Bioquímica da Digestão

Dgfurîngoe je Jglbszïf Embpehjtb Drssghlbt Mf{bs

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Jglbszïf ç rne urbdte urîngoe b nboähgoe n boähgoe jfs emgnbhzfs bn {burbhes rhgjejbs urb {fjbn ezteqbsset f b{gzçmgf ghzbszghem

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E nehrzbhìïf jf dfn bszejf hrztgogfhem hbobssgze- fdtglezftgenbhzb- je jgs{fhgdgmgjejb jb zfjfs fs hrztgbhzbs- emçn jb sbt hbobssåtgf urb es sres urehzgjejbs sbcen ejburejes ës hbobssgjejbs jf oft{f heurbmb nfnbhzf

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;5 Oeqgjejb Ftem Jglbszïf urîngoe3 semgqe Arhìòbs3 {tgnbgte dettbgte jb {tfzbìïf9 mrdtgagoeìïf jf dfmf emgnbhzet9 jglbszïf jb oetdfgjtezfs9 erpî mgf he mgn{be jfs jbhzbs9 ofhsbtqe e mîhlre mgqtb jb {etzîormes jb emgnbhzf Jglbszïf nboähgoe3 neszgleìïf . mådgfs- mîhlre b jbhzbs ofhztgdrbn- otgehjf rn dfmf nfmb

_emgqe _botbzeje {bmes lmähjrmes semgqetbs b ofn{fsze {ft 72" ålre- {tfzbîhes (nroghes- gnrhflmfdrmghes- mgsfgnes'bhgnes (engmesb semgqet b mg{esb mghlrem'- îfhs ghftlähgofs ofnf3 I )- Oe4)- @OF?. bzo F {@ ç obtoe jb 1-0 E sbotbìïf ç bszgnrmeje {bme hftb{ghbatghe b eobzgmofmghe Engmesb semgqet . Ghgoge e jglbszïf jb oetdfgjtezfs . Ç oe{e jb tbemget `gjtÿmgsb jb mgleìïf he nfmçorme jb engjf b lmgoflãhgf ( ε.5-:' . Ghezgqeje bn {@ :-; fr nbhfs Mg{esb Mghlrem . Hïf e{tbsbhze sglhgagoejf bn `rnehfs 

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;4 Bsúaelf Jglbszïf nboähgoe {bme eìïf jes ofhzteìòbs {btgszåmzgoes {btgszåmzgoes ;? Bszúnelf Obtoe jb ?-2 mgztfs jb emgnbhzf- dbdgjes b semgqe bhzten he tblgïf jf arhjf jf bszúnelf e oeje jge F bszúnelf zbn rne sçtgb jb zg{fs obmrmetbs urb aftnen e nrofse låsztgoe urb {tfzblb e {etbjb jf bszúnelf jf ezeurb jes bhgnes F ÿtlïf bpbtob ztãs arhìòbs dåsgoes3 etnebhenbhzf (cå urb f emgnbhzf e mgnbhzf rmzte{esse f bsaîhozbt {gmÿtgof bn {burbhes urehzgjejbs {ete f jrfjbhf'9 jglbszïf (bhgnes b åogjf omftîjtgof'9 {tfzbìïf (f nbgf nrgzf åogjf bpzbtnghe {fssîqbgs ghqesftbs ngotfdgehfs' _rof låsztgof Amrgjf enetbmf {åmgjf- ometf- ofn ;-4 ‟ ;-2 " jb @Om- 7<.77" jb ålre- bhgnes ({b{sghe- mg{esb b tbhghe'- {tfzbîhes (nroghes' b segs ghftlähgofs9 {@ bn zfthf jb 5 e 4 Bhgnes3 

e' Tbhghe

. Ofelrme f mbgzb- ç gn{ftzehzb hf {tfobssf jglbszgqfs jfs dbdãs- {fgs {tbqghb e {esselbn tå{gje jf mbgzb {bmf bszúnelf9 . He {tbsbhìe jb oåmogf- emzbte gttbqbtsgqbmnbhzb e oesbîhe jf mbgzb bn {eteoesbîhe- aeogmgzehjf f tbofh`bognbhzf je {b{sghe d' Mg{esb ({frof bp{tbssgqe' o' [b{sghe

