Doenças Da Tireóide

I - Assunto: BIOQUÍMICA : DOENÇAS DA TIREÓIDE

II - Experimento:

III - Objetivo:

IV - Tempo previsto:

V - Materiais, equipamentos e reagentes : MATERIAL MATERIAL NESCESSÁRIO PARA AS AS EXPERIÊNCIAS 

VI - Metodologia TEÓI!A: " - #OM$%IO& 'A TIÓI'E:  A Tireóide Tireóide é u! "#$%du#! e%dó&ri%! e%dó&ri%! 'r(du)(r! de * +(r,%i(+(r,%i(- d( )i'( !i%!: ./ Tri0 Tri0i(d i(d() ()ir ir(%i (%i%! %! (u T1 */ Tir(2i% (2i%! ! (u (u T3 T3 S4( !5(- +(r,%i(- de !64( ui)( 7!ri!d!8 de%)re !- 9u!i- !- !i- e7ide%)e- -4(:  Aue%)!r ( &(%-u( de (2i"%i( 'e#! &é#u#!8 &( !ue%)( d! 'r(du64( de &!#(r Pr(7!7e#e%)e !ue%)!r ! -;%)e-e d( ATP ATP E-)iu#!r ! -;%)e-e de RNA e ! 5i(--;%)e-e 'r()éi&! < E%=i!- d! C!dei! >#i&(#;)i&!8 '/ e2/ O re-u#)!d( é u u  !ue%)( d( METABOLISMO BASAL d( (r"!%i-(/ A--i e-)e- +(r,%i(- -4( &(%-ider!d(- re"u#!d(re- de-)e e)!5(#i-(/ Bi(--;%)e-e:  A 5i(--;%)e-e 5i(--;%)e-e d( T1 e d( T3 de'e%de d! &!')!64( de IODO IODO 'e#!- &é#u#!- d! "#$%du#!8 e d! d! !64( d! TIREO>LOBULINA8 ! 'r()e;%!04e de !5(- (- +(r,%i(-/ O I(d( é &!')!d( e (r"!%i?i&!d( 'e#! &é#u#!/ A e%=i! e%=i! &+!7e de )(d( ( 'r(&e--( é ! IODO0PEROXIDASE8 9ue: O2id! ( i(de)( ! i(d( @!= ! i(di=!64( d( !%e# d(- re-;du(- de )ir(-i%! d! )ire("#(5u#i%! C!)!#i-! ! #i"!64( de * !%éi- i(d!d(-/ N( #u"!r d( d(!d(r de )ir(-i# -ur"e u re-;du( de -eri%!/ • • •

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 Ar!=e%!e%)(:  A )ir("#(5u#i%! é !r!=e%!d! %( #e% d( ?(#;&u#( ?(#;&u#( )ire(idi!%(8 &(%)e%d( re-;du(- de )ir(-i%! e de T1/ N! %e&e--id!de de #i5er!64( d(- +(r,%i(-8 ! )ire("#(5u#i%! e%)r! %! &é#u#! e é &i%did! '(r 'r()e!-e-8 #i5er!%d( re-;du(- de T1 e 'ri%&i'!#e%)e T3/ Cer&! de   d( T1 é 'r(du=id( %(- )e&id(- 'eri?éri&(- ! '!r)ir d( T3/

