APPLICATION APPLICATION FOR DBT RESEARCH ASSOCIATESHIP IN BIOTECHNOLOGY AND LIFE SCIENCES (NATIONAL & NE) 1. Name of the App!"a#t$ Dr. Amrita Srivastava %. Date of B!th$ 24.09.83
A'e (ea)$ 34 years
*. Co#ta"t Deta! *.1 Compete A++e fo Coepo#+e#"e (,!th p!#"o+e)$ At Ganga Pradushan Niyantran
Kendra Gate, Bhagan!ur, "an#a, $aranasi $aranasi %&. P.', Pin ()de*22+00. *.% Ema! ID (1-- #e"ea)$ amrita.airy-gmai./)m *.* Teepho#e No./ 0o!e$ 038809+110 2. E+3"at!o#a 43a!f!"at!o#$ %n /hr)n))gi/a )rder r)m Graduati)n )nards'. n/)se se* attested !h)t)/)!ies ) the degree /ertii/ates. N) )ther /ertii/ates are ne/essary.
Degree BS/5B5:BBS5 B$S/5B Pharm, et/ :S/5:=e/h, et/ Ph D5:D5:S>
&niversity5 nstitute $.B.S Purvan/ha &niversity %&.P.'.
6ear !assing 2001
Su7e/ts
Aaha7ad Agri/utura nstitute*Deemed &niv. %&.P.'. &niversity ) "u/#n) %&.P.'
2008
Bi)/hemistry
92.2
20+1
;)))gy
NA
B)tany, ;) ;)))gy < (hemistry
Divisi)n5 mar#s 11
> Ph D5:D5:S %:edi/a' degree /ertii/ate is n)t avaia7e, en/)se a /)!y ) !r)visi)na aard aard /erti /ertii/at i/ate5! e5!r)) r)) ) thesi thesiss su7mis su7missi) si)n n /erti /ertii/ i/ate ate r)m r)m ?egist ?egistrar rar5() 5()ntr ntr) )er er ) @aminati)ns. (ertii/ate issued r)m any )ther auth)rity in this regard is n)t a//e! ta7e.
5. T!te of the Ph D/0D/0S (0e+!"a) The!$ ?)e ) Gn? and Gn in reguati)n )
seas)na 7reeding ) s!)tted munia % Lonchura Lonchura punctulata'C punctulata'C
5.1 Name & A++e of Ph.D. S3pe6!o$ Dr. Shaie :ai#, Ass)/iate Pr)ess)r, De!artment
) ;)))gy, &niversity ) "u/#n), "u/#n) %&.P.'
5.% B!ef S#op! of Ph D/0D/0S (0e+!"a) The! (ma7!m3m %5- ,o+).
Atta/hed as en/)sure 4
8. L!t of Reea"h P3!"at!o# E S!6ata6a9 a9 A., :ai :ai# #, S., S., 6adav adav,, G., ?ani ?ani,, S., S., %-15. nterm ntermitt itten entt F))d F))d A7sen/ A7sen/ee :)tiva :)tivates tes 1) S!6ata6
?ea) ?ea)/at /ati)n i)n ) ")/)m) ")/)m)ti) ti)n n and Feedin Feeding g in S!)tt S!)tted ed :unia :unia % Lonchura punctulata punctulata'. '. )ur )urna na ) (ir/adian ?hythms DHE
[email protected])i.)rg5+0.3345/r.a
[email protected])i.)rg5+0.3345/r.a %m!. %m!. Fa/t)r*n)n im!a/tted'
rivedi di,, N., :ai :ai#, #, S., S., ?ani ?ani,, S., S., Kuma Kumarr, $., %-12. :)e/u :)e/uar ar 7asis 7asis ) %) S!6at S!6ata6a9 a6a9 A., =rive !h)t)!eri)di/ /)ntr) ) re!r)du/tive /y/e / y/e in a su7tr)!i/a s)ng7ird, the ndian eaver 7ird % Ploceus Ploceus philippinus'. philippinus'. Genera and ()m!arative nd)/rin))gy nd)/rin))gy 20, 4+*4. %m!. a/t)r*2.1' Pu7i/ati)ns are atta/hed as en/)sure and 1. :. Deta! of ea!e ta!#!#'/ feo,h!p (!f a#) pat!"3a at pot Ph D/0D/0S e6e.