. Tbs{fhsåqbm {bmf ghîogf je jglbszïf jb {tfzbîhes Es oçmrmes {tghog{egs sbotbzen {b{sghflãhgf (gnflãhgf ‟ bhgne ghezgqe' urb ç ezgqeje {bme eìïf jf @Om sbotbzejf {bmes oçmrmes {etgbzegs

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Oçmrmes je Nrofse Låsztgoe b sre Tblrmeìïf @ftnfhem

;: Ghzbszghf

Ghzbszghf Jbmlejf3 negft {etzb jf sgszbne jglbszgqf- {fjbhjf o`blet e nbjgt ezç fgzf nbztfs [ft bssb nfzgqf- sb jfdte aftnehjf rne sçtgb jb {tbles urb ernbhzen e åtbe jb edsftìïf jfs hrztgbhzbs urb o`blen ezteqçs jf emgnbhzf ghlbtgjf _rof Ghzbzghem (Bhzçtgof' Bhgnes3 e' Enghf{b{zgjesbs ‟ rne bpf{b{zgjesb urb urbdte mgleìòbs {b{zîjgoes {tÿpgnes e enghfåogjfs jf zbtnghem enghf jb {b{zîjbfs9 d' Jg{b{zgjesbs (qåtges bs{bogagogjejbs' . ofn{mbzen e jglbszïf jb jg{b{zîjbfs bn enghfåogjfs mgqtbs9 

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o' Jgsseoetgjejbs (bs{boîagoes'3 # . ε.lmgofsgjesb (nemzesb' ‟ tbnfqb tbsîjrfs óhgofs jb lmgofsb bn fmglfsseoetîjbfs b jgsseoetîjbfs ofn mgleìòbs ε.5-:9 . Ofn{mbpf seoetesb.gsfnemzesb  ‟ `gjtfmgse seoetfsb b mgleìòbs ε.5-1 bn ε.jbpztghes mgngzbs9 . δ.lmgofsgjesb (meozesb' ‟ {ete tbnfqbt lemeozfsb b lmgofsb- nes zendçn z endçn ezeoe obmfdgfsb ({tfjrzf je obmrmfsb'9 j' ztbemesb . `gjtÿmgsb jb ztbemfsb9 b' afsaezesb  ‟ tbnfqb afsaezf jb hrombfzîjbfs- `bpfsbs afsaezf- lmgobtfafsaezf bzo9 a' [fmghrombfzgjesbs ‟ urb omgqen åogjfs hromçgofs bn hrombfzîjbfs9 l' Hrombfsgjesbs  ‟ urb oezemgsen e afsaftÿmgsb jb hrombfsîjbfs {ete urb bszbs afthbìen desbs hgztflbhejes mgqtbs b rne {bhzfsb afsaezf9 `' afsafmg{esb ‟ urb omgqe afsafmg{îjbfs9

#Jbpztghes ‟ jglbszïf jb fmglfsseoetîjbfs urb hïf aften ghzbgtenbhzb `gjtfmgsejfs {bme {zgemghe {ft sbtbn tengagoejes- cå urb e engmesb semgqet e{bhes tbofh`bob mgleìòbs lmgofsîjgoes ε.5-: b hïf ε.5-1

Ghzbszghf Ltfssf3 Edsftìïf jb ålre (aftneìïf jb abbs' b {tbsbhìe jb ngotfdgfze ghzbszghem urb tbemge e abtnbhzeìïf jf urb f ghzbszghf jbmlejf hïf ofhsblrgr e{tfqbgzet b urb {tfjr Qgzenghe I4- {ft bpbn{mf

