronavirus navirusinfect infectionhas ionhasnogoo nogood d reasonstobeincorrect? A coronavirusinfectionsin humansmostlyconfinedtoURI

C incubationperiod5-8days D coronavirusinfectionsin humansmostlycause gastroenteritis

B coronavirusisthecausative agentofSARSoutbreak

15. Mostse Mostsensitivet nsitivetest estfor fordetec detectionof tionofrot rotaviruses avirusesinsto instoolspecim olspecimens ens A EIA

D cellculture(HEK)

B nucleicacidhybridization

E ELISA

C RNAgenotypingbyPCR 16. Atranspor Atransportm tmedium ediumfor forstr streptoc eptococcus occuspyoge pyogenes nes A CaryBlairmedium

D Pikesmedium

B Bilepeptonemedium

E Stuartmedium

C Glycerolsalinemedium 17. Whichoft Whichofthefo hefollowingisanenrich llowingisanenrichmen mentm tmedium? edium? A Loeffler’sserumslope

D chocolateagar

B BilepeptoneMedium

E Nutrientbroth

C MacConkeyAgarMedium 18. Acuteuncom Acuteuncomplicatedc plicatedcystitis ystitisisusuallyca isusuallycausedb usedby y A Proteus

D Enterobactor

B Staphylococcus

E E.coli

C alloftheabove 19. Bacteriuriaissignificant Bacteriuriaissignificantwhent whenthenum henumbero berofcolonies fcoloniesare aregreat greatert erthan han A 10-2CFU/mlofurine

C 10-5CFU/mlofurine

B 10-3CFU/mlofurine

D 10-7CFU/mlofurine


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Series I-C

Model Paper

Microbiology

20. Antibody-depende Antibody-dependentc ntcell-mediat ell-mediatedcy edcytoto totoxicity( xicity(ADCC)isac ADCC)isacomp omponent onentof of A innateimmunesystem

C adaptiveimmunesystem

B cellmediatedimmunesystem

D nonspecificimmunesystem

21. Mostco Mostcomm mmonclinicaltyp onclinicaltypeof eofre-inf re-infection ectioncutan cutaneoust eoustubercu uberculosisis losisis A scrofuloderma

D tuberculousverucossacutis

B lupusvulgaris

E lichenscrofulosorum

C papulonecrotic 22. Allofthefollowingtes Allofthefollowingtestsa tsareus reusedinlabor edinlaborator atorydiagnos ydiagnosisofh isofhydatidos ydatidosisexce isexcept: pt: A counterimmunoelectrophoresis

D electroimmunotransferblotassay

B indirecthaemagglutination

E indirectimmunofluorescence assay

C serumagglutinationtest

23. Acombinationo AcombinationofSer fSerum umagglutinat agglutinationtes iontestwithCo twithCoomb omb'stes 'stestisdiagn tisdiagnostico osticof f A Hydatosis

C QFever

B Cysticercosis

D Brucellosis

24. Themost Themostfreq frequent uentlaborat laboratory-a ory-acquired cquiredbact bacterialinfect erialinfection: ion: A Brucellosis

D QFever

B Coccidioidomycosis

E Neisseriameningitidis

C Tularemia 25. TypeIIhyp TypeIIhypersen ersensitivityr sitivityreact eactionisasso ionisassociated ciatedwith with A Henoch-Schönleinpurpura

C Goodpasture'ssyndrome

B Systemiclupuserythematosus

D Hemolyticdiseaseofthenewborn

26. Mitsudare Mitsudareaction actionisseen isseeninwhichfor inwhichformo moflepro fleprosy? sy? A lepromatousform

C Both

B tuberculoidform

D None

27. Whichoft Whichofthefo hefollowingorganism llowingorganismsist sisthelarges helargestintes tintestinalpara tinalparasiteof siteofhum humans? ans? A Entamoebahartmanni

D Balantidiumcoli

B Entamoebahistolytica

E Escherichiacoli

C Entamoebacoli


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Series I-C

Model Paper

Microbiology

28. Tickborndiseas Tickborndiseases/illnesses es/illnessesincludeallof includeallofthef thefollowingexcept ollowingexcept:: A Tularemia

C Lymedisease

B Relapsingfever

D Denguehemorrhagicfever

29. Followingstateme Followingstatementsa ntsabout boutrota rotavirush virushasno asnogoodr goodreasons easonsto tobecor becorrect rect A RotavirusAcauses gastroenteritis>90%inhumans