Presenty )r#ing as P)st D)/t)ra Fe) at de!artment ) Pharma/euti/a ngineering and =e/hn))gy e/hn))gy in nan)medi/ine nan)medi/ine a7 in ndian nstitute ) =e/hn))gy, Banaras indu &niversity %=* B&',$aranasi, ndia % Sin/e 08.0.+1'.
=)!i/E ?)e ) :eat)nin )aded nan)!arti/es )n /e !r)ierati)n signaing in 7reast /an/er. %Funded 7y =*B&' A!!)intment etter $ Atta/hed as en/)sure ;.
8.+ yes, then state the nature ) m!)yment5designati)n5 =em!)rary5 Permanent. ?)ute y)ur a!!i/ati)n thr)ugh !r)!er /hanne. N) 8.2 Address ) the nstitute5&niversity N)E
>. T!te a#+ #op! of the popoe+ eea"h ,o? (%5- ,o+)$ T!te$ S#the! a#+ in vivo e6a3at!o# of #a#o"a!e tem fo e#ha#"e+ a#t!hpe'"em!" a"t!6!t of Aegle marmelos (Bae) marmelos (Bae) eaf E7ta"t.
S#op!$ Atta/hed as en/)sure 8 >.1 Popoe+ pa"e of eea"h$
De!artment ) ;)))gy, S/h)) ) Bi))gi/a S/ien/es Dr. Dr. arisingh G)ur (entra &niversity Sagar I 40003 %:.P.'
>.% Name of the "!e#t!t 3#+e ,hom po@e"t to e !mpeme#te+ %en/)se /)nsent etter r)m
the !r)!)sed su!ervis)r'. Pr). Su7)dh Kumar ain Pr)ess)rJ De!artment ) ;)))gy, S/h)) ) Bi))gi/a S/ien/es Dr. Dr. arisingh G)ur (entra &niversity Sagar I 40003 %:.P.' %:.P.' ()nsent etter r)m !r)!)sed su!ervis)r is atta/hed as en/)sure 9
1-. E#"oe E#"oe t,o ette ette of e"om e"omme# me#+at! +at!o# o# %)ne %)ne sh)ud sh)ud 7e r)m r)m thesis thesis su!ervi su!ervis)r s)r'' fom pofeo o empoe ,!th ,hom o36e ha+ a "oe ,o?!#' eat!o#h!p.
i' ?e/)mmendati)n r)m su!ervis)r %Dr. Shaie :ai#', De!artment ) ;)))gy, &niversity ) "u/#n), "u/#n) %&.P.' %&.P.' is atta/hed as en/)sure +0 ii' ?e/)mmendati)n r)m Pr). Sangeeta ?ani, De!artment ) ;)))gy, &niversity ) "u/#n), "u/#n) %&.P.' %&.P.' is atta/hed as en/)sure ++
11. De"aat!o# fom the "a#+!+ate that !f ee"te+ he/he ,! #ot e!#3!h the RAh!p ,!th!# % ea9 e7"ept fo a""ept!#' @o/feo,h!p ,!th!# I#+!a.
