Anabolic Peptide Beta eBook

Anabolic Collection Best © 2012 Thatotherguy

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Anabolic Collection Best © 2012 Thatotherguy

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Anabolic Collection Best

Table of Contents Foreword

7

9

Part I Disclaimer Part II Welcome topic

11

Part III Chapter 1: The history and basics of steroids

13

1

What is Testosterone? ................................................................................................................................... 17 2 Main Kinds .......................................................................................................................................................... of Steroids

18

CLASS I -......................................................................................................................................................... INJECTABLE STEROIDS (Esters) CLASS II ......................................................................................................................................................... – ORAL STEROIDS (methylated)

18 18

21

Part IV Chapter 2: What kind of steroid do I take? 1

How Steroids ................................................................................................................................... Work in the Body 21

2

A Comprehensive Comprehens ................................................................................................................................... ive Look at Lab Tests 22

3

Best Steroids ................................................................................................................................... 34

38

Part V Chapter 3: Proper Cycling of Steroids 1

Beginners Cycle ................................................................................................................................... 38 Novice Cycle .......................................................................................................................................................... #1

38

2

Intermediate................................................................................................................................... Cycle 40

3

Advanced Cycle ................................................................................................................................... 42

4

PCT

................................................................................................................................... 44

Post Cycle Therapy ..........................................................................................................................................................

Part VI Chapter 4: Administering an Injection

45

53

1

Subcutaneous ................................................................................................................................... Injection Procedure 53

2

Intra muscle................................................................................................................................... Injection Procedure 58

3

Intramuscular ................................................................................................................................... Injection Sites 61

Part VII Chapter 5: Side Effects 1

64

Basic Side Effects ................................................................................................................................... Information 64

Part VIII Chapter 6: Detection Time of Anabolics

67

Part IX Chapter 7: Steroid Ranking Chart

69

Part X Chapter 8:Making Finaplix (Trenbolone Acetate)

71

1

Tren and Liver ................................................................................................................................... Toxicity 71

2

The Good and ................................................................................................................................... Bad sides of TREN 72 © 2012 Thatotherguy

Contents 3

5

Step by Step................................................................................................................................... Finaplix to Tren Conversion 75

Part XI Chapter 9: Common Body Terms Part XII Chapter 10: Insulin

82 86

1

Insulin: The ................................................................................................................................... Overview 90

2

Monster's Insulin ................................................................................................................................... Primer 94

3

Basic Insulin ................................................................................................................................... guide for beginners 96

4

Mutant's Insulin ................................................................................................................................... Protocal 98

5

How to use................................................................................................................................... insulin - the most anabolic hormone 100

6

Why Insulin................................................................................................................................... works. Steroid Insulin Synergy 102

7

Insulin: The................................................................................................................................... Most Anabolic Hormone 104

8

The Skinny................................................................................................................................... on Insulin 107

9

How To Use ................................................................................................................................... Insulin Without Gaining Fat 120

10

Acnemans ................................................................................................................................... Insulin FAQ 124

Part XIII Chapter 11: Peptides

130

1

Reconstituting ................................................................................................................................... and Measuring Peptides 130

2

HGH + IGF-1 ................................................................................................................................... + Insulin - A basic guide 131

3

A basic IGF-1 ................................................................................................................................... cycle guide 134

4

Peptide Powder ................................................................................................................................... Reconstituting 136

5

AICAR, GW1516 ................................................................................................................................... - Exercise In A Pill 138

6

CJC-1295 Shows ................................................................................................................................... Promise HGH Release 141

7

GRF - GHRP ................................................................................................................................... - GH a comprehensive dosing protocol 142

8

GHRP-2 growth ................................................................................................................................... hormone releasing-hormone 143

9

Growth Hormone ................................................................................................................................... Releasing Hormone (GHRH)/CJC-1295 (GHRH)/CJC-1295 144

10

Mechano Growth ................................................................................................................................... Factor - MGF 147

11

Peptide Profiles ................................................................................................................................... 149 AICAR

..........................................................................................................................................................

151

Bremelanotide .......................................................................................................................................................... PT-141

153

CJC-1295

..........................................................................................................................................................

155

GHRP-6

..........................................................................................................................................................

156

Hexarelin

..........................................................................................................................................................

157

Ipamorelin ..........................................................................................................................................................

159

Melanotan II..........................................................................................................................................................

160

Modified GRF .......................................................................................................................................................... 1-29

162

Sermorelin -.......................................................................................................................................................... synthetic version of the peptide hormone GHRH

165

Part XIV Chapter 12: Profiles 1

Anti-Estrogens ................................................................................................................................... 168 Anti-Estrogen .......................................................................................................................................................... products

2

168 168

Steroid Profiles ................................................................................................................................... 170 1-Testosterone ..........................................................................................................................................................

170

© 2012 Thatotherguy

5

6

Anabolic Collection Best Anadrol (Oxymetholone) ..........................................................................................................................................................

173

Anadur

..........................................................................................................................................................

176

Anavar (Oxandrolone) ..........................................................................................................................................................

177

Dynabol (Dianabol) .......................................................................................................................................................... (nandrolone undecanoate)

179

Equipoise (Boldenone .......................................................................................................................................................... Undecylenate)

180

Halotestin (Fluoxymesterone) ..........................................................................................................................................................

182

Masteron (Drostanolone .......................................................................................................................................................... Propionate)

184

Oxandrolone..........................................................................................................................................................

186

Pituitary Growth .......................................................................................................................................................... Hormone (pGH)

188

Primobolan (methenolone .......................................................................................................................................................... acetate)

189

Primoteston..........................................................................................................................................................

191

Sustanon

..........................................................................................................................................................

194

Testosterone ..........................................................................................................................................................

198

Testosterone .......................................................................................................................................................... Cypionate

204

Testosterone .......................................................................................................................................................... Enanthate

205

Testosterone .......................................................................................................................................................... Heptylate

209

Testosterone .......................................................................................................................................................... Propionate

210

Testosterone ......................................................................................................................................................... Propionate

210

Tren

..........................................................................................................................................................

215

Trenbolone (Trenbolone .......................................................................................................................................................... Acetate)

217

Winstrol (Stanozolol) ..........................................................................................................................................................

220

Part XV Links of Interest Index

223 224


Foreword

Foreword

This is just another title page placed between table of contents and topics


7

Top Level Intro This page is printed before a new top-level chapter starts

Part

I

Disclaimer

1

9

Disclaimer

Disclaimer: This ebook is for educational and/or entertainment purposes only. All information in this ebook is offered only as a general guide and is used at your own risk. The authors and publishers cannot ensure that the information is accurate and current and are not responsible for any errors. The authors and publishers are not offering a guarantee or warranty of any kind regarding the quality or adequacy of the information contained in this ebook. The authors and publishers will assume no responsibility or liability for any damage or loss to any p erson or entity resulting either directly or indirectly from the information in this ebook. The authors and publishers will not provide any reimbursement for any kind of damages resulting from the use or misuse of the information contained in this ebook, including loss of revenue, profit, or money of any kind. By viewing, reading, or in any way using the information contained in this ebook you are agreeing to take full responsibility for any and all consequen ces that may result from your use of this ebook. This ebook also has links to other sites. When you follow a link to one of these sites the authors or publishers of this site are not responsible for the accuracy or reliability of any information published by these other sites, and cannot be held liable for any losses caused by reliance on information on these external sites.



Part

II

Welcome topic

2

11

Welcome topic Welcome - This is test prototype file of Anabolic Steroid Open Source internet book that is going to be published in the future of information from across the internet. Author of this this isn't responsible for any copyrighted copyrighted material. We have inserted a few articles for test (This is ebook is a collection of open source info from across the internet). To come out next is UGL's and Humangrade Anabolics with photos and descriptions; quality, years etc etc or anything anyone else in submitting. Enjoy and spread the wealth.



Part

III

Chap Chapte terr 1: 1: The The his histo tory ry and and bas basic ics s of of ste stero roid ids s

3

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Chapter 1: The history and basics of ster teroids An Introduction to AAS Today’s culture makes it easy to forget that anabolic androgenic steroids (AAS) were actually developed for legitimate medical purposes, and not for physique and performance enhancement. This introduction will provide a comprehensive overview of AAS including information on its: discovery and evolution; basic forms and applications; contemporary terminology and abbreviations; abuse related definition and reasons; methods of acquisition; and many of the dangers surrounding purchase, purity, legal implications and side effects. Background Puberty has always provided visual evidence of distinct changes from childhood to young adulthood. Unfortunately the mechanism within the male body responsible for this transformation was poorly understood. It was not until the 19th century that clinical experiments revealed a hormone within the testes which was the catalyst for these changes. Testosterone (aptly named after the testes) was discovered, isolated, and later synthesized. The 1930’s synthesizing of testosterone marked the invention of AAS, as we know them today. Since then literally hundreds of different forms have been catalogued, while far fewer numbers were commercially produced. Shortly after development, AAS were adapted for a variety of purposes including the increase of aggression in Nazi soldiers, elite-level athletics in the1950’s, and the very specific production for weightlifting athletes. However, by the 1960’s several major sporting organizations had already banned their use, and initiated extensive drug testing policies. In the mid 1990’s, the first Anabolic Steroid Control Act was passed under President George Bush. A decade later congressional hearings were held to curtail the growing AAS problem in athletics. By this time, every major reputable sporting organization from the high school level through the professional ranks had followed suit with anti-AAS regulations and testing policies. Types and Medical Applications There are two basic forms of AAS, actual testosterone, and a chemically modified version it. By making simple chemical modifications to the basic testosterone molecule, an almost infinite variety of steroids have been created. In this way scientists are able to increase certain properties of the drug and decrease others. From a medical perspective, AAS are both naturally occurring (created within the body) and synthetic (created within the lab). In the human body these hormones promote cell growth and division which results in the development of muscle tissue, cartilage and bone. This is achieved through Anabolism which is the metabolic process of building larger molecules from smaller ones. Although AAS were first developed to treat male hypogonadism (a deficiency in the hormone testosterone), since inception they have been found useful in the treatment of other various other conditions as well. Beyond simply being anabolic they possess many physiological properties including the ability to increase protein synthesis, muscle mass, strength, appetite, and bone growth. Numerous wasting diseases such as Cancer, HIV, AIDS, and others have been successfully successfully combated through through AAS administration. This is possible primarily through testosterone’s unique ability to reverse the wasting mechanism, and permit sufficient maintenance and increase in bodyweight. The most recent medically approved use of AAS i s for treatment of a condition known as ‘Andropause’, the decline of androgen levels in older men. This condition is similar to ‘Menopause’, the lowering of estrogen in women, and is typically treated by testosterone administration. Although used to treat medical conditions, AAS are still very powerful powerful drugs. As such, such, they possess possess a wide range of possible side effects including but not limited to: deleterious effects on cholesterol (either an increase in LDL, decreased HDL levels, or both); acne; elevated blood pressure; alterations in


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cardiac (heart) tissue; increased growth of body hair; i ncreased aggression; loss of hair on the scalp including Male Pattern Baldness; and possibly the stunting of growth (vertically and developmentally) in adolescents. As indicated above, AAS medical use should be closely supervised by a physician. Forms of Administration ·

·

·

·

Intramuscular Injection: This injection is deep within the muscle, typically the buttocks. Although there are stigmas associated with injectable AAS, this form is much safer than the oral versions. Oral Administration: Several steroids are available in tablet, capsule and liquid (often black market) form for use orally. Typically oral AAS require an alteration to the base molecule in order to survive passing through the liver. This causes elevated liver enzymes, which increase the organ’s toxicity. Transdermal Administration: Some AAS are available as creams, gels, or patches. They are absorbed through the skin, and are rubbed on directly as one would apply a lotion. This type of administration is generally used during hormone replacement therapy, as it provides the most constant rate of release into the bloodstream. *Subcutaneous Injection: Human Growth Hormone and other related compounds are applied by injection under the skin. This requires pulling the skin away from the muscle and injecting i n the pocket of air that is formed.

Steroid Abuse Abuse is often defined defined as the inability to to refrain from using or participating in something that is dangerous to one’s health or well being. Though AAS abuse is often accompanied by psychological dependence, and a myriad of physical and physiological harm, it is typically defined as any nonprescribed usage. Some Facts on Steroid Abuse:Research indicates that cosmetic purposes represent the primary reason for the abuse of AAS. Social pressure to achieve an unrealistic body type has been cited as the main offender. This i s closely related to the psychological disorders responsible for Anorexia and Buli mia. Nearly 80% of all AAS users do not participate in competitive sports or bodybuilding. In the world of competitive athletics, bodybuilding is the biggest offender with regards to steroid abuse. A virtually non-existent non-existent drug testing testing protocol combined combined with widespread acceptance of AAS abuse within the sport makes bodybuilding a haven for steroid use at all l evels. It was previously thought that abuse was mostly limited to bodybuilders, muscle building enthusiasts, and various professional athletes. It is now known that abuse is far more widespread. At the time of this writing AAS have found their way into nearly every professional and amateur sport, many of which have instituted their own doping policies. In the professional ranks these drugs are often abused in order to gain a competitive edge on other athletes, and to help recover more quickly from training sessions and injury. Males between the ages of 19 and 40 are the most common abusers of AAS. The National Institute on Drug Abuse (NIDA) recently estimated that over half of a million 8th through 10th grade students are abusing AAS, and that many high school seniors do not believe beli eve their use constitutes a health risk. In another study NIDA found that 1,084,000 Americans, or 0.5% of the adult population, admitted to using AAS. Industry Jargon © 2012 Thatotherguy


·

·

·

·

Cycle: A period of steroid use often 8 or more weeks in length, followed by a similar period of disuse. This is known as cycling on and off AAS. Pyramiding: This is when users build up to their heaviest dose on a cycle. Though prevalent in the early days of steroid use, this method was found unnecessary and is virtually no longer practiced. Stacking: The process of combining drugs, or using more than one drug within a cycle. Tapering: This is the opposite of Pyramiding. Users begin with their highest dose and gradually decrease in an effort to minimize the the side effects associated with coming off. off. As with pyramiding, this method is obsolete.

·

Pin or Dart: These are needles used with syringes for injection.

·

UG or UGL: Underground Labs, or clandestine laboratories that produce AAS.

·

Gear, Juice, Vitamin S: AAS

·

Test: Testosterone

·

·

·

·

·

·

·

·

·

15

Deca: This is a slang name for Nandrolone Decanoate, which was originally sold under the trade name Deca-Durablin. D-bol: This is a slang name for Methandrostenolone, which was originally sold under the trade name Dianabol. A-bombs: This is a slang name for Oxymetholone, which was originally sold under the trade name Anadrol. Var: This is a slang name for Oxandrolone, which was originally sold under the trade name Anavar. Winny/Winnie: This is a slang name for Stanozolol, which was originally sold under the trade name Winstrol. EQ: This is a slang name for a veterinary drug called Boldenone Undeclynate, originally sold under the trade name Equipoise. AAS: Anabolic Androgenic Androgenic Steroids, this is the medically accepted abbreviation for steroids. Tren: This is a slang name for any form of the drug “Trenbolone” which is available in several forms. Clen: Clenbuterol is not an anabolic steroid. It is a prescription asthma medication that if used in high enough doses increases the metabolic rate, thus reducing body fat.

·

How are steroids obtained? In the past AAS were obtained via face-to-face deals conducted with drug traffickers known as ‘sources’, and often took place in gym parking lots and locker rooms. People seeking to resell them for profit purchased and transported most of these compounds from Mexico into the United States. In a covert sting operation, the BALCO scandal of 2003 exposed the nationwide involvement of many coaches who provided AAS to their players. Recently, and hopefully reducing this route of access, a new law was passed levying extremely harsh sentencing guidelines for coaches who distribute AAS to athletes in their care. Today the internet serves as the primary source for obtaining AAS. Though gym sources still exist, the web makes them readily available to anyone capable of logging on and arranging payment. Lastly, © 2012 Thatotherguy

16


although it seemingly defies the traditional definition of abuse, another method employed to obtain AAS is through a prescription. Because Because there are a myriad of legitimate uses, some some physicians actually actually write prescriptions for amounts well in excess of therapeutic purposes and circulate them throughout the bodybuilding community. The Black Market The ‘Black Market’ (BM) is the illegal underground production and sells of goods and services. Since the 2004 Anabolic Steroid Control Act placed AAS on the controlled substances list, the BM has been flooded with them. However, there are a significant number of hazards associated with the purchase and usage of underground drugs. The question of product integrity is always central in the minds of BM customers, “Can I purchase safe products from this source?” The virtually anonymity of internet sites coupled with traditionally high provider turnover rates has made answering this question even harder in today’s society. The BM is filled with “scammers”, individuals who simply set up shop to dupe customers out of money with no plan or intention of delivering on the promised AAS. These are actually the good guys, those who promote the once bitten syndrome and scare many would-be buyers/users away from further attempts at steroids. At least they have the decency (used lightly) to take your money and run. Numerous dealers run repackaging scams in which very cheap steroids are placed in expensive product labeling and sold at a premium. These less expensive forms of AAS produce greater side effects, which can be particularly dangerous to women who think they are buying a very mild steroid only to receive a significantly harsher product. Still others produce imposter or fake steroids, which are often bottles of vegetable oils labeled to look like AAS. Along the same li nes are those manufactured under conditions that are far less sanitary than required by the FDA. All of the above hazards can lead to health problems ranging from minor such as abscesses and infections, to major like severe illness and death. Last but certainly not least, are the legal ramification of obtaining AAS from the BM. Harsh sentencing guidelines and tough prosecution are often seen in the handling of AAS cases. But for all of its shortcomings and dangers the BM has persisted, sustained by word of mouth, repeat business and the seemingly methodical process of cleansing itself of would be scammers. List of Anabolic Steroid Side effects: Many androgens are capable of being metabolized into compounds which can interact with other steroid hormone receptors and by combining with estrogen, progesterone, and glucocorticoid receptors produce additional unwanted effects: General · · · · · · · · · · · · · · · ·

Stunted growth Increased risk of HIV, Hepatitis Increased risk of Male Pattern Baldness Hypogonadism (shrinking of testicles, etc…) Increased risk of bodily hair growth Elevated blood pressure Elevated LDL Cholesterol (Bad Cholesterol) Lowered HDL Cholesterol (Good Cholesterol) Addiction Increased Aggression Enlargement of the Left Ventricle of the heart (which can cause cardiac issues) Liver Toxicity Edema, or water retention Increased risk of stroke Increased risk of Heart Attack Male Side Effects © 2012 Thatotherguy


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Prostate Problems: Some AAS convert to Dihydrotestosterone or variants of that hormone, and can enlarge the prostate causing problems urinating or even prostate cancer. Testicular atrophy: Since AAS mimic the male hormone testosterone, the testicles can shrink as a result of their no longer being needed to produce the hormone. Gynecomastia: This female-like breast tissue development in males is caused when steroids aromatize, or convert into high levels of estrogen . Sexual Dysfunction: Some steroids can cause sexual dysfunction and temporary impotence. Reduced reproductive function: AAS can cause a reduction in sperm count, resulting in decreased ability to reproduce. Male Pattern Baldness: The genetically patterned loss of hair on the scalp caused by the AAS conversion into Dihydrotestosterone or its variants. Female Side Effects · · · · · ·

Facial and Body hair increases Thinning of the hair on the scalp Deepening of the voice Clitoral Hypertrophy (an increase in the size of the clitoris) Menstrual cycle irregularity (leading to decreased reproductive function) Adolescent Side Effects Effects

Although any of the the general side effects, effects, and gender specific side effects can also happen in adolescents, there are also some side effects which their undeveloped bodies are more susceptible to. Certain AAS can stunt growth by prematurely stopping the lengthening of bone tissue and fusing growth plates. This causes a decrease in overall height, as total height potential goes unreached. An increased rate rate of bodily maturation. The final adult bodyweight and overall size can be achieved though the user is still too young. There is an increased risk of psychological problems due to the underdevelopment of various parts of the brain.

3.1

What is Testosterone?

Steroids are a synthetically manufactured form of testosterone. Therefore, if you want to learn about steroids, you better learn about testosterone itself first. I am not going to bore you with all the lame shit you have read since you were in grade school. You know your body produces testosterone, testosterone, namely in the Leydig’s Cells in your balls. About 95% is done there. We produce 2.5-11 mg of testosterone per day for males and .25 mg per day for females, on average of course. The more testosterone we have the more protein synthesis happens in our bodies. This means your body can build muscle from the amino acids that are available. © 2012 Thatotherguy

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Normally we are limited to the amount of lean tissue we can synthesize by the amount of testosterone available, so it makes sense that the more testosterone we have the more muscle building capabilities we have right? Wrong! Actually it is much more complex than that. But basically we will start with the testosterone itself. 3.1.1 .1.1

2 Ma Main Kind Kinds s of of Ste Sterroids oids Injectable and Oral Steroids

3.1.1. 3.1.1.1 1

CLASS CLASS I - INJ INJEC ECTAB TABLE LE STER STEROID OIDS S (Este (Esters) rs)

Injectable steroids are basically testosterone with an ester attached to the 17 beta-hydroxyl group. What that gibberish means is that this alteration will make the testosterone last longer in our system before breakdown. Deca Durabolin (Nandrolone Decanoate) can stay traceable in our systems for over a year! Not that it will be giving results for a year though. This alteration also makes the testosterone more soluble in oil rather than in water. When an ester is injected it forms a deposit called a “depot” (pronounced “deepo”) in the muscle tissue. This depot will slowly break down and enter the bloodstream. Some break down faster than others. An ester of Decanoatecan Decanoatecan take up to a month to break break down, where as as Propionate or Acetate only lasts days. The frequency of injections will usually reflect the breakdown time of the steroid (you would be injecting Propionate several times a week to keep constant elevated testosterone levels, where as injections of Nandrolone Decanoate would be less often). 3.1.1. 3.1.1.2 2

CLASS CLASS II II – ORAL ORAL STER STEROID OIDS S (meth (methyla ylated ted))

Oral steroids differ from testosterone in that they usually have their hydrogen atom in the 17 th alpha position replaced with a methyl group. This is done through a process called alkylation. What the hell does that mean? CH3 is the “methyl” group. Thisform allows the new “steroid” to be resistant to breakdown by the liver. (Here is that part where you can recite that “orals” arebad on the liver! Ha!). © 2012 Thatotherguy


19

A caution must be made when using using orals due to the fact fact that they must go through the liver. That added methyl group on the 17 th alpha position cannot be removed by the liver too easily, so you have a lot of stress happening. Oral steroids usually give quick results, which is the reason most people will have an oral like Dianabol, or Norethandrolone (Nilevar) in their cycle at the beginning. Chemists created forms of orals that did not put as much stress upon the liver as the alkylated steroids. Some examples of these are Primobolan, Proviron, Andriol, and Anabolicum Vistor. I am not going to bore you with the methods they used to create these types, you can get a textbook for that. They are much less resistant to breakdown than the 17 alpha alkylated steroids, but produce much less bang for the buck. Basically you’re going to get smaller gains from safer drugs.



Part

IV

Chap Chapte terr 2: 2: Wha Whatt kin kind d of of ste stero roid id do I tak take? e?

4

Chapter 2: What kind of steroid do I take?

4.1

How Steroids Work in the Body

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Take a good look at any bodybuilder who uses steroids and there is one certain conclusion that can be drawn about how these drugs work. But knowing that steroids will pump you up isn’t enough to insure that using them will sculpt you into the physical specimen you see in i n men’s fitness magazines. Knowing the biological and pharmacological functions of how these drugs pump you up is an important step to safe and effective steroid use. Steroids, like all drugs, act by manipulating the levels of chemicals the body already produces. It the case of steroids, the chemical is the hormone testosterone. Testosterone is found in both men and women but it is far more prevalent in men. It is the hormone that gives men facial hair, deeper voices and, of coarse, larger muscles. When a user ingests steroids there are several processes that the body goes through. The first process, called absorption, deals with how the drug is administered. Steroids are either taken orally, in pill form, or intramuscularly by hypodermic needle. Oral steroids are ingested like food, through the stomach and small intestine. Acids in the stomach break down the pills and separate the testosterone from the carrier substances in the pill. The drugs are then carried through the small intestine and the © 2012 Thatotherguy

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liver before entering the blood stream. Injecting steroids bypasses the digestive tract and puts the drug directly into the bloodstream. During the distribution process is when steroids begin their work. Distribution is just the drug moving through the body by way of the blood stream. Testosterone, like all hormones, acts as a chemical messenger to the body. As steroids move through the body, they send their message by attaching themselves to specialized protein receptors in cells that trigger the growth of new proteins. These proteins build muscle mass and strength throughout the body. This process occurs naturally in the body without the use of steroids, but the drugs increase the amount of testosterone in the body and the frequency in which they bind to the proteins in the cells. It is this increase in biological activity, called Ribonucleic Acid Activity, or RNA activity, that gives steroid users their exaggerated muscle mass. Even as the testosterone is being picked up by the receptors to begin the process of creating new proteins, the body starts another process to get rid of the unwanted toxins associated with steroids. Metabolism occurs in the liver where these toxins are broken down and made ready to be excreted from the body. The higher the dose of steroids ingested, the higher the amount of toxins the body must metabolize. Detoxifying the body is hard on the liver and is one of the most harmful side effects of steroid use. After the liver has metabolized the steroids, the body body gets rid of the toxins and waste through excretion. Drug toxins can leave the body through urine, sweat glands and even breath from the lungs. In the case of steroids, the body uses a combination of the three, which is why acne on the skin and bad breath are often associated with use of anabolic steroids.

4.2

A Com Compreh rehensiv nsive e Look at Lab Tests sts by Cy Willson You just had some blood work done, and the friggin doctor or his nurses are guarding the results as if they’re state secrets. However, after much cajoling and explaining that you’d li ke to at least be an informed partner in your own gosh darn health care, they begrudgingly give you a copy of your lab tests. Trouble is, as much as you’ve been posturing about how you’ve had more than a smattering of medical education, you still can’t figure out what half the tests are for and whether or not those abnormal values are anything to worry about. Well, in the following article, I’m going to go over each of the most common tests. I’ll include why it’s performed, what it tells you, and what the typical ranges are for normal humans. That way, you’ll have something more to go on in assessing your health other than your family doctor saying, “Well, these few values are a little worrisome, but you’ll probably be okay.” One note, though, before I get started. The values I’ll be listing are merely averages and the ranges may vary slightly from laboratory to laboratory. Also, if there’s only one range given, it applies to both men and women. Lipid Panel ” Used to determine possible risk for coronary and vascular disease. In other words, heart disease. HDL/LDL and Total Cholesterol These lipo proteins should look rather familiar to most of you. HDL is simply the “good” lipo protein that acts as a scavenger molecule and prevents a buildup of material. LDL is the “bad” lipo protein which collects in arterial walls and causes blockage or a reduction in blood flow. The total cholesterol to HDL ratio is also important. I went in to detail about this particular subject ” as well as how to improve your lipid profile ” in my article “Bad Blood”. Nevertheless, a quick reminder: your HDL should be 35 or higher; LDL below 130; and total to HDL © 2012 Thatotherguy


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ratio should be below 3.5. Oh and don’t forget VLDL (very low density lipoprotein) which can be extremely worrisome. You should have less than 30 mg/dl in order to not be considered at risk for heart disease. On a side note, I’m sure some of you are wishing that you had abnormally low plasma cholesterol levels (as if it’s something to brag about), but the fact is that having extremely low cholesterol levels is actually indicative of severe liver disease. Triglycerides Triglycerides are simply a form of fat that exists in the bloodstream. They’re transported by two other culprits, VLDL and LDL. A high level of triglycerides is also a risk factor for heart disease as well. Triglycerides levels can be increased if food or alcohol is consumed 12 to 24 hours prior to the blood draw and this is the reason why you’re asked to fast for 12-14 hours from food and abstain from alcohol for 24 hours. Here are the normal ranges for healthy humans. 16-19 yr. old male 40-163 mg/dl Adult Male 40-160 mg/dl 16-19 yr. old female 40-128 mg/dl Adult Female 35-135 mg/dl Homocysteine Unfortunately, this test isn’t always ordered by the doctor. It should be. Homocysteine is formed in the metabolism of the dietary amino acid methionine. The problem is that it’s a strong risk factor for atherosclerosis. In other words, high levels may cause you to have a heart attack. A good number of lifters should be concerned with this value as homocysteine levels rise with anabolic steroid usage. Luckily, taking folic acid (about 400-800 mcg.) as well as taking a good amount of all B vitamins in general will go a long way in terms of preventing a rise in levels of homocysteine. Normal ranges: Males and Females age 0-30 4.6-8.1 umol/L Males age 30-59 6.3-11.2 umol/L Females age 30-59 4.5-7.9 umol/L >59 years of age 5.8-11.9 umol/L The Hemo Profile These are various tests that examine a number of components of your blood and look for any abnormalities that could be indicative of serious diseases that may result in you being an extra in the HBO show, “Six Feet Under.”