Re"u#!64(: * +(r,%i(-: ! TRF: Ou T+Gr()r('+G%0Re#e!-i%"0F(r(%e < Fi'()!#$i&(H !)u! -(5re ! +i'ó?i-e re"u#!%d( ! #i5er!64( d( TSF/ 5 TSF: Ou T+Gre(id0S)iu#!)i%"0F(r(%e8 Tire()r(?i%! (u !i%d! Tire()r('i%! < Fi'(?i-ri(8 !)u! -(5re ! Tireóide re"u#!%d( ! #i5er!64( de T1 e T38 '(r e-);u#( d! -!;d! d! )ire("#(5u#i%! d( ?(#;&u#( e e%)r!d! d! e-! %! &é#u#!/ T(d( ( 'r(&e--( é 5!-e!d( %( e&!%i-( de J@eed0B!&KJ/ Tr!%-'(r)e: 8  d( T1 e d( T3 -éri&(- e-)4( #i"!d(- ! 'r()e;%!- )r!%-'(r)!d(r!-: ! TB>: T+Gr(2G%0Bi%di%"0>#(5u#i%e 0   5 A#5ui%! e Pré0A#5ui%! 0 1  A TB> é u! 'r()e;%! 9ue )e -u! &(%&e%)r!64( -éri&! !r&!d!e%)e i%?#ue%&i!d! '(r di7er-(- ?!)(re-8 &(( ! 're-e%6! de e-)ró"e%(-8 '(r e2e'#(/ De"r!d!64(:  A )ir(2i%! )e u! .* 7id! de  di!-H ! )ri0i(d()ir(%i%! )e  7id! de !'e%!- . di!8 'r(7!7e#e%)e '(r e%(r !?i%id!de de #i"!64( &( ! TB>/ O 'r(&e--( de 5i()r!%-?(r!64( e%7(#7e !- e)!'!- de &(%u"!64(8 de-!i%!64( de-&!r5(2i#!64( e dei(di=!64( ! RT1  T1 re7er-(8 i%!)i7(/ (- #I)E*+%O 'A TIEÓI'E: * @(r!- 'ri%&i'!i-: ! Fi'er?u%64( Di?u-! (u D(e%6! de B!-ed(0>r!7e-H 5 Ade%(!- Tó2i&(- de Tireóide/ ./ D(e%6! de B!-ed(0>r!7e-: D(e%6! !u)(0iu%e &!u-!d! 'e#! 're-e%6! d( LATS8 (u JL(%" A&)i%" T+Gr(id S)iu#!)(rJ u !%)i&(r'( &( e-'e&i?i&id!de '!r! re&e')(re- d( TSF %( )e&id( )ire(idi!%(/ Qu!dr( C#;%i&( < Fi'ere2&i)!5i#id!de8 )!9ui&!rdi!8 'erd! de 'e-( e8 %(- &!-(- !i- "r!7e-8 e2(?)!#i!/ S4( &(%-e9%&i!- d( !ue%)( e2!"er!d( d( e)!5(#i-( 5!-!# d( '!&ie%)e/ ./ Ade%(! Tó2i&(: Pe9ue%!- re!- +i'er!)i7!- d! "#$%du#!8 )!5é &+!!d(- de J%ódu#(- 9ue%)e-J/ @u%&i(%! de ?(r! i%de'e%de%)e !( &(%)r(#e d! +i'ó?i-e/ Qu!dr( C#;%i&( < O e-( (5-er7!d( '!r! J!J8 e%(- !&e%)u!d( e -e e2(?)!#i!/ Tr!)!e%)( < Cirr"i&( (u &( d(-e )er!'u)i&! de I(d( r!di(!)i7(/ . - #I)O*+%O 'A TIEÓI'E: E "er!# &!u-!d! '(r: ! De?ei)( "e%é)i&( < Vri(- #(&!i-W 5 Tireóide +i'('#-i&! & De?i&i%&i! de I(d( d Pr(du64( de !u)(0!%)i&(r'(- < Tire(idi)e-  I%?#!!64( &r,%i&! &( de-)rui64( de )e&id( )ire(idi!%(/ Qu!dr( C#;%i&( >er!#: ! N! Cri!%6!: Re)!rd( ?;-i&( e e%)!#8 e7e%)u!#e%)e !&('!%+!d( de -urde=ude=  Cre)i%i-(/ 5 N( !du#)(: M!i(r -e%-i5i#id!de !( ?ri(8 !)i7id!de- ?;-i&!- e i%)e#e&)u!i- !i- #e%)!-8 i2ede! 'e#e re--e&!d!/ Tr!)!e%)(:  Adi%i-)r!64( de Tir(2i%!/ / - O+TA& 'OE%A& TIEOI'IA%A&: . 0 Bó&i(: C!u-!d( 'e#! de?i&i%&i! de I(d(/ F ( e-);u#( d! -;%)e-e d! 'r()e;%! &!')!d(r! de i(d(8 9ue #e7! ! u! +i'er)r(?i! d! "#$%du#!/  A 'r(du64( de T1 e T3 é NORMALWW O )r!)!e%)( 'r(?i#)i&( 5!-ei!0-e %! !di64( de i(d( %! "u! e %( -!#H ( )r!)!e%)( )er!'u)i&( #ii)!0-e Y !di%i-)r!64( de i(d(/ * 0 Tire(idi)e-: I%?#!!6Ze- d! )ireóide8 &#!--i?i&!d!- e 1 "ru'(-: ! A"ud!: Mui)( r!r!8 "er!#e%)e &!u-!d! '(r i%?e&64( 5!&)eri!%!/ O '!&ie%)e é "er!#e%)e eu)ire(ide!%(/ A &i%)i#("r!?i! re7e#! re!- +i'(&!')!%)e-/ •