D double-strandedRNAvirus E causativeagentof"stomachflu"

B RotavirusDcauses gastroenteritis>90%inhumans C single-strandedRNAvirus

30. Hydatidcyst Hydatidcystiscaus iscausedby edbythelar thelarvalfor valformo mofwhicho fwhichoft fthefo hefollowingorganism llowingorganism? ? A Taeniasolium

D Hymenolepsisnana

B Echinococcus

E Toxocaracanis

C Diphyllobothriumlatum 31. Organism Organismtha thatcau tcausesa sesamoe moebicdyse bicdysenter nteryinhum yinhumans ans A Entamoebacoli

C Entamoebahistolytica

B Balantidiumcoli

D Entamoebadispar

32. Whichorgan Whichorganismc ismconstit onstitutes utesabout about30% 30%ofa ofallgutflor llgutflora(m a(microflora icrofloraof oftheg thegut)? ut)? A Bacteroides

D Esch.coli

B Clostridium

E Lactobacillus

C Peptococcus 33. Thevirusthat Thevirusthatcaus causesM esMolluscum olluscumcont contagiosum agiosumbelongs belongstowh towhichfam ichfamily? ily? A Picornaviridae

C Parvoviridae

B Poxviridae

D Orthomyxoviridae

34. Whichoft Whichofthefo hefollowingisaoncog llowingisaoncogenicRNAvirus enicRNAvirus? ? A Papillomaviruses

C Polyomavirus

B HumanTcellleukemiavirus

D Cytomegalovirus


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Series I-C

Model Paper

Microbiology

35. Pickthemo Pickthemosta stappropr ppropriatest iatestatem atementa entabout boutpneum pneumocyst ocystiscarinii iscarinii A P.cariniicanbeculturedinvitro

C laboratorydiagnosisisby microscopyorPCRonly

B occursalmostexclusivelyin immunocompromisedhosts

D itisprotozoaninfectionconfined onlytolungs

36. Immun Immunoglobulinwithaleas oglobulinwithaleastcon tcontent tent(lowest (lowest%) %)of ofcarboh carbohydrat ydratee A IgE

C IgD

B IgM

D IgG

37. InTypeI InTypeIhyper hypersensitivity sensitivity,t ,theant heantibodyis ibodyis A IgA

C IgG

B IgE

D IgM

38. Organism Organismwhichisa whichisacausat causativeagen iveagentof tofSanJ SanJoaquinf oaquinfever ever A Coccidioidesimmitis

C Rickettsiarickettsii

B Cryptococcusneoformans

D Coxiellaburnetii

39. RegardingRabiesinfec RegardingRabiesinfection, tion,pickth picktheincorr eincorrect ectstat statem ements: ents: A rabiesvirusreplicatesatthesite ofbitewound

C FAstainingisusefulfor diagnosisofrabies

B non-envelopeddoublestranded DNAgenome

D envelopedsinglestrandedRNA genome

40. Softc Softchanc hancre reisc iscaus aused edby by A Chlamydiatrachomatis

C Haemophilusducreyi

B Mycoplasmagenitalium

D Humanpapillomavirus(HPV)

41. Thecausative Thecausativeagent agentof ofFifthd Fifthdisease( isease(Eryt Erythem hemainfect ainfectiosum) iosum) A Humanherpesvirus7

C Humanpapillomavirus

B Humanherpesvirus6

D HumanparvovirusB19

42. Thecausative Thecausativeagent agentof ofprogr progressivem essivemultifocalleuk ultifocalleukoencep oencephalopath halopathy y A polyomavirus

C papillomavirus

B BKvirus

D parvovirus

43. Thenaturaldef Thenaturaldefinitivehost initivehostfor forGn Gnathos athostom tomaspinigeru aspinigerumis mis A human

C dog

B cyclops

D fish


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Series I-C

Model Paper

Microbiology

44. Causat Causativea iveagen gento tof fScr Scrub ubtyp typhus husis is A Rickettsiatyphi

C Orientiatsutsugamushi

B Rickettsiaprowazeki

D Borreliaburgdorferi

45. Whichtype Whichtypeofh ofhuma umanpapilloma npapillomavirus( virus(HPV)isclass HPV)isclassifiedaslow-r ifiedaslow-riskm iskmucosa ucosaltype ltype HPV? A type6,11,40

D type16and18

B type6,16,18

E noneoftheabove

C type30,31,22 46. Swimmin Swimmingp gpoolg oolgran ranulom ulomais aiscau caused sedby by A Mycobacteriumfortuitum