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WBC Total (White Blood Cell) Also referred to as leukocytes, a fluctuation in the number of these types of cells can be an indicator of things like infections and disease states dealing with immunity, cancer, stress, etc. Normal ranges: 4,500-11,000/mm3 Neutrophils This is one type of white blood cell that’s in circulation for only a very short time. Essentially their job is phagocytosis, which is the process of killi ng and digesting bacteria that cause infection. Both severe trauma and bacterial infections, as well as inflammatory or metabolic disorders and even stress, can cause an increase in the number of these cells. Having a low number of neutrophils can be i ndicative of a viral infection, a bacterial infection, or a rotten diet. Normal ranges: 2,500-8,000 cells per mm3 RBC (Red Blood Cell) These blood cells also called erythrocytes and their primary function is to carry oxygen (via the hemoglobin contained in each RBC) to various tissues as well as giving our blood that cool “red” color. Unlike WBC, RBC survive in peripheral blood circulation for approximately 120 days. A decrease in the number of these cells can result in anemia which could stem from dietary insufficiencies. An increase in number can occur when androgens are used. This is because androgens increase EPO (erythropoietin) production which in turn increases RBC count and thus elevates blood volume. This is essentially why some androgens are better than others at increasing “vascularity.” Anyhow, the danger in this could be an increase in blood pressure or a stroke. Androgen-using lifters who have high values should consider making modifications modifications to their stack stack and/ or immediately donating some blood. Normal ranges: Adult Male 4,700,000-6,100,000 cells/uL Adult Female 4,200,000-5,400,000 cells/uL Hemoglobin Hemoglobin is what serves as a carrier for both oxygen and carbon dioxide transportation. Molecules of this are found within each red blood cell. An increase in hemoglobin can be an indicator of congenital heart disease, congestive heart failure, sever burns, or dehydration. Being at high altitudes, or the use of androgens, can cause an increase as well. A decrease in number can be a sign of anemia, lymphoma, kidney disease, sever hemorrhage, cancer, sickle cell anemia, etc. Normal ranges: Males and females 6-18 years 10-15.5 g/dl Adult Males 14-18 g/dl © 2012 Thatotherguy


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Adult Females 12-16 g/dl Hematocrit The hematocrit is used to measure the percentage of the total blood volume that’s made up of red blood cells. An increase in percentage may be indicative of congenital heart disease, dehydration, diarrhea, burns, etc. A decrease in levels may be indicative of anemia, hyperthyroidism, cirrhosis, hemorrhage, leukemia, rheumatoid arthritis, pregnancy, malnutrition, a sucking knife wound to the chest, etc. Normal ranges: Male and Females age 6-18 years 32-44% Adult Men 42-52% Adult Women 37-47% MCV (Mean Corpuscular Volume) This is one of three red blood cell indices used to check for abnormalities. The MCV is the size or volume of the average red blood cell. A decrease in MCV would then indicate that the RBC’s are abnormally large(or macrocytic), and this may be an indicator of iron deficiency anemia or thalassemia. When an increase is noted, that would indicate abnormally small RBC (microcytic), and this may be indicative of a vitamin B12 or folic acid deficiency as well as liver disease. Normal ranges: Adult Male 80-100 fL Adult Female 79-98 fL 12-18 year olds 78-100 fL MCH (Mean Corpuscular Hemoglobin) The MCH is the weight of hemoglobin present in the average red blood cell. This is yet another way to assess whether some sort of anemia or deficiency is present. Normal ranges: 12-18 year old 35-45 pg Adult Male 26-34 pg Adult Female 26-34 pg MCHC (Mean Corpuscular Hemoglobin Concentration) © 2012 Thatotherguy

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The MCHC is the measurement of the amount of hemoglobin present in the average red blood cell as compared to its size. A decrease in number is an indicator of iron deficiency, thalassemia, lead poisoning, etc. An increase is sometimes seen after androgen use. Normal ranges: 12-18 year old 31-37 g/dl Adult Male 31-37 g/dl Adult Female 30-36 g/dl RDW (Red Cell Distribution Width) The RDW is an indicator of the variation in red blood cell size. It’s used in order to help classify certain types of anemia, and to see if some of the red blood cells need their suits tailored. An increase in RDW can be indicative of iron deficiency anemia, vitamin B12 or folate deficiency anemia, and diseases like sickle cell anemia. Normal ranges: Adult Mal 11.7-14.2% Adult Female 11.7-14.2% Platelets Platelets or thrombocytes are essential for your body’s ability to form blood clots and thus stop bleeding. They’re measured in order to assess the likelihood of certain disorders or diseases. An increase can be indicative of a malignant disorder, rheumatoid arthritis, iron deficiency anemia, etc. A decrease can be indicative of much more, including things like infection, various types of anemia, leukemia, etc. On a side note for these ranges, anything above 1 million/mm3 would be considered a critical value and should warrant concern and/or giving second thoughts as to whether you should purchase a lifetime subscription to Muscle Media. Normal ranges: Child 150,000-400,000/mm3 (Most commonly displayed in SI units of 150-400 x 10(9th)/L Adult 150,000-400,000/mm3 (Most commonly displayed in SI units of 150-400 x 10(9th)/L ABS (Differential Count) Count) The differential count measures the percentage of each type of leukocyte or white blood cell present in the same specimen. Using this, they can determine whether there’s a bacterial or parasitic infection, as well as immune reactions, etc. © 2012 Thatotherguy


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Pt. 2 Neutrophils As explained previously, severe trauma and bacterial infections, infections, as well as inflammatory inflammatory disorders, disorders, metabolic disorders, and even stress can cause an increase in the number of these cells. Also, on the other side of the spectrum, a low number of these cells can indicate a viral infection, a bacterial infection, or a deficient diet. Percentile Range: 55-70% Basophils These cells, and in particular, eosinophils, are present in the event of an allergic reaction as well as when a parasite is present. These types of cells don’t increase in response to viral or bacterial infections so if an increased count is noted, it can be deduced that either an allergic response has occurred or a parasite has taken up residence in your shorts. Percentile Range: Basophils 0.5-1% Eosinophils 1-4% Lymphocytes and Monocytes Lymphocytes can be divided in to two different types of cells: T cells and B cells. T cells are involved in immune reactions and B cells are involved in antibody production. The main j ob of lymphocytes in general is to fight off â€” Bruce Lee style â€” bacterial and viral infections. Monocytes are similar to neutrophils but are produced more rapidly and stay in the system for a longer period of time. Percentile Range: Lymphocytes 20-40% Monocytes 2-8% Selected Clinical Values Sodium This cation (an ion with a postive charge) is mainly found in extracellular spaces and is responsible for maintaining a balance of water in the body. When sodium in the blood rises, the kidneys will conserve water and when the sodium concentration is low, the kidneys conserve sodium and excrete water. Increased levels can result from excessive dietary intake, Cushing’s syndrome, excessive sweating, burns, forgetting to drink for a week, etc. Decreased levels can result from a deficient diet, Addison’s disease, diarrhea, vomiting, chronic renal insufficiency, excessive water intake, congestive heart failure, etc. Anabolic steroids will lead to an increased level of sodium as well.


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Normal range: Adults 136-145 mEq/L Potassium On the other side of the spectrum, you have the most important intracellular cation. Increased levels can be an indicator of excessive dietary intake, acute renal failure, aldosterone-inhibiting diuretics, a crushing injury to tissues, infection, acidosis, dehydration, etc. Decreased levels can be i ndicative of a deficient dietary intake, burns, diarrhea or vomiting, diuretics, Cushing’s syndrome, licorice consumption, insulin use, cystic fibrosis, trauma, surgery, etc. Normal range: Adults 3.5-5 mEq/L Chloride This is the major extracellular anion (an ion carrying a negative charge). Its purpose it is to maintain electrical neutrality with sodium. It also serves as a buffer in order to maintain the pH balance of the blood. Chloride typically accompanies sodium and thus the causes for change are essentially the same. Normal range: Adult 98-106 mEq/L Carbon Dioxide The CO2 content is used to evaluate the pH of the blood as well as aid in evaluation of electrolyte levels. Increased levels can be indicative of severe diarrhea, starvation, vomiting, emphysema, metabolic alkalosis, etc. Increased levels could also mean that you’re a plant. Decreased levels can be indicative of kidney failure, metabolic acidosis, shock, and starvation. Normal range: Adults 23-30 mEq/L Glucose The amount of glucose in the blood after a prolonged period of fasting (12-14 hours) is used to determine whether a person is in a hypoglycemic (low blood glucose) or hyperglycemic (high blood glucose) state. Both can be indicators of serious conditions. Increased levels can be indicative of diabetes mellitus, acute stress, Cushing’s syndrome, chronic renal failure, corticosteroid therapy, acromegaly, etc. Decreased levels could be indicative of hypothyroidism, insulinoma, liver disease, insulin overdose, and starvation. Normal range: Adult Male 65-120 mg/dl Adult Female 65-120 mg/dl © 2012 Thatotherguy


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BUN (Blood Urea Nitrogen) This test measures the amount of urea nitrogen that’s present in the blood. When protein is metabolized, the end product is urea which is formed in the liver and excreted from the bloodstream via the kidneys. This is why BUN is a good indicator of both liver and kidney function. Increased levels can stem from shock, burns, dehydration, congestive hear failure, myocardial infarction, excessive protein ingestion, excessive protein catabolism, starvation, sepsis, renal disease, renal failure, etc. Causes of a decrease in levels can be liver failure, overhydration, negative nitrogen balance via malnutrition, pregnancy, etc. Normal range: Adults 10-20 mg/dl Creatinine Creatinine is a byproduct of creatine phosphate, the chemical used in contraction of skeletal muscle. So, the more muscle mass you have, the higher the creatine levels and therefore the higher the levels of creatinine. Also, when you ingest large amounts of beef or other meats that have high levels of creatine in them, you can increase creatinine levels as well. Since creatinine levels are used to measure the functioning of the kidneys, this easily explains why creatine has been accused of causing kidney damage, since it naturally results in an increase in creatinine levels. However, we need to remember that these tests are only indicators of functioning and thus outside drugs and supplements can influence them and give false results, as creatine may do. This is why creatine, while increasing creatinine levels, does not cause renal damage or impair function. Generally speaking, though, increased levels are indicative of urinary tract obstruction, acute tubular necrosis, reduced renal blood flow (stemming from shock, dehydration, congestive heart failure, atherosclerosis), as well as acromegaly. Decreased levels can be indicative of debilitation, and decreased muscle mass via disease or some other cause. Normal range: Adult Male 0.6-1.2 mg/dl Adult Female 0.5-1.1 mg/dl BUN/Creatinine Ratio A high ratio may may be found in states of shock, volume depletion, depletion, hypotension, dehydration, gastrointestinal bleeding, and in some cases, a catabolic state. A low ratio can be indicative of a low protein diet, malnutrition, pregnancy, severe liver disease, ketosis, etc. Keep in mind, though, that the term BUN, when used in the same sentence as hamburger or hotdog, usually means something else entirely. An important thing to note again is that with a high protein diet, you’ll likely have a higher ratio and this is nothing to worry about. Normal range: Adult 6-25 Calcium Calcium is measured in order to assess the function of the parathyroid and calcium metabolism. © 2012 Thatotherguy

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Increased levels can stem from hyperparathyroidism, metastatic tumor to the bone, prolonged immobilization, lymphoma, hyperthyroidism, acromegaly, etc. It’s also important to note that anabolic steroids can also increase calcium levels. Decreased levels can stem from renal failure, rickets, vitamin D deficiency, malabsorption, pancreatitis, and alkalosis. Normal range: Adult 9-10.5 mg/dl Liver Function Total Protein This measures the total level of albumin and globulin in the body. Albumin is synthesized by the liver and as such is used as an indicator of liver function. It functions to transport hormones, enzymes, drugs and other constituents of the blood. Globulins are the building blocks of your body’s antibodies. Measuring the levels of these two proteins is also an indicator i ndicator of nutritional status. Increased albumin levels can result from dehydration, while decreased albumin levels can result from malnutrition, pregnancy, liver disease, overhydration, inflammatory diseases, etc. Increased globulin levels can result from inflammatory diseases, hypercholesterolemia (high cholesterol), iron deficiency anemia, as well as infections. Decreased globulin levels can result from hyperthyroidism, liver dysfunction, malnutrition, and immune deficiencies or disorders. As another important important side note, anabolic steroids, growth growth hormone, and insulin can all increase increase protein levels. Normal range: Adult Total Protein: 6.4-8.3 g/dl Albumin: 3.5-5 g/dl g/dl Globulin: 2.3-3.4 g/dl Albumin/Globulin Ratio: Adult 0.8-2.0 Bilirubin Bilirubin is one of the many constituents of bile, which is formed in the liver. An increase in levels of bilirubin can be indicative i ndicative of liver stress or damage/inflammation. Drugs that may increase bilirubin include oral anabolic steroids (17-AA), antibiotics, diuretics, morphine, codeine, contraceptives, etc. Drugs that may decrease levels are barbiturates and caffeine. Non-drug induced increased levels can be indicative of gallstones, extensive l iver metastasis, and cholestasis from certain drugs, hepatitis, sepsis, sickle cell anemia, cirrhosis, etc. Normal range: Total Bilirubin for Adult 0.3-1.0 mg/dl Alkaline Phosphatase This enzyme is found in very high concentrations in the liver and for this reason is used as an indicator © 2012 Thatotherguy


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of liver stress or damage. Increased levels can stem from cirrhosis, liver tumor, pregnancy, healing fracture, normal bones of growing children, and rheumatoid arthritis. Decreased levels can stem from hypothyroidism, malnutrition, pernicious anemia, scurvy (vitamin C deficiency) and excess vitamin B ingestion. As a side note, antibiotics can cause an increase in the enzyme levels. l evels. Normal range: 16-21 years 30-200 U/L Adult 30-120 U/L Pt. 3 AST (Aspartate Aminotransferase, Aminotransferase, previously previously known as SGOT) This is yet another enzyme that’s used to determine if there’s damage or stress to the liver. It may also be used to see if heart disease is a possibility as well, but this isn’t as accurate. When the liver is damaged or inflamed, AST levels can rise to a very high level (20 times the normal value). This happens because AST is released when the cells of that particular organ (liver) are lysed. The AST then enters blood circulation and an elevation can be seen. Increased levels can be indicative of heart disease, liver disease, skeletal muscle disease or injuries, as well as heat stroke. Decreased levels can be indicative of acute kidney disease, beriberi, diabetic ketoacidosis, pregnancy, and renal dialysis. Normal range: Adult 0-35 U/L (Females may have slightly lower levels) ALT (Alanine Aminotransferase, Aminotransferase, previously known as SGPT) This is yet another enzyme that is found in high levels within the li ver. Injury or disease of the liver will result in an increase in levels of ALT. I should note however, that because lesser quantities are found in skeletal muscle, there could be a weight-training induced increase . Weight training causes damage to muscle tissue and thus could slightly sli ghtly elevate these levels, giving a false indicator for liver disease. Still, for the most part, it’s a rather accurate diagnostic tool. Increased levels can be indicative of hepatitis, hepatic necrosis, cirrhosis, cholestasis, hepatic tumor, hepatotoxic drugs, and jaundice, as well as severe burns, trauma to striated muscle (via weight training), myocardial infarction, mononucleosis, and shock. Normal range: Adult 4-36 U/L Endocrine Function Testosterone (Free and Total) This is of course the hormone that you should all be extremely familiar with as it’s the name of this here magazine! Anyhow, just as some background info, about 95% of the circulating Testosterone in a man’s body is formed by the Leydig cells, which are found in the testicles. Women also have a small amount of Testosterone in their body as well. (Some more than others, which accounts for the bearded ladies you see at the circus, or hanging around with Chris Shugart.) This is from a very small amount of Testosterone secreted by the ovaries and the adrenal gland (in which the majority is made from the adrenal conversion of androstenedione to Testosterone via 17-beta HSD). © 2012 Thatotherguy

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Nomral range, total Testosterone: Male Age 14 <1200 ng/dl Age 15-16 100-1200 ng/dl Age 17-18 300-1200 ng/dl Age 19-40 300-950 ng/dl Over 40 240-950 ng/dl Female Age 17-18 20-120 ng/dl Over 18 20-80 ng/dl Normal range, free Testosterone: Male 50-210 pg/ml LH (Luteinizing Hormone) LH is a glycoprotein that’s secreted by the anterior pituitary gland and is responsible for signaling the leydig cells to produce Testosterone. Measuring LH can be very useful in terms of determining whether a hypogonadic state (low Testosterone) is caused by the testicles not being responsive despite high or normal LH levels (primary), or whether it’s the pituitary gland not secreting enough LH (secondary). Of course, the hypothalamus â€” which secretes LH-RH (luteinizing hormone releasing hormone) â€” could also be the culprit, as well as perhaps both the hypothalamus and the pituitary. If it’s a case of the testicles not being responsive to LH, then things like clomiphene and hCG really won’t help. If the problem is secondary, then there’s a better chance for improvement with drug therapy. Increased levels can be indicative of hypogonadism, precocious puberty, and pituitary adenoma. Decreased levels can be indicative of pituitary failure, hypothalamic failure, stress, and malnutrition. Normal ranges: Adult Male 1.24-7.8 IU/L Adult Female Follicular phase: 1.68-15 IU/L Ovulatory phase: 21.9-56.6 IU/L Luteal phase: 0.61-16.3 IU/L Postmenopausal: 14.2-52.3 IU/L © 2012 Thatotherguy


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Estradiol With this being the most potent of the estrogens, I’m sure you’re all aware that it can be responsible for things like water retention, hypertrophy of adipose tissue, gynecomastia, and perhaps even prostate hypertrophy and tumors. As a male it’s very important to get your levels of this hormone checked for the above reasons. Also, it’s the primary estrogen that’s responsible for the negative feedback loop which suppresses endogenous Testosterone production. So, if your levels of estradiol are rather high, you can bet your ass that you’ll be hypogonadal as well. Increased estradiol levels can be indicative of a testicular tumor, adrenal tumor, hepatic cirrhosis, necrosis of the liver, hyperthyroidism, etc. Normal ranges: Adult Male 10-50 pg/ml Adult Female Follicular phase: 20-350 pg/ml Midcycle peak: 150-750 pg/ml Luteal phase: 30-450 pg/ml Postmenopausal: 20 pg/ml or less Thyroid (T3, T4 Total and Free, TSH) t3 (Triiodothyronine) t3 is the more metabolically active hormone out of T4 and t3. When levels are below normal it’s generally safe to assume that the individual is suffering from hypothyroidism. Drugs that may increase t3 levels include estrogen and oral contraceptives. Drugs that may decrease t3 levels include anabolic steroids/androgens as well as propanolol (a beta adrenergic blocker) and high dosages of salicylates. Increased levels can be indicative of Graves disease, acute thyroiditis, pregnancy, hepatitis, etc. Decreased levels can be indicative of hypothyroidism, protein malnutrition, kidney failure, Cushing’s syndrome, cirrhosis, and liver diseases. Normal ranges: 16-20 years old 80-210 ng/dl 20-50 years 75-220 ng/dl or 1.2-3.4 nmol/L Over 50 40-180 ng/dl or 0.6-2.8 nmol/L T4 (Thyroxine) T4 is just another indicator of whether or not someone is in a hypo or hyperthyroid state. It too is rather reliable but free thyroxine levels should be assessed as well. Drugs that increase of decrease t3 will, in most cases, do the same with T4. Increased levels are indicative of the same things as t3 and a decrease can be indicative of protein depleted states, iodine i nsufficiency, kidney failure, Cushing’s syndrome, and cirrhosis. Normal ranges: Adult Male 4-12 ug/dl or 51-154 nmol/L Adult Female © 2012 Thatotherguy

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5-12 ug/dl or 64-154 nmol/L Free T4 or Thyroxine Since only 1-5% of the total amount of T4 is actually free and useable, this test is a far better indicator of the thyroid status of the patient. An increase indicates a hyperthyroid state and a decrease indicates a hypothyroid state. Drugs that increase free T4 are heparin, aspirin, danazol, and propanolol. Drugs that decrease it are furosemide, methadone, and rifampicin. Increased and decreased levels are indicative of the same possible diseases and states that are seen with T4 and t3. Normal ranges: 0.8-2.8 ng/dl or 10-36 pmol/L TSH (Thyroid Stimulating Hormone) Measuring the level of TSH can be very helpful in terms of determining if the problem resides with the thyroid itself or the pituitary gland. If TSH levels are high, then it’s merely the thyroid gland not responding for some reason but if TSH levels are low, it’s the hypothalamus or pituitary gland that has something wrong with it. The problem could be a tumor, some type of trauma, or an infarction. Drugs that can increase levels of TSH include lithium, potassium iodide and TSH itself. Drugs that may decrease TSH are aspirin, heparin, dopamine, t3, etc. Increased TSH is indicative of thyroiditis, hypothyroidism, and congenital cretinism. Decreased levels are indicative of hypothyroidism (pituitary dysfunction), hyperthyroidism, and pituitary hypofunction. Normal ranges: Adult 2-10 uU/ml or 2-10 mU/L Knowing how to interpret these tests can be a very valuable tool in terms of health and your body building and athletic progress. Use your new knowledge wisely!

4.3

Best Steroids Best steroids? Which are they? Are there steroids out there which are better for the user or produce better gains? Yes, there are best steroids! However, the results a particular steroid produces, and the quality of such results is purely based on the goals set before the steroid cycle. We cannot say which are best steroids for you, but we can tell you which are the best steroids to reach your goals. Let’s look at some examples of goals set pre-steroid-cycle: Goal 1: Bulk Up – Best Steroids for Bulking Up 1) Danabol 2) Nandrolone Decanoate 3) Testosterone (esters – enanthate, cypionate) 4) Androlic 5) Sustanon 250 6) Trenbolone 7) Boldenone (Equipoise) When you are trying to bulk up, you are looking for steroid compounds which produce the most gains in the shortest period of time. Whether it’s lean gains or not, the steroids used in bulking will literally blow you up. Some of these steroids, such as Nandrolone Decanoate and Danabol is the favorite stack of many bodybuilders. Try to ask Arnold Schwarzenegger about his bulking best steroids cycles, and what he thinks are the best steroids for bulking. Arnold Schwarzenegger will tell you they are Nandrolone Decanoate and Danabol for bulking up. © 2012 Thatotherguy


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Nowadays, many extreme bodybuilders tend to stacking steroids such as Androlic and Danabol as well as Testosterone with Nandrolone Decanoate as one of full bulking stacks. We don’t recommend mixing Androlic and Danabol, for it is very liver toxic combination ! And this steroid combination can be very bad for your health in the long term. It’s not the best steroids steroids combination at all. The Trenbolone critics will get upset that trenbolone is not no. 1, why is it so? The popular belief is that trenbolone is a cutting/bulking substances, which brings you lean mass, however, any real trenbolone user will tell you that trenbolone injections every day are not reasonable. It’s not possible to inject yourself daily a dose of trenbolone unless you have an unlimited pain threshold; thus, it’s more clever to add trenbolone to an already existing steroid cycle such as Testosterone and Danabol. On top of the daily injection problem, trenbolone is known for being terrible on cardio shape of the user. Cardio shape is diminished terribly with trenbolone. Last on the list, you can see Boldenone. Boldenone is not so much on the list as a best steroids for bulking but for its’ ability to make you huge, but moreso for its’ ability to make you eat like a horse. Boldenone is one of the best steroids for increasing your appetite (probably the best one) than any other steroid, even better than B12 injections. On top of that, Boldenone is known to increase red blood cell count, which makes cardiovascular activity a breeze. Why is this good for your body? Well, if you’ve ever been on a bulking steroid cycle, walking around at 300lbs., you’d know why any help with your cardio shape is beneficial at all. Finally, many critics ask why Boldenone was not added i n the Goal 2 section (*Best Steroids for Lean Out). It is easy to answer! How can you lean l ean out when you appetite is asking you to eat as a small elephant? Goal 2: Lean Mass (cut up) – Best Steroids for Lean Mass 1) Primobolan 2) Bonavar 3) Winstrol 4) Testosterone Propionate 5) Trenbolone 6) Masteron Now, on to leaning out, what are the best steroids for leaning out and cutting up? Well, let’s take a look at our list above. The most prominent of the steroids is probably winstrol, which has been known for years to be one the best steroids for leaning out (rumored as the best steroids to lean out). Almost every steroid user has heard about or knows Winstrol in one way or another. Winstrol is on the list of best steroids for cutting up because of its’ unique ability to harden up muscle mass, making muscles appear harder and rounder. Bonavar, coming in at no. 2 on the list of the best steroids is probably one of the best known steroids after winstrol. Bonavar is used by many bodybuilders as well as professional power lifters. Bonavar has an amazing ability to increase strength while helping you burn bodyfat. A study done with Bonavar use in adult males suggest that average dosage of anavar between 10-20mgs per day increases fat burning capacity by 80%. This is not magic, but it’s significant. Trenbolone, making the cutting list as well as the bulking list of best steroids, trenbolone is such a unique steroid that it deserves a lot of respect. Out of all the steroids available, trenbolone is one of the most effective, but also one of the most side effect filled drugs (right after Adrolic). So, why is it at no. 5? That’s because Trenbolone use is usually limited to 6 week periods, making it unrealistic for long term use in a 16 week cutting steroid cycle. Primobolan is no. 1 of our list of Best Steroids for cutting up and leaning out! Primobolan is by far the best steroid for cutting up. Primobolan allows user to keep a low calorie diet while increasing muscle mass. Imagine a BodyOpus diet by Dan Duchaine, with primobolan and winstrol. It’s estimated a proper BodyOpus diet with the usage of Primobolan, Winstrol and Bonavar can acheive an average fat loss of 15-20% bodyfat as well as a muscle gain of around 10-15lbs. in a 12-16 week period. If that’s not the best steroids stack you’ve seen, we can’t say much more. © 2012 Thatotherguy

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It was rumored that Arnold Schwarzenegger used Primobolan with Danabol to cut up for a bodybuilding show. We think this rumor is a bit overblown. It’s more likely Arnold Schwarzenegger used Primobolan as well as other steroids to cut up; however, the real belief is that Arnold Schwarzenegger used Primobolan, Danabol as well as human growth hormone (HGH). Human growth hormone (HGH) is the early version of HGH which was derived from dead human cadavers! These days all HGH is synthetic and belongs to the best steroids list.



