Pathophysiology-leptospirosis

Pathophysiology: Age, Sex,

Leptospire 

Geographic, Season

from infected animals

Direct invasion of tissue on susceptible host; induced endotoxins,hemolysin & lipase

capillary vasculitis

endothelial edema, necrosis, lymphocytic infiltration

loss of RBC & fluid via enlarged conjunction & fenestrae

CBC

x-ray

urinalysis

ECG

PT  Jaundice,

Alveolar

Tubular

Cardiac

Hemorrhage,

intraparenchy

vascular

capillary

necrosis,

lesions,

focal

mal bleeding,

congestion &

injury (focal/

epicardial

necrosis,

bleeding along

disorganizati

diffuse),

interstitial nephritis

&

infiltration

serosa &

on of liver cell plates

interstitial &

endocardial

within the

intra-

petechiae,

alveolar

myocardial

adrenal gland

edema &

interstitial

bleeding,

edema,

frank hemorrhage

coronary arteritis

Petechiae,

mucosa; thrombocytope nia