Pa/eE $aranasi DateE 2+.09.20+
%Signature ) A!!i/ant'
L!t of e#"o3e
+. B.S/ B.S/.. Degr Degree ee (er (erti tii i/a /ate te 2. :.S/ :.S/.. Degr Degree ee (er (erti tii i/at /atee 3. Ph.D. Ph.D. Deg Degre reee (ert (erti ii/ i/at atee 4. Ph.D Ph.D.. Syn Syn)! )!si siss . ?ese ?esear ar/h /h !u7 !u7i i/a /ati ti)n )n + 1. ?ese ?esear ar/h /h !u7 !u7i i/a /ati ti)n )n 2 . A!!)i A!!)int ntme ment nt ett etter er PDF PDF 8. Syn)!si Syn)!siss ) !r)!)s !r)!)sed ed rese resear/ ar/h h )r# )r# 9. ()nsen ()nsentt etter etter r)m r)m the the !r)!)s !r)!)sed ed su!erv su!ervis) is)r r +0. ?e/)mmendati ?e/)mmendati)n )n r)m Ph. D. su!ervis)r su!ervis)r ++. ?e/)mmendati ?e/)mmendati)n )n r)m Pr)ess)r Pr)ess)r
E#"o3e 2 Ph.D. S#op!$ Roe of G#RH a#+ G#IH !# e'3at!o# of eao#a ee+!#' of potte+ m3#!a ( Lonchura punctulata)
=he u/tuating envir)nment give rise t) seas)naity and its ass)/iated !hen)mena i#e seas)na re!r)du/ti)n in 7irds, hi/h is /)nsidered as a resut ) /)m!e@ intera/ti)n ) vari)us neur)na and h)rm)na a/t)rs. =he hy!)thaami/ neur)ns integrate e@terna and interna signas t) reeas reeasee the neur)h neur)h)rm )rm)nes )nes %g)nad %g)nad)tr )tr)!i )!in*r n*ree eeasi asing ng h)rm)n h)rm)ne, e, Gn? Gn? and g)nad)t g)nad)tr)! r)!in* in* inhi7it)r inhi7it)ry y h)rm)ne, h)rm)ne, Gn' t) reguate reguate the !h)t)!eri) !h)t)!eri)di/ di/ a@isL %hy!)thaam %hy!)thaam)*hy!)!h )*hy!)!hysea ysea** g)nada a@is'. =he !ituitary gand synthesiMes and reeases g)nad)tr)!ins %uteiniMing h)rm)ne, " and )i/e )i/e stimuating stimuating h)rm)ne, FS' hi/h stimuate stimuate g)nads )r gamet)genesis gamet)genesis and se@ ster)id se/reti)n. Gn? a/tivates the re!r)du/ti)n 7y stimuating g)nad)tr)!in synthesis and reease and Gn d)es the reverseJ it inhi7its g)nad)tr)!in synthesis and reease dire/ty 7y a/ting )n the !ituitary gand )r indire/ty 7y de/reasing the a/tivity ) Gn? neu r)ns. =here)re, it is im!)rtant t) understand seas)na re!r)du/ti)n 7y investigating the distri7uti)n and a/tivities ) Gn? and Gn neur)ns in the 7rain. :)st ) the studies dem)nstrating neur)end)/rine reguati)n ) re!r)du/ti)n have 7een d)ne )n !h)t)!eri)di/ 7irds. )ever, itte is #n)n a7)ut h) the t) !e!tides intera/t t) reguate annua re!r)du/ti)n in a /ir/annua s!e/ies in hi/h /ir/annua rhythm n)t the !h)t)!eri)d reguates the annua g)nada /y/e. Di Dier eren entt r)m r)m the the !h)t) !h)t)!e !eri ri)d )di/ i/ 7ree 7reeder ders, s, the the m)de m)de s!e/ s!e/ie iess i.e. s!)tte s!)tted d munia munia % Lonchura Lonchura punctulata' punctulata' sh)s the /ir/annua /ir/annua !ersisten/e !ersisten/e in the re!r)du/ti re!r)du/tive ve !hysi))gy !hysi))gy even in the a!eri)di/ /)nditi)n %Bud#i et a., 20+2'. S) it 7e/)mes )7igat)ry t) study the d)nstream events inv)ved in its re!r)du/tive !hen))gy. t is a n)ve study here e tried t) understand the r)e ) Gn? and Gn h)rm)nes in !h)t)!eri)di/ reguati)n in a !h)t)*n)nres!)nsive 7ird and dem)nstrate the /)nserved r)e ) Gn? and Gn in su/h s!e/ies as e.