Part

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5


Chapter 3: Proper Cycling of Steroids Steroid Cycles - More to come later

5.1

Beginners Cy Cycle More to come... in 1.0

5.1.1

Novice Cy Cycle #1 #1 Novice Steroid Cycles (Cycle #1) Steroid Cycles for Beginners If I were just entering the world of anabolic steroids, I wouldn't know what to do with all of the information available today. I remember a decade ago when I first read the Underground Steroid Handbook by Dan Duchaine. The thing that stuck with me from that book was that he always said there was no magic in steroids. I read his handbook, and just as was promised, I learned that the rabbit was always in the hat, and the cards were up a sleeve all along. Steroids look like magic to beginners, because its hard to believe you can take a few pills and become more muscular seemingly overnight. Well, its not magic, but if you're a beginner and have seen their effects first hand (perhaps in a friend or teammate), they probably seem that way to you. But there's no magic here. I'm going to also say that if you're a beginner (i.e. have never used steroids), and you're reading this article, you're considering using them. A beginner is someone who has done two cycles or less, in my opinion. Instead of just throwing some drugs and dosages at you, I´m going to do something a bit different. First I´m going to ask you some questions. If you answer no to any of them, then you´re probably not ready to use anabolic steroids. Are you a male over eighteen eighteen years old? Have you been training for at least two or three years seriously? Can you devote at least half a year to working out consistently? Can you be sure you can get real steroids? If you are under eighteen years old, you probably haven´t stopped growing yet. So answering no to my first question means you run a very real risk of stunting your growth if you should choose to use steroids. In addition, I suppose there´s some kind of moral/ethical/legal issue in telling a minor that its alright to use steroids. So lets assume that if you´re still reading this, you´re of legal age to vote (but perhaps not to buy a beer which is another issue altogether ). If you answered no to my second question, you still need some natural training in the gym. This isn't because you need to reach some mythical natural limit first, but rather because without a couple of years of serious training, you simply won´t know how your body reacts to different exercises. As for my third question, I´m I´m not going to tell you to do a 6 month month cycle, but if you can´t devote devote at least as much time after the cycle to recovering as you did to the cycle (a three month one), then you´ll lose too much of your hard earned gains to make it worth it to even do a cycle. Finally, do I even need to elaborate on why answering no to the last question means you shouldn't be considering a cycle? Good. I´m going to limit my suggestions for beginner´s cycles to basically two compounds at most. And I´m going to also limit my suggestions to the most cost effective cycles and I´m not going to include any bizarre or hard to find drugs. Chances are if you´re a beginner, you can´t get all the exotic drugs people talk about. And, as a beginner, you're better off without them. Here's the cycle we´re going to discuss: Week © 2012 Thatotherguy

Chap Chapte terr 3: Prop Proper er Cycl Cyclin ing g of of Ster Steroi oids ds

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Testosterone (Cypionate or Enanthate) (optional) Dianabol 1 400 mgs 20 mgs/day 2 400 mgs 20 mgs/day 3 400 mgs 20 mgs/day 3 400 mgs 20 mgs/day 4 400 mgs 20 mgs/day 5 400 mgs 6 400 mgs 7 400 mgs 8 400 mgs 9 400 mgs 10 400 mgs 11 400 mgs 12 400 mgs So you´ll notice a few things here, and I´ll explain them one by one. The first thing that I suggest is a twelve week cycle. This is because as a beginner, I feel like you want to have some time to deal with your cycle and make gains from it. You´re going to gain a lot of weight at first, and you need to get used to it. Gains will begin to taper off towards the end of this cycle. Most people find minor side effects to begin immediately upon starting a cycle (acne, etc... ) and subside within the first month also. This is as a result of your body trying to normalize itself´ or maintain/restore homeostasis in geekspeak. The first compound were looking at for this cycle is testosterone. Testosterone Testosterone is a great compound for use as the base of every cycle, and especially a beginner´s cycle This is because it is the primary male sexual hormone and it will have a variety of beneficial effects in your body including the synthesis of new protein and increase in IGF (both of which will build muscle), increasing red blood cell count (thus increasing endurance), and will provide an increase i n both strength and aggressiveness in the gym. Additionally, it will convert convert to a much stronger androgen called Dihydrotestosterone Dihydrotestosterone (DHT) (DHT) and also the the female sex hormone Estrogen. This will give you the full spectrum of effects provided by your own natural testosterone. At this dose, not too many side effects should manifest. If your nipples get sore, then 10mgs/day of Nolvadex would be a welcome addition to this cycle. If hair loss is a concern, © 2012 Thatotherguy

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Nizoral shampoo (Ketoconazole) or Propecia (Finasteride) can be added into the cycle as per the manufacturer´s instructions. You´ll need to inject either Testosterone Enanthate or Testosterone Cypionate at a dose of 400mgs once a week, and have the suggested medications to treat side effects on hand, just in case you need them. The second, and optional, compound in this cycle is Dianabol (Methandrostenolone). (Methandrostenolone). This is an oral version of testosterone that has been tweaked by scientists to have less conversion to estrogen. In this case, they added what's known as a c1-2 double bond, and this slows conversion to estrogen, and appears to do the same with conversion to DHT. They also made an adjustment called c17 alpha alkylation, making it orally active (unlike the testosterone you are using in this cycle). Adding this steroid into a beginners cycle will allow the user to achieve more gains in strength and muscle mass more quickly. Its known to experienced steroid users as kick starting a cycle. Remember, the testosterone is the bread and butter of this cycle, and the Dianabol is a nice addition, but not to be used alone. A cycle like this should provide a beginning beginning steroid user with a good twenty twenty (or more) pounds or more if a proper diet and training regimen is followed. Some of this weight is going to be water retention, since the two steroids being used can both convert to estrogen. If a clean, high calorie diet is followed, then that bloated watery look that's common with first time steroid users can be avoided. Also, it´s important to note that it´s a very good idea to do at least 20 minutes of cardio work three or four times a week while on a cycle, to keep your cardiovascular system running optimally, and able to support all of the new weight (and stress) you are placing on it.

5.2

Intermediate Cy Cycle The following cycles are not intended to be used by people who have never cycled before. You should have completed at least one or two cycles before considering the ones below. Intermediate Steroid Cycles (Cycle #1: Bulking) If you´re anything like me, you took a look at the title of this article and wondered what an intermediate is. It´s relatively easy to figure out what a beginner is, because chances are if you haven´t done steroids, you already know that you´re a beginner. And if you´ve been using steroids for nearly a decade (as I have), you would probably have assumed you would need an advanced cycle. But i f you fall in this grey area in the middle, then you´re probably wondering what kind of cycles you need. Well, I´m going to set up some guidelines to figure out whether you´re an intermediate, ok? You´re an intermediate if you´ve been lifting for at least 3 years and have done at least 3 cycles. And I think, to make my definition of intermediate a little easier to understand, I´ll also suggest that you need to have done at least 3 different anabolic steroids, and stacked them in at least one of your cycles. You with wi th me, so far? What I´m saying is that in order to be an i ntermediate, you have: Done 3 cycles or more Used three different Anabolic steroids Stacked 2 steroids in at least one cycle If you´ve done all of the above then you are (at least) an intermediate steroid user, and the cycle I´m going to outline here is for you. SO let´s take a look at a sample intermediate bulking cycle, and then I ´ll give you the reasoning behind it. Week Testosterone (Cypionate or Enanthate) Deca-Durabolin (Nandrolone Decanoate) Dianabol (Methandrostenolone) Arimidex* © 2012 Thatotherguy


(Anastrozole) 1 500 mgs 400 mgs 25-50 mgs/day 0.5 mgs/day 2 500 mgs 400 mgs 25-50 mgs/day 0.5 mgs/day 3 500 mgs 400 mgs 25-50 mgs/day 0.5 mgs/day 3 500 mgs 400 mgs 25-50 mgs/day 0.5 mgs/day 4 500 mgs 400 mgs 25-50 mgs/day 0.5 mgs/day 5 500 mgs 400 mgs 25-50 mgs/day 0.5 mgs/day 6 500 mgs 400 mgs 0.5 mgs/day 7 500 mgs 400 mgs 0.5 mgs/day 8 500 mgs 400 mgs 0.5 mgs/day 9 500 mgs 400 mgs 0.5 mgs/day 10 500 mgs 400 mgs 0.5 mgs/day 11 500 mgs © 2012 Thatotherguy

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400 mgs 0.5 mgs/day 12 500 mgs 0.5 mgs/day *If necessary. Ok, so what we have here is a nice bulking cycle that uses about a gram per week of anabolics, on average, and makes use of orals in the beginning to help you see results more quickly. In the beginning, you´re going to be running between 25 and 50mgs per day of Dianabol, which will allow you to see results very quickly while blood plasma levels of the long estered Testosterone and Nandrolone products to build up to their peak levels. I´m a firm believer that when you run a bulking cycle, you want to maximize the amount of weight you gain for the time that you´re on steroids. Typically, people don´t "feel" the long estered products effects until a quite a few weeks into the cycle. That´s why I like to kickstart a bulking cycle with an oral like Dianabol. I look at it as a numbers game& if you can manage to keep 50% of the weight you gain on a bulking cycle, and you gain 25lbs, you´ll end up with wi th more muscle in the end then if you gain 20lbs, even if you lose half. On a bulking cycle, you need to bulk. This is a bit "old school" of me, but to be totally honest, I could never hold 200 very lean pounds until I went to 225 and cut back down (I´m 5´7"). I think Dianabol is a nice bulking drug, and with the recent emergence of so many quality UG Labs, it´s relatively cheap. It gives the user an increase in strength and size almost immediately, and usually a heightened sense of well being. Of course, some users prefer Anadrol, because it can be a bit cheaper on a mg for mg basis, but really this isn´t enough of a difference to matter, in my opinion. I get headaches on Anadrol, but if you like it, then by all means, substitute it for the Dianabol. The suggested testosterones in this cycle are long estered testosterone products, and are usually injected every 3.5-7th day. Testosterone stacks well with anything, and produces a nice anabolic (muscle building) effect, in addition to a distinct androgenic effect. Naturally, both of these effects will work together to help you achieve a significant increase in weight-load capacity, and a gain in Body weight. Nandrolone Decanoate is a good choice for inclusion into a bulking cycle because it is very anabolic and slightly androgenic. It has two primary benefits on a bulking cycle, and the first is of course i ts ability to help you retain nitrogen, and thus build more muscle. The other very beneficial effect you will experience with the use of Nandrolone i s a joint soothing/healing effect. Conversion to estrogen with this product is low, and combined with its other effects, it´s a natural choice for adding into a bulking cycle. A cycle like this will give the user user a good twenty plus pounds pounds of new body weight, as well as the strength that accompanies it. If water retention becomes a problem, or your nipples get tender (a beginning sign of Gynocomastia), add in some Arimidex (Anastrozole) at half a milligram every day.

5.3

Advanced Cycle Advanced Steroid Steroid Cycles (Cycle #1: Cutting) Anabolic Steroids - Stacks and Cycles The following cycle is not for a beginner and should only be attempted by those with a fair amount of experience under their belt. Advanced Cycle #1-1 An advanced cycle and stack will generally generally include numerous numerous compounds and it is here we will see the © 2012 Thatotherguy


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highest doses. Advanced cycles are not for beginners as they have not yet learned how they respond to certain hormones. To be ready for an advanced cycle you will have numerous cycles under your belt, you will have supplemented with several anabolic steroids and other performance enhancing drugs and have a good understanding as to how each affects your body. Further, you will only attempt an advanced cycle if you truly desire strong effects that will also carry the greatest level of risk. Absolutely, advanced cycles can be completed very safely but the probability of adverse adverse effects does increase. For the healthy adult male, if he supplements responsibly, understands how certain hormones affect him he can remain safe. We must also state and cannot over emphasize enough; if you have numerous or even countless cycles under your belt yet are losing half or even more than half your gains from each one you are not ready for an advance cycle. The reason is simple; youre obviously doing something wrong. Absolutely, when a cycle has ended and some time has passed some of the progress will be lost. Without the high influx of hormones in your system you will not be able to maintain what you have achieved at a 100% level. Even so, you should be able to maintain a great deal of it, especially when referring to bulking. Cutting can be a little different as once a diet is over, anabolic steroid use or not you will not hold peaked conditioning but this doesnt mean you have to turn into a fat pig. The point; you should be able to hold onto progress to a large degree and if you cant you need to revisit more moderate cycles and most importantly revisit your nutritional and training plans. The following cycle and stack will be our optimal advanced cutting cycle that will yield the strongest effect. It is a 16 week plan perfect for a competitive bodybuilder and one that may be used by a physique minded individual who has no competition in mind but enjoys such a lifestyle; that is the majority of performance enhancers. Performance athletes looking for a cycle wil l normally never need to go beyond intermediate level cycles Week eek Testosterone-EnanthateTe eTestosterone-Propionate Equipoise Trenbolone-Acetate Winstrol HGH Arimidex 1 250mg/eod 200mg/eod 4iu/ed 1mg/eod 2 250mg/eod 200mg/eod 4iu/ed 1mg/eod 3 250mg/eod 200mg/eod 4iu/ed 1mg/eod 4 250mg/eod 200mg/eod 4iu/ed 1mg/eod 5 250mg/eod 200mg/eod 4iu/ed 1mg/eod 6 250mg/eod 200mg/eod 4iu/ed 1mg/eod 7 250mg/eod 200mg/eod 4iu/ed 1mg/eod 8 250mg/eod 200mg/eod 4iu/ed 1mg/eod 9 200mg/eod 100mg/eod 50mg/ed 4iu/ed 1mg/eod 10 200mg/eod 100mg/eod 50mg/ed 4iu/ed 1mg/eod 11 200mg/eod 100mg/eod 50mg/ed 4iu/ed 1mg/eod 12 200mg/eod 100mg/eod 50mg/ed 4iu/ed 1mg/eod 13 200mg/eod 100mg/eod 50mg/ed 4iu/ed 1mg/eod 14 200mg/eod 100mg/eod 50mg/ed 4iu/ed 1mg/eod 15 200mg/eod 100mg/ed 100mg/ed 4iu/ed 1mg/ed 16 200mg/eod 100mg/ed 100mg/ed 1mg/ed Notes on Advanced Cycle: The switch from Testosterone-Enanthate to Testosterone-Propionate is not without reason. The l ast 8 weeks of the cycle, when we will be our leanest, as the Propionate version will yield less water it is optimal here. If you cannot use Testosterone-Propionate, as quite a few cannot due to negative reactions, you can stick with Testosterone-Enanthate or Testosterone-Cypionate the entire time. Moreover, while testosterone is simply testosterone, using one form and switching to another can provide benefit simply by the way the body responds. It may not be much but when cutting well take all we can get. One thing many will notice is the injection frequency of large ester steroids Testosterone-Enanthate Testosterone-Enanthate and Equipoise. It is true, neither has to be injected more than once or twice per week but this doesnt mean there is no advantage in i n more frequent injections. The frequent schedule will keep your total levels peaked throughout the entire diet at their highest level throughout. Again, this provides an advantage and when dieting we want every last advantage we can get. © 2012 Thatotherguy

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The last 2 weeks the Trenbolone, Winstrol and Arimidex doses are doubled simply to provide a dryer and more enhanced look at the conclusion of the diet. These are not doses one would want to hold to for the entire duration of the cycle. HGH is dropped the last week due to water retention it can cause many to hold. Many may find adding Clenbuterol and Cytomel into the equation to be very beneficial. Where you add it in will depend on your needs but both can be used the entire cycle if needed. This cycle will provide a lean and cut look that is hard, dry and vascular like no other; of course you will have to diet hard to truly reap the ultimate reward. If this cycle does not achieve the desired end something else is wrong. It may be your diet and it could be the quality of the hormones you have in hand but if all things are as they should be this is the ultimate cutting cycle to use. Post Cycle Therapy (PCT) Week hCG Nolvadex Clenbuterol 1 1,000iu/ed 40mcg/ed 2 1,000iu/ed (1st 3 Days) 40mg/ed 3 40mg/ed 4 40mg/ed 5 20mg/ed 6 20mg/ed

Cytomel 25mcg/ed 40mcg/ed

25mcg/ed

Notes on PCT PCT should start approximately 3 days after youre your anabolic steroid cycle ends. If it ended with Testosterone-Enanthate Testosterone-Enanthate or Testosterone-Cypionate instead of the Propionate version you will wait 10 days before you start hCG therapy. hCG is used the first 10 days for 10 days straight. This will be all of week 1 and into the 3rd day of week 2. Nolvadex begins the day after your last injection of hCG. Clenbuterol and Cytomel are only taken during the PCT period if they were added in during the actual anabolic steroid cycle. An optional week of Nolvadex therapy therapy may be added if needed. Clomid may be used in the place of Nolvadex; both will get the job done. If you supplement with Clomid the dosing plan will be as follows: PCT Option 2 Week hCG Clomid 1 1,000iu/ed 2 1,000iu/ed (1st 3 Days) 150mg/ed 3 150mg/ed 4 150mg/ed 5 100mg/ed 6 50mg/ed

5.4

PCT Post cycle therapy is a method of employing drugs which work via various mechanisms to go about trying to aid stabilising and restoring a users hormones back to normal once a suppressive anabolic androgenic steroid cycle has been ceased. Once a user has ceased use of anabolic androgenic steroids they are left in a situation where their natural testosterone production has been suppressed , sometimes severely by androgens and aromatising drugs. Add this onto the fact the levels of steroids are forever diminishing in their system, © 2012 Thatotherguy


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this can leave the user in a very catabolic state post cycle, which may reflect in their ability to maintain muscle mass gained whilst on cycle. It is therefore easy to conclude that we would like to find a way to restore ones natural testosterone production to bring about a better environment for overall health and to maintain muscle tissue. Clomid and tamoxifen Clomiphene citrate ( clomid) and tamoxifen(nolvadex) can be employed post cycle to aid restoring the users natural testosterone testosterone production. Many find just using nolvadex on its own post cycle is efficient enough to recover from their anabolic androgenic steroid cycles. Some however prefer to use both drugs to cover all angles. It is worth noting nolvadex is more profound in stimulating the increase of LH over time, on a milligram to milligram standpoint compared to that of clomid. Also many users complain of side effects from clomid such as visual implications and mood swings. Dosages of nolvadex for PCT protocol Day 1 100mg Following 10 days 60mg Following 10 days 40mg HCG HCG, or Human Chorionic Gonadotrophin, is a peptide hormone which can be useful to bodybuilders who suffer from testicular atrophy whilst on cycle. The drug mimics the effects of LH in the body, stimulating the Leydig cells to produce testosterone in the testes. This can be fruitful in rectify existing, or avoiding testicular atrophy on cycle. It will not aid the process of recovery in the post cycle phrase however, as the drug will bring about heightened estrogen levels due to the greater aromatising of the testosterone being produced in the testes, thus bringing about greater inhibition of the HPTA. It is therefore wise to use HCG for rectify existing, or avoiding testicular atrophy on cycle, and possibly prior to PCT to help bring the testes back up to condition so they are more effective at producing testosterone. We should leave about a week prior to PCT, with any HCG administration occurring before this. It is wise to use HCG in smaller frequent amounts over the course of two weeks to help minimise side effects and give more fruitful results. This i s usually accompanied by nolvadex at 20-40mg each day to avoid estrogen related side effects becoming pronounced due to the greater aromatisation occurring. 500-1000IU over a two week period should prove effective interims of results and minimizing estrogen related side effects. When to start your PCT protocol after ceasing your cycle? Steroid Steroid When to start after after last administrat administration ion Length of PCT Testosterone Enanthate Testosterone Cypionate Testosterone Propionate Testosterone Suspension Sustanon Winstrol Dianabol Trenbolone Deca durabolan Primabolan depot Anavar

5.4.1

2 weeks 3 weeks 2 weeks 3 weeks 3 days 3 weeks 6-8 hours 3 weeks 3 weeks 3 weeks 12 hours 2/3 weeks 6-8 hours 3 weeks 3 days 4 weeks 3 weeks 4 weeks 14 days 2 weeks 8-10 hours 2 weeks

Post Cy Cycle Th Therapy Hypogonadotropic Hypogonadism:


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Pulsatile secretion of gonadotropin releasing hormone (GnRH) from the hypothalamus is required for both the initiation and maintenance of the reproductive axis in the human. Pulsatile GnRH stimulates the biosynthesis of luteinizing hormone (LH) and follicle stimulating hormone (FSH) that in turn initiates endogenous testosterone production and spermatogenesis as well as systemic testosterone secretion and virilization. Failure of this episodic GnRH secretion or disruption of gonadotropin secretion results in the clinical syndrome of hypogonadotropic hypogonadism (HH). The usage of anabolic androgenic steroids (AAS) may result in a functional form of HH known as Secondary Acquired Hypogonadotropic Hypogonadism and is diagnosed in the setting of a low testosterone level and sperm count in association with low or inappropriately normal serum LH and FSH concentrations. In order to avoid any unnecessary confusion, it is important to understand what the actions of Gonadatropin therapy and Selective Estrogen Receptor Modulators are as well as how they differ from each other and more specifically, during post cycle recovery (PCT). Gonadotropin Therapy: There is nothing more effective than Human Chorionic Gonadotropin (HCG). The action of HCG is identical to that of pituitary LH. This takes place independently and is not affected by exogenous hormones and/or preexisting HPTA suppression. Therefore, it directly stimulates a dramatic increase in endogenous testosterone production, spermatogenesis and testicular volume. The primary goal during the first few weeks of PCT is to quickly restore testicular volume and function. Also, the dramatic increase in testosterone production is necessary to avoid and/or minimize the unfavorable "crash" effect. In the majority of individuals with larger testes at baseline, HCG alone is sufficient in restoring endogenous testosterone production as well at the induction of spermatogenesis which is most likely a result of residual FSH secretion. Once there is a plateau in the response to HCG, treatment with an FSH preparation such as human menopausal gonadotropin (HMG) or recombinant follicle stimulating hormone (rFSH) should be added in combination to HCG. *The addition of an FSH preparation is rarely required and is best suited for severe cases of HH. FSH preparations are not readily available to most individuals. Therefore, there is no need to go into details with respect to its application at this time. HCG is administered by subcutaneous (SC) or intramuscular (IM) injection. The average (3ml 22-25G x â…?-1Â½â€?) syringe is adequate for IM injections but insulin syringes (Â½-1ml 28-30G x Â½-1â€?) are recommended for SC injections. In regards to effectiveness, there should be no discernable difference between either of the techniques. The individual should opt for the most comfortable and/or convenient form of administration. The following is a description of the available preparations by Serono: HCG ampoules are supplied in 500, 1,000, 2,000, 5,000 and 10,000 IU preparations accompanied by 1 ml of sterile dilluent. It should be stored at a controlled room temperature (15-30 degrees degrees C or 59-86 degrees F) and should be used immediately after reconstitution. HCG multidose vials are supplied in 2,000, 5,000 and 10,000 IU preparations accompanied by 10 ml of bacteriostatic water. It should be stored at a controlled room temperature (15-30 degrees C or 59-86 degrees F), refrigerated (2-8 degrees C or 36-46 degrees F) after reconstitution and used within 30 days. Other manufacturers are available and preparations may vary. The terms international units (IUs) can occasionally cause confusion when reconstituting and measuring HCG. The actual process is quite elementary and the concentration per ml (cc) is dependant on the concentration of the lyophilized powder and the volume of dilluent used for reconstitution. For example, if you dilute 5,000 IUs HCG with 5ml (cc) solvent, the end result is 1,000 IUs per ml (cc). Divide the same 5,000 IUs with 10 ml (cc) and the end result is 500 IUs per ml (cc). © 2012 Thatotherguy


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*Bacteriostatic water should always be utilized during reconstitution when long term (30 day) storage and multi dose administration are required. Selective Estrogen Receptor Modulators: Selective estrogen receptor modulators (SERMs) such as Clomiphine (Clomid) and Tamoxifen (Nolvadex) increase pituitary LH secretion in secondary manner by blocking estrogen negative feedback on the HPTA. On average, this is not strong enough by itself to counteract the severe imbalance of the androgen:estrogen ratio that is encountered post cycle, especially in the presence of testicular atrophy. Therefore, SERMs are used during PCT primarily as an anti estrogen and to continue the stimulation of pituitary LH after HCG has been discontinued. Nolvadex is widely available in 10 mg or 20 mg tablet preparations and Clomid is available in 50 mg tablet preparations. Before Beginning PCT: It is highly recommended to establish baseline blood values before beginning a cycle. The same principle applies to establishing post cycle blood values, which are necessary for evaluating recovery. Post cycle blood work should be obtained approximately 4 weeks after the cessation of PCT in order to determine accurate readings. Additional blood work should be performed when applicable and/or required. The following are Fasting blood values: Hormone 1. Cortisol, Total 2. Estradiol, Extraction 3. Prolactin 4. LH 5. FSH 6. T3, Free 7. T4, Free 8. TSH 9. Testosterone, Total, Free and Weakly Bound 10. Hemoglobin A1C 11. Fasting Insulin 12. Somatomedian C (optional) Cardiovascular 13. CBC 14. Comprehensive Metabolic Panel 15. Lipid Panel Other 16. GGT Important Liver Value not included in Comp Metabolic Panel When to begin PCT: On average, begin PCT approximately 5-10 days after your last i njection regardless of longer acting esters. Begin PCT 1-3 days after your last injection and/or intake when using short acting esters. Keep in mind, pituitary LH secretion automatically increases as the hormones diminish from your system. The elevated androgen levels are from an exogenous source and your endogenous © 2012 Thatotherguy

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production is suppressed. Therefore, waiting for the exogenous androgens to completely clear from your system, ultimately results in lower total concentrations of androgens in your system when beginning PCT. This leads to an unfavorable andgrogen:estrogen ratio and the well known â€œcrashâ €? effect. *As previously mentioned, the actions of HCG take place i ndependently and is not affected by exogenous hormones and/or preexisting HPTA suppression. There are no contradictions with respect to the effectiveness of HCG usage whi le exogenous hormones are present in your system. PCT Protocol(s): 1.) 1,000 IUs HCG 3x/wk (mon/wed/fri) in combination with 20 mgs Nolvadex ED for the first 3 weeks. After, discontinue HCG and continue with 20 mgs Nolvadex ED for an additional additional 3 weeks. 2.) 1,000 IUs HCG 3x/wk (mon/wed/fri) in combination with 20 mgs Nolvadex ED and 50 mgs Clomid ED for the first 3 weeks. After, discontinue HCG and continue with 20 mgs Nolvadex ED and 50 mgs Clomid ED for an additional 3 weeks. 3.) 1,500 IUs HCG 3x/wk (mon/wed/fri) in combination with 20 mgs Nolvadex ED for the first 3 weeks. After, discontinue HCG and continue 20 mgs Nolvadex ED for for an additional 3 weeks. 4.) 1,500 IUs HCG 3x/wk (mon/wed/fri) in combination with 100 mgs Clomid ED and 20 mgs Nolvadex ED for the first 3 weeks. After, discontinue HCG and continue with 50 mgs Clomid ED and 20 mgs Nolvadex ED for an additional 3 weeks. Option one can be considered as a standard PCT protocol. This should apply to all basic cycles. Option 2 is generally the same as option one except for the addition of Clomid which is added as a supporting recovery aid. Option three and four incorporate a higher HCG dosage and have a relationship similar to options one and two in the sense that Clomid is incorporated in the latter as a supporting recovery aid. *The majority of my experience is with intermediate to advanced athletes whom have completed multiple cycles with higher dosages. Therefore, based upon previous blood work results and considering the common or convenient preparations available, we have established that 1,500 IUs 3x/ wk (mon/wed/fri) to be the optimal HCG dosage to begin with. The Nolvadex dosage remains unchanged however Clomid is utilized throughout the entire PCT at 100 mgs ED during the first 3 weeks and 50 mgs ED for the last 3 weeks. HCG During Cycle: HCG in combination with Nolvadex can and should be used during prolonged (12+/wks) and high dosage (1,000+mgs/wk) cycles. In this case, 500-1,000 IUs HCG ED in combination with 20 mgs Nolvadex ED for 7-10 days consecutively is administered mid cycle or intermittently (every 6-8 weeks) during the cycle. Maintaining testicular volume during cycle does in fact improve recovery when compared to atrophied testes when beginning PCT. This solution addresses both testicular atrophy and prevention of Leydig cell desensitization (discussed next) associated with HCG usage. Leydig Cell Desensitization: Leydig cell desensitization does in fact occur to some degree with prolonged or high dose HCG usage. Using it continuously during a cycle could possibly cause the LH receptor to desensitize which in turn would ultimately render the PCT to be either less effective or possibly useless. This seems counterproductive. HCG will not be needed on cycles where the proper ancillaries are used and where the dosages/durations are realistic. The previous summary was a general statement. The reality and good news is that Leydig cell © 2012 Thatotherguy


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desensitization due to HCG usage is blocked and/or minimized by Nolvadex. This occurs by suppressing HCG's ability to inhibit i nhibit the conversion of 17 alpha hydroxyprogesterone to testosterone. Additional Factors That That Influence Recovery: Recovery: Factors that may complicate and/or delay recovery are elevated levels of estrogen and prolactin. Both of these hormones, when elevated, exert negative feedback on the HPTA. Estrogen and its side effects can be controlled by using an aromatase inhibitor such as Aromasin, Femara and Arimidex during cycles including aromatizing AAS. Prolactin and its side effects can be controlled by using an anti Prolactin such as Cabergoline (Dostinex) or Bromocriptine (Parodel) during cycles containing nandrolones. If these measures have not been addressed during the cycle, they will more than likely need to be addressed during PCT. In this scenario, the objective is to lower these hormones to acceptable levels in order to avoid the complications and/or delay in recovery. Blood work is imperative in evaluating the effectiveness of therapy. This will provide a clear and concise answer in regards to the adjustment of dosages and continuation of medication if necessary. *There are numerous studies which support and refute the association of nandrolones and prolactin. However, based on first hand experience and blood work results, there are far more individuals today whom can testify that the usage of nandrolones can attribute to an increase in prolactin concentrations. In addition, many individuals have reported elevated prolactin levels during cycles which do not contain nandrolones. The common factor within these cases is supraphysiological levels of estrogen. Estrogens act directly at the pituitary level by causing the stimulation of lactotrophs which in turn enhances prolactin secretion. This is another reason why estrogen management in the form of an aromatase inhibitor should be included with cycles containing aromatizing AAS. Although not absolutely necessary and considering the necessary restoration of physiological estrogen values, there is sufficient evidence which suggests that aromatase inhibitors can improve and increase recovery rates. Unsuccessful PCT: In some cases the aforementioned post cycle therapy protocols as wel l as those which are not mentioned may be unsuccessful in the restoration of homeostasis. This should not warrant immediate concern. Many endocrinologists have concluded that the only form of treatment in this particular scenario is hormone replacement therapy (HRT). This is far from the truth. The reason many endocrinologists have come to this conclusion is due to the fact that very few of them have the experience treating severe forms of secondary acquired hypogonadotropic hypogonadism. They are unfamiliar with proper protocols which include high dosage HCG administration and additional gonadotropin preparations such as HMG or rFSH. This complication puts the patient at risk for potential and unknown side effects in the eyes of the doctor. Therefore, HRT is a reasonable solution since it will quickly alleviate the majority of the uncomfortable symptoms that the patient is experiencing. Aside from disappointing disappointing blood work results which illustrate the typical signs of an unsuccessful recovery, the key physical indicator that the treatment is unsuccessful is testicular atrophy. In this case, HCG is continued with the necessary adjustments in dosage and frequency until an increase in testicular volume has been achieved. There is no one size fits all protocol since every case varies and deserves an individualized approach. Subsequent changes will be based upon the individualâ€™s response to each particular stage. All the variable factors involved during the recovery process need to be considered. It's far from accurate to reach the conclusion that HRT is needed if one specific recovery protocol is not successful. Ongoing Argument(s): Hypothetically speaking, if testicular function and volume have been maintained during cycle with HCG, SERMs are then utilized to counteract the imbalance in the androgen:estrogen ratio encountered post cycle as the exogenous androgens diminish. This results in the prevention of estrogenic side effects while increasing pituitary LH secretion which in turn increases testosterone © 2012 Thatotherguy