C Mycobacteriumulcerans

B Mycobacteriumchelonei

D Mycobacteriumabscessus

47. Whichoft Whichofthefo hefollowingmicroor llowingmicroorganism ganismsbelong sbelongsto stoAscom Ascomycet ycetes? es? A Trichophyton

C C.neoformans

B Rhizopus

Absidia D Absidia

48. Ringworminfect Ringworminfectionoft ionofthesc hescalpandh alpandhair: air: A Tineaunguium

C Tineacorporis

B Tineacapitis

D Tineapedis

49. Massof Massofimm immunoglobulinD( unoglobulinD(IgD)h IgD)heavy eavychain chain A 65kDa

C 70kDa

B 56kDa

D 72kDa

50. Whichoft Whichofthefo hefollowingconditionsis llowingconditionsisares aresultof ultofType TypeIVhyp IVhypersen ersensitivityr sitivityreact eaction? ion? A Crohn'sdisease

C Graves'disease

B Behçet'sdisease

D Myastheniagravis

51. Thecorrect Thecorrectfor formula mulaofim ofimmun munoglobulinM oglobulinM(Ig (IgM) M)isotype isotypeJch Jchain ain A 5[2μ+2kor2λ]+J B 5[2μd+2kor2λ]+J

C 2[2α1+2kor2λ]+J D 2[2α2+2kor2λ]+J

52. Whichoft Whichofthefo hefollowingimmun llowingimmunoglobulinant oglobulinantibodiesdon ibodiesdonotf otfixcom ixcomplemen plement? t? A IgG

C sIgA

B IgD

D IgM


-7-

Series I-C

Model Paper

Microbiology

53. Thecausative Thecausativeagent agentof ofJapane JapaneseLun seLungfluke gfluke A Clonorchissinensis

C Paragonimuswestermani

B Fasciolopsisbuski

D Leucochloridiumparadoxum

54. Anexampleof AnexampleofTypeI TypeIIIh IIhypers ypersensitivity ensitivityreact reaction(imm ion(immuner unerespons esponse): e): A transplantrejection

C anaphylaxis

B serumsickness

D Multiplesclerosis

55. Whichoft Whichofthefo hefollowingisnotan llowingisnotaninfect infectiontra iontransm nsmitted ittedtom tomanby anbytickb tickbites? ites? A RockyMountainSpottedfever

C Babesiosis

B Relapsingfever

D Qfever

56. Thecausative Thecausativeagent agentof ofRocky RockyMou MountainSpo ntainSpotted ttedfev fever er A R.rickettsii

D R.prowazekii

B Ehrlichiachaffeensis

E R.typhi

C Coxiellaburnetti 57. Whichoft Whichofthefo hefollowingorganism llowingorganismisres isresponsiblef ponsibleforca orcausingQ usingQfev fever? er? A Rickettsiarickettsii

C Coxiellaburnetii

B Borreliaburgdorferi

Amblyomm mmaa aame merica ricanum num D Amblyo

58. Followingsymptom Followingsymptomisnot isnotchar characte acteristicof risticofReiter's Reiter'ssyndr syndrome ome:: A urethritis

C oligoarthritis

B orchitis

D conjunctivitis

59. Case CaseS Stu tudy dy: : A31yr A31yrold oldma malep lepres resent entswit swithc hcom omplaint plaintso sof fpor porridg ridge-lik e-liked ediarr iarrhea hea,a ,abdo bdomin minal al pain,fever,andweightloss.Onbeingexamined,thestoolisfoulsmellingand containsexcessfat,butdoesnotcontainanyblood.Whatisthemostprobable diagnosis? A Crohn'sdisease

Amoebicd icdyse ysente ntery ry C Amoeb

B Ulcerativecolitis

D Campylobacteriosis

60. Chikungunyavirus Chikungunyavirusbelongst belongstowhichv owhichviralfam iralfamily? ily? A Bunyaviridae

C Coronaviridae

B Flaviviridae

D Togaviridae


-8-

Series I-C

Model Paper

Microbiology

61. Case CaseS Stu tudy dy: : A16-ye A16-yearar-oldb oldboy oypre presen sents tswith withhigh highf feve everf rfor orthe thepa past stfou fourd rdays ays,b ,besid esides essor sore e throat,malaise,andwithinflamedeyesbutnodischargeofpus.Onphysical examination,lymphnodesofhisneckarefoundtobeslightlyenlarged.Hehasa H/Oofavisittoasummercam H/Oofavisittoasum mercampthepreviousweek.Whatcouldbethem pthepreviousweek.Whatcouldbethemost ost probablediagnosis? A Pharyngoconjunctivalfever