E#"o3e ; Popoe+ pa# of ,o?$ Top!"$ S#the! a#+ in vivo e6a3at!o# of #a#o"a!e tem fo marmelos (Bae) eaf E7ta"t. e#ha#"e+ a#t!hpe'"em!" a"t!6!t of Aegle marmelos (Bae)
Dia7et Dia7etes es meit meitus us is a ma)r ma)r heath heath !r)7e !r)7em m ith ith /)ntinu /)ntinu)us )usy y in/rea in/reasin sing g rates rates ) in/iden/e and m)rtaity. t is /hara/teriMed 7y in/reased !asma gu/)se /)n/entrati)ns resuting r)m insui/ient insuin and insuin resistan/e, )r 7)th, eading t) meta7)i/ a7n)rmaities in meta7)ism. et un/ured, it may even ead t) a/ute )r /hr)ni/ )ut/)mes. Hut ) hi/h dia7etes is 7e/)ming the third #ierC ) the man#indLs heath a)ng ith /an/er, /ardi)vas/uar diseases. =here)re, )n/e diagn)sed, it sh)ud 7e e /)ntr)ed 7y vari)us thera!euti/ means.
:edi/ina !ants have an ever emerging r)e t) !ay in treatment and management ) ie)ng !r))nging diseases i#e dia7etes meitus. =he treatment ) ea/h ) su/h disease /an 7e d)ne 7y e@!)iting the her7a integrity ) ndia. Severa earier studies have adv)/ated the medi/ina 7eneits ) Aegle ) Aegle marmelos. marmelos. =he eaves and ruit ) this !ant have medi/ina vaue and ere ere used used t) treat treat anti* anti* hy!erg hy!ergy/ y/emi emi/, /, anti*h anti*hy!er y!eri! i!ide idemi/ mi/,, anti*m anti*mi/r i/r)7i )7ia a and anti* anti* inam inammat mat)ry )ry a/tivi a/tiviti ties es et/. et/. "eaves "eaves ) the A. marmelos /)ntain /)ntain a#a) a#a)id id i.e., i.e., aegeine %N*2* hydr)@y*2%4*meth)@y!heny' ethyO*3* !heny*2*!r)!enamide' hi/h is #n)n t) )ers the 7))d gu/)se eve. ?e/enty, ?e/enty, nan)!arti/es are gaining im!)rtan/e in the ieds ) medi/ine )ing t) their uniue !hysi/a and 7i))gi/a !r)!erty. (hemi/ay synthesiMed dia7etes drugs have side ee/ts i#e #idney /)m!i/ati)ns et/. n )rder t) redu/e these /)m!ains, nan)/arrier system might !r)ve t) 7e a !)tentia ! )tentia drug deivary sysytem.
n the !resent study, e i 7e using Aegle using Aegle marmelos ea e@tra/ts e@tra/ts )r the synthesis synthesis ) nan)/arriers. Further, the anti*hy!ergy/emi/ a/tivity ) the 7i)synthesiMed nan)/arriers i 7e tested tested in stre!t stre!t)M)t )M)t)/in )/in indu/e indu/ed d rat m)de. m)de. P)ssi7 P)ssi7y y this this study study i i enhan/e enhan/e the medi/i medi/ina na ei ei/a/ /a/y y ) Aegle marmelos ea ea e@tra/ e@tra/tt and thus have !)tent !)tent !harma !harma/) /))gi )gi/a /a r)e r)e in the treatment ) dia7etes meitus.