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production. There is nothing wrong with using a commonly referred to protocol which recommends 250-500 IUs HCG 1-2x/wk to be incorporated throughout the cycle. However, a significant cause for concern in regards to this protocol relates to the cessation of HCG once the cycle has completed and from that point on, the only substances used during PCT are SERMs which consist of Nolvadex and/or Clomid. Realistically, there is absolutely no guarantee that this formula prevents testicular atrophy to the extent where the overall volume and function of the testes are in an optimal state. Unfortunately, a large majority of individuals do not realize or are not aware that Leydig cell desensitization does in fact occur with prolonged or high dosage HCG usage. Therefore, users which follow this protocol whom do not incorporate Nolvadex or an aromatase inhibitor are now susceptible to Leydig cell desensitization which may render HCG usage post cycle ineffective when and if needed. During conservative cycles, there is substantial evidence which exists that supports the effectiveness of the HCG during cycle and SERMs only post cycle protocol, especially when proper estrogen and prolactin management has been incorporated. However, this conclusion is much more difficult to achieve on heavy or prolonged cycles. Testicular volume should be maintained to an acceptable extent but that does not necessarily result in an improved recovery as severe HTPA suppression still exists which is not immediately repairable through the usage of SERMs. The most common argument here when incorporating HCG during PCT is that HCG itself is suppressive. This is true and one particular way this occurs is though the constant binding of HCG which disrupts the endogenous pulsatile secretion of LH. A recent study which included the usage of 250 mcgs Ovidrel (rHCG) 2x/wk for 12 weeks demonstrated that the patients resumed normal HPTA function within four weeks upon cessation, without the usage of SERMs. Whatâ€™s even more interesting is that 250 mcgs rHCG is the equivalent of approximately 5,000 IUs uHCG. Therefore, putting things into perspective, a few additional weeks of suppression is nothing to be overly concerned about compared to and considering the 12 weeks of suppression incurred during the average cycle. The usage of HCG during PCT is a minimally intrusive variable where the benefits clearly exceed the associated costs. Conclusion: PCT should begin after the last injection and/or AAS intake. More specifically, a relative guideline to begin PCT is within 5-10 days when using long acting esters or 1-3 days when using short acting esters. This PCT protocol should consist of 1,000-1,500 IUs HCG 3x/wk (mod/wed/fri) in combination with 20 mgs Nolvadex ED and, if necessary, 50-100 mgs Clomid ED. The mid/intermittent cycle protocol of 500-1,000 IUs HCG and 20 mgs Nolvadex ED for 7 days consecutively can and should be utilized when necessary during prolonged (12+/wks) or heavy dosage (1,000+mgs/wk) cycles. In addition, blood work should be performed before beginning a cycle and after completing a cycle in order to establish baseline values and evaluate recovery, respectively. If recovery is unsuccessful, HCG is continued with an adjustment in dosage and frequency as necessary until the increase in testicular volume and function have been achieved which is unlike the more typical, yet incorrect belief that HCG is only to be used for a short period of time. Once there is a plateau in the response to HCG, treatment with an FSH preparation such as human menopausal gonadotropin (HMG) or recombinant follicle stimulating hormone (rFSH) should be added at a starting dose of 75-150 IUs on alternate days. This continual usage is not necessary and avoidable in most cases by utilizing the mid/intermittent protocol previously mentioned, but it is much more common and less avoidable with long term (1+/yr) users, whom have not taken the suggested preventive measures, and/or improper recovery from previous cycles regardless of which protocol is chosen. With the usage of HCG post cycle, your androgens are elevated but well below that of supraphysiological concentrations from exogenous hormones. In addition, a noteworthy difference is that the effect is through a direct stimulation of testicular production compared to the secondary nature of SERMs in conjunction in the presence of testis that are not guaranteed to be in an optimal functioning state. Upon completion, blood work will display significantly higher levels of LH, FSH and testosterone in this environment which includes HCG and SERMs during PCT versus HCG during © 2012 Thatotherguy


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cycle and SERMs only during PCT. This ultimately results in a more comfortable as well as tolerable recovery both physically and psychologically. In conclusion, HCG should always be included during PCT in combination with SERMs regardless of what protocol has been utilized during cycle to prevent testicular atrophy, in order to achieve an optimal recovery.



Part

VI

Chap Chapte terr 4: 4: Adm Admin inis iste teri ring ng an Inje Inject ctio ion n

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Chapter 4: Administering an Injection ADMINISTERING AN INJECTION INJECTION

6.1

Sub Su bcuta cutan neou eous In Injec jection tion Pr Proc oced edu ure What is a subcutaneous injection? A subcutaneous injection is also called a subQ injection. It is a "shot" of medicine given into the layer between the skin and the muscle. A syringe with medicine in it is attached to a needle. The needle goes through the skin and into subcutaneous tissue. The medicine is pushed into subcutaneous tissue by pressing on the syringe plunger. When the medicine has been pushed into subcutaneous tissue, the needle is removed. Why did my caregiver choose this kind of shot? Your caregiver chose this kind of shot because of one or more of these reasons: The amount of medicine to be given. Small amounts of medicine are given subQ. The kind of medicine to be given. Certain medicines must be given into the subcutaneous space. The speed at which the medicine needs to act. Medicine that needs to work slowly is given subQ. What should I know about the syringe? A syringe has 3 major parts: the the needle, the barrel barrel and the plunger. plunger. The needle goes under the skin to to put in medicine. The barrel holds the medicine. The barrel has markings on it like a ruler. The markings are for mL's (milliliters). The plunger is used to get medicine into and out of the syringe.

Subcutaneous shots must be given in small amounts. You wi ll usually get an "insulin syringe" for a subQ shot. Insulin syringes will hold a maximum of 1 mL of medicine. The syringe shows divisions well marked with 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100. 100 is the same as 1 mL. The marking at 50 is the same as half of a mL. You may get a "TB syringe". A TB syringe holds up to 1 mL of medicine, and has a needle that is slightly longer than an insulin syringe. What should I know about the medicine? Always know the name of your your medicine, and why you take it. Know how much medicine you need to take or give. If you have questions about your medicine ask your caregiver before taking it. Medicine given in a shot is measured in mL's (millil iters). If you are using a pre-filled cartridge, check your doctor's orders. Be sure you need to use all the medicine in the cartridge. If there is too much medicine, take the cover off the needle and squirt the extra medicine into a sink. Look carefully at the ampule, vial, or pre-filled syringe containing the medicine. Check it to make sure 4 things are there:


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The name of the medicine. The number of mL's in the vial or ampule. The amount of medicine in each mL. The last date the medicine is safe to use. This is called the expiration date. Make sure you have enough medicine for several doses. How will I know the medicine is safe to give? Check the ampule or vial to make sure: The medicine is not past the expiration date on the bottle. There are no crystals or lumps in the ampule or vial. The medicine is the correct color. Ask your caregiver or pharmacist what color the medicine should be. The name of the medicine is the same name your caregiver told you or wrote down. If you are not sure, call your caregiver. How do I get the medicine out of an ampule? An ampule is a tiny bottle with a narrow neck and a long, thin, thin, hollow top. The ampule neck may be scored to make it easier to break. The ampule may be colored or clear. The ampule may be a dark color or clear, with clear medicine. If it i s, it will be hard to see the medicine inside. This is important because the hollow top of the ampule can trap enough medicine to keep you from getting the correct dose. You may not take medicine out of the top of the ampule after it is broken. You need to make the medicine go into the bottom of the ampule before you break it. To make the medicine go from the top of the ampule to the bottom, flick or snap the top with your finger. You may have to flick it a few times. To break the ampule, wrap a wet alcohol wipe completely around the neck of the ampule. Hold the top and the wrapped neck with the fingers of your writing hand. Hold the bottom with the fingers of your other hand. Break the ampule. Put the bottom of the ampule on a flat surface. Take the cap off the syringe by pulling it straight off. Carefully aim the needle through the broken neck of the ampule into the liquid in the bottom. Pull back on the plunger to suck the medicine into the syringe. Once the syringe has the medicine in it, turn it upside down. The needle should point straight up with the plunger below it. Pull down on the plunger until you see that the needle and a small area at the top have no medicine. If necessary flick the side of the barrel. This will make any air bubbles rise to the top of the barrel. Push up on the plunger to the correct marking. This will make some medicine squirt out of the needle. It will also force all the air out of the syringe.



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How do I get the medicine out of a vial? A vial is a small bottle with a plastic or metal top covering a rubber stopper. The vial may hold enough medicine for one or more doses. If the vial will be used for more than one dose (a multiple dose vial), make sure you write the date you open it on the vial. The medicine may be a powder or a liquid. If the medicine is a powder, it has to be made into a liquid: Your caregiver will order the correct liquid to add to the powder. There are only two kinds of sterile liquids that may be used: sterile saline and sterile distilled water. They are packaged in vials with metal or plastic tops covering a rubber stopper. Use only the liquid that your caregiver provided or ordered. If you were told to use sterile saline, you may not use sterile distilled water. If you were told to use sterile distilled water you may not use sterile saline. Never use tap water. Remove a syringe from its wrapper. If you need to add more than 1 mL of liquid to a multiple dose vial, you will need to use two syringes. The first syringe is needed to add the liquid. The second syringe is needed to give the shot. If you have instructions from your caregiver, follow them. If you do not have instructions from your caregiver, read the label or the package insert information. It will tell you how much liquid you will wi ll need to add to the powder to make the correct solution. Take the metal or plastic top off the sterile saline or sterile distilled water vial. Do not take the rubber stopper off. Use an alcohol wipe to wipe the top of the vial with the sterile liquid used to add to the powder. Wipe the top of the vial with the powdered medicine in it. Do not touch the tops of the vials after wiping them. A vial has a certain amount amount of pressure in it. When air or liquid is removed, it must be replaced. To do this: Put the vial on a flat surface. You will only remove air from the vial. Leave the powder at the bottom of the vial. To remove air, insert the needle into the top of the vial and pull back the plunger. Pull it back the same number of mL's you will need to add liquid to the powder. You may have to pull back harder on the plunger than you expect. Remove the needle from the vial with the powdered medicine, and stick the needle into the top of the vial with the sterile liquid. Inject the air into the sterile liquid vial. Turn the vial attached to the syringe upside down. Make sure the tip of the needle is in the sterile water or saline. The sterile liquid will fill the syringe to about the same amount of air that you put in. If you need some more liquid, pull the plunger back a li ttle to get the correct amount. Remove the needle from the sterile liquid bottle. Stick the needle into the vial with the medicine and push the plunger all the way down. The liquid should go in easily. With the needle still in the vial, push it up to the hub. You do this so you cannot touch the sterile needle. Gently mix the liquid and the powder i nto a solution. If you see powder in the vial, keep mixing it until you only see liquid. If you needed to use a large syringe to add liquid, remove the needle and follow the directions below: "If the medicine is already in liquid form" . You may use the same syringe to prepare the medicine and to give the shot. If so, turn the medicine © 2012 Thatotherguy

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and the syringe upside down. Pull the needle down so the tip of the needle is in the medicine. Pull the plunger back to the correct marking on the syringe barrel for the dose. When you have the correct amount of medicine in the syringe, remove the needle and carefully put the cover back over the needle. If the medicine is already in liquid form: Do not use any medicine that has crystals or lumps in the vial. Ask your caregiver or pharmacist what color the medicine medicine should be. Do not give a medicine that is not the correct color. You need to add air to the vial in the same amount that you plan to take out in order to get the medicine out of the vial. To do this, you must know how much medicine to inject. Pull the plunger on the syringe back to the amount you plan to give. Insert the needle into the vial and push down on the plunger. Once the air has been pushed into i nto the vial, turn the vial, attached to the syringe, upside down. Make sure the tip of the needle is in the medicine. The medicine wil l come back into the syringe and stop at or near the correct place. When you have the correct amount of medicine in the syringe, remove the needle and carefully put the cover back over the needle. Things that may go wrong: If you put in too much air, the plunger will be difficult to push. If you do not put in enough air, the plunger will be difficult to pull. If you are using a multiple dose vial, too much or too little air may have been put in for a previous dose. If so, you will have to adjust your pull or push on the plunger. Where can I give a subcutaneous shot? There are many sites on the body that are safe to give subcutaneous shots. Following is a list li st of the sites where subcutaneous shots may be given:



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Upper Arm: Uncover the arm to the shoulder to see the whole arm. Have the person getting the shot stand with hand on hip. Stand next to and a little behind the person. Find the area in the middle part of the arm, halfway between the elbow and shoulder. Gently grasp the skin at the back of the arm between your thumb and first 2 fingers. You should have 1-2 inches of skin. Abdomen: Uncover the abdomen to to see the whole area. Find the waist area. You may give a shot shot bounded by these landmarks: below the waist, to just above the hip bone, and from where the body curves at the side to about 2 inches from the middle of the abdomen. Avoid the bellybutton. Use the natural line in the middle of the body as a marker. It may be hard to see, but it i s there unless it was removed by surgery. Thigh: Uncover the entire leg. Find the area between the knee and hip. The middle of the thigh, from mid-front to mid-side, on the outside part of the thigh is a safe site. Gently grasp the area to make sure you can pinch one to two inches of skin. Lower back: Uncover the back from the waist to the top of the rear-end. A shot may be given just below the waist to a line that runs across the back above the crack between rear end cheeks. Give the shot between the area where the body curves at the hip and a few inches from the spine. How do I choose a good place for the shot? Any of the following sites may be used: upper arm, abdomen, thigh, lower back. It is important to keep track of the sites you use and to use a different site each time you give a shot. Some sites are preferred for certain medicines. Ask your caregiver if the medicine you are taking has a preferred site. If you are giving shots to yourself you may not be able to use your back or your arm. To keep track of where you are giving shots, make a li st of the sites you use. Write down the date, time, and the site each time you give a shot. The sites where shots are given should be at least 1 inch away from each other. Picture 1 inch squares, like a checkerboard. A shot may be given into each of those squares. You may choose to rotate your shots through one area, like the left thigh, then begin again in the same area. Or you may rotate through one area then go to another. It is very important to rotate sites. Giving a shot in the same site can make the site scarred and hard. Hard areas will keep you from using all the medicine. What do I need to give a subcutaneous shot? One alcohol wipe wrapped in foil. One sterile 2 x 2 gauze pad. An ampule, vial, or pre-filled syringe syringe containing the medicine. The correct size syringe and needle. Your caregiver should give you this information. How do I inject medicine into subcutaneous tissue? Please read this section all the way through before giving the shot. It is important to get the general idea of what you are about to do before you begin. You may read this step-by-step procedure again as you do it. Subcutaneous shots can be given straight in at a 90 degree angle, or at a 45 degree angle. Give the shot straight in at a 90 degree angle if 2 inches of skin can be grasped between your thumb and first (index) finger. If only 1 inch of skin can be grasped, give the shot at a 45 degree angle. Lower back: Uncover the back from the waist to the top of the rear-end. A shot may be given just below the waist to a line that runs across the back above the crack between rear end cheeks. Give the shot between the area where the body curves at the hip and a few inches from the spine. How can I get rid of used syringes and needles? Your caregiver may have given you a hard plastic container made especially for used syringes and needles. If you were not given this kind of container, look around your home for a hard plastic container with a screw-on top such as:


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A clothes softener softener bottle or a hard plastic detergent detergent bottle for washing clothes. A 2 liter pop or soda bottle. Make sure you can put both the syringe and needle into the container easily. Whatever container you choose, make sure that the needles cannot break through the sides, bottom or top. Call your caregiver or a pharmacy to find out what your state or local requirements are for getting rid of used syringes and needles. -----You can buy all your medical supplies at www.directlinemedical.com

6.2

Int Intra muscl scle Inje Inject ctio ion n Pr Pro ocedu edure As with most things in life there are right & wrong, proper & improper, acceptable acceptable & unacceptable ways to conduct intramuscular injections. Sound injection protocol (the correct steps to follow) exists to protect the patient from harm (Infection). Following the said protocol, along with proper handling procedures can prevent a variety of minor and major negative effects that can occur during intramuscular injections. Unfortunately many users are either unaware of, do not understand, or simply don't care about the importance of practicing the appropriate injection procedures. As a result, they routinely disregard even the simplest principles, from basic hygiene to determinations of where and how to inject these hormones. This section will discuss injection methodology along with the very important 'WHY THEY SHOULD BE USED' reasoning, and includes: selecting the proper equipment; rules for practicing safe hygiene; choosing the correct injection sites & specific spots on the body and; the step-by-step principles that should be followed in the practice of safe intramuscular injections. The following is a small informational component of a larger educational website designed to raise awareness. More specifically, it is NOT intended to help readers learn how to inject, i nject, but rather to equip them with the truth about the WHATs, HOWs & WHYs behind injecting protocols. Equipment Choosing the proper needle (the very thin pin that is stuck into the body) and syringe (the chamber that holds the fluid for injection) is an important usage component, but first it's necessary to learn a little about them. The gauge represents the diameter or size of a needle, a.k.a. pin. The larger the gauge number, the thinner the pin. For example, a 25 gauge needle is a whole lot thinner than a 20 gauge needle. The types of needles chosen vary in i n size based on the users': (oil and/or water-based) substances; amount injected (it takes longer to inject with a thinner pin); size of the muscle group being injected (typically larger groups have less residual pain) and; very individualized preferences for all of the above. For intramuscular injection typically choose sizes they can apply to both water and oil-based injectable oil, thus generally speaking, the most common sizes for intramuscular injection use are 22 & 23 gauge needles. These needles also come in a variety of lengths which are selected based on how deeply they must penetrate in order to reach the muscle for injection. For example, a small 1'' needle (and if appropriate even smaller) is often used to inject into the smaller muscle groups like the deltoids/shoulders or pectorals/chest muscles that are covered by very little fatty tissue, whereas longer 1.5 - 2''needles are reserved for the buttocks and other deeper muscle regions. Syringes also come in a diversity of sizes, or capacities (the amount of fluid they hold) which are measured in milliliters abbreviated 'ml' or cubic centimeters abbreviated 'cc', both of which are equal in measurement . Typical substance being injected ranges from 1 - 3ml, based on how much the user intends to inject at one time. Needles and syringes can be purchased together as unit, or separately © 2012 Thatotherguy


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for later assembly. The Importance of Hygiene Hygiene is a very important issue when it comes to injecting anything into the body. As mentioned earlier, people often overlooks or simply neglects this component. Nevertheless, much of the world is comprised of open and closed systems. A house during a birthday party, where visitors are constantly going in and out, is an example of an open system into which insects, dirt, pests, germs and other undesirables have access. After the party, when the doors and windows are closed and locked, it becomes a closed system that only the family can access. Other systems like the brake line on a car are more permanently closed in order to resist contaminants such as air, dust and dirt. Similarly, the body is made up of both open systems accessed by upper (on the head), and lower (for elimination) openings that make it (much like the house during a party) susceptible to infection from germs, bacteria and viruses. However, the body also contains closed systems among which is the circulatory system. Just as the brake line on a car can be opened for repair, so the circulatory system can be injected with medicinal repairs like immunizations, pain-killers, and numerous other medical treatments. Whenever a closed system is accessed there is the potential for contamination. In the case of intramuscular injection, contaminants like germs, dirt and debris can easily be introduced at the patient's injection site along with the needle. Because of this threat, some very good principles have been put into place to l imit the possibility of infection which can swiftly result in the development of abscesses (large, localized collections of pus-filled infection sites, often surrounded by very painful, swollen and inflamed tissue). Abscesses really hurt, I repeat abscesses hurt%u2026BADLY, and unfortunately they can take a long time to go away. Although abscesses are probably the most visible short-term problem, there are a host of far more dangerous long-term ones that can occur from reusing and sharing needles, not properly preparing the skin for injection, and failing to keep both the skin and equipment sanitary throughout the injection process. About Injecting Injections of medications that are shot directly into the bloodstream are called intravenous or IV injections. This is often done very deliberately and intentionally. Whether injecting or drawing blood a nurse will usually search for the best vein, and then (so as not to pass through the vein) inject sideways into it. This is NOT the procedure used for intramuscular injection! Medical personnel NEVER inject oil substances and non-intravenous meds intravenously as this can have very immediate negative and possibly fatal (resulting in death) consequences. Injectable oils are ONLY intended for intramuscular, also called IM injections! This means that the needle has to go through the skin as well as the fat and tissue layers beneath it, then on into the muscle itself. For an illustration of this, see the pictures beneath 'Injection Protocol' #9 below. Pictured in order here are several of the ways to inject into muscle groups. Favorites among these groups include the Buttocks, the outer Quadriceps/Thighs, and the lateral (top outside) surface of the Hips (SEE: the section entitled 'Best Injection Spots' for an illustration of this one). POPULARLY INJECTED MUSCLE GROUPS Other less popular muscle groups are often injected by experienced professionals who require more frequent shots, and include the Deltoids (Shoulders), Calves, Pectorals (chest/breast muscle area), Lats (Latissimus Dorsi muscle), Biceps & Triceps all of which are pictured below i n the order listed here: LESS POPULAR INJECTED MUSCLE GROUPS Medical Personnel single out these locations because they are densely muscled; containing numerous muscle fibers and vast amounts of connective tissue (those that cover, connect and separate the bones from one another and their adjacent muscles). These areas provide excellent conditions for fast diffusion (spreading and absorption). However, very specific 'spots' within even these choice muscle © 2012 Thatotherguy

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groups must be located in order for users to avoid injecting into large groups of nerves and blood vessels. As a rule, inexperienced person shouldn't inject more than 2cc's of any substance (or combination of substances) at one time, and are careful not to inject the same spot more than once a week. Changing the injected muscle groups, or at least switching to the corresponding group on the other side of the body with every shot, is a practice known as 'Spot Rotation'. By observing the 2cc limit the user prevents discomfort while the substance i s being absorbed, whereas rotating spots permits them to resist the building of hardened callous-like tissue beneath the injection site, b.k.a. scar tissue. Best Injection Spots Most medical professionals consider the upper-outer quarter of the buttock, also known as the Dorsogluteal site, to be one of the best areas for intramuscular injections. Another common site for injection is the Ventrogluteal area of the Gluteus/Buttock region. This injection site is located between the index and middle fingers, and is slightly higher and to the outside of the Dorsogluteal site. These are spots are deemed optimal choices because: 1) the area is massive; 2) they have relatively few nerve endings; 3) the chance of the substance entering a blood vessel is very low here and; 4) by injecting here one lowers the probability of touching the sciatic nerve - a very large nerve network that passes through the lower & median buttock areas, and on into the lower body. Injection Protocol The 'Two-Pin' technique increases sanitation for multiple dose vial drawing. They draw with the first pin, and then shoot/inject into the body with a new one. This procedure prevents any residual contaminants that may have remained on the drawing pin from being transferred into the body via the injection site. It also makes injection less painful since the drawing needle is necessarily dulled during passage through the rubber stopper atop the vial. A dulled needle increases injection pain because it doesn't pierce the body as cleanly as an unused one. The protocol below is followed by those who draw from multiple dose vials, but steps 4 - 8 are routinely disregarded by those users who draw from ampoules (also called ampules). 1. A shower is STRONGLY recommended. If one is not taken, then wash hands thoroughly with soap and warm water. 2. Thoroughly cleanse (with soap), rinse (with clean warm water), and dry the intended injection area. 3. Sanitize the intended injection area with an alcohol swab. 4. If using a multiple dose vial, be sure to clean the rubber stopper with alcohol. 5. Fill the syringe with an equal amount of air in comparison to the intended dose. Then inject the air into the vial (this practice helps keep a balance of internal/external pressure which makes future withdrawals easier). 6. Holding the vial upside down as depicted in the picture, draw solution into the syringe. 7. Continuing to hold the syringe pointing upwards, replace the needle cover and carefully unscrew the needle. 8. Leaving the protective cover on the new/sterile needle, screw it into place. 9. Relax the injection site, and if possible, stretch the skin taught (tightly) with the thumb and forefinger. This action makes the skin tight and provides for an easier i njection. Once the skin is stretched, while holding the needle like a dart, insert it with one swift motion all the way to the end of the needle. This step varies depending on the size of the needle and the depth required for selected injection site). Nevertheless, make sure the needle is long enough to reach the muscle. Do this at a 90 degree angle relative to the muscle being injected as illustrated below. Shooting on a 45 degree angle (also illustrated below) may not permit full passage through the fat and tissue layers and into the muscle fibers. 1. Then aspirate, which means to pull back on the plunger to confirm that blood is NOT entering the syringe. As long as NO blood has entered (signifying that a blood vessel was not hit, and that this is a good injection to continue), proceed by pushing down on the plunger with slow steady pressure. 2. Once the syringe is empty, pull the needle out with one swift motion, and put pressure on the area with a sterile alcohol pad while massaging in a circular motion. 3. Apply a bandage, recap the needle, and dispose of everything in a safe manner to prevent later © 2012 Thatotherguy


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injury to yourself or others. It is recommended that you seek a medical professional advice before referencing this material; which is for educational use only. Get your medical supplies at: www.directlinemedical.com

6.3

Intram ramuscular Inj Injection Si Sites Ventrogluteal

Ventrogluteal site: Is the most comfortable and safest for IM injections. This site is not close to any major blood vessels or nerves. The landmarks for this site include the greater trochanter, anterior superior iliac spine and iliac crest. With the patient on their side place the palm of your hand on the greater trochanter, the index finger on the anterior superior iliac spine and the middle finger pointing toward the iliac crest.

Deltoid site: Deltoid site: This site is most common for small volumes. To inject into this site you must first locate the acromion process, place a finger on the process and measure 3 finger breadths down. The injection is given into the fullest part of the deltoid.


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Vastus Lateralis Vastus Lateralis: Is located on the lateral aspect of the thigh, it is the number one site for newborns and infants who have not developed any of the gluteal muscles or the deltoid muscle. Have patient assume a supine position, divide the thigh into thirds. Place one hand next to the head of the trochanter and the other hand just above the patella. The area between your hands is the middle third; this is where the injection is given into the fullest portion of the muscle.

Dorsogluteal site Dorsogluteal site: This site is never used in infants and small children. Because of the proximity to the sciatic nerve it is only used as a last resort in adults. The landmarks for this site are the posterior superior iliac spine and the greater trochanter. An imaginary line is drawn between the two landmarks. Find the center of the line and move one inch above the line.



Part

VII

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7

Chapter 5: Side Effects

7.1

Basic Si Side Ef Effects In Inform rma ation Taking steroids is known to improve muscle strength and size and give a competitive edge to athletes who train with them. Users are usually impressed with the results of taking the drugs and with their slimmer, more-fit bodies. But there is a downside to taking steroids side effects that can cause serious damage to many of the bodies functions. Like all drugs, steroids have two types of effects on the body has therapeutic effects and nontherapeutic effects. Therapeutic Therapeutic effects of steroids are the desired effects effects of taking steroid for a leaner physic, larger and stronger muscles. Non-therapeutic effects are the unwanted side effects of steroids that can cause damage to the body. Anyone considering using steroids should learn about these side effects and their dangers because many of them can be irreversible, even fatal if the steroids are used improperly. There are many precautions steroid users can take to minimize the side effects associated with steroid use. Proper dosage, the right physical training, a planned recovery and the use of certain supplements to counteract side effects can make steroid use safer and less harmful. In fact, there is some debate to just how harmful steroids are when properly used. Most studies on steroids side effects were conducted at a time when users were unaware of their dangers and tended to take much larger amounts of the drugs than were needed and supplements to counteract the side effects weren’t yet developed. Also, the steroids themselves were not as advanced as ones available today. According to Jerald Bain of the University of Toronto, many of the side effects associated with steroids, like liver damage and heart problems, are related to the classical anabolic agents 17alkylated steroids. He points out, however, that these steroids are not pure testosterone, the basis for steroids, and that increased levels of testosterone in the body show no signs of causing these harmful side effects, and may in fact be helpful to the body. As the science of steroids improves, there may be a time when their use use will be safe. But for now, their side effects should be looked upon with serious consideration before using any kind of steroid. The following are some of the known side effects of steroids: Liver damage – Steroids contain toxins that the liver cleanses from the body, which may lead to cysts or tumors. Kidney damage – Kidneys also help cleanse the body of toxins, and although it is rare, steroid use may lead to kidney damage. Cardiovascular problems – Steroids affect the cardiovascular system in many ways. Steroids can raise cholesterol levels in the body, which can lead to blocked arteries around the heart or blood clots throughout the body, including the brain. Also, steroid use can lead to cardiomyopathy where the heart muscle grows larger and weaker and is unable to pump blood throughout the body. Finally, steroid use can lead to high blood pressure, which is the leading cause of heart attacks and strokes. Problems with the reproductive system – Steroid use affect the reproductive systems of both men and women. In men, high doses of steroid lead to infertility while they are using steroids. Also, steroid use may cause men to develop female characteristics such as loss of body hair, decreased size of testicles and they may also develop larger breasts. In women, the use of steroids may lead to male characteristics like facial hair and loss of scalp hair. Steroids also alter a woman’s menstrual cycle and make them unable to become pregnant while using steroids. Stunted skeletal growth – Testosterone is the body’s chemical messenger that slows growth of bones © 2012 Thatotherguy

Chapter 5: Side Effects

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during puberty. Adolescents who use steroids can seriously stunt their growth and become less developed than they would be without using steroids. Skin problems – The toxins in steroids when excreted through glands in the skin cause users to suffer from acne. Psychological problems – Steroid use can affect peoples moods in a variety of ways. Some users report a high from taking steroids, which is often followed by a low. Long-term use without the proper recovery plan can lead to serious depression. Also, many users report heightened feelings of aggression, a state that is now coined as roid rage.