5 Su50A"ud!: E)i(#("i! 're-ui7e#e%)e 7ir!#8 &( 9u!dr( -ee#+!%)e ! J!J e #(%"! dur!64( -e!%!- ! e-e-/ & Cr,%i&!: D(e%6! de F!-+i()(: U! d!- ?(r!- !i- &(u%- e i'(r)!%)e- de d(e%6! )ire(idi!%!/ [ ! &!u-! !i- &(u de +i'()ire(idi-(/ E)i(#("i! !u)(iu%e de !'re-e%)!64( &#;%i&! 7!ri7e#8 de'e%de%d( d! ?!-e d! d(e%6!/ @!-e I%i&i!#: T1 e T3 %(r!i-/ @!-e A7!%6!d!: T1 e T3 5!i2(- e TSF E#e7!d( &( 5!i2! &!')!64( de i(d(/ N! i%7e-)i"!64( d! d(e%6! é ui)( i'(r)!%)e ! 'e-9ui-! de !%)i&(r'(- !%)i0)ire(idi!%(-/ 10 Nódu#(- Tire(idi!%(-:  A !i(ri!: Be%i"%(-W  A !7!#i!64( L!5(r!)(ri!# (-)r! ui)!- 7e=e- u 9u!dr( eu)ire(idi!%(8 e (- )e-)e- de &!')!64( de i(d( -4( ?u%d!e%)!i- '!r! ! &#!--i?i&!64( d( %ódu#( e: Que%)e < Fi'er&!')!%)e e 9u!-e -e're 5e%i"%( M(r%( < Eu&!')!%)e @ri( < Fi'(&!')!%)e N(- &!-(- de %ódu#(- (r%(- (u ?ri(- ! '(--i5i#id!de de !#i"%id!de é !i(r e ! &i)(#("i! (%&ó)i&! é de&i-i7!/ 30 Ne('#!-i!- de Tireóide: Te(- 7!#(re- de )ire("#(5u#i%! !ue%)!d(- %( -(r( %! !i(ri! !5-(#u)! d(- &!-(-8 de !%eir! %4( e-'e&;?i&!/ O d!d( é )i# %( !&('!%+!e%)( 'ó-0)r!)!e%)( d( &!-(/ •