C Epidemickeratoconjunctivitis

B Stevens-Johnsonsyndrome

D Springcatarrh

62. Whichoft Whichofthefo hefollowingagentis llowingagentisasec asecondary ondaryvect vectorof orofdengu denguevirus evirus? ? Aedespolyn olynesien esiensis sis A Aedesp

Aedesalbopic lbopictus tus C Aedesa

Anophelesga gamb mbiae iae B Anopheles

Aedisegypt yptii D Aediseg

63. Interleukinth Interleukinthata ataugm ugments entsthec thecytot ytotoxicf oxicfunction unctionofNKc ofNKcells ells A interleukin-12

C interleukin-13

B interleukin-17

D interleukin-15

64. Case CaseS Stu tudy dy:: A54-ye A54-yearar-oldm oldman ancom complaint plaintso sofc fcoug ough, h,m mediastina ediastinalpain lpain, ,and andsh short ortnes nesso sof f breadthwhenbreathingin.HeisachronicsmokerandhasaH/Oofchronic alcoholconsumption.Physicalexaminationofthepatientotherwisedonotreveal much,exceptforfewredskinbumpsonhislowerrightleg.Whatcouldbethe possiblediagnosis? A Tuberculosis

C Sporotrichosis

B Coccidioidomycosis

D Histoplasmosis

65. Whichoft Whichofthefo hefollowingimmun llowingimmunoglobulinsis/a oglobulinsis/areus reusedto edtodete detecto ctordiagnos rdiagnosedeng edengue ue virusinfectionusingELISA? A IgM

C IgA

B IgD

D IgG

66. Matcht Matchthefo hefollowingwiththeirc llowingwiththeircorre orrectc ctchoices: hoices: A.

Dengue Dengueviru virus s

A. Picornav Picornavirus irus

B.

Hepatitis A virus

B. dsDNA-RT

C.

Hepatitis B virus

C. Flaviviridae

D.

Hepatitis C virus

D. Coronavirus

E.

SARS

E. +ssRNA


-9-

Series I-C

Model Paper

Microbiology

67. Mostco Mostcomm mmoncau oncauseof seofacut acuteviralhe eviralhepatitisinI patitisinIndiaisdue ndiaisdueto: to: A HepatitisAvirus(HAV)

C HepatitisCvirus(HCV)

B HepatitisBvirus(HBV)

D HepatitisEvirus(HEV)

68. Allofthefollowingfea Allofthefollowingfeature turesare sarechar character acteristicsof isticsofHIVinfe HIVinfectione ctionexcept xcept:: A maculopapularrash

C lymphocytosis

B fever

D inversionofCD4 +Tcells:CD8 + Tcellsratio

69. Lymphocy Lymphocytopenia topeniaoccur occursinallof sinallofthef thefollowingconditions ollowingconditionsexcep except: t: A Typhoid

C Systemiclupuserythematosis

B hepatitis

D Rheumatoidarthritis

70. Causesofr Causesofrelativelym elativelymphocy phocytosisinc tosisincludesallof ludesallofthef thefollowingexcept ollowingexcept:: A thyrotoxicosis

Addison'sdis diseas ease e C Addison's

B toxoplasmosis

D acuteviralinfections

71. Majorcom Majorcomponent ponentoft oftheimm heimmunesy unesystem steminDroso inDrosophilame philamelanogast lanogaster: er: A plasmatocyte

C plasmacyte

B hemocyte

D plasmalogen

72. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsab tsaboutG outGiardialamb iardialambliais/areinc liais/areincorrec orrect? t? A colonizesthelargeintestine

C lacksmitochondria

B cystsresistanttochlorination

D lacksmicrotubules

73. Whichoft Whichofthefo hefollowingInter llowingInterleukinsisa leukinsisamed mediatoro iatorofinflam finflammat mation? ion? A IL-2

C IL-6

B IL-1

D IL-4

74. Pjeroviciiisthecaus Pjeroviciiisthecausativeag ativeagento entofpn fpneum eumocyst ocystispneum ispneumoniainhum oniainhumans. ans.Which Which ofthefollowingstatementsregardingP.jeroviciidoyouthinkisincorrect? A occursinHIVpatientswhenCD4 count<200cells/microliter B identifiedbyhematoxylinand eosinstainedlungtissue