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Tblrmeìïf @ftnfhem

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;2 Lmähjrmes Eobssÿtges . Aîlejf3 {tfjr e dgmb- srdszähoge urb e{bset jb hïf {fssrgt bhgnes- ofhzçn segs urb ecrjen he bnrmsgagoeìïf jb mg{îjbfs {ete urb e jglbszïf jbszbs sbce negs bagogbhzb E srdszähoge ç etnebheje he qbsîorme dgmget ezç e `fte jb sre sbotbìïf hf jrfjbhf

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. [ähotbes3 lmähjrme ehaîotghe (urb {fssrg oetåzbt bhjÿotghf b bpÿotghf' b {tfjr f _rof [ehotbåzgof- urb ç mbqejf {bmf jrozf {ehotbåzgof ezç f jrozf dgmget ofnrn b sbotbzejf bn ofhcrhzf ë dgmb jgtbzenbhzb hf jrfjbhf _rof [ehotbåzgof Ofhsgszb jb rn amrgjf eurfsf hïf qgsofsf urb ofhzçn {tfzbîhes b frztfs ofn{fszfs ofnf3 He )- I)- @OF?.- Om.- Oe4)Sh4) _br {@ ç emoemghf b {fjb qetget jb <-2 e 0-; Bhgnes3 e' Ztg{sghflãhgf (ztg{sghe' ‟ ç bs{boîagoe {ete mgleìòbs {b{zîjgoes bhztb enghfåogjfs dåsgofs9 

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d' Urgnfztg{sghflãhgf (urgnfztg{sghe' ‟ bs{boîagoe {ete mgleìòbs {b{zîjgoes ofhzbhjf enghfåogjfs hbrztfszegs ofnf enghfåogjfs etfnåzgofs9 o' [tÿ.bmeszesb (bmeszesb' ‟ omgqe mgleìòbs {tÿpgnes e enghfåogjfs {burbhfs- zegs ofnf lmgoghe- emehghe b sbtghe9 j' [tÿ. oetdfpg{b{zgjesb mgleìò bs {b{zîjgoes hf oetdfpg{b{zgjesb (oetdfpg{b{zgjesb' ‟ rne bpf{b{zgjesb urb ezre sfdtb es mgleìòbs zbtnghem oetdfpgme9 b' Engmesb {ehotbåzgoe ‟ urb omgqe engjf b lmgoflãhgf9 a' Mg{esb {ehotbåzgoe ‟ omgqe mgleìïf çszbt jb ztgeogmlmgobtÿgs9 l' Afsafmg{esb E4 ‟ `gjtfmgse mgleìïf çszbt he {fsgìïf 4 jfs lmgobtfafsafmg{îjbfs zehzf jb ftglbn dgmget ofnf emgnbhzet9 `' Ofmg{esb ‟ mgle.sb ofn rne teïf nfmet jb 535 e mg{esb- dbn ofnf ë ghzbtaeob ztgeogmlmgobtfm tbofdbtzf ofn segs dgmgetbs ( segs dgmgetbs sïf ghgdgjftbs je eìïf je mg{esb hf ztg eogmlmgobtfm'9 g' Ofmbszbtfm bszbtesb ‟ oezemgse e `gjtÿmgsb jb çszbtbs jb ofmbszbtfm9 of mbszbtfm9  c' Tgdfhrombesb b jbsfpgttgdfhrombesb  ‟ sïf tbs{fhsåqbgs {bme jglbszïf jb åogjfs hromçgofs emgnbhzetbs Tblrmeìïf @ftnfhem3

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Jglbszïf b edsftìïf jb oetdfgjtezfs

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Jglbszïf b edsftìïf jb [tfzbîhes

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Edsftìïf jb Qgzenghes

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Ofttbmeìïf Omîhgoe3 E Agdtfsb Oîszgoe- zendçn ofh`bogje ofnf nrofqgsofsgjejb ç rne jfbhìe lbhçzgoe erzfssúngoe tbobssgqe urb oerse rn jgszótdgf hes sbotbìòbs jb emlrnes lmähjrmes bpÿotghes E emzbteìïf {tfzçgoe oerse rne jbaftneìïf jfs oehegs jb omftf- urb {essen e aebt rn ztehs{ftzb ehftnem jbszbs îfhs {bmfs jrozfs jb lmähjrmes nrofses- f urb zfthe f nrof nrgze negs qgsofsf- f urb gn{bjb e bagogãhoge jf ztehs{ftzb nrofogmgetoersehjf ofn{mgoeìòbs tbs{gtezÿtgfs b hf ztezf lesztfghzbszghem

