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Buerger's Disease Pathophysiology
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Buerger's Disease Pathophysiology
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Author:
Bon Guevarra Sagun
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APPENDICITIS PATHOPHYSIOLOGY
pathophysiology of appendicitis, peritonitis, septic shock
Pathophysiology
Predisposing Factors;
Precipitating Factor;
Lifestyle (Cigarette
Gender: Male
Age: 20-60 y/o
smoking, chewing
History (HPN,
of tobacco,
Hyperlipidemia
sedentary lifestyle)
Environment:
Genetics
Race: Southeast
exposure to cold,
Asian
stressful
environment
CIGARETTE SMOKING
Nicotine
Carbon Monoxide
Carbon Dioxide
Vasoconstriction of
Destruction of the lining
Decrease Oxygen
arteries
of blood vessel
Transport to tissue
TRIGGERS AUTOIMMUNE RESPONSE (IDIOPATHIC)
Tissue Ischemia
Anaerobic Metabolism
Lactic Acid Formation
cyanosis
Intermittent Claudication
Tissue Hyoxia
Rest Pain
Trophic changes – dryness, scaling of skin, loss of hair, thickened and ridge
toenails
Tissue Necrosis
Numbness
Pallor
Tissue Ulceration
Gangrene
Amputation
Coldness
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