- 10 -

C cannotbegrowninculture D isanintracellularfungalparasite

Series I-C

Model Paper

Microbiology

75. Cryptosporidiosis: Cryptosporidiosis:Pickth Picktheincorr eincorrect ectstat stateme ements nts A incubationperiod5-12days

C self-limitinginhealthyindividuals

B itraconazoleisaneffective treatment

D isazoonoticinfection

76. Primaryvec Primaryvector torfor forbubonicp bubonicplagueis lagueis A Nosopsyllusfasciatus

C Spilopsylluscuniculi

B Dasypsyllusgallinulae

D Xenopsyllacheopsis

77. Nottru Nottruea eabou boutI tInte nterf rfero eron-α n-α A producedbymonocytes

C usedtotreathepatitisB

B formationinhibitedby interleukin-10

D activatedbyinterleukin-12

78. StagesofPlas StagesofPlasmod modiumlifecy iumlifecyclethat clethatdoes doesnot notoccur occurinhum inhumans ans A formationofmerozoites

C formationofzygotes

B latenthypnozoitesstage

D erythrocyticschizogony

79. Apatientwithca Apatientwithcancer nceronche onchemot motherap herapyhas yhasaplatelet aplateletcount countof4 of46,000 6,000per per microliter.Whichofthefollowingagentsdoyouthinkisthebesttotreat thrombocytopenia? A lithiumcarbonate

C interleukin-2

B interleukin-4

D interleukin-11

80. Case CaseS Stu tudy dy:: A45-ye A45-yearar-oldm oldmale alepat patient ientpr prese esents ntswit withf hfeve ever, r,co cough ugh, ,art arthra hralgia, lgia,and andper persist sistent ent weightlossattheoutpatientdepartment.Onphysicalexamination,hecomplains ofpleuriticchestpainandnightsweats.Whatcouldbethemostprobable diagnosis? A Histoplamosis

C Blastomycosis

B Sporotrichosis

D Tuberculosis

81. Arrangethe Arrangetheitem itemsinth sintheircor eircorrect rectorder orderof ofevent events/se s/sequence quencerega regardingplasm rdingplasmodium odium parasite: A.

meroz merozoite oites s

B.

zygotes

C.

trophozoites

D.

schizonts

E.

sporozoites


- 11 -

Series I-C

Model Paper

Microbiology

82. Allofthefollowingagen Allofthefollowingagentsar tsarem emycot ycoticmy icmytot toticinhibitorse icinhibitorsexcept xcept:: A neoxaline

C aurantiamine

B griseofulvin

D colchicine

83. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsab tsaboutt outthem hemechanism echanismof ofaction actionofAm ofAmphote photericin ricin Biscorrect? A interferewithpeptidechain synthesis

C inhibitorofcellmembrane function

B inhibitofnucleicacidsynthesis

D inhibitcellwallsynthesis

84. Anacuteadve Anacuteadverse rsereact reactionchar ioncharacter acterizedby izedby"shake "shakeandba andbake"ef ke"effect fectm maysee ayseen n withtheuseof A quinine

C penicillin

B amphotericinB

D amoxicillin

85. Whichoft Whichofthefo hefollowingisa"rest llowingisa"restingspor ingspore"off e"offungi? ungi? A chlamydospore

C ascospore

B zygospore

D basidiospore

86. Granulom Granulomaswithn aswithnume umerous rouseosinophilss eosinophilssuggest uggests s A blastomycosis

D granulomatosiswithpolyangitis

B coccidioidomycosis

E cat-scratchdisease

C aspirationpneumonia 87. Fungusthat Fungusthatfor formb mblastosp lastospores: ores: A saccharomycescerevisiae

C candidaalbicans

B cryptococcusneoformans

D pneumocystisjirovecci

88. Anexam Anexampleo pleof fase asexua xualsp lspore ore:: A ascospores

C chlamydospores

B sporangiospores

D basidiospores

89. Whatdiff Whatdifferent erentiatesf iatesfungifr ungifrom omslimem slimemolds? olds? A sporeformation

C movement

B plasmodium

D presenceofmitochondria


- 12 -

Series I-C

Model Paper

Microbiology

90. Antibioticscanbe Antibioticscanbeextr extracted actedfro from mallofthe allofthefollowingorg followingorganism anismsexc sexcept: ept: A Fuligoseptica