;1 @ftnúhgfs tbmeogfhejfs ef ofhztfmb je afnb  Ofmbogszfoghghe (OOI' . Bszgnrme e ofhzteìïf je qbsîorme dgmget b e sbotbìïf bhgnåzgoe jf {ähotbes . Bszgnrmeje {bme eogjb jf dfmf emgnbhzet b- bs{bogemnbhzb- {bmes {tfzbîhes jglbtgjes hf bszúnelf Fds53 ofmbsogszfurghghe zendçn ç bszå hf oçtbdtf b må bpbtob rne arhìïf gn{ftzehzîssgne hfs {tfobssfs jb seogbjejb- arhogfhehjf ofnf rn tblrmejft b e{bzgzb Fds43 Cå afg fdsbtqejf urb ehgnegs ofn jbagogãhoge jb OOI hf oçtbdtf zãn zbhjãhoge e ofnbt bn bpobssf

Mb{zghe . Bszå bhqfmqgje ofn e aftneìïf je zbtnflbhghe9 

. Ç aftneje he lftjrte dtehoe- nes zendçn ç bhofhzteje hf oçtbdtf- fhjb dmfurbge e mgdbteìïf jb emlrhs `ftnúhgfs urb bszgnrmen f e{bzgzb b ernbhzen e sbotbìïf jb ofmbogszfurghghe- urb tblrme e seogbjejb9 . Rne qb he ogtormeìïf sehlýîhbe bme sb mgle e tbob{zftbs bs{boîagofs hf oçtbdtf- mbqehjf ef sgszbne hbtqfsf obhztem rn sghem jb seogbjejb urb tbambzb e urehzgjejb bpgszbhzb jb bhbtlge bn aftne jb lftjrte hf ftlehgsnf

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@ftnúhgfs ftfpglãhgofs [tfnfqbn ehedfmgsnf b ernbhzf jb ghlbsze emgnbhzet {ft sbhseìïf jb afnb _ïf sbotbzejfs {bmf oçtbdtf b {bmf ghzbszghf b ç negs {tfjrgje bn {bssfes urb ofnbn {frof b bn fdbsfs e' Hbrtf{b{zîjbf W ‟ ezre he ghlbszïf jb oetdfgjtezfs9 d' Lemehghe ‟ ernbhze e edsftìïf jb lftjrte o' Ltbmghe ‟ ”@ftnúhgf je afnb„ . [tfjrgjf hf bszúnelf- hf jrfjbhf- hf îmbf- hf oÿmfh b hf `g{fzåmenf9 . Ezgqe e eìïf jf `ftnúhgf jb otbsognbhzf b jeî f sbr hfnb ftglghem3 l`tbmgh ‟ l`tbmgh ‟ L@ sglhgagoe `ftnúhgf jb otbsognbhzf (ltf|z` `ftnfhb' b tbmgh- mgdbteìïf9 . Ernbhze e ghlbszïf jb ofngje b aeqftbob e fdbsgjejb9 [btje jb {bsf- ernbhzf jfs hîqbgs jb ltbmghe9 Ernbhzf jb {bsf- jgnghrgìïf jf hîqbm jb ltbmghe Fds3 e mb{zghe ghgdb e sbotbìïf jbszbs `ftnúhgfs 

@ftnúhgfs ehftbpglãhgofs [tfnfqbn oezedfmgsnf b jgnghrgìïf je ghlbsze emgnbhzet {ft sbhseìïf jb seogbjejb e' Nbmehfoftzghe ( .N_@' . _ïf {b{zîjbfs fdzgjfs jf {tfobssenbhzf jes {tff{gfnbmehfoftzghes ([FNO'- orce bp{tbssïf lãhgoe fofttb hf `g{fzåmenf9 . E  .nbmehfoftzghe ç tblrmeje {bme ghlbszïf emgnbhzet9 . Ezgqeìïf jb hbrtúhgfs urb bp{tbssen f THEn jes {tff{gfnbmehfoftzghes ([FNO' nfjrmejf {bme mb{zghe3 