Part

VIII

Chap Chapte terr 6: Dete Detect ctio ion n Tim Time e of of Anab Anabol olic ics s

8

Chapter 6: Detection Time of Anabolics 18 Months 12 months 5 Months

3 Months

2 Months

5 Weeks

3 Weeks 2 Weeks 1 Weeks 4 Days


Nandrolone Decanoate (Deca Durabolin) Nandrolone Phenylpropiona P henylpropionate te Boldenone Undecyclate (Equipoise) Methenolone Enanthate (Primobolan) Trenbolone (Finaject) Trenbolone Acetate Injectable Methandienone (Dianabol) Testosterone-mix (Sustanon & Omnadren) Testosterone Enanthate Testosterone Cypionate Oxymetholone (Anadrol & Anapolan) Fluoxymesterone (Halotestin) Indictable Stanozolol (Winstrol) Formebolone Drostanolone Propionate (Masteron) Methandienone (Dianabol) Mesterolone (Proviron) Ethylestrenole Noretadrolone (Nilevar) Oxandrolone (Anavar) Oral Stanozolol (Winstrol) Testosterone Propionate Testosterone Undecanoate (Andriol) Clenbuterol Ephedrine Hydrochloride

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Part

IX

Chapt hapter er 7: Steroi eroid d Ran Ranki king ng Chart art

9

Chapter 7: Steroid Ranking Chart Coming in next version....


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Part

X

Chap Chapte terr 8:Ma 8:Maki king ng Fina Finapl plix ix (Tre (Trenb nbol olon one e Ace Aceta tate te))

10

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Chap Chapte terr 8:M 8:Mak akin ing g Fin Finap apli lix x (Tr (Tren enbo bolo lone ne Acet Acetat ate) e) Finaplix information here.

10.1 0.1

Tren ren an and Liv Liver er Tox Toxici icity On The Issue Of Tren Toxicity I wanted to share this with everyone on worldclassbodybuilding.com because this is a question I see commonly asked on the boards. This is Author L. Rea's commentary on trenbolone toxicity. Question: I've got the following problem: In many books(including CME, WAR) I can read trenbolone is quite toxic, and you should use low dosages for short periods. I now some people who used Parabolan pissed blood. BUT I can also read that trenbolone isn't toxic (Bill Roberts: WAR revisited): "I have found no indication in the scientific literature of particular kidney toxicity with trenbolone. I know of a number of users, at doses of typically 50 mg/day, who have experienced no problems. There are however anecdotal claims of kidney problems. It seems to me, however, that this is occurring only with athletes stacking an incredible amount of drugs, and how the blame can fairly be laid at trenbolone (actually at Parabolan, not trenbolone acetate) is not clear." In Anabolics 2002 nor William Llewellyn mentioned anything about this toxicity. I know people using trenbolone acetate 100mg/day for 10 weeks without any problem. Just see Nevertoobig's stack: he uses 100mg trenbolone acetate ED. As I know liver toxicity is in connection with the hexahydrobenzylcarbonate hexahydrobenzylcarbonate ester and it can be a problem with Parabolan but you don't have to worry if you uses other ester like acetate. So what is the truth? And if I'm right why was finajet so toxic? Just because it was for animals and the oil was not clear enough? Answer: Trenbolone acetate acetate preperations are toxic to both liver and kidney tissue. The extent is a matter of period of administration for the most part. The reasons are strange but true. At one time there there were the many black-market black-market preperations preperations of Finaplix, FinaJect and others. Most of these contained simple ground Finaplex-H implants...as most are painfully aware. With the process (if you can refer to a caveman approach as a process. The idea of "I have a rock and can make my own AAS" is not a good one) came many many foreign non-kidney-friendly non-kidney-friendly materials, some of which were were nonsoluable. The use of Fina-kits eleminated some of the material concerns due to the use of benzyl alcohol as a solvent to seperate the binders from the AAS in Finaplex-H implants. But there is another concern. The EOD or ED administration of trenbolone acetate preperations also means an accumulation of benzyl alcohol (which is quite high in these kits). Personally I felt that in itself this would not be a huge concern. Unfortunately athlete liver and kidney stress markers consistantly showed in those who utilized the drug. (A little research to discuss) TR-343 Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CAS No. 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) Chemical Formula: C7H8O - 3D Structure*

Toxicology and carcinogenesis studies of technical-grade benzyl alcohol (99% pure), a textile dye additive, solvent, and food flavoring agent, were conducted by administering the chemical by gavage in corn oil vehicle to groups of F344/N rats and B6C3F1 mice of each sex for 16 days, 13 weeks, or 2 years.


72


Short-Term Studies: In 16-day studies, all five male and five female rats and mice dosed with 2,000 mg/kg benzyl alcohol died. Two of five male and 3/5 female rats and 1/5 male and 2/5 female mice dosed wi th 1,000 mg/kg died. Rats and mice of each sex in the two highest dose groups were lethargic after dosing. Other toxic responses to benzyl alcohol in these dose groups included blood around the mouth and nose, subcutaneous hemorrhages, and blood in the urinary and gastrointestinal tracts of rats and blood in the urinary bladder of mice. Animals administered lower doses of benzyl alcohol (125, 250, or 500 mg/ kg) had no compound-related histologic lesions. Doses selected for the 13-week studies were 0, 50, 100, 200, 400, and 800 mg/kg for rats and mice. Eight of 10 male rats dosed with 800 mg/kg died during weeks 7 and 8; four of these deaths were described as gavage related. Rats dosed with 800 mg/kg exhibited clinical signs indicative of neurotoxicity including staggering, respiratory difficulty, and lethargy. Hemorrhages occurred around the mouth and nose, and there were histologic lesions in the brain, thymus, skeletal muscle, and kidney. In truth I now feel that it iiss the accumulative benzyl alcohol that had altered the liver and kidney markers disfavorably far more so than the trenbolone itself. One must remember that the amount of benzyl alcohol in 1ml of most kit preperations is several times higher than an entire 10ml vial of testosterone enanthate. Written by Jason Meuller.

10.2 10.2

The The Goo Good d and and Bad Bad sid sides es of TREN TREN Trenbolone is not "new" it was synthesized in the mid 1960's by Hoescht Roussel. Bodybuilders have been using it since the late 60's. Original Trenbolone Acetate was marketed as Finaject and was 30mg/ml. It was taken off the market in 1987, Parabolan the long acting human version of Trenbolone was trashed in 1996 there are human studies done of course with Parabolan and most of the ones noted were on the psychological effects caused even by the long ester. TA is a veterinary drug and no human studies are available. Equipoise Boldenone Undecylate is also a vet drug but it is used more often than tren. Laurabolin is the vet version of deca -but that stuff is another story as drugs-hormones for the most part aren't species selective. Trenbolone is the most used and abused anabolic steroids in the US today. Why? because the availability of pellets and these "kits". Every kid and his brother not connected with regular anabolic steroids supplies or sources have access to this "wonder drug"and will eat it, snort it, rub it, and shoot it. The kits produce a clean but yet dirty product for the body. Clean as it may be bacteria free but contain clean contaminants or irritants. Examples: A. Way too much much solvent is used for the body to appropriately handle handle safely. Most kits are a combo combo of BA and BB and require 10 mls for 4 grams. There is no magic solution-solvents are solvents and cause discomfort-some more than others. Solvents are about the only thing anabolic steroids are soluable in besides oil-which we know has minimal toxicity. (comment from basskiller: Most kits only use 3 to 4 mls of the combined BA and BB, not the 10mls as mentioned here) Now here is the part most will disagree with. These kits produce about 50-70% of the dose they say they do. Most kits would test out at 35-60 mg per ml if that. I was going to make some and test it through San Raf, but there was/is not much support nor do I care to use these anyway anymore. (comment from © 2012 Thatotherguy


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basskiller: He pulled these numbers from where? There was a test done on a finaplix conversion and it came out to be 95mgs/1ml) And plus people would would scream BIAS if I was involved involved in anyway because because the magic solvents have been exposed a while ago. Why less than dose per ml than advertised or promised? Because 10 mls solvent is not enough to extract 4 grams of hormone from the pressed cellulose acetate in the pellets to which the tren is bound to. A friend of mine did a study years ago and he sells TP kits so he can back me me up. He was looking at the various solvents used to extract tren from pellets and their yield. Each experiment was performed twice and using 2 grams pellets in 100 mls solvent coffee filtered and allowed to evap with the tren powder recovered and weighed. Results: 1. Ether-yielded 1.86 grams 2. Methanol yielded 1.74 Grams 3 Acetone yielded 1.64 grams BA BB was not done because of the very high evaporation points. So someone explain to me how 10 mls of solvent will yield 100% extraction and no cellulose will be in the end product? If kit makers provided you with a molecular weight syringe filter in addition to the sterile filters maybe it would be a cleaner product.... Kits produce a very allergic, toxic product in their own even though sterile filtered and baked.

Three toxic products from the kit that make it through the filter are the solvent, the partially dissolved Cellulose acetate, the oil and the trenbelone mix itself. These toxic products in the tren produce unflattering reactions in the body itself amplifying the already irritating effect of the trenbelone itself. I have used a lot of kits and even made my own with BA/BB and some of the most "memorable" effects were: 1. The "Rush and Flush"-this is i s the allergic, almost anaphylatic reaction you get after i njecting tren from a kit. Some of the excess solvent in the depot gets absorbed very quickly as does some of the tren. This leads to-in some-coughing fits, red face, increased blood pressure, increased body heat, headaches and fatigue or lethargy after you recover. Depending upon solvent levels you will have pain and swelling at the injection site. *I will note that to reduce these sides I have used 400mg of ibuprofen and at least 100mg of Aspirin to fight the "inflammatory effects" mentioned above. Taken 30 minutes before a pop and the sides were less noticeable. 2. Fatigue and Lethargy, High BP, Sweating, Insomnia, Moodiness, headaches, reduced appetite, missed training sessions...basically the "tren Flu" are all part of the tren hangover as I call it. The body is fighting a lot of the impurities as a mild infection...and the sides of the drug itself can be potentiated by all these factors listed above. *Some of these effects can be eliminated by using tren powder and a minimum amount of solvent-.751.0 ml per gram. I wil l post a method-nothing new-but it yields pure trenbelone acetate powder from pellets. © 2012 Thatotherguy

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tren and cancer tren and pneumonia-as in scar tissue in the lungs, tren and kidney failure, tren and sterilizing effects, etc... None of these have been proven, but certainly possible in the vast array of doses and tren products and methods used to make tren. Each individuals experiences will vary as the increase in the amount of the Gene Pool-(more users experimenting with tren). I could elaborate more but I too am unsure of the long term effects of tren-especially from "kitted tren". Negative Side Effects of tren: High BP Progesterone induced gynecomastia-for some Headaches Fatigue Lethargy Loss of Appetite Moodiness Aggression Depression Anxiety Insomnia Night and Day Sweats Increased body temp, metabloism tren Reduced sex drive Posititve Side Effects of tren: Increased strength gains Increased muscle mass Decreased Catabolism Increased fat metabolism Reduced water retention Aggression-the good kind kind Literally a poor man's GH with more toxic sides After reading this list, you would be hell bent on using tren but there are are ways I have have found to minimize the sides and potentiate the gains and still use tren in a safer manner. 1. Only use tren a couple of times per year with test and 1-2 other anabolics. 2. Use low doses-35-70 mg a day ED dosing. 3. Cycle for short periods 6 weeks 4. Take the necessary ancillaries A. Liver protection-Tyler's, protection-Tyler's, milk thistle, alpha lipoic acid, acid, Liv-52, Picro-Liv Picro-Liv etc B. Cranberry juice C. Extra vitamins and minerals especially electrolytes and anti-oxidants Vit C Vit E etc. D. Double your water intake E. Use prescribed BP meds when necessary-don't self medicate. F. Use tren made from powder when ever necessary or available



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G. Don't kit your tren from pellets-use it as a last resort Written by Jason Meuller

10.3 10.3

Step Step by by Step Step Fin Finap apli lix x to Tre Tren n Conv Conver ersi sion on So, I figured since I was doing another Finaplix to Trenbolone Acetate conversion, my second one, I might as well document it as much as possible so that anyone else considering doing it will have a place with pictures to reference. By The Terminator The following conversion is based on 2 carts of Tren Pellets with comes to a 4 gram kit. For the conversion, you will need the following: 2 Carts Finaplix .8mL BA (Gives 2% overall volume) 7.2mL BB 30mL Sterile Oil (I used grape seed oil I sterilized myself). 2 Sterile jars with lids or large Beakers Coffee Filter Funnel 1 sterile 40 to 50mL vial 2x3mL syringes 2x18g needles 1x21g needle Sterile blunt instrument to bust pellets up with .22 or .45um Whatman filter (I used a .45) Open your tren packages and remove the carts. Find something small to poke the finaplix pellets out with. I used a paper clip that I bent into a straight line, and it worked very well.


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Place Finaplix Cartridge on the top side of the glass jars or open Glass Beaker, and push all of the pellets into it using your device (mine was the aforementioned paperclip).

All of the finaplix pellets pellets out of the cartridge and into the bottom of the beaker. Once all of your pellets are in there, take your sterile blunt object, and break down the pellets. You should be able to get it down to a fairly fine powder. Remember that the finer it is, the faster the process is to complete. I used a strong metal spoon for this.

Picture of the totally crushed Finaplix pellets. Crushing the pellets speeds up the dissolving process



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Now, get your BB(benzyl benzoate), BA(benzyl alcohol), one syringe, an 18g needle, and sterile oil ready.

Measure .8mL BA, 7.2mL BB and squirt it into the powder. Then, measure out 28mL of oil and place that in the jar as well. Take the other 2mL of sterile oil and place that in your syringe. This is for purging the Whatman filter later on so that no precious tren is wasted.

Seal the lid of the jar. If you wish to accelerate the breaking down of the powder into suspending into the oil/BA/BB mixture, place it in a bowl of hot water like I have done. It's advisable to change and swirl every 20 to 30 minutes if you're wanting to do this quickly. I used boiling water to heat it up that extra little bit.


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After the first few swirls, it will look like this from from the bottom. This shows that it is not fully broken down. Don't be in a hurry while doing this conversion.

Once it is fully dissolved, you're want to grab the other jar, the funnel, and the coffee filter. Now, I did get a bit ahead of myself on this one, so I don't actually have pictures of the actual filtration. However, here is what I did. Take the jar with the lid on it, and puncture the lid with a knife or screwdriver. You want to make a hole that will firmly hold the funnel. Once the funnel is secure, you can put the coffee filter in it. From there, poor the tren mixture in after swirling, leaving the jar or vial upside down in the funnel if possible so that every last drop is allowed to be filtered. Once everything has drained, and the filter is wet with no visible oil still draining, put on a pair of gloves (or clean your hands really good) and squeeze out the filter into the funnel, taking care to not turn the filter upside down. We want to keep the gooey fillers and crap out of the mixture, as this will save you Whatman's. If you like wasting money, don't prefilter. All of the above steps steps work best if the oil is hot when starting the pre filter process.



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Now, you're going to need your other syringe, 18g needle, 21g needle, sterile vial, and Whatman. It's also helpful to place the filtered mixture in that jar with the "holy" lid in a bowl of boiling water to heat the oil, as the thinner the oil the easier it is to filter.

Place an 18g needle on the end of the Whatman filter, and insert into the sterile vial. Then vent the vial with the 21g needle so that air can escape easily. This will make filtering much easier. Take the syringe with another 18g needle on it, and then draw oil up into it from the jar.


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Cap the needle and then place the syringe on the end of the Whatman. Now comes everyone's favorite part - the filtering! If you push too hard, you'll blow the Whatman, and not hard enough nothing will go through. Keep a tight grasp on the bottom of the Whatman and the "T" grips on the syringe as it's happened to me many times where the amount of pressure being placed on the syringe plunger exceeds the force I'm holding the T grip with, and the end of the syringe will pop out of the Whatman. I lost 3mL of tren like that tonight.

After you're done filtering, you have a dilemma to face - to bake or not to bake? Baking will provide that extra bit of sterility, as anything over 200F will kill off any bacteria, but also poses the possible issue of oxidizing the tren which can decrease potency. With BA in the mix you should be fine, however, go with wi th what makes you more comfortable. I chose not to bake this time as I was very careful throughout the process, and things went smoothly. Your finished product should come out to be a nice golden color, such as this. This conversion makes 40mL of tren at 100mg/ mL. I know you're thinking that there was only 38mL of liquid involved, however don't forget about the tren powder, which comes out to 2mL of total volume. The Terminator Buy Vials and supplies here: www.bodyvanity. com



Part

XI

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11


Chapter 9: Common Body Terms

Anabolic= promoting anabolism.

·

Anabolic steroid= any any one of several several compounds derived derived from testosterone or prepared synthetically to promote general body growth, to oppose the effects of endogenous estrogen, estrogen, or to promote masculinization effects. They have a chemical structure similar to cholesterol. •

Anabolism= constructive metabolism characterized characterized by the building of tissue into more complex living matter, mainly muscle. •

Androgen= any steroid steroid hormone that promotes male characteristics. •

Aromatize= the conversion of testosterone testosterone to estrogen. estrogen.

•

ATP= adenosine triphosphate triphosphate is a molecule used to store store and release energy in the muscle.

·

Atrophy= refers to a state state of deterioration deterioration usually within the muscle or bodily organ due to a lack of use or health. •

•

Bitch Tits= a slang term for gynecomastia.

Catabolism= a complex metabolic process in which energy is liberated for use in work, energy storage, or heat production by the destruction of complex substances. Basically muscle tissue is broken down when a person is in a catabolic state and the use of anabolic steroids will change this. •

Cholesterol= a fatty substance found in animals that performs many vital functions and is synthesized by the liver and the adrenal cortex. •

Creatine= a nitrogenous compound that when combined with phosphate produces ATP. •

Cycle= the time in which a certain supplement is taken. If you take a supplement for 6 weeks it is a 6-week cycle. Usually the time on a cycle is followed by the same amount of time off of •


Chapter 9: 9: Co Common Bo Body Te Terms

the cycle. •

Dart, pin, poke, ned= slang terms for syringes.

Diuretic= a substance that increases the amount of urine which is released by the kidneys. •

Estrogen= natural hormone that promotes the growth and development of female characteristics Fakes or basement drug= refers to counterfeit or fake steroids. •

Freaky= A bodybuilding term used to describe a person who is huge and obviously on steroids. •

Gear= slang for steroids, syringes, anything associated with the use of steroids. •

Gynecomastia= an abnormal enlargement of one or both breasts in men. This condition is usually temporary due to a hormonal imbalance brought on by the use of steroids, however, can occur naturally as well. •

Immune system= the system in a persons body that wards off infection and responds to illness. •

•

Juice= slang term for injectable steroids.

•

Lean body mass= the amount of muscle on a persons body.

•

Libido= a persons sex drive.

Steroid= any of a large number of hormonal substances with the same basic chemical structure produced mainly in the adrenal cortex and gonads. •

Testosterone= an androgenic hormone which is used to produce anabolic steroids. •

Thermogenisis= the production of heat. Raises metabolism making it easier to burn fat. •

Trade name= the name given to a particular substance by each company that manufactures it. •

•

Virilization= the process in which a person takes on the


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characteristics of a mature male. Masculinization.



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Chapter 10: Insulin Insulin is Dangerous use at your own risk. But its good stuff. Read more. (insulin)

Insulin is one of the most powerful anabolic agents in the world. Used properly, it can add weight to you more quickly than any other compound at our disposal. Used improperly, insulin will kill you. Before I delve too deeply into explaining this compound, I feel that its important to stress that last part: Screw up with this stuff, and you die. You will go into a coma, and die. And Im talking about simply taking too much of this stuff once. Ok? This drug needs to be treated with caution. If you arent willing to read as much as possible on insulin before using it, then you arent ready to use i t at all. So first, lets talk about the insulin thats floating around in your body right now, and what it does; then well talk about how adding exogenous insulin (insulin from outside your body) could possibly help you. Insulin is a protein secreted by the pancreas which acts on the liver to stimulate the formation of glycogen from glucose and to inhibit the conversion of non-carbohydrates into glucose. Insulin also promotes facilitated diffusion of glucose through cells with insulin receptors, and of course this means muscle tissue (1). As you may expect, very high concentrations of insulin have been soundly result in markedly stimulated muscle protein synthesis (2)(3)(4)(9). It does this mainly at the translational level by enhancing peptide chain initiation (11). This property and its consequent results are probably the things which makes it most interesting to bodybuilders and athletes. This is because those factors combine to make ingested protein more efficient by promoting the transport of amino acids into muscle cells. Ergo, we can clearly say that insulin is undoubtedly anabolic in muscle tissue. It also has an anabolic effect in bone, and thereby increases bone density as well (8). Another mechanism by which insulin is anabolic is i s via increasing your bodys IGF (Insulin-like Growth Factor) levels (6). IGF is an extremely anabolic hormone.

Another unexpected aspect of insulin use use is its ability to to increase both LH (Leutenizing Hormone) Hormone) and FSH (Follicle Stimulating Hormone), both of which in turn stimulate testosterone production. What Im getting at here is that insulin stimulates gonadotropin secretion, meaning that its use may actually provide an anabolic effect through increasing your HPTAs abili ty to stimulate the production of testosterone (Hypothalamic-Pituitary-Testicular-Axis)(11) (Hypothalamic-Pituitary-Testicular-Axis)(11) This effect is often manifested as virilization (development of male sexual characteristics) in women. Insulin also increases the binding ability of anabolic steroids to the androgen receptors (14),which would clearly suggest strongly the possibility of a synergistic effect of insulin when combined with steroids. Most people also think that insulin has some anabolic synergy when combined with growth hormone, and certainly there is a lot of anecdotal evidence for this as well. In addition to anecdotal research, its important to note that Insulin is actually so anabolic that some researchers have speculated that Growth Hormones (GH) ability to stimulate Protein Synthesis may actually be,in part, due to GHs ability to increase insulin sensitivity (12). Certainly the complex relationship between insulin, IGF, and GH is very synergistic and all interrelated to each others actions (13) (15) (16) (17). Using all three of them plus anabolic steroids and a fatburner is the most potent muscle-building & fat -burning cycle possible. Of course, when something seems too good to be true, it usually is. Unfortunately, the bad news is that insulin can easily stimulate adipose (fat) storage. Generally, though, most bodybuilders take insulin with a fat burner or 2 (Thyroid meds are the most popular choice), as well as anabolic steroids and © 2012 Thatotherguy

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sometimes even GH and IGF, for reasons previously explained. All of this adds up to decreasing the chance that fat is stored, and greatly increases the amount of muscle that will be gained. Anyway, as you probably guessed, endogenous endogenous insulin (the (the stuff naturally found in your body) body) operates on feedback from within your body. When your glucose levels get high, which is what happens when you eat a sugary snack, insulin is then released from your beta cells. When glucose is low, insulin is, of course, low. In fact, simply adding liquid glucose to a liquid amino-acid meal (thereby raising insulin levels) will increase the absorption of the ingested amino acids by roughly 50%!(7) Now, think about this: If a natural insulin response to ingested glucose can give you 50% better absorption of protein, think about how much protein absorption injecting it will give you.. So, now that we have some kind of understanding as to what endogenous insulin does, lets try to figure out exactly what exogenous insulin can do (thats the kind you get from a bottle..). Medically, of course, insulin is used to treat diabetes...thus becoming diabetic is a real risk with improper insulin usage. First, Im going to give you some clinical examples of how insulin has been used as an anti-catabolic agent. In the first study I read, insulin levels were increased 15-fold in infants suffering extreme catabolism. This level of insulin administration produced a 32% reduction in protein breakdown (4). In the second study I read exogenous insulin impeded muscle protein loss in burn victims (5). Its important to note that you MUST have enough amino acids (protein) in your body for insulin to exert an anabolic effect. If there are not enough amino acids floating around in your body from your last few meals, insulin will not be anabolic at all. On the other hand, If amino acid concentrations are maintained at normal or high levels as they would be in a typical athlete or bodybuilders diet, a net protein deposition in muscle will occur (more protein deposited in your muscle = more muscle gained). This effect of insulin depositing protein in your muscles is primarily because of an actual stimulation of protein synthesis and also owing to an inhibition of protein breakdown (10). The l esson here is that even with insulin, diet is the key to it all. You need to have enough protein in order to build muscle, regardless of how much insulin you take. Lets quantify this a bit. What about the anabolic and anti-catabolic properties of insulin? Can we put some solid numbers on any of this? Sure. From the following chat, you can see that insulin puts your protein balance into a much more beneficial state, and concomitantly lowers protein degradation by inhibition of the lysosomal pathway (this is its anti-catabolic effect) (11) and raises protein synthesis (this i s its anabolic effect).