C Ganodermalucidum

Aspergilluste terr rreus eus B Aspergillus

D Penicilliumpatulum

91. Statemen Statementwhichis twhichisnott nottruea rueabout boutproka prokaryot ryoticribosom icribosomes: es: A 70Sribosomesedimentfaster than80Sribosome

C sedimentationcoefficientoflarge subunitis30S

B smallsubunitcontains20 proteins

D hasamassofabout2.5MDa

92. Considerthefo Considerthefollowingstatem llowingstatements entsabout aboutinterf interferon: eron: Statement1:interferonsactivateNKcellsandmacrophages Statement1:interferonsactivateNKcellsandmacrophages Statement2:interferonsactasantigenpresentingcells Statement2: interferonsactasantigenpresentingcells Statement3:interferon-β1aisusedtotreatmultiplesclerosis Statement3: interferon-β1aisusedtotreatmultiplesclerosis Whichofthestatementsgivenabovearecorrect? A 1and2

C 1and3

B 2and3

D 1,2,and3

93. Regardinggenet Regardinggeneticreass icreassortm ortmentinv entinviruses, iruses,pickt pickthecor hecorrect rectsta statem tement( ent(s): s): A reassortmentacceleratestherate ofmutationsininfluenzavirus

C reassortmentoccursbetween twoinfluenzavirusspeciesA&B

B occursexclusivelyinsegmented RNAvirus

D reassortmentoccursthrough templateswitchmechanism

94. Thevector Thevectorwhichact whichactsinm sinmechanica echanicaltrans ltransmission missionofJa ofJapanese paneseence encephalitisvirus phalitisvirus A Culextitraeniorhynchus

Aedesvexa exans ns C Aedesv

Aedesaegy egypti pti B Aedesa

D Culexvishnui

95. Matcht Matchthefo hefollowingcausative llowingcausativeorga organisms nismswithth withthediseas ediseasethe etheycau ycause: se: A.

Arena Arenaviru virus s

A. Epizoot Epizootiche ichemo morr rrhagic hagicdis diseas ease e

B.

Bunyaviridae

B. Aseptic meningitis

C.

Hantavirus

C. Acute hemorrhagic gastroenteritis

D.

Nairovirus

D. Crimean-Congo hemorrhagic fever

E.

Orbivirus

E. Hemorrhagic fever with renal syndrome


- 13 -

Series I-C

Model Paper

Microbiology

96. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsr tsregard egardingNatur ingNaturalkillercells(NKce alkillercells(NKcells)and lls)and CytotoxicTlymphocytes(CTL)aptlydistinguishtheformerwiththelatter? A NKcellscanactinabsenceof triggerresponsefromMHC

C CTLexpressesCD8whichbinds toclassIMHCcomplex

B NKcellsareactivatedbyclassI restrictedantigens

D NKcellsareabletoproduce IFN-αandIL-4

97. Nottrueab Nottrueaboutt outthelysoge helysogeniccyc niccycleandlyt leandlyticcycleo iccycleofBac fBacterioph teriophage: age: A lysogeniccycleisavirulentor temperate

C inlysogeniccycle,viralgenome getsintegratedwithhostDNA

B lyticcycleischaracterizedby formationofprophage

D Inlyticcycle,phageDNA integratesintohostDNA

98. Matcht Matchthefo hefollowingitems llowingitemswiththe withtheircorr ircorrecta ectalternat lternatives: ives: A.

Woron Woroninbo inbody dy

A. Candida Candidaalbica albicans ns

B.

Aflatoxin B1

B. Histoplas Histoplasma maca capsu psulatu latum m

C.

Ergot alkaloids

C. Aspergillus flavus

D.

Yeast

D. As Aspergillus fumigatus

E.

Dimorphic fungi

E. Claviceps purpurea

99. Whichoneof Whichoneofthe thefollowingisnot followingisnotanon anoncogenic cogenicvirus? virus? A hepatitisCvirus

D Epstein-Barrvirus

B adenovirus

E HHV8

C HPV 100. Abasetriplet Abasetripletof3'of3'-TAC-5'inan TAC-5'inantisense tisenseDNAstr DNAstrandm andmostlikelyis: ostlikelyis: A 3'-UAG-5'basetripletinmRNA

C astartacodonmethionine

B 5'-AUG-3'basetripletinmRNA

D astopcodoninmRNA


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MCQs in Medical Microbiology

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