DEPART0ENT OF OOLOGY NIERSITY OF LCNO< LCNO< %%8 --: D. Sha!e 0a!? Associate Professor
ha!ema!?e+!ffma!."om
DateE +8.09.20+
To ,homoe6e !t ma "o#"e#
am ha!!y t) rite this etter in av)ur ) Dr. Amrita Srivastava h)m have #n)n )r m)re than si@ years. She had /)m!eted her Ph.D. resear/h )r# entited ?)e ) Gn? and Gn in reguati)n ) seas)na 7reeding ) s!)tted munia % Lonchura Lonchura punctulata'C punctulata'C under my su!ervisi)n su!ervisi)n r)m r)m De!art De!artmen mentt ) ;)))g ;)))gy y, &niver &niversit sity y ) "u/#n) "u/#n).. She )r#ed )r#ed as ?F )r t) years years %+.04.2009*+.04.20++' and S?F )r + year %+1.04.20++*+.04.20+2' in a DS= unded resear/h !r)e/t. Dr. Srivastava has dis!ayed her /a!a7iities ) )rigina thin#ing and dee! gras! ) the su7e/t. She has earnt and handed vari)us te/hniues in the ied ) /hr)n)7i))gy, m)e/uar 7i))gy a)ng ith 7asi/ neur)7i))gy. neur)7i))gy. Dr. Srivastava 7ears a g))d m)ra /hara/ter. She is a team !ayer and #ee!s )n e ith her e) /)eagues. am uy /)nvin/ed that she i 7e a g))d additi)n t) y)ur )rganisati)n. str)ngy re/)mmend her /andidature and 7eieve that she i !r)ve t) my )rds.
Shaie :ai#
DEPART0ENT OF OOLOGY NIERSITY OF LCNO< LCNO< %%8 --: Pof. Sa#'eeta Ra#! Professor
a#'eetaa#!:ahoo."om
DateE 2+.09.20+
To ,homoe6e !t ma "o#"e#
have great !easure in testiying t) the a/t that have #n)n Dr. Amrita Srivastava )r a !eri)d ) ar) ar)und und 1 yea years rs h) has re/ re/ent enty y /)m /)m!e !eted ted her Ph.D Ph.D.. resear resear/h /h )r )r# # in De! De!art artmen mentt ) ;)))gy,, &niversity ) "u/#n), "u/#n). ;)))gy She dis!ays her /a!a7iities ) )rigina thin#ing and dee! gras! ) su7e/t. She has 7een )r# ) r#in ing g in ve very ry /) /)m! m!et etit itiv ivee an and d dy dyna nami mi// ar area eass r r)m )m 7a 7asi si/s /s ) !h !h)t )t)! )!er eri) i)di dism sm an and d /hr)n)7i))gy t) un/ti)na neur)end)/rin)gy neur)end)/rin)gy.. Dr. Srivastava 7ears a g))d m)ra /hara/ter. She #ee!s )n e ith her tea/hers and e) /)ea /) eague guess and )v )ves es t) iv ivee dis dis/i! /i!i ined ned and sin sin/er /eree ay ) i ie e it ith h an a/u a/ute te dev) dev)ti) ti)n n t) resear/h. ee that this !r)gram /an 7e ) great he! in sha!ing her /areer as an inde!endent resear/her. =his i !r)vide her ith an )!!)rtunity t) !ursue the high end )r# in ndia. n vie ) immense !)tentias, str)ngy re/)mmend her /andidature )r this !r)gram. ish her grand su//ess in a her uture !an and endeav)rs.
Sangeeta ?ani
DBTJReea"h DBTJReea"h Ao"!ateh!p Ao "!ateh!p
To9 CoJo+!#ato DBTJReea"h Ao"!ateh!p Po'am9 Depatme#t of B!o"hem!t9 I#+!a# I#t!t3te of S"!e#"e "amp39 Ba#'aoe9 58--1%
Amrita Srivastava D5H Amarnath At Ganga Pradushan Niyantran Kendra Gate, Bhagan!ur, "an#a, $aranasi, Pin ()de*22+00 %&. P.'