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Protein kinetics. Protein balance, degradation, and synthesis rates are shown (measured in nmol phenylalanine " min 1 " 100 ml 1). Values represent means SE for the basal (open bars) and last 30 min of the insulin infusion (filled bars) periods with the 3 different rates of amino acid infusion (in ml " min 1 " kg 1) (* P < 0.05 and ** P < 0.01 for basal vs. infusion period).(5) What this chart tells me is that insulin can efficiently utilize a great deal of protein above and beyond what your body could normally utilize, and that if you should decide to use insulin, you should be taking in at least 2.2g/kg of bodyweight, and preferably 3-4.5g/kg of bodyweight. So now we know how & why insulin works, and how well it works. Ok, lets figure out how to use it. Ill give you two basic ideas on how to safely use insulin, as well as a third "hybrid idea," and a dirty little trick on how to use insulin with a cyclic ketogenic diet, to get into ketosis earlier. Whichever way you decide to use, remember, insulin has the ability to stimulate fat storage, so you want to make sure you are using anabolic steroids with it, as they will preferentially drive protein and nutrients towards being used for the accumulation of lean body mass over adipose tissue (fat). Personally, I also like to use a thyroid medication (Synthroid) to further insure none of my injectable insulin is going to put any fat on me. If youve been paying attention up until now, Im sure I dont have to tell you that GH and IGF are also very potent (and expensive) additions to any stack containing insulin. If all of that didnt whet your appetite, then consider the fact that insulin, GH, and IGF are undetectable on drug tests! Currently, theres speculative ways to test for them, but nothing consistent has been established. I suspect that many a top level "natural" bodybuilder has been helped out by insulin, GH, and IGF. So now that we know something about insulin, lets see what kind is most appropriate for bodybuilding or athletic purposes, as there are several types of insulin available, and choosing the correct type i s of © 2012 Thatotherguy

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utmost importance. Basically there are 5 different types of insulin well look at, and from them, well pick the type which will best suit our purposes of building muscle: Humalog and Humulin Insulin Humalog (Insulin lispro inj.) is the fastest acting insulin available Humulin-R (Regular Insulin) has a short duration of effect Humulin-N (Insulin Isophane) is intermediate length insulin Humulin-U(Medium Zinc Suspension) is another intermediate length insulin Humulin-U, utalente (Prolonged Zinc Suspension) is Long acting insulin (*there are also blends available of two or more of these types of insulin, in varying ratios of Long:Short or anything in-between) Of these 6 possible choices, the first would appear to be the best and safest, but that particular type of insulin is (unfortunately) only available with a prescription, and getting it through a typical steroid source (which usually means through the mail) is not advisable, since you can not be sure it has been properly stored and refrigerated throughout the shipping and handling process. Needless to say, attempting to forge a prescription for this stuff is an exceptionally poor idea. Our next best choice for an injectable insulin is Humulin-R, so thats what were going to be using. Humulin R is available without a prescription, from any pharmacy. This stuff has a fairly rapid onset and peak, and ergo is much easier to deal with than the other forms of insulin available, some last very long, or have varying peaks and spikes throughout their duration, and as such are just too difficult to monitor and control. The first and most obvious way to utilize insulin for its anabolic effect is to take a little bit with each meal, possibly 1-2ius up to 5-6x a day (insulin is measured in international units, not mgs as is common with anabolic steroids). This way youd be getting the greatest benefit of insulin possible with each meal and the least risk of using too much and going into shock. Of course some bodybuilders have reported using up to 20-40iu/day, but I wouldnt recommend this unless you are very experienced, and have your diet in perfect order. Youll want to take in a tiny bit of essential fats, a decent amount of mixed carbs (i.e. carbs of varying glycemic i ndexes), and at least 40g of protein with each meal, when using this method of insulin use. And clearly, youll want to work up to this amount of insulin use, perhaps adding 1iu per day until you reach a level you are comfortable with. This holds true for either method of insulin use Im presenting. The second way you can use it is to take 1iu of insulin with your post workout meal, eventually working up to 1iu/10kgs of bodyweight. When using this method, youll want a post workout shake consisting of roughly 100-200g of mixed carbs and 40-50 grams of protein... nd dont forget a small amount of essential fats with your shake. I have used insulin this way, along with anabolic steroids and a thyroid med, and have found it to enhance the gains from my cycle by around 15-20% as compared with a similar cycle which did not include insulin. i nsulin. The final method is to use the first method as well as the second. SO youd be taking in 1-2ius with each regular meal and up to 1iu/10kgs of bodyweight with your post workout meal. This would ensure maximum efficiency from each bite of food you eat, but this way is also the most dangerous, and you need to monitor your blood sugar. If you get tired after a shot youll need to get some mixed carbs into you quickly (Gatoraid and a few Granola bars and/or candy bars), its a good idea to carry those kinds of things around with you as insurance that your blood sugar doesnt go too low. You also dont want to take this stuff at night before bed, because you wont know if your blood sugar is going low and thats making you drowsy (meaning you could be facing hypoglycemia, and about to go into a coma) or you are just tired because its your normal bedtime. And as for that that dirty little trick I was telling telling you about...a small amount of insulin may be taken taken when starting a cyclic ketogenic diet, with your first meal of the day you begin. This meal would be fats and proteins, without carbs, and only 2-4iu of insulin would be taken. The following meal, you can use half the dose of insulin as you did at your first meal. The result would be that you could be in ketosis before the end of that first day, where as usually it would take 2 or even up to 3 days to accomplish this. Using insulin in this manner is very dangerous, and was even called "Death Wish Dieting" by Dan Duchaine.. © 2012 Thatotherguy

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Whichever method you use, remember to keep your insulin refrigerated, as Insulin will degrade very quickly outside of a refrigerated environment. Dont leave this stuff out of the fridge too long, either. Insulin Syringes The other thing you dont want to do is use regular syringes to inject insulin. You NEED insulin pins to accurately dose this stuff, remember, too much can be deadly, and the syringes you would use to inject steroids are too big to measure out units of insulin with. Insulin is given via a subcutaneous injection (below the skin but above the muscle), and regular needles are just too big to do that. Insulin (or at least Humulin-R) is currently not a controlled substance, and you should be able to buy it at your local drug store pretty cheaply: a 10cc multi-use vial dosed at 100iu/cc will cost you around $50. Buy insulin needles at www.directlinemedical.com or www.bodyvanity.com or www.bodyvanity.com References: Human Anatomy and Physiology, 6th Edition, John W. Hole hyperinsulinemia unmasks insulins effect to stimulate protein synthesis in human forearm.Am. J. Physiol. 274 (Endocrinol. Metab. 37): E1067-E1074, 1999 Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J. 2004 Oct;18(13):1586-7. Epub 2004 Aug 19. Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation. oxygenation. J Pediatr Surg. 2004 Jun;39(6):839-44; discussion 839-44. Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patients Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E529-34. Epub 2003 Dec 9. Insulin: the other anabolic hormone of puberty. Acta Paediatr Suppl. 1999 Dec;88(433):84-7. Review. Contribution of amino acids and insulin to protein anabolism during meal absorption. Diabetes. 1996 Sep;45(9):1245-52. Anabolic effects of insulin on bone suggest a role for chromium picolinate in preservation of bone density.Med Hypotheses. 1995 Sep;45(3):241-6. Review. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J Clin Invest. 1995 Feb;95(2):811-9. Insulin action on protein metabolism.Baillieres Clin Endocrinol Metab. 1993 Oct;7(4):989-1005. Review. Effects of chronic hyperandrogenism and/or administered central nervous system insulin on ovarian manifestation and gonadotropin and steroid secretion. Fertil Steril. 2005 Apr;83 Suppl 4:1319-26. Metabolic effects of growth hormone in humans. Metabolism. 1995 Oct;44(10 Suppl 4):33-6. Clinical uses of insulin-like growth factor I. Ann Intern Med. 1994 Apr 1;120(7):593-601. Binding of methyltrienolone to androgen receptors in human skin fibroblasts is enhanced by insulin.J Androl. 1992 May-Jun;13(3):242-8. May-Jun;13(3):242-8. Are the metabolic effects effects of GH and IGF-I IGF-I separable?Growth separable?Growth Horm IGF Res. 2005 2005 Feb;15(1):19-27 IGF-1 and insulin as growth hormones.Novartis Found Symp. 2004;262:56-77; discussion 77-83, 2658. Review Divergent effect of endogenous and exogenous sex steroids on the insulin-like growth factor I response to growth hormone in short normal adolescents.J Clin Endocrinol Metab. 2004 Dec;89 (12):6185-92

12.1 2.1

Insu Insuli lin n: The The Over Overvi view ew In the last half-decade bodybuilders have been getting much larger much quicker. Certain professionals have added twenty pounds to their contest weight in one season, after having seemingly reached a plateau. The bodybuilding audience loves to hear that this weight gain is due to some secret drug or some newly discovered gene therapy. Elaborate theories are developed to explain these rapid weight gains and the professionals themselves are not helpful; they claim that it's the new X-brand supplement that's doing it and leave i t at that. © 2012 Thatotherguy

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The truth is that bodybuilders have discovered the most anabolic hormone produced by the body, insulin. Additionally, insulin has the benefit of being not only legal and over the counter in most states, but it is very cheap. A bottle costs less then thirty dollars and there is no need to worry about counterfeits. By correctly using insulin, in conjunction with human growth hormone and anabolic steroids, modern professionals have added pounds of mass onto seemingly stagnant physiques. This chapter will give a brief overview of insulin and the methods by which its anabolic action is exerted. We will outline how to correctly and safely use insulin both to gain size and to prepare for a contest (or simply diet).

Insulin: The Overview

Insulin is a peptide hormone, secreted by the pancreatic islets of Langerhans. Insulin promotes glucose utilization, protein synthesis, and regulates the metabolism of sugar. Insulin travels until it reaches receptor sites on cells. At these sites insulin facilitates the transport of glucose and amino acids across the cell membrane to be used inside the cell for energy and protein synthesis. This is insulin's anabolic effect, not only in super-saturating the cells with nutrients, but also helping to volumize the cell.

Insulin Safety:

There are significant risks that accompany the use of insulin. The greatest risk is an over-dose of insulin, which leads to hypoglycemic shock. This is not an overdose in the typical sense of the word; in this case it means that too much insulin was administered for the amount of glucose in the bloodstream. To this end, it is important to choose the correct type of insulin and to know when it peaks and the effective period of action of the drug in your body. This information is provided later in this chapter.

The symptoms of insulin shock are easy to recognize. · · · · · · · · · ·

Distress is relatively rapid, usually in a matter of minutes. Hunger. Sweating. Cold, clammy feeling. Paleness. Trembling, anxiety. Rapid heartbeat. Feeling of weakness or faintness. Irritability and change in mood or personality. Loss of consciousness.

Treatment:

Feed the person a source of quickly absorbed sugar. If the person is conscious, table sugar, fruit juice, honey, a non-diet soft drink, or any other available sugar source will do. If the person is unconscious, do not try to force sugar or liquid down his throat. Honey, granulated sugar, or a special capsule (such as D-glucose) containing concentrated sugars, which some diabetics carry, can be carefully placed under the tongue where it is absorbed into the body. However, this may be difficult to do. There is another rapid form of intervention that anyone using insulin should know about; a glycogen pen. Injectable glycogen is a hormone, normally produced in the pancreas, which has effects opposite to those of insulin. It is commonly used to treat hypoglycemia or low blood sugar. It may also be used to relax parts of the gastrointestinal tract for certain examinations. It is not a controlled substance. In the event of the onset of hypoglycemia, this emergency injection will pull your blood sugar back up. If you are using insulin, you should have one of these pens with you at all times. Take the person to a hospital emergency room as quickly as possible. Severe insulin reactions can be fatal. Do not be afraid of getting i nto "trouble", the use of insulin is legal. You will certainly get a lecture about how crazy it is to use insulin, but you wil l not be arrested or detained in anyway. © 2012 Thatotherguy

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It is extremely important to have someone who you can trust monitor you when you are using insulin. They should be aware of the signs of insulin shock as well as the course of action to follow in the event that you do slip into a hypoglycemic state. Some insulin users will go so far as to purchase a medic alert bracelet that indicates them as a diabetic in the even that they pass out in public. During a bulking phase, when calorie intake is deliberately high, insulin shock is not likely to be a problem assuming that post injection nutrition is precise (as outlined later in the chapter). In the even that you begin to feel any of the above symptoms immediately begin to consume the most simple sugars you can find, particularly look for glucose polymers and dextrose. Avoid fructose, as it is ineffective at raising blood sugar levels rapidly. In the even that you are using insulin in dieting, do not be afraid to "blow your diet" by eating candy if you feel your blood sugar getting dangerously low. Your diet is not worth your life.

Types of Insulin:

There are three important characteristics that differentiate the available types of modern insulin. To properly use insulin in bodybuilding it is important to know the following characteristics:

1. Onset:the time it takes the injected insulin to reach the blood stream and begin to work. 2. Peak:the time period in which the insulin is working it's hardest to lower the blood sugar. 3. Duration:the length of time the insulin will be working in the bloodstream. It is important to remember that insulin is an indiscriminate storage hormone. It doesn't care if its storing fat or glucose. Therefore fat intake should be as low as possible during the effective period of the insulin in the body. This will help prevent excessive fat gain. For bodybuilding purposes we will only be concerned with three types of insulin; Humalin "R", Humalin "N" and Humalog are the most useful types of insulin. The other varieties are mixes of the above types in set ratios. Humalin "N" is the longest acting insulin; it is active in the body for 24 hours. Additionally, it peaks several times throughout throughout the day. day. Humalin "N' is useful useful in the high calorie offseason when there will always be an abundant supply of glucose. However, even the most dedicated bodybuilder who is eating many small meals may run into serious trouble in the insulin peak corresponds to a period of low blood sugar. Also, the long duration of Humalin "N' means that the bodybuilder must adhere to a low fat diet throughout the day, which is i ncongruously with the eating necessary to achieve brutal size. Humalin "R" is known as the rapid insulin. The manufacturers claim that this type of insulin is active in the body for up to six hours; in reality it's closer to four and a half hours. The onset time of "R" is roughly thirty minutes and the drug peaks in one and a half to two and a half hours after injection. Humalog is the fastest acting insulin. It has duration of about 2 hours, peaks in fifteen minutes, and is ideal for bodybuilding purposes because it is out of the body quickly. The speed at which Humalog works is beneficial because it allows us more precise control and lets us know exactly when food needs to be consumed.

Insulin Injection Procedure:

Insulin can be injected intravenously, intra muscularly, or subcutaneously. Injection insulin into the veins is creepy, but safe. However, it is not necessary to do this, as injection insulin into muscle or under the skin is just as effective. The injection site, exercise, and the accuracy of the dosage measurement, the depth of injection and by environmental temperatures, can affect insulin absorption. To obtain consistency in daily insulin absorption and action, you should vary injection sites within the same anatomical region. The abdomen provides an excellent area for consistent absorption of insulin, whereas the leg and arm areas are often affected more by exercise.


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Repeated injection in the same area may cause a delay in absorption whereas massaging the site of injection may lead to an increased rate of absorption. Insulin should be injected at a 90-degree angle using an insulin syringe (25 unit, 30 unit, 50 unit, or 100 unit size) or with an insulin pen. If redness, pain, or lumps are noted at the injection site, this area should be avoided until the problem goes away. Be sure to follow proper sterilization procedures. Wipe down the injection area with alcohol. The insulin needle is very thin so bleeding should be minimal. However, press a swab of cotton soaked in alcohol over the injection site after you withdraw the needle. This will protect almost entirely against infection. An increase in blood flow to an injection injection site will increase the rate that insulin is absorbed. So, exercise will cause insulin to be absorbed more rapidly, because blood flow has increased to the exerted muscle groups. You will need to either inject less insulin or eat more carbohydrates after exercise. exercise. Rubbing the injected area increases blood flow, and hence, absorption.

Post Injection Meals and Supplements:

Depending on the onset time of the insulin type you are using you have varying lengths of time in which to ingest the post-insulin meal. Generally your post insulin meals should follow these guidelines. 60-80 grams of a good quality protein powder. Whey protein is ideal. This is taken immediately after the injection. 7 grams of simple carbohydrates (not fructose as it does not raise blood sugar quickly enough) per IU of insulin injected. Every 15-20 minutes after the first shot, take a few glucose tablets. This is will increase the amount of glucose available to your body for storage. 200 mg of chromium picolinate (this is optional). 200 mg of lipoic acid (this is optional). 30 mg vandal sulfate (this is optional). 2000 mg of hydroxy citric acid (this is optional). 5-7 grams of creatine mono hydrate. This is crucial. 5-7 grams of glutamine powder. This is also crucial. The total amount of insulin that you will be using daily is roughly 15-45 IUs depending on how many carbohydrates you can eat that day. During dieting periods, the total amount of insulin will be greatly reduced. Typically, three injections of insulin are used daily. The first is taken immediately upon awaking; this is an appropriate time to use the Humalin "R". The second shot is taken mid-day and Humalog is recommended. The last injection is taken immediately after the workout of the day. If you are doing a double split training program, then take one shot after each workout and adjust your other injection accordingly. Do not take an injection too late at night; you want to be able to stay awake through the entire period of action so you can monitor yourself for signs of low blood sugar. Anyone who is going to to use insulin should take take some time to familiarize him or herself with the the glycemic index. The glycemic index is a ranking of foods based on how they effect the body's blood sugar levels. There are many resources that provide elaborate listing of many types of foods including fast foods. For our purposes it is merely important to identify the foods with high glycemic index scores to consume with the insulin injection. Below is a list of foods (or sugars) that scored very highly on the glycemic index. Whole Foods or Candies Jelly Beans Dates Sugar types (in ascending order; Maltose elevates blood sugar the most) Lactose Honey High fructose corn syrup Glucose Glucose tablets © 2012 Thatotherguy

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Maltodextrin Maltose

Conclusion

For many, insulin may seem like the perfect bodybuilding drug. It's legal, cheap, effective, and easy to obtain. However, the decision to use insulin is not one that can be made lightly. At worst, the misuse or abuse of anabolic steroids will probably result in no more than elevated liver enzymes and a host of undesirable cosmetic side effects. Improper use of insulin will result in much more serious consequences, including death. Bodybuilders must first ask themselves if they possess the necessary maturity and intelligence to responsibly use this hormone. Look before you leap my friends.

by Grendel

12.2 12.2

Mons Monste ter' r's s Insu Insuli lin n Pr Prim imer er From my experiences with insulin, you must first feel out how the insulin effects you. I have used with great success multiple times. The most important thing I found out about myself is that I didn't have to consume 10 grams of carbs per iu. I have gone down as low as 1 gram and felt hypo once. Drank a coke and the feeling went away. I am completely comfortable taking only 4-5 grams of carbs on a regular basis. Just listen to your body!!

Ok, lets have a look at insulin. Its highly anabolic and non-androgenic, and in case some of you are in the dark (I'd like to think we're all clear on anabolic versus androgenic, but ya never know) I'll briefly touch on the subject before diving in... if you're ok on anabolic/androgenic concepts, skip to the INSULIN part... ANDROGENIC VERSUS ANABOLIC ANABOLIC is defined as "The process process of constructive metabolism" or of building complex complex substances out of simple substances. The way your body processes protein, carbohydrates, and fat (all simple substances) and makes muscle (a complex substance) is ANABOLISM. ANDROGENIC is basically defined defined as pertaining to to male sex characteristics. characteristics. ANDROGENIC/ANABOLIC "Steroids" are actually called "Anabolic Androgenic Steroids." They accomplish "anabolism" through "anabolic" pathways, some being more androgenic (testosterone esters) and some less (winstrol, Anavar, primobolan, ect...). Most often, with reduced androgenic properties comes reduced anabolic properties, but it isn't always cut and dry. If anyone is interested I'll go into it another time, but lets head toward the insulin topic. INSULIN: Non-Androgenic but Anabolic Insulin is NOT a sex hormone. It is not related in any way to testosterone, or to estrogen for that matter. It is a product of the pancreas as opposed to testosterone which is a product of the HPTA, pituitary, gonadal, leydig, mishmash of interconnected glands... WHY IS INSULIN ANABOLIC So why is insulin anabolic then? Insulin is a partitioning agent. A "shuttle" if you will. Picture insulin as a bus. Nutrients board the bus, and insulin pulls away and drops off the nutrients at the proper bus stop. That is basically what it does, and for all intents and purposes that is everything you need to know to understand how it works. © 2012 Thatotherguy

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So by insulin shuttling these nutrient where they need to go, it enables anabolism and is therefore anabolic! WHY NOT JUST TAKE CARBS TO RAISE INSULIN Well, the amount of carbs you would need to take in to increase natural insulin levels to the degree a 10 i.u. shot would would be far more dangerous than using insulin (and using insulin is NOT that hard OR dangerous). Carbs at that level would eventually lead to diabetes and fat gains. If insulin is a bus taking nutrients where they need to go, then exogenous insulin is a bullet train! It can hold far more nutrients than a normal naturally produced burst of insulin can, and it works quicker. Exogenous insulin is the most efficient way to accomplish glycogen overcompensation, period. WHAT KIND DO I TAKE I'm a major supporter of fast acting insulin. The faster the better! Currently he fastest acting insulin available is Humalog. It is active in 15 minutes, peaks in 1 hour and clears the system around 2 hours. Next would be Humulin-R. It is active in about 30 minutes, peaks at the 2 hour mark, and clears the system at the 4 hour mark. "Biophasics" are mixtures of fast and slow acting insulin's, but are not the best choice in my opinion, due to an active dose being in you throughout the day. The reason you don't want that will be covered in the "HOW DO I USE IT" section. There are also Humulin-L and Humulin-S, but they are long acting, and are no more use to me than the Biophasics. There are also porccine and bovine derived insulin, but I am against injecting animal derived substances. WHEN (AND HOW MUCH) TO USE Im going to assume we want to avoid any fat gains at all. Even bulking I don't like to gain any unnecessary fat, so I'm going to discuss it from that stand point. The ultra conservative time to use insulin is post-workout. Most people who are concerned about fat don't go over 10 i.u. as a total dose. Some people us it on waking, before breakfast, since your body is in a basically carb depleted state. Its the kind of thing you have to try for yourself, and if it works for you, do it. If you think you're gaining fat, stop. BUT! Don't start it at both times at once. Make sure you get your post workout dosage worked out and that you know it iiss not causing you any fat gains before you try pre-breakfast shots. That way you can take out all the guess work as to where any fat gains may come from. DISPELLING A FEW MYTHS There is a commonly held perception that you Must take in 10grams of carbs per I.U. of insulin, some radicals say 5 grams... well, they're both wrong. I got curious about this when I discovered that my insulin dependant diabetic friend didn't even keep track of what she ate post injection. She would feel hypoglycemic after a shot and take a Glucose Tablet. A glucose tablet is only 5 grams of glucose (carbs)! So I started to think, "Hmmm, maybe everyone is off point on this?" After conducting a few experiments experiments on myself, I found that you can go considerably considerably lower in carbs carbs than people previously believed. Now it doesn't make sense to go low in carbs, because that defies the purpose of using the insulin in the first place, but it does free us from having to use so much that there might be some "spill over" in carbs that cant be utilized. So it really makes us able to have more freedom in carbs choices and amounts. The "risk" in insulin use is not as risky as people believe. Any person with an ounce of sense can see the warning signs of a problem coming, and remedy the situation. HOW DO I DO IT © 2012 Thatotherguy

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If you look at the drug store, you can get these little pen cases that hold a loaded insulin syringe. They are great for our need, you load up the syringe, and put it in the case, and throw it in your bag/purse/ whatever. After the workout, head to a bathroom stall and inject it under the skin! Pull up a little skin from the abdomen or upper thigh (anywhere will do, but these are easiest) and inject. Do not shoot into a muscle. This rushes the dose and makes it harder to predict when it will spike. So now you have 15 minutes to get some carbs (actually you have longer, since the initial hit of the dose is mild and easy to cope with, the spike is a little more harsh, but still nothing unbearable. If you use the carbs, you probably wont notice the initial dose OR the spike.) (this is based on Humalog at 10 i.u.) I use a powder with a 20% simple/80% complex ratio (actually its 17% mono, 5% di, 7% tri, 5%tetra, and 66% penta-saccharides). I use about 60grams of carbs to the 10 i.u. of insulin. This gives me a nice soli d stream of carbs to overcompensate my depleted muscles, but not so many that I risk fat accumulation from the excess. Now you are good to go till around 1 hour after the initial injection. At this 1 hour mark, the majority of the dose hits your system. Now is the time to eat a good balanced (AND FAT FREE!) meal. The fatfree emphasis will be explained in the POTENTIAL PROBLEMS section. This balance meal of carbs and protein and little to know fat can be anything from a protein drink and a crab drink, to a low fat MRP, to some lean chicken and rice... your choice. After this meal, you don't need to pay anymore consideration consideration to the insulin, it will gradually gradually decrease and will be out of your system at the 2 hour mark. Till you get accustomed to the use of insulin, start low and slow. Start at 2 i.u. then 5 i.u. then 7 i.u. then 10 i.u. That way you get a better understanding of any hypoglycemia you may encounter. I've went as high as 35 i.u., just to try it, but at a certain point a higher dosage doesn't yield any better results (except fat!) POTENTIAL PROBLEMS Insulin is relatively safe. If you don't take in any carbs after using it, your body will give you PLENTY of warning! You'll feel dizzy, tired, achy... hypoglycemic. What is happening is your body has no glycogen to use as fuel. Your muscles re depleted from working out, and often times you've tapped your liver for any remaining glycogen. The insulin does, searching for glycogen to use, takes the rest from your li ver, and in the absence of carbs coming in to make more, it heads for the brain. Your brain uses glucose as its primary fuel source (a little fat, too.) That's why you get dizzy and light headed, the same with during a ketogenic di et... low glucose equals light headedness. So if you forget about the carbs, you'll get a warning from your body, and you can get your ass in gear and get some carbs in you. If you get to the point where you're nauseated, just drink some sugary beverage and get some carbs in you quickly. You're still a long long way from any major danger, but don't mess around. "Fat Free" I said earlier about the 1 hour mark meal. During the 2 hours of the dosage duration, you should avoid fat like it is the plague! Insulin's partitioning properties are as effective at sending fat to the fat stores as it is carbs and protein to muscles! So till the dose is clear of your system, NO FAT! ( That's another reason why I advocate the fastest acting insulin you can get.) Well, I cant think of anything else off hand that needs to be said, but if I missed anything, just ask. I may have taken something for granted and figured everyone would know or assume on their own...

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Basi Basic c Ins Insul ulin in guid guide e for for begi beginn nner ers s If you are a seasoned insulin user, this post is going to be WAY too basic to be of value to you. The purpose of this post is to answer the very basic questions for those completely unfamiliar with insulin and its use in the body and for bodybuilding purposes. -RedBaron There are a lot of posts on message boards about insulin and how it is used for bodybuilding purposes. But more basic than this, I am frequently asked....what exactly is insulin and what is it really doing for my body. Here is just a REALLY basic overview of what insulin is in the most basic of terms. © 2012 Thatotherguy

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What is Insulin for? Your body's main source of fuel is a form of sugar called glucose. It gives us energy. After we eat, glucose enters the bloodstream and signals a gland near the stomach, the pancreas, to make insulin. Insulin is a chemical that helps cells in your body use glucose. Insulin is the storage hormone, glucose disposal chemical, and the main shuttle of glucose into our muscles and other cells. As cells use glucose for energy, the level of glucose in the bloodstream drops. If there is no insulin or the insulin isn't doing its job too much glucose builds up in the bloodstream. This is the condition (hyperglycemia) you find when you have diabetes. Basic Types of Insulin There are many different types of prescription insulin. Some are designed to work right away and don't last very long. Other types act more slowly over longer periods of time. Doctors routinely prescribe the type of insulin that matches your body's needs for diabetics. Each case of diabetes is slightly different, and depending on the length of time and severity of the condition, the individual need for insulin and its active window varies greatly. This is why you see so many different brands and types on the market. Depending on the symptoms and condition of the diabetic, the insulin type is tailored to their needs. Bodybuilding use of Insulin Now let's cut forward to all of us that are NOT diabetic. Our reason for using i nsulin is to use its inherent shuttling ability to shuttle nutrients to the muscles. For our purpose we are not trying to achieve long term control of glucose buildup in the bloodstream. We are trying to transport supraphysiological amounts of protein and sugars to the muscles for fuel, repair, and growth. For our purposes, we want to use a quick acting, short lasting insulin. Longer lasting insulin will most likely just equate to added fat ... and not provide any additional positive function. We are using this ONLY as a nutrient shuttle ... which is only needed after we have worked out our muscles and torn them down .... this is when they are screaming out for glycogen and protein. As we learned above, above, insulin's purpose is to pull glucose out of the bloodstream bloodstream and ship it out ... helping cells use it. The problem with this is the brain has a really, really small limited range of blood sugar levels that it will function within. If we put too much sugar into our system uncontrolled by insulin, we check out for good. If we have too much insulin and our blood sugar drops too low, same result.... we check out. This is the danger that is inherent in manipulating insulin for our bodybuilding purposes. This is also why the timing of carbs immediately after insulin injections is critical. What, When, and How? For the purpose of bodybuilding, we want to use a short acting insulin (such as Humalog, or if not available next best Humulin-R). Either of these should be very inexpensive to purchase (under $40). The dose required will end up being between 4-10 IU's, and even in the most advanced users under 15 IU's should get the job done. For beginners, stay in the 8-10 IU range. The most advantageous time to use this is immediately post workout, when our muscles are screaming out for nutrients and are in a catabolic state. We use a U-100 insulin syringe with 1/2" needle to inject IM immediately post workout. Alternatively, you can inject sub-q if desired. When starting starting out using insulin, begin with a dose of 2IU's or so, and increase the dose each workout day until you reach your desired maximum. Immediately following your injection, you will want to do the following religiously: injection + 5 minutes – drink shake with 10g glutamine / 10g creatine / 55g dextrose (based on 7-8 IU's - 7-8 grams per IU more precisely) Injection + 15 minutes – drink shake with 80g of whey protein in water Injection + 60 – 75 minutes – eat a protein / carb meal with 40-50g of protein, 40-50g of carbs, NO FATS Avoid fats for 2-3 hours hours for Humalog IM, 3-4 hours for Humalog Humalog sub-q, 4-5 hours for for Humulin-R. Things to Watch for Insulin's most commons side effect is HYPOGLYCEMIA (low blood glucose). It is important that you know the signs of hypoglycemia they may occur quickly! They are: - Shakiness © 2012 Thatotherguy

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- Anxiety - Fast heart beat - Hunger - Sweating - Blurred vision - Dizziness - Weakness - Headache - Irritability Irritability If any of these symptoms occur, you should eat some form of quick acting sugar to prevent the symptoms from getting worse (e.g., two or three glucose tablets, one tube of glucose gel, one-half cup of fruit juice or regular soft drink, one tablespoon of honey, or one tablespoon of sugar dissolved in water) Always have something something like the above on hand when using insulin. Hypo symptoms can and will hit hard and fast, and you will have a very small window of time to react. Be ready!! Well, hopefully you now have a basic understanding of insulin. There are many other in-depth articles and studies available that I would encourage you to read and study, especially before venturing into insulin use. While it is extremely useful for bodybuilding, it is also dangerous enough to not be taken lightly.....know what you are doing and have a plan BEFORE you begin to consider using insulin. As in anything we do, research, research, research!!! Hopefully this post will whet your appetite to look into insulin.....used properly it is definitely one of modern bodybuilding's great tools.