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VII 0 METO'O1O2IA E3)EIME%TA1 4 - )OVA& 1A5OATOIAI&: * >ru'(-: . 0 Mede (- 'r(&e--(- -e&re)óri(- d! "#$%du#!: ! D(-!"e de T1 e T3 -éri&(5 A7!#i!64( d( ei2( Fi'()#!(Fi'ó?i-eTireóide D(-!"e de TSF Te-)e de E-);u#( &( TRF * 0 I%di&!-u"ere ! %!)ure=! d! d(e%6! )ire(idi!%!: ! Ci%)i#("r!?i! 5 U#)r!0S(%("r!?i! & De)e&64( de Au)(0A%)i&(r'(d Ci)(#("i! A-'ir!)i7! %o #ipertireoidismo: ! D(-!"e de T3 T()!#: O T3 T()!# e-) e#e7!d( e   d(- &!-(- de +i'er)ire(idi-(/ >er!#e%)e '(r RIA8 ( )e-)e ede ( T3 #i7re 83 e ( T3 #i"!d( Y TB>/ L("(8 ( )e-)e -(?re "r!%de i%?#u%&i! d! &(%&e%)r!64( -éri&! de TB>/ O )e-)e de Re)e%64( de T1 '(de -er u)i#i=!d( '!r! &(rri"ir !- di-)(r6Ze&!u-!d!- 'e#! TB>/ 5 D(-!"e de T3 Li7re: @T3: Mede !'e%!- ( T3 %4( #i"!d( Y TB>/ [ u )e-)e ui)( !i- -e%-;7e# e 're&i-(/ & D(-!"e d( T1 T()!#: [ ( )e-)e !i- -e%-;7e# '!r! i%7e-)i"!64( de +i'er)ire(idi-(H ( T1 -(5e !%)ee-( 9ue !- !#)er!6Ze- %( TSF/ T!5é -(?re i%?#u%&i! d! TB>8 e e%(r e-&!#!/ P(de e-)!r !-&!r!d( 'e#! J-;%dr(e d( T1 B!i2(J/ d D(-!"e de TSF: [ ( )e-)e !i- -e%-;7e# de i%7e-)i"!64( de d(e%6!- d! TireóideW E-) . 7e=e!ue%)!d( 9u!%d( de u !ue%)( de * 7e=e- d ( @T3/ N( Fi'er)ire(idi-( e-) -e're dii%u;d(8 'e#! !64( i%i5id(r! '(r ?eed05!&K d( T1 e T3 !ue%)!d(- %( -!%"ue/ e Te-)e de E-);u#( &( TRF: Veri?i&! ! re-'(-)! d( TSF -éri&( !'ó- !di%i-)r!64( e%d(7e%(-! de TRF/ [ )i# %! di?ere%&i!64( e%)re +i'er)ire(idi-( -e&u%dri( e )er&iri(/ ? Ci%)i#("r!?i! de Tireóide: [ ( !'e!e%)( d! "#$%du#! !'ó- i%"e-)4( e &!')!64( de i(d( r!di(!)i7( I .1./ @(r%e&e u e-)ud( (r?(#ó"i&( e ?u%&i(%!# d! "#$%du#!/ A &!')!64( de i(d( é !ue%)!d! %! D(e%6! de • •

%o #ipotireoidismo: ! D(-!"e de T3 T()!#: Dii%u;d( %! !i(ri! d(- &!-(-/ S(?re ! e-! i%?#u%&i! d! TB>8 9ue '(de -er e#ii%!d! &( (- )e-)e- de re)e%64( de T1 e d(-!"e de T3 Li7re/ 5 D(-!"e de T1 T()!#: E-) %(r!# %!- ?!-e- i%i&i!i- d( +i'()ire(idi-(/ \ S;%dr(e d( T1 B!i2(: A'#! 7!ried!de de -i)u!6Ze- e)!5ó#i&!- 9ue #e7! ! u! dii%ui64( d( T1 -éri&(8 )!i- &((: De-%u)ri64(8 IAM8 C+(9ue8 Ne('#!-i!-8 I%-u?i&i%&i! C!rd;!&!8 e)&/ L("(8 ! d(-!"e de T1 T()!# )e '(u&( 7!#(r %( di!"%ó-)i&( de +i'()ire(idi-(/ & D(-!"e de TSF:   d(- &!-(- de +i'()ire(idi-( -4( 'riri(-8 #("( ( TSF é !ue%)!d(W [ ( 'rieir( )e-)e ! -e !#)er!rW O )e-)e de e-);u#( &( TRF é %e&e--ri( '!r! ! di?ere%&i!64( -e ( &!-( ?(r de d(e%6! -e&u%dri! (u )er&iri! TSF 5!i2(/ d Ci%)i#("r!?i!: De7e -er re!#i=!d! e ! --(&i!64( &( ( )e-)e de (r"!%i?i&!64( d( i(d( 9ue8 9u!%d( dii%u;d(8 é -u"e-)i7( de Tire(idi)e de F!-+i()(/ e Pe-9ui-! de A%)i&(r'(-: I'(r)!%)e %! i%7e-)i"!64( d! Tire(idi)e de F!-+i()(8 9ue é !u)(0iu%eW Pe-9ui-!0-e 'ri%&i'!#e%)e * !%)i&(r'(-: 0 A%)i0Tire("#(5u#i%! 0 A%)i0Mi&r(-(!# (u A%)i0Per(2id!-e/ \\A)u!#e%)e: O 'r()(&(#( 5-i&( de i%7e-)i"!64( de d(e%6!- )ire(idi!%!- i%&#ui !- d(-!"e%- de @T38 T1 e TSF/\\