biperiden Drug study

DRUG STUDY

Drug Data Generic Gene ric Name Nam e biperiden Trade Trad e Name Na me  Akineton !ati ents Dose Dos e 2g tab OD PO

Minimum Dose 6mg/day

Ma"imum Dose 16mg/day Contents Cont ents biperiden

Classification Therapeutic$  Antiparkinson  Antiparkinson agents !harmacologic$  Anticholinergics  Anticholinergics !regnanc# Categor# C

Mechanism of Action Is a tertiary amine antimscarinic !ith central and peripheral actions" It stimlates and then depresses the #$%, it also has antispasmodic actions on smooth mscle and redces secretions, esp sali&ary and bronchial secretions" !harmaco%ineti cs A$ 'eadily Absorbed (rom the )I tract" D$ *nkno!n D$ *nkno!n M&'$ +tensi&e (irstpass e((ect"

General Indications  Adncti&e treatment treatment o( all (orms o( Parkinson disease, inclding drgindced etrapyramid e((ects and acte dystonic reactions" !atients Actual Indication 0o pre&ent drg indced etrapyramid e((ects and acte dystonic reactions

(nse (n sett nkno!n

Availailit# and color  Talets$ 2mg, 4mg, 8mg

!ea% !e a% nkno!n

Routes of administration

Duration Dura tion nkno!n

PO

Indication

Drug )alf )a lf *ife *i fe  Abot 2. hrs"

Source$ Deglin, <" et" Al" 2..=" Da&iss Drg )ide (or $rses" 12th ed" >"A" Da&is" Da&is" pp 192.

Contraindications ypersensiti&ity  Angleclosre glacoma glacoma 3o!el obstrction egacolon0ardi&e dyskinesia" !recauti !rec auti on Prostatic enlargement %ei5re disorders#ardiac arrhythmias O3, actation7 %a(ety not established )eri7 Increased risk o( ad&erse reactions lo!er doses may be necessary" Drug interaction +drug to drug

.

Amantadine ay increase anticholinergic anticholinergi c ad&erse reactions" Digo"in ay increase digoin serm le&els, especially !ith slo!dissoltion oral digoin tablets" )aloperidol ay !orsen schi5ophren schi5ophrenic ic symptoms may decrease haloperidol serm le&els tardi&e dyskinesia may de&elop" ay decrease action o( phenothia5ines" phenothia5in es" ay increase incidence o( anticholinergic anticholinergi c ad&erse reactions"

Adverse Reaction

Nursing Responsiilities

CNS$ con(sion, depression, di55iness, hallcinations, headache, sedation, !eakness" ''NT$ blrred ''NT$ blrred &ision, dry eyes, mydriasis" C,$ arrhythmias, hypotension, palpitations, tachycardia" GI$ constipation, GI$ constipation, dry moth, iles, nasea" GU$ hesitancy, rinary retention" Misc$ decreased s!eating"

-ef ore 1" Asses Asses patients patients diagnosis" 2" Assess Assess patients patients mental stats" 9" Assess patients &isal acity" 4" #on(irm #on(irm medicatio medication n (rom doctors orders" :" Assess Assess blood pressre" pressre" Dur ing 1" #on(i #on(irm rm patient patients s identity" 2" Administe Administerr medic medication ation at the right prescribed rote" 9" st st admin administ ister er medication !ith (ood" 4" Practi Practice ce asepti aseptic c techni;e" :" Administe Administerr medic medication ation at the prescribed time" After Aft er 1" Obser Obser&e &e prop proper er docmentation o( administered medication" 2" +nsre +nsre that that patien patientt has (lly s!allo!ed oral (orm o( medication" 9" Obser&e Obser&e patients patients beha&ior closely (or atleast 1:-9. mintes a(ter administration" 4" Instrct Instrct patien patientt to mo&e slo!ly to pre&ent di55iness" :" +ncorag +ncorage e patien patientt to increase (lid intake to pre&ent drying o( moth"