12.4 12.4

Muta Mutant nt's 's Insu Insuli lin n Pro Proto toca call Ok, so after talking to some professional and elite bodybuilders, I have learned quite a bit about what a well known professional trainer is having these bodybuilders to do to obtain the retarded amounts of weight they have been added to their bodies. It's simply taking their insulin pre-workout, combined with 3 "shakes". I looked at this Insulin protocol, and the ingredients in the shakes, and designed my own Insulin Protacol to better suit my goals and routine. I use better quality of ingredients in my shakes, and added my HGH pre-workout, and igf-1lr3 post workout as well. Now, the theory behind this insulin protocol is, "Why break the body down, only to rebuild it? When you can simply keep adding onto the Body!" So basically, by forcing the carbohydrates and Essential Amino Acids into your muscles while you train, the muscle tissue is not breaking down in the same manner that they normally would. It is actually being both protected and forced to grow at the same time. I have not done too much research behind the theory, but it sure sounded good to me, based on what I know about enhancing drugs and supplementation. I prefer trying things out myself, and going by results. Well, the results were spectacular. Before I begin, I want to say that this typed out protocol is just a base. It is to give you a base to work from/with. Everybody is different. Some people will need more or less carbs and amino acids. This is based on the amount of insulin that they are using and how their bodies react. This is why I gave a range for the supplements and insulin doses. You will need to adjust it based on how you react. For the carbohydrates, always start high, and lower it accordingly, once you get the feel of it. We start off by taking our HGH, and give it a few minutes to get circulating, before we add our insulin. The idea behind this, is to make sure that the HGH passes the liver while we have a substantial amount of insulin in the body. This is how we produce large IGF-1 spikes. After the workout, we go home and take our IGF-1LR3. We are taking this to increase our insulin sensitivity, and to help use up any of those receptors that we have not filled. I could go more into detail, but if you are using this protocol, you should already know all about the drugs, and should be able to put it together yourself. - -30 min prior to workout: Take 10iu HGH subq © 2012 Thatotherguy

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- -15 min prior to workout: Take 6-16iu Novalog subq - -10 min prior to workout: Drink shake #1 - -After every working set: Sip on shake #2, and finish by end of workout - -Go home - -Take 100mcg of the IGF-1lr3 (for it's insulin sensitizing effects) - -Take down shake #3 - -Done..now you are huge Ok, now what is in the shakes... Shake 1: 10-20g EAA's or PeptoPro, 40-60g Low DE Maltodextrin, 5g Micronized Creatine Monohydrate, 200mg Caffeine (or pre-workout powdered mix of choice in place of caffeine) Shake 2: 10-20g EAA's or PeptoPro, 50-100g Dextrose, 5g Micronized Creatine Monohydrate Shake 3: 2 cups pasteurized egg whites, 1 cup dry oats, 1 banana or 1 cup blueberries (I prefer them to be frozen), splenda or stevia *There is no need for a supplemented post workout shake because your glycogen will not be depleted, and you will have been ingesting aminos the whole time too. So dense whole food calories with low fat content, are going to be the best option here. So we throw it in a blender and take it down. Now, I would like to advise you cheap-skates, not to go out and buy the cheapest ingredients that you can find. Please pick quality supplements. It does and will make a difference. Spend the extra 2$ and buy some quality shit, or your results may be skewed. Thinks about it this way: Your body is a Lamborghini. Would you fill your tank with low grade octane from Costco? No, of course not, it would run like shit. So use quality supplements, not bulk junk crap, and your results will be that much better! Supplement idea for those of you who need to be pointed in the right direction: EAA's: Champion Nutrition makes a good EAA product that has creatine in it, and also one that has caffeine too. It's called Amino Shooter. There are 3 versions. None are a proprietary blend, and they are made with pharmacy grade aminos. PeptoPro: This can be used in place of the EAA's. It is a high quality peptide/EAA product made from hydrolyzed casein. Different companies buy PeptoPro and flavor it. One brand I have tried that is flavored is MAP by Primordial Performance. Low DE Maltodextrin: This means Low Dextrose Equivalency. The lower the equivalence, the more complex of a chain it is, and the slower it will break down into a sugar. A couple good ones are Carb Complex by Nutek, and Cytocarb 2 by Cytosport. If corn maltodextrins give you stomach problems, then other water soluble carbohydrates like Karbolyn can work. They just tend to be expensive, and do the same exact thing. Some people that have used this protocol with success, have actually used dextrose in place of the maltodextrin due to stomach problems. Dextrose: Yes, you can find this anywhere, but I prefer AST's DGC because it also contains vitamins. Micronized Creatine Monohydrate: Well, the name says it all. Any brand that uses Creapure as the source of their creatine monohydrate, should be just fine. I use Bioplex. *Do not use cheap starch carbs, like waxy maize, in the shakes. The carbs need to be water soluble and easily digested. By keeping them soluble, they help pull the aminos in. © 2012 Thatotherguy

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I decided to throw this protocol together after I had my leg surgery, in hopes of gaining some abnormal amounts of muscle back that I had lost. I can tell you that I did, and this protocol works better than any protocol I have ever used. I started off at 204 - 205lb, and ended up at 234 after 4-5 weeks! I was taking anabolics on the side, but I guarantee that amount of insane weight, that fast, was not from the long estered steroids I was taking. I literally filled out instantly. When I dropped the insulin, I only lost a few pounds of water, and retained most, if not all, of my strength. So the gains were very solid, and not just a bunch of glycogen storage. I do not want to post this on the open forums because there are too many idiot kids out there that will attempt this protocol in hopes of becoming an instant monster (which wont happen for them), and they will mess it up somehow. Maybe by being stupid, maybe by cutting corners, maybe by using cheap ingredients. Who knows? I don't need people hurting themselves, or not having good results, and them coming back and complaining. Even though they were the ones cutting corners! So, there it is boys. Some people are paying big money for this type of info. It's nothing special. It's just different, but it makes sense and it works. *Added note: Since this protocol was designed and posted, a handful of advanced users have tried it as part of their bulking regime. They have also had great success. Good Luck and Stay safe MUTANT

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How to use insuli insulin n - the most most anab anaboli olic c horm hormon one e This is pretty much a beginners guide to getting started on insulin. Directions for first time insulin users This is an article I wrote a little while ago and posted on several boards. I know its a long post but take the time and read it because your life does in fact depend on it. There are a couple other articles on the anabolic Review board in the Hot Topics Section but I think they all pretty much have the same info. Please Please...Ask if you have any questions Insulin is the most anabolic hormone you can take. On the other hand its also one of the most dangerous for two reasons availability and ignorance. I will be the first to tell you that every time I have been hypoglycemic (when blood sugar drops to dangerous levels) its has been as a result of something I did wrong. Used responsibility and with respect for the potential sides it is quite safe and extremely effective. That being said we'll start off with what you are going to need. Equipment: There are several types of insulin out there but for our purposes we are only interested in two. The first being my favorite Humulin R and the other being a bit newer to the body building community Humalog. Humulin R is the most widely used and time tested insulin in our arsenal. It has a max duration of 4hrs and its peak can been seen around 2hrs after injection. This becomes particularly important when planning out you meals for the day so keep the timetables in mind. Humalog is a bit newer but some feel just as effective and a bit safer. Humalog has a max duration of 2hrs and its peak can be seen around 1hr after injection. When selecting to use one or the other keep in mind your schedule, meals, and physical activity for the day as it will all play a role. One other point that needs mentioning is that Humulin R is available over the counter at pretty much every pharmacy in the country for about $25 for 10ml (which will last you a very long time) and Humalog is available only through a prescription or over the black market for a price about double that of Humulin R. When approaching a pharmacist keep in mind that its a lot more convincing if you buy the needles at the © 2012 Thatotherguy

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same time you get the insulin. This way they are less likely to refuse to sell it to you which they have been known to do from time to time. If this should happen just continue on to the next pharmacy and despite what they tell you "you dont need a prescription" it might be their store policy to see one but legally it is not required and if you make enough of a fuss you will get what you need. The next thing you will need is the actual needles for injection. These are not the same type that you would use for anabolics or other androgens. The type of needles you will need are U100 insulin needles. That is exactly what you need to say when are trying to buy them. A box of 100 will usually run about $15-$25 and again will last you quite a while. NOTE: Be fore warned now, using a syringe labeled wi th cc/ml or anything other than u100 is potentially fatal. The difference between the amount of insulin used for our purpose and that which will kill you is l ess than 1/2 a cc. The next two things I think you will need and I highly recommend having on you is a wrist watch with a chronograph (stopwatch) and glucose tabs and/or a can of soda. First I'll explain the wrist watch. The stop watch is to be started immediately after the injection and monitored periodically to keep track of what is in your body and how long it is active. This can also be used to determine whether or not you are feeling side effects or simply just nerves from the fear that follows using for the first time. For instance I always use Humulin R which we know has a duration of 4 hours and a peak at 2 hours. This means that the greatest effects will be felt somewhere between 1-1/2 to 2 hours after injection and then they will steadily lessen till it is no longer active 4 hours after injection. When you use a stopwatch you have an accurate record of when you felt the effects which will become more important as you get more experienced using insulin. The glucose tabs are your safety net. If you are feeling hypo (hypoglycemic) these tabs will return your blood sugar levels to a safe range where you can get some food. They are available at all pharmacies for about $1.00. I have also used a soda. Soda is high in simple carbs which act quickly when blood sugar is low and allow you to get to a safe range where you can get some food in you. Now that we've covered all the equipment needed to safely use insulin we'll move on to dosage diet and scheduling.

Dosage diet and scheduling: Whenever you start insulin its always wise to start at a lower dose and taper up over the first couple of days of use. insulin is still new in our community and there is a potential for becoming diabetic so don't take chances start small more is not better where insulin is concerned more is simply more fat and more dangerous. This is a schedule I use when just starting insulin: day1: 5iu's post workout day2: 6iu's post workout day3: 7iu's post workout day4: 8iu's post workout day5: 9iu's post workout day6: 10iu's post workout day7: same as day 6 This concludes week once from here on out this is how I proceed. If I am going to be increasing my dose even further. day8-10: 10iu's morning, 10iu's post workout day11-14: 10iu's morning, 10iu's noon, 10iu's post workout day15 and on: increase post workout dose till I start to feel symptoms of hypoglycemia and then back the dose down accordingly. NOTE: THIS IS ONLY FOR ADVANCED USERS, DON'T EXCEED THE DAY 7 DOSE TILL YOU GET SOME TIME UNDER YOUR BELT. I AM NOT KIDDING YOU WILL DIE!!!


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Your diet will depend on the amount of slin you take per injection. The rule is 10 grams of carbs per IU of insulin. Therefore if you take 10iu's at an injection you need 100 grams of carbs. This is a bit overkill the actual figure is about 5-7 grams but its best to stick with the 10 rule while starting out. I feel that the best most accurate way to consume the proper amount of carbs after an injection is through MRP's or other shakes. The amounts of carbs on these are far more accurate than those you will find on the back of a bread bag. My meals are usually layed out like this: 7am: 10iu's insulin, shake 9am: shake 12pm: 10iu's insulin, lunch 2pm: shake 4pm: shake 6pm: workout 7pm: 10iu's insulin, shake, higher in carbs than others 9pm: dinner 11pm: safe for bed If you'll notice there is a method to the madness above. After taking your first injection if insulin you will need a shake immediately. After this you are good for the next 2 hrs till the insulin peaks. Once you hit the 2hr mark you will need more carbs either another shake or a meal with sufficient carbs. After you have cleared the 4hr mark you will be clear from danger. Now this is all based on using Humulin R. If you are using Humalog you will need to take your first meal after injection and another "1hr" after. Then after the 2hr mark you will be safe. My shakes are made up of 1/2 pack of MetRX (berry) and 2 scoops GNC brand weight gainer (vanilla) and 16oz of whole milk. This shake has a caloric value of about 800 cals and around 50grams of protein and 150+grams of carbs. This i s a good meal for those starting out. As you progress though you will want to decrease the carbs and eliminate the fat completely to maximize lean mass gains and minimize water and fat retention but for the purposes of starting out simply taking T3 will offset any fat gained. One thing to keep in mind is that T3 will reduce your sensitivity to insulin allowing you to take a higher dose but again save this till you get some more time in. Side effects and procedures: After injection and starting starting your stopwatch stopwatch your first task is to get some some carbs in. Next the first sides you will feel is tired. This is normal and is to be expected. You will usually feel this somewhere between 15-30 minutes after your injection. The key here is not to sleep, i f you sleep you wont feel further more dangerous sides and therefore you wont be able to save your ass. The next thing you need to do is have another meal/shake at the 2hr mark. If you miss this just get it in as soon as possible. If you delay long enough you will start to feel hypo around 3 to 3-1/2 hours after injection. When this happens you will feel a sort of numbness that I can only relate to ephedrine. After this you will start to get some shakes in your hands followed by a cold sweat. Once you get to this point you are full blown hypo, the next thing that will follow will be a bit of tunnel vision and this is as far as I’ve been after this its all textbook I imagine coma will follow shortly after passing out. When you get the symptoms listed above don’t hesitate. Get some soda/glucose tabs followed by a meal or shake. One other fact I neglected to mention is that a mix of carbs is necessary when consuming a meal. Simple carbs are used to quickly and complex don’t kick in fast enough. A good mix is the way to go.

12.6 12.6

Why Insuli Insulin n works works.. Steroi Steroid d Insul Insulin in Synerg Synergy y Should anabolic steroids be used with insulin or is it best to use insulin while off steroids in order to hold onto muscle mass? We are going to demonstrate that they have to be used together. We will also try to provide some clues about their respective contribution to the synergy both hormones create. This will help us to handle both drugs better. Here are some general observations: © 2012 Thatotherguy


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It is safe to conclude something else is needed to uncover the full anabolic effect of steroids. The hormone which is the most affected by a high calorie or by a low calorie diet is insulin. Also, heavy steroid users know that past a certain amount of steroids, adding insulin will make a big difference as far as muscle gains are concerned. Insulin is thus a strong candidate as a potentiator of anabolic steroids (which we will indiscriminately refer to as androgens, steroids or anabolics). Furthermore, studies performed in trained dogs have shown a lack of insulin completely negates the anabolic effects of steroids on protein synthesis. There are some easy hypotheses such as a possible androgen receptor up regulation, a stimulation of androgen secretion, an antiaromatase effect arising from insulin. But, there is still something missing. Using anabolics plus insulin will wil l not make you much bigger unless you weight train. The synergy can only be realized if insulin + steroids + training are present. What is the link between those three factors? A very likely candidate is an enzyme called insulinase. As its name implies, i t is an enzyme responsible for the destruction of insulin. But we are going to see it does much more than that. It is found inside many tissues of the body, particularly in muscle. What science is telling us is that insulinase is essential for insulin to provide its anti-catabolic effect on our muscles. It is also likely that insulinase is able to multiply the anabolic effects of androgens. It's worth repeating: insulin cannot stop protein catabolism without insulinase and the effects of steroids are potentiated by insulinase. It sure looks good. Androgens are very very powerful stimulators stimulators of the muscle muscle protein synthesis synthesis rate. On the other hand, the muscle gains provided by androgens do not match this elevation in synthesis. Steroids promote anabolism to a much higher rate than they make our muscles grow. The reason for this discrepancy is that they also stimulate protein degradation. I know many people think they are anti-catabolic, but it is not the case. Anabolics stimulate protein turnover. This means they increase both synthesis and degradation of proteins. They are simply more effective at stimulating synthesis than degradation, which is why they make our muscles grow but not at a super fast rate. Look at how long it takes to grow huge muscles. If androgens were stimulating synthesis while inhibiting degradation, one would grow very, very quickly. This is where insulin comes in. As we said, it mostly reduces protein degradation rate. It might stimulate protein synthesis right after training, but this effect is very limited in duration. Ideally, using insulin along with steroids would allow us to accelerate synthesis (thanks to anabolics) and reduce degradation (thanks to insulin). This is the best way to grow muscle fast. Unfortunately, as both insulin and anabolics need insulinase to work better, they will compete against each other for this enzyme. For natural athletes, the supply of muscle insulinase should roughly meet the demand. Now if you add anabolics, there will be less insulinase for insulin. If you do not take too high a dose of steroids, the level of insulinase should still be sufficient to allow a fair insulin-induced anti-catabolism. But as you take more steroids, the insulinase available for insulin will be lower and lower. Insulin will lose its anti-catabolic effect. As it wi ll still bind some insulinase, the enzyme availability for steroids will not be optimal either. Anabolics will lose some of their potency. What is important to understand is that past a certain dose, anabolics will provide their own antidote against muscle growth. The only solution (besides using fewer steroids) is to increase insulinase level. At least two factors factors can accomplish this feat: feat: The first one is insulin itself. The higher the insulin level is in a target organ (muscle for example) the higher the insulinase level will be. You would expect that the body would detect the shortage of insulinase for insulin and so produce more insulin (or more insulinase). Unfortunately, this does not seem to be the case. While insulinase is crucial for the anti-catabolic effect of insulin, it does not seem as important for glucose disposal. Insulin's main function is not to assist in muscle growth but to control glucose homeostasis. As a result, it is likely our body does not really care about a relative shortage of insulinase. In any case, we are left with a less than optimal equilibrium. It is up to the bodybuilder to react to this imbalance. One way of increasing insulin secretion is to eat more, but you can only do so up to a point. You cannot increase your carb intake in parallel with the amount of steroids without getting too fat. Another solution is to use drugs to add or to stimulate insulin secretion. This way you get the insulin without the © 2012 Thatotherguy

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excess of calories. In any case you now understand why steroids work better while on a high calorie diet while they lose their potency during a diet or a shortage of insulin. Here is a way of "artificially increasing insulin level": One dose of long acting insulin first thing in the morning (this is the only injection). Before each meal (except the pre-workout one), take a sulfonylurea (an oral anti-diabetic drug which will boost food induced insulin secretion). I like Glipizide because of its short half-life. In case you experience hypoglycaemia, you know it will not last. This is the main problem with the long acting sulfonylurea. When you are hypoglycaemic, you try to compensate by absorbing carbs. But the drug will make your pancreas secrete even more insulin before the carbs can hit the blood. It makes the hypoglycaemia worse - not better. In case of problems, make sure you get some ready-to-inject Glucagon (sold as "insulin emergency kits" in drugstores). An additional benefit of the Glipizide is that it induces the release of GH on top of insulin which is beneficial for non diabetics. This is a nice way to fix the reduced anticatabolic property of insulin. Unfortunately, this will not yet provide the optimal amount of insulinase to have steroids work better. We said that training was the third key ingredient in this synergy. This is because training can stimulate insulinase activity. Not any exercise will do. The traumatic ones inducing muscle soreness are the most effective. It is the factors inducing soreness which will trigger this increase in insulinase. On the other hand, you do not want to create too much soreness as it will temporarily reduce the effects of insulin and androgens by impairing their effects at the level of their respective receptors. What you want is mild but frequent soreness along with some very frequent pumping sessions. Do not forget both androgens and insulin circulates in the blood. The more blood you get into the muscles (and the longer it stays), the more your muscles will be "drenched" in those two hormones. Please note that insulinase is produced locally in the trained muscles only. It does not circulate into the blood. By Michalovich Greutstein

12.7 12.7

Insu Insuli lin: n: The The Mos Mostt Ana Anabo boli lic c Hor Hormo mone ne Look back through picture archives of bodybuilding and you will be struck by a startling fact. In the last half-decade bodybuilders have been getting much larger much quicker. Certain professionals have added twenty pounds to their contest weight in one season, after having seemingly reached a plateau. The bodybuilding audience loves to hear that this weight gain is due to some secret drug or some newly discovered gene therapy. Elaborate theories are developed to explain these rapid weight gains and the professionals themselves are not helpful; they claim that it's the new X-brand supplement that's doing it and leave it at that. The truth is that bodybuilders have discovered the most anabolic hormone produced by the body, insulin. Additionally, insulin has the benefit of being not only legal and over the counter in most states, but it is very cheap. A bottle costs less then thirty dollars and there is no need to worry about counterfeits. By correctly using insulin, in conjunction with human growth hormone and anabolic steroids, modern professionals have added pounds of mass onto seemingly stagnant physiques. This chapter will give a brief overview of insulin and the methods by which its anabolic action is exerted. We will outline how to correctly and safely use insulin both to gain size and to prepare for a contest (or simply diet). Insulin: The Overview Insulin is a peptide hormone, secreted by the pancreatic islets of Langerhans. Insulin promotes glucose utilization, protein synthesis, and regulates the metabolism of sugar. Insulin travels until it reaches receptor sites on cells. At these sites insulin facilitates the transport of glucose and amino acids across the cell membrane to be used inside the cell for energy and protein synthesis. This is insulin's anabolic effect, not only in super-saturating the cells with nutrients, but also helping to © 2012 Thatotherguy


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volumize the cell. Insulin Safety: There are significant risks that accompany the use of insulin. The greatest risk is an over-dose of insulin, which leads to hypoglycemic shock. This is not an overdose in the typical sense of the word; in this case it means that too much insulin was administered for the amount of glucose in the bloodstream. To this end, it is important to choose the correct type of insulin and to know when it peaks and the effective period of action of the drug in your body. This information is provided later in this chapter. The symptoms of insulin shock are easy to recognize. Distress is relatively rapid, usually in a matter of minutes. Hunger. Sweating. Cold, clammy feeling. Paleness. Trembling, anxiety. Rapid heartbeat. Feeling of weakness or faintness. Irritability and change in mood or personality. Loss of consciousness. Treatment: Feed the person a source of quickly absorbed sugar. If the person is conscious, table sugar, fruit juice, honey, a non-diet soft drink, or any other available sugar source will do. If the person is unconscious, do not try to force sugar or liquid down his throat. Honey, granulated sugar, or a special capsule (such as D-glucose) containing concentrated sugars, which some diabetics carry, can be carefully placed under the tongue where it is absorbed into the body. However, this may be difficult to do. There is another rapid form of intervention that anyone using insulin should know about; a glucagon pen. Injectable glucagon is a hormone, normally produced in the pancreas, which has effects opposite to those of insulin. It is commonly used to treat hypoglycemia or low blood sugar. It may also be used to relax parts of the gastrointestinal tract for certain examinations. It is not a controlled substance. In the event of the onset of hypoglycemia, this emergency injection will pull your blood sugar back up. If you are using insulin, you should have one of these pens with you at all times. Take the person to a hospital emergency room as quickly as possible. Severe insulin reactions can be fatal. Do not be afraid of getting i nto "trouble", the use of insulin is legal. You will certainly get a lecture about how crazy it is to use insulin, but you wil l not be arrested or detained in anyway. It is extremely important to have someone who you can trust monitor you when you are using insulin. They should be aware of the signs of insulin shock as well as the course of action to follow in the event that you do slip into a hypoglycemic state. Some insulin users will go so far as to purchase a medic alert bracelet that indicates them as a diabetic in the even that they pass out in public. During a bulking phase, when calorie intake is deliberately high, insulin shock is not likely to be a problem assuming that post injection nutrition is precise (as outlined later in the chapter). In the even that you begin to feel any of the above symptoms immediately begin to consume the most simple sugars you can find, particularly look for glucose polymers and dextrose. Avoid fructose, as it is ineffective at raising blood sugar levels rapidly. In the even that you are using insulin in dieting, do not be afraid to "blow your diet" by eating candy if you feel your blood sugar getting dangerously low. Your diet is not worth your life. Types of Insulin: There are three important characteristics that differentiate the available types of modern insulin. To properly use insulin in bodybuilding it is important to know the following characteristics: Onset: the time it takes the injected insulin to reach the blood stream and begin to work. Peak: © 2012 Thatotherguy

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the time period in which the insulin is working it's hardest to lower the blood sugar. Duration: the length of time the insulin will be working in the bloodstream. It is important to remember that insulin is an indiscriminate storage hormone. It doesn't care if its storing fat or glucose. Therefore fat intake should be as low as possible during the effective period of the insulin in the body. This will help prevent excessive fat gain. For bodybuilding purposes we will only be concerned with three types of insulin; Humalin "R", Humalin "N" and Humalog are the most useful types of insulin. The other varieties are mixes of the above types in set ratios. Humalin "N" is the longest acting insulin; it is active in the body for 24 hours. Additionally, it peaks several times throughout throughout the day. day. Humalin "N' is useful useful in the high calorie offseason when there will always be an abundant supply of glucose. However, even the most dedicated bodybuilder who is eating many small meals may run into serious trouble in the insulin peak corresponds to a period of low blood sugar. Also, the long duration of Humalin "N' means that the bodybuilder must adhere to a low fat diet throughout the day, which is i ncongruously with the eating necessary to achieve brutal size. Humalin "R" is known as the rapid insulin. The manufacturers claim that this type of insulin is active in the body for up to six hours; in reality it's closer to four and a half hours. The onset time of "R" is roughly thirty minutes and the drug peaks in one and a half to two and a half hours after injection. Humalog is the fastest acting insulin. It has duration of about 2 hours, peaks in fifteen minutes, and is ideal for bodybuilding purposes because it is out of the body quickly. The speed at which Humalog works is beneficial because it allows us more precise control and lets us know exactly when food needs to be consumed. Insulin Injection Procedure: Insulin can be injected i njected intravenously, intramuscularly, or subcutaneously. Injection insulin into the veins is creepy, but safe. However, it is not necessary to do this, as injection insulin into muscle or under the skin is just as effective. The injection site, exercise, and the accuracy of the dosage measurement, the depth of injection and by environmental temperatures, can affect insulin absorption. To obtain consistency in daily insulin absorption and action, you should vary injection sites within the same anatomical region. The abdomen provides an excellent area for consistent absorption of insulin, whereas the leg and arm areas are often affected more by exercise. Repeated injection in the same area may cause a delay in absorption whereas massaging the site of injection may lead to an increased rate of absorption. Insulin should be injected at a 90-degree angle using an insulin syringe (25 unit, 30 unit, 50 unit, or 100 unit size) or with an insulin pen. If redness, pain, or lumps are noted at the injection site, this area should be avoided until the problem goes away. Be sure to follow proper sterilization procedures. Wipe down the injection area with alcohol. The insulin needle is very thin so bleeding should be minimal. However, press a swab of cotton soaked in alcohol over the injection site after you withdraw the needle. This will protect almost entirely against infection. An increase in blood flow to an injection injection site will increase the rate that insulin is absorbed. So, exercise will cause insulin to be absorbed more rapidly, because blood flow has increased to the exerted muscle groups. You will need to either inject less insulin or eat more carbohydrates after exercise. exercise. Rubbing the injected area increases blood flow, and hence, absorption. Post Injection Meals and Supplements: Depending on the onset time of the insulin type you are using you have varying lengths of time in which to ingest the post-insulin meal. Generally your post insulin meals should follow these guidelines. 60-80 grams of a good quality protein powder. Whey protein is ideal. This is taken immediately after the injection. 7 grams of simple carbohydrates (not fructose as it does not raise blood sugar quickly enough) per IU © 2012 Thatotherguy


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of insulin injected. Every 15-20 minutes after the first shot, take a few glucose tablets. This is will increase the amount of glucose available to your body for storage. 200 mg of chromium picolinate (this is optional). 200 mg of lipoic acid (this is optional). 30 mg vanadyl sulfate (this is optional). 2000 mg of hydroxy citric acid (this is optional). 5-7 grams of creatine monohydrate. This is crucial. 5-7 grams of glutamine powder. This is also crucial. The total amount of insulin that you will be using daily is roughly 15-45 IUs depending on how many carbohydrates you can eat that day. During dieting periods, the total amount of insulin will be greatly reduced. Typically, three injections of insulin are used daily. The first is taken immediately upon awaking; this is an appropriate time to use the Humalin "R". The second shot is taken mid-day and Humalog is recommended. The last injection is taken immediately after the workout of the day. If you are doing a double split training program, then take one shot after each workout and adjust your other injection accordingly. Do not take an injection too late at night; you want to be able to stay awake through the entire period of action so you can monitor yourself for signs of low blood sugar. Anyone who is going to to use insulin should take take some time to familiarize him or herself with the the glycemic index. The glycemic index is a ranking of foods based on how they effect the body's blood sugar levels. There are many resources that provide elaborate listing of many types of foods including fast foods. For our purposes it is merely important to identify the foods with high glycemic index scores to consume with the insulin injection. Below is a list of foods (or sugars) that scored very highly on the glycemic index. Whole Foods or Candies Jelly Beans Dates Sugar types (in ascending order; Maltose elevates blood sugar the most) Lactose Honey High fructose corn syrup Glucose Glucose tablets Maltodextrin Maltose Conclusion For many, insulin may seem like the perfect bodybuilding drug. It's legal, cheap, effective, and easy to obtain. However, the decision to use insulin is not one that can be made lightly. At worst, the misuse or abuse of anabolic steroids will probably result in no more than elevated liver enzymes and a host of undesirable cosmetic side effects. Improper use of insulin will result in much more serious consequences, including death. Bodybuilders must first ask themselves if they possess the necessary maturity and intelligence to responsibly use this hormone. Look before you leap my friends.

12.8 2.8

The Ski Skin nny on on Ins Insu ulin lin INSULIN AND ANABOLIC STEROIDS Of course when everyone thinks of bodybuilding drugs anabolic steroids (AS) are the first things to come to mind, but how do they work with insulin? VERY WELL! AS decrease insulin induced fat accumulation through a number of ways. One is through creatine synthetase, which is an enzyme that goes crazy after workouts trying to store carbohydrates in the muscles (as glycogen, creatine phosphate etc.). For every gram of carbohydrate stored in muscle, roughly four grams of water go along with it (this is how creatine monohydrate achieves such dramatic results). How does this relate to insulin and AS? Well, the "harder" AS (exemplified by oxymethelone) increase creatine synthetase levels dramatically, giving insulin a place to do its' job and store carbohydrates.