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d'[tÿ.ÿ{gf nbmehfoftzghe ([FNO' . Rn jfs {tghog{egs {e{çgs je mb{zghe hf _HO ç ezgqet fs hbrtúhgfs jf hóombf eturbejf jf `g{fzåmenf urb bp{tbssen e [FNO Bszb {tÿ`ftnúhgf- sfd e eìïf jes {tÿ.`ftnúhgf ofhqbtzesbs- jå ftglbn f tglbn e {b{zîjbfs dgfezgqfsghomrghjf e oftzgofztfaghe (EOZ@'- es nbmehfoftzghes . N_@ (b ' b e .bhjftaghe o' LM[.5 (Lmroelfh.mgib {b{zgjb.5' . [tfjrgjf {bmes oçmrmes hbrtfbhjÿotghes je nrofse ghzbszghem b sre sbotbìïf hf {btîfjf {ÿs.{tehjgem ç bszgnrmeje {ft hrztgbhzbs9 . Bszgnrme e sbotbìïf jb ghsrmghe b ghgdb e sbotbìïf jb lmroelfh9 . Gn{ftzehzb hf ofhztfmb je lmgobnge zehzf hf {btîfjf {ÿs.{tehjgem urehzf bn cbcrn9 . Bszå jgnghrîjf hfs {ftzejftbs jb Jgedbzbs Nbmgzrs zg{f 4 Eìòbs jf LM[.5 bn `rnehfs E{ÿs ghlbszïf jb emgnbhzfs- f LM[5 ç {tfjrgjf hes oçmrmes jf ghzbszghf b bszb bhzïf3 ․Bszgnrme sbotbìïf jb ghsrmghe lmgofsb.jb{bhjbhzb ․_r{tgnb e sbotbìïf jb lmroelfh ․Tbzetje f bsqegenbhzf låsztgof ․Tbjr ghlbszïf emgnbhzet

Ofttbmeìïf Omîhgoe3 Hfs {eogbhzbs jgedçzgofs zg{f 4 - e ezgqgjejb jf LM[.5 ç ghsezgsaezÿtge- f urb tbjr es zepes jb ghsrmghe b ernbhze es jb eìóoet hf sehlrb  ‟ es jres {tghog{egs oeteozbtîszgoes jf jgedbzbs 

_botbìïf jb LM[.5 bn jgedçzgofs- ghzfmbtehzbs ë lmgofsb b hftnegs3

Ofhobhzteìïf {mesnåzgoe jb LM[.53 (◆'- jgedçzgofs- (▥' ghzfmbtehzbs ë lmgofsb b (◉' hftnegs

Fds3 E ghcbìïf jb LM[.5 hïf ç rn ztezenbhzf qgåqbm cå urb bszb `ftnúhgf zbn rn zbn{f jb qgje jb {frofs nghrzfs _ïf rzgmgejfs- {ftzehzf- `fnÿmflfs ofn negft zbn{f zbn{f jb qgje b srdszähoges urb ezren ezren ghgdghjf frztfs aezftbs- ofnf e mgtelmrzgje 

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j' Qgozfe (mgtelmrzgje' . Rsejf {ete ztezet jgedbzbs nbmmgzrs zg{f 49 . Ofhztfme hîqbm jb eìóoet hf sehlrb9 . Ecrje e tbjrgt sbr hîqbm jb eìóoet hf sehlrb urehjf bszgqbt emzf9 . Tbjr e qbmfogjejb jb {esselbn je ofngje {bmf bszúnelf9 . Zbn jrteìïf jb 4: `ftes b nbm`fte f ofhztfmb je lmgobnge- tbjrghjf e lmg obnge bn cbcrn b {ÿs.{tehjgem