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Okay, this also counts for a combined anabolic effect, but it prevents insulin from converting any "excess" carbohydrate in to fat (which would subsequently be stored)! AS also decrease levels of the main fat storage enzyme that insulin increases (called lipoprotein lipase). A big effect is through glucocorticoid antagonism, which means that AS indirectly increase insulin sensitivity (as well as act anti-catabolically). This allows insulin to bind to its' receptors more easily and accomplish its' job rather, than converting more macronutrients in to fat. Finally, the demand for nutrients by muscles is so high, in an AS enhanced state, that there is rarely any excess of nutrients to actually be stored as fat! A mere 400 mgs of enanthate didn't allow me to accumulate fat whether I was using i nsulin or not. From a muscular anabolic perspective, there is a synergistic effect between AS and insulin. This is because they both directly stimulate protein synthesis as well as other mechanisms. One such mechanism involves AS hepatic mediated somatomedin release. Simply put: IGF-1 production in the liver. Again, the more powerful the AS, the more IGF-1 release, with orals having a much greater effect than injectables. Insulin increases the duration of time that IGF-1 is active in the bloodstream, and enhances receptor mediated IGF-1 activity (all through enhancing specific IGF-1 binding proteins). Another great combined combined effect is that that insulin reduces the amount amount of Sex Hormone Hormone Binding Proteins (SHBP) in the blood stream. This allows more AS to be active and do their job of making you grow! Great effects were seen while using 10 units of insulin only three times a week, with AS. For the first few weeks of my next cycle I'm not going off the stuff, and I expect the effects to be scary! INSULIN AND THE C/A/E STACK In case you've been living on Mars for the past few years, CAE stands for Caffeine, Aspirin, and Ephedrine. This stack has been shown to synergistically strip off fat, while preserving muscle mass. It is considered here because it is the minimum requirement, while using insulin, to prevent you from looking like the StayPuft marshmallow man. Also of benefit is that it is cheap and easily accessible. Using three times a day helps slow the fat accumulation, but strict dietary control is also necessary. The ephedrine: suppresses appetite, stimulates thermogenesis, and promotes and fat release from cells (beta receptor, and catecholamine, mediated), while the other two components of the stack increase thermogenesis by inhibiting certain enzymes and transmitters that try to slow down the thermic effect. Ultimately the appetite suppression effectiveness of ephedrine wears off, but this is replaced by a greater thermogenic effect (5-deiodinase, or Beta-3, mediated). The CAE stack does nothing for muscle anabolism in a hyper caloric situation, but that's what the insulin is for. INSULIN AND CLENBUTEROL This "soon to be classic" post-cycle stack not only increases muscle mass, but keeps fat off at the same time. Fat loss from clen is legendary for the first two weeks. After that time, the beta-2 receptors that it activates, attenuate (because of the extremely high binding specificity), dropping the fat burning effects to minimal levels. There should still be beta-1 receptor activation (which stimulates fat release from adipocytes) and beta-3 stimulation (the big thermogenic wonders), because they attenuate slower or not at all (respectively) compared to beta-2 receptors. Clen is a much better fat burner than ephedrine, due not only to its' higher receptor specificity, but also due to it's extremely long half life (the exact reason it's not approved for use in humans). This means that the drug is constantly burning fat, especially at night when serum glucose, and insulin, are low. Using aspirin and caffeine might slow the receptor attenuation, or at least increase the thermogenesis while its there (I can certainly attest to this!). Why hasn't anyone done this sooner? Clen, like AS, directly combats the fat storing enzyme that insulin promotes (lipoprotein lipase again) in white fat. However it actually increases this enzymatic activity in brown fat (hence the thermogenesis) and muscle. The latter event could promote muscle anabolism through a similar mechanism to HMB, or at least i ncreases muscular fat storage (merely increasing muscle size). This may not seem significant, but the way that people are going nuts over synthol, you never know! The mechanism of action of clens' muscle building effect is not known, but it appears to be anti-catabolic rather than directly anabolic. It should be noted that this anticatabolism is not beta receptor mediated , and therefore does not attenuate. At any rate, the combined effect of the two drugs can be noticeable muscle gain while keeping fat off for the first two weeks. Can fat accumulation be slowed with this stack continue past this time? I'll let you know!



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THE SKINNY ON INSULIN: PART II

There has been increasing popularity, and curiosity, concerning exogenous use of "the most anabolic hormone in the body". This makes it necessary to inform people how to maximize muscle mass acquisition and minimize nasty body fat accumulation when using it. The following is the second article dealing with the effects of exogenous insulin use, combined with several other bodybuilding drugs and supplements, from a muscle anabolism and fat catabolism point of view. Part I outlined insulin use combined with: anabolic steroids, the C/A/E stack, and clenbuterol. *WARNING* Insulin has one of the highest potentials for danger of all bodybuilding drugs. It shouldn't be screwed around with. INSULIN AND GROWTH HORMONE Growth hormone (GH) is one of the most sought after bodybuilding drugs due to its' legendary abilities abil ities to strip off body fat and increase muscle mass. The former is accomplished through direct lipolysis (fat release from adipocytes), which GH does to an incredible degree. Muscle mass acquisition is accomplished through: the direct stimulation of protein synthesis, increasing amino acid uptake by muscle cells, and by greatly stimulating IGF-1 synthesis in the liver. It is this l ast point that is of interest to us because it is the main anabolic mechanism for GH, and it is also where insulin comes in to play. More than half of GHs' anabolic effect is due to IGF-1 production, but unfortunately this is quite often wasted. This is because IGF-1 has an extremely short half life in the bloodstream, so it usually doesn't reach many target tissues (muscles for our interest) to exert maximum anabolic effect. To rectify this situation, insulin can be used to increase the amount of an IGF-1 binding protein (specifically IGF1BP3) that actually helps IGF-1 to reach the muscles and exert its' extreme anabolism. Insulin also reduces the amount of "bad" IGF1 BP's, (BP's 2 and 4) that would normally interfere with IGF-1 uptake and use by muscle. To say that there is a synergistic effect between insulin and GH doesn't do the combination justice. It makes me shudder to think of the hundreds of thousands of dollars spent on GH, without using it to the maximum anabolic potential. From a fat loss perspective, GH is incredible. It should directly negate the lipogenic effect of insulin, leaving you with one KICK ASS combination. INSULIN AND THYROID HORMONES With the huge increases in fat mass often accompanying insulin use, i t seems like a simple solution to use thyroid hormone. Unfortunately, this doesn't work out very well. The reason is that thyroid hormone (specifically T3 and possibly T4) increases the amount of the "bad" IGF1-BP's mentioned earlier; IGFBP2 and IGFBP4. This may not seem like a big deal if one is not using drugs to stimulate IGF-1 synthesis, but IGF-1 levels are naturally stimulated through acts like stretching, and even natural testosterone/GH testosterone/GH increases. All of these things normally accompany workouts (if you know what you're doing), which is the best time to take insulin. So by having all of the free IGF-1 bound by IGFBP3s' evil siblings, much of the anabolic effect of insulin is lost! Since T3 (triiodothyronine) is the main culprit, does that mean that T4 (tetraiodothyronine) can be used with no detrimental effect? NO, because T4 is mostly effective by converting to T3, which leaves you with the same problem. In fact, T4 could very well do the same thing. So if you want to maximize the anabolic effectiveness of insulin while minimizing bodyfat accumulation, use another fat burner and leave the thyroid alone. INSULIN AND CREATINE These compounds may have an anti-synergistic effect on each other, meaning that the combined effect is less than the sum of the individual effects. This possibility exists due to both components' ability to store water in muscle cells. If only a certain amount of water can be stored in the cells through each mechanism of action, then the anti-synergistic condition would exist. Although this condition is unlikely, it is worth mentioning for future experimentation purposes (lab rats know where to contact me). One definite advantage of this combination is that creatine is best absorbed by the muscles when insulin serum levels are high, insuring maximum effectiveness. BTW-if one is not doing something as fundamental as using creatine, there is no way they should be using insulin (so basically insulin i nsulin use requires creatine use). © 2012 Thatotherguy

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INSULIN AND HCA Getting straight to the point, unless you are a moron and are eating fat during insulin use, or you have crappy insulin sensitivity, HCA is the second most effective fat gain inhibitor next to clenbuterol (which is only more effective due to its' ridiculously long half life). Hydroxy Citric Acid (HCA) is the main ingredient in Citrimax, and is a bargain in terms of its': relative effectiveness (when using insulin), cost (cheap, cheap, cheap), and availability. It works by inhibiting an enzyme called ATP citrate ly(s)ase (ACL), which basically converts ingested carbs to fat (which insulin promptly stores). This is normally NOT a big deal since ACL levels are normally low in most humans. However, insulin drastically increases ACL levels (which should make sense based on what you now know about insulin) accounting for most of the, responsible use, fat gain associated with insulin use. This is the most exciting find since the discovery of insulin as an anabolic! Using insulin and not gaining fat while gaining muscle? What a concept! Although I don't like to go into the details of use directly, I believe it is warranted here. 500-750mgs HCA should be taken with or within half an hour after the insulin shot. The usually recommended 250mgs is ineffective in dealing with the drastic increase in ACL levels. The HCA is taken with the shot because both start to work on about one half hour, so the HCA can begin to be effective at the same time that insulin is trying to increase ACL levels. This regimen (only 3X500mgs HCA) prevented fat gain during a day when I used 3 separate insulin shots! To make things even better there is a mild glycogen storage property associated with HCA use. Since ingested carbs cannot be converted to, or stored as, fat, they are generally stored (due to insulin) as glycogen in muscle giving the user a mild but noticeable pump (similar to the first day of creatine use). To end this portion of the list, I give HCA my highest recommendation as the number 1 supplement to use with insulin! INSULIN AND FLAX SEED OIL Short and sweet. Don't use flax seed oil with insulin, because it is fat and *will* be stored. The fat storage rules totally change when insulin is involved (I even avoid vitamin E capsules because mine are oil based). INSULIN AND CLENBUTEROL UPDATE This may look like an ideal combination at first, but research has shown why my muscle gains with this combo were minimal. Clen reduces insulin sensitivity, which means that insulin will have a much harder time doing its' anabolic job on muscle tissue. In addition to storing amino acids as muscle, insulin also stores carbs in muscle (which gives a very "full" look to the muscles), which reduced insulin sensitivity also hinders. This is also combined with the fact that clen reduces Glut-4 transporters (which allow glucose passage, and subsequent storage, into muscle) in skeletal muscle which probably accounts for clens' ability to reduce muscle glycogen concentration. On a lighter note, the fat burning effects of clen are potentiated by aspirin and caffeine (through personal experience) but still die off after a few weeks. Overall the only time I would recommend this combination occurs when coming off a cycle and every bit of anabolism is needed, otherwise the two drugs have a bad effect (from an anabolic standpoint) on each other. SIMPLE TIPS TO MAXIMIZE ANABOLISM AND MINIMIZE FAT GAIN WITH INSULIN USE -USE HCA - use testosterone enhancing compounds to increase hepatic IGF-1 production - only use insulin first thing in the morning or during/after workouts - don't consume *any* fat 2 hours before (due to digestion time) or one hour after (due to induced enzyme activity) insulin use - stretch to locally increase IGF-1 levels - continually eat protein spread over the 4-5 hour duration of insulin activity Finally, my favourite tip from Docroid: (I) use one shot of insulin just before a one hour workout and another shot two hours after the first. This creates synergism between the activity of the two shots by the later shot increasing in activity at the same time as the first shot decreases in activity, giving one a steady high insulin level at the most important time for anabolism! The only time I can say that I have © 2012 Thatotherguy


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seen dramatic results from insulin use (in terms of muscle anabolism) occurs when I do this "technique". HOWEVER, this is *very* tricky, in terms of serum glucose levels, even for seasoned insulin users. After using for a while, one can get used to the "feel" of i nsulin, blood sugar crashes, feeding times etc. but things change when one has a high level of insulin for 3-4 hours straight. I've had to eat every hour for three hours during one of my first attempts at this technique, but every two hours some other attempts. This is the only time I don't feel secure with my own insulin use. It's actually a good thing I can now recognize what a blood sugar crash feels like or I'd probably be dead due to this technique. I don't recommend this technique to anyone (and if that's not a big deal to you, just remember who is writing this) but if you feel like using it, make sure sure that you have have had a couple of, (horrible) insulin induced, serum glucose crashes so you can recognize the early warning signs for when you have them (and you *will* have them).

THE SKINNY ON INSULIN: PART III *WARNING*: Insulin is not a drug to be taken lightly. It's use can harm or even kill an ignorant user. If you plan on using, educate yourself and at least read the last part of this article. INSULIN AND ANDROSTENDIONE This combo has potential due to the interesting ability of insulin to increase levels of 17B hydroxysteroid dehydrogenase(17B), dehydrogenase(17B), which is the enzyme that converts andro. into testosterone. If the increase is anything near the 17B levels that women have, this could become the stack for "natural" Ïbodybuilders. Another possible benefit of this stack is the idea that insulin probably exhibits mild antiaromatase properties. If this occurs to any significant level it could be great in increasing the 17B levels even more! Although I hate to rain on this theory parade, I have to say that I can't notice ANY anti-aromatase activity from insulin(see first update section). Other possible benefits of this stack are shown in the first part of this series under: "INSULIN AND ANABOLIC STEROIDS". Of course any potential similarities with AS would be drastically minimized with andro. It should be noted that the term "natural" is used quite loosely. INSULIN AND CAPTOPRIL Captopril is an angiotensin converting enzyme(ACE)inhibitor. Its' medical function is to reduce blood pressure. The reason it is included here is because it can have great effects with insulin and AS. I wouldn't reccomend captopril to anyone unless you are hypertensive or are using AS, because it can drop blood pressure to a sub-normal level. A reason captopril is so great is because it increases endogenous growth hormone levels, which you know can be amazing, assuming you've read last month's article. Another benefit to captopril is i ts' decrease in protein urea(protein loss in urine). No other drug I'm aware of, including AS, GH, or insulin, does this. This means that there will be more protein for those other anabolic drugs to assimilate! Another great use of captopril is the fat loss effect it has. For me it removes the necessity of HCA while using insulin (with AS). Although I still use one 250mgs of HCA/day just for good measure, I could probably get away witho!ut it despite the extreme carb intake after a workout. On a more esoteric note, long term captopril use actually prevents the formation of new Alpha2 adregenic receptors, which would further potentiate fat loss. Also, water retention is minimized through captopril use, which ties into the blood pressure effects. A potential risk while using captopril with insulin is that both drugs do a good job of making one tired/sleepy. Add in a late night, high intensity workout and you'rer ready for bedtime. One can NOT fall asleep while using insulin or you would experience all of the dangerous side effects associated with its' use. A final warning about captopril is that it increases the retention of potassium which makes hyperkalemia (too much potassium)a possibility. Unexcessive intake of this electrolyte should allow for avoidance of any problems in most people. This stack really doesn't have any problems associated with it, as long as © 2012 Thatotherguy

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common sense is used. It is merely a matter !of responsibility to point out every potential problem, sim! ply so it can be avoided. It should be noted that beta agonists and even working out increase proteinurea. INSULIN AND ANABOLIC STEROIDS UPDATE I hyped up insulin and AS in the first article in this series and I don't take any of it back. Simply put: this combo rocks! Using these compounds I put on 10lbs in 4days! It wasn't fat or subcutaneous water so it had to be muscle! Okay, it was just intracellular water, but the results are still dramatic to say the least. Three 14IU shots a day keeps my body in a ridiculously powerful state of anabolism. I recommend that 100grams of easily digestible protein be consumed during the 4 hour duration of the drug (while juicing). At this time time it can be assumed that every every gram will be assimilated. My HCA use is down to every third shot of insulin, and that may be slightly unnecessary. Please note that I am also using captopril which exhibits fat loss characteristics. I have no other big tips to offer, except (I'd) use insulin as much as possible while on a heavy cycle. Since I'm getting gyno while using anti-estrogens, I have to say that the anti-aromatase ability of insuli!n is next to non-existent. I'd like to note that another AS/ insulin user was also using GH and still gaining fat, although I don't know what his eating was like. INSULIN AND BETA-AGONIST UPDATE I now realize that the use of beta-andregenic agonists is useless while on insulin. They decrease insulin sensitivity and increase cortisol levels. Their fat loss abilities are overshadowed by the negative effects on insulin and anabolism. HCA should prevent any responsible use fat gain, making use of these compounds all the more futile. The only time I'd recommend clen and insulin is when coming off a cycle(I obviously don't buy the "clen is not anabolic" theory). QUICK INSULIN USE TIP Although nocturnal feedings feedings are effective effective in keeping positive positive nitrogen balance, and decreasing the the diurnal (daily) morning cortisol rush, they should not be used while using insulin during the day. These nocturnal feedings may prevent insulin sensitivity from improving as much as normal, which would lead to less anabolism and greater fat gain. The use of AS or doing insulin shots only after workouts negate this suggestion. STATEMENT ABOUT PERMANENT INSULIN DEPENDENCE This potential side effect has been WAY too hyped by the anti-insulin propogandists. The idea of your own pancreas shutting down insulin production due to exogenous use is silly, and requires massive irresponsible use over extended time periods. Using myself as an example, I've been using insulin for 7 months straight. "WHAT?! Why did my pancreas not explode long ago?" You ask. For a simple reason: responsible use. I think that peoples fear of becoming dependant on insulin stems from minor knowledge about the testosterone feedback loop and AS cycles. Another part of this moronic recipe is peoples'ignorance about their own body and that brilliant bullshit anti-insulin propaganda. Quick lesson. Your body(beta cells of the pancreas)produces insulin in response to increased serum glucose levels, specific amino acids etc. As long as you don't shut this mechanism down from exogenous insulin use for long periods of time there should be no pr!oblems(unless you're fucked to begin with). This means that you'd have to use insulin for 12 hours a day(3 perfectly spaced out shots)for over three months while insuring that you are not stimulating endogenous insulin production. Only a moron could do this which makes me wonder why it doesn't happen all the time). Another problem could arise if one uses an insulin shot every day at the same time for months on end. For example if one did a shot upon arising for many months, prior to eating. After a while the body would become conditioned (due to external/internal cues) to not produce insulin at that time. [note:I used morning insulin shots for 4 months without adverse effects] This situation could be easily remedied by tapering down the dosage of insulin over a period of weeks (although I hesitate to make the connection with AS). The bottom line is that using insulin before/after workouts for any length of time will not shut down the beta cells for long enough to cause this !problem. Remember that the beta cells are normally shut do!wn for at least 8 hours a day, while sleeping, and this happens for 80 years without adverse effect. © 2012 Thatotherguy


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INSULIN USE: IS IT WORTH IT? Although I despise the anti-insulin propaganda, propaganda, which I have contributed to in the past, it does have some merit. Personally I wouldn't care about people dying from insulin use, if only i t didn't expose this drug in a negative li ght. I simply see insulin screwups as somebody sticking shit into their bodies that they know nothing about(meaning: it is on 8 thier 8 head).But in my position I have to wonder why the person tried the stuff in the first place. Lately I've been quite curious about peoples'insulin use because, to be honest, the shit just isn't that great! Don't get me wrong I'd never recommend another AS cycle without it, and you'd have to be a moron to spend $8000. on GH without learning learning the finer points of insulin use...but there's no reason for people to be using this stuff on a "try it and see" basis. Personally I wouldn't let some guy in an article stop me from trying this normally safe (with responsible use) drug, and I would never try to dis!suade anyone who "has to know" that it is like. But seriously, there's no other reason, for anyone not trying to maximize muscle mass, to use this drug. I don't like it but it's the truth, so I have to report it. For me(the genetic loser of the century), insulin doesn't do much without AS. I will always use it i t as a training aid, but that's only because I've already gone through the bullshit of planning out my body's reaction to the stuff. I also like the fact that I've come to know my body better than I could have without insulin, but that's only because I've had (too) many sugar crashes to help me feel my serum glucose status. To end this depressing section I have to restate that this is not intended as some "life-saving", anti-insulin propaganda. I'm just stating that insulin doesn't do that much (notable exceptions already mentioned) and certainly doesn't deserve all the hype (good or bad). [I think I'm going to cry now.] Description: This description was taken directly from Brian Raupp's Anabolix Research page since this drug is so dangerous and his description is by far the most comprehensive that I have found on the internet. Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-timed injections, insulin will help to bring glycogen and other nutrients to the muscles. In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company. It costs about $20 for a 10 ml vial with a strength of 100 IU per ml. Eli Lilly and Company also produces 5 other insulin formulations, but none of these should be used by bodybuilders. Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer time period and can put the user in an unexpected state of hypoglycemia. Hypoglycemia occurs when blood glucose levels are too l ow. It is a commonand potentially fatal reaction experienced by insulin users. Before an athlete begins taking insulin, it is critical that he understands the warning signs and symptoms of hypoglycemia. The following is a list of symptoms which may indicate a mild to moderate hypoglycemia: hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling in the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personality changes. If any of these warning signs should occur, an athlete should immediately consume a food or drink containing sugar such as a candy bar or carbohydrate drink. This will treat a mild to moderate hypoglycemia and prevent a severe state of hypoglycemia. Severe hypoglycemia is a serious condition that may require medical attention. Symptoms include disorientation, seizure, unconsciousness, and death. Insulin is used in a wide variety of ways. Most athletes choose to use it immediately after a workout. Dosages used are usually 1 IU per 10-20 pounds of lean bodyweight. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout. This will allow the athlete to safely determine a dosage. Insulin dosages can vary significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone and thyroid will have higher insulin requirements, and © 2012 Thatotherguy

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therefore, will be able to handle higher dosages. Humilin R should be injected subcutaneously only with a U-100 insulin syringe. Insulin syringes are available without a prescription in many states. If the athlete can not purchase the syringes at a pharmacy, he can mail order them or buy them on the black market. Using a syringe other than a U100 is dangerous since it will be difficult to measure out the correct dosage. Subcutaneous insulin injections are usually given by pinching a fold of skin i n the abdomen area. To speed up the effect of the insulin, many athletes will inject their dose into the thigh or triceps Most athletes will bring their insulin with them to the gym. Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected. Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely li kely go into a state of hypoglycemia. Many athletes will get sleepy after injecting insulin. This may be a symptom of hypoglycemia, and an athlete should probably consume more carbohydrates. Avoid the temptation to go to bed since the insulin may take its peak effect during sleep and significantly drop glucose l evels. Being unaware of the warning signs during his slumber, the athlete is at a high risk of going into a state of severe hypoglycemia without anyone realizing it. Humulin R usually remains active for only 4 hours with a peak at about two hours after injecting. An athlete would be wise to stay up for the 4 hours after injecting. Rather than waiting to the end of a workout, many athletes prefer to inject their insulin dosage 30 minutes before their training session is over and then consume a carbohydrate drink immediately following the workout. This will make the insulin more efficient at bringing glycogen to the muscles, but it will also increase the danger of hypoglycemia. Some athletes will even inj ect a few IUs before lifting to improve their pump. This practice is extremely risky and best left to athletes with experience using insulin. Finally, some athletes like to inject insulin upon waking in the morning. After the injection, they will consume a carbohydrate drink and then have breakfast within the next hour. Some athletes find this application of insulin very beneficial for putting on mass, while others will tend to put on excess fat using insulin in this way. Insulin use can not be detected during a drug test. For this reason, along with the fact that it is cheap and readily available, insulin has become a popular drug among the competitive athlete. However, before an athlete attempts to use insulin, he should educate himself and make himself aware of the consequences. One mistake in dosage or diet can be potentially fatal. Effective Dose: 1 IU per 10 - 20 lbs. of body weight Street Price: Can be bought over-the-counter for around $15 - 20 / 10 cc. bottle Humulin-R The Physiological Role of Insulin in the Body: Insulin is a hormone which is manufactured in the pancreas and which has a number of important physiological actions in the body. It is an essential hormone in maintaining the body's blood glucose level so that the brain, muscles, heart and other tissues are adequately supplied with the fuel they require for normal cellular metabolism and normal function. Insulin also plays an essential role in fat and protein metabolism. For example, it promotes transport of amino acids from the bloodstream into muscle and other cells. Within these cells, insulin increases the rate of incorporation of amino acids into protein (amino acids are the building blocks of protein) and reduces protein break down in the body ("catabolism"). These physiological actions probably form the basis of speculation regarding the additional anabolic gains which might be made through the use of exogenously administered insulin.



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Normally, blood glucose and blood insulin levels are not both elevated for any extended period of time as these two chemicals influence each other through a feedback system in the body. In the postabsorptive state, the blood insulin concentration tends to decrease during exercise, allowing the blood glucose to be maintained at or above resting levels and to provide i ncreased energy supplies (fuel) to muscle cells. Following a meal, the blood glucose and amino acid levels rise (the absorptive state) and this triggers an increase in insulin release from the pancreas, driving glucose and amino acids from the blood into cells and maintaining the blood glucose level within a certain physiological (operating) range. Intending users should also be aware that insulin stimulates lipid (fat) synthesis from carbohydrate ("lipogenesis"), decreases fatty acid release from tissues ("lipolysis") and leads to a net increase in total body lipid stores. The development of such increased body fat stores runs counter to the training goals of most body builders, athletes and those seeking to improve their physical appearance. In striving to become bigger, stronger, more competitive or more physically attractive you should also remember that no matter what you do, your genetic make-up will have an influence on what you are able to achieve. It is i mportant to realize that you cannot look exactly like the role model you admire because you have inherited a different set of genes. The Glycemic Index Factor: Scientists have discovered that carbohydrate containing foods can be measured and ranked on the basis of the rate and level of blood glucose increase they cause when eaten. This measurement is called the "Glycemic Index" or "G.I. factor". The rate at which glucose enters the bloodstream affects the insulin response to that food and ultimately affects the rate at which this glucose (fuel) is made available to exercising muscles. (2) Low G.I. foods are those measuring less than 50 on a scale of 1-100. Moderate G.I. foods are those with a reading of 50-70 and high G.I. foods are those measuring 71 or greater on this scale. Pure glucose has a G.I. of 100. Foods which have a high G.I. produce a rapid increase in blood glucose and blood insulin levels. Examples of such high G.I. foods are potatoes, ice cream, many cereals particularly those with a high sugar content, some varieties of rice (e.g. Calrose) and sweets. Foods with an moderate G.I. include some brands of muesli, some varieties of rice, white or brown bread, honey and some cereals. Foods with a low G.I. produce a slower, smaller but more sustained increase in blood glucose levels. Examples of such low G.I. foods are pasta, varieties of high amylose rice, barley, instant noodles, oats, heavy grain breads, lentils, and many fruits such as apples and dried apricots. Low G.I foods are advantageous if consumed at least two hours before an event. This gives time for this food to be emptied from the stomach into the small intestine. Since these foods are digested di gested and absorbed slowly from the gastro-intestinal tract, they continue to provide glucose to muscle cells for a longer period of time than moderate or high G.I. foods, particularly towards the end of an event when muscle glycogen stores may be running low. In this way, low G.I. foods can increase a person's exercise endurance and prolong the time before exhaustion sets in.(2) High G.I. foods, preferably in the form of liquid foods or glucose drinks of approximately 6% in concentration, can enhance endurance during a very strenuous event lasting more than 90 minutes. ("strenuous" being defined as an athlete exercising at more than 65% of their maximum capacity). Some athletes may prefer food rather than liquid replenishment. Miller(2) suggests glucose enriched honey sandwiches, which have a G.I. factor of 75 or jelly beans, which have a G.I. factor of 80. Miller suggests that an athlete who is engaged in a prolonged strenuous event should consume between 30 and 60 grams of carbohydrate per hour during the event. High G.I. foods are also desirable after completing an exhausting sporting or training event when muscle and liver glycogen stores have been depleted, as they provide a rapidly absorbed source of glucose and stimulate insulin release from the pancreas. This insulin in turn stimulates the absorption of glucose into liver and muscle cells and its storage as hepatic and muscle glycogen, optimizing recovery and preparation for the next training or competitive event.


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It has been shown that greatest benefit can be had if an athlete consumes these high G.I. carbohydrate foods as soon as possible after an event, preferably within an hour or less. It is further recommended that a high carbohydrate intake be maintained during the next 24 hours. Miller suggests eating at least one gram of carbohydrate per kilogram body weight each 2 hours after prolonged heavy exercise and at least 10 grams of high G.I. carbohydrate per kilogram body weight over the 24 hour period following this exercise. For these reasons, an athlete who needs to maintain a high level of activity and performance on consecutive days or more extended periods of time should eat large amounts of high G.I. foods. However, a reasonable quantity of low G.I. carbohydrate food should be consumed before an event in order to improve endurance. A Natural Method Method of Maintaining Maintaining an Elevated Blood Insulin Level: Noting the hypothesis hypothesis that an elevated blood insulin level may be of some advantage to bodybuilders, Fahey and his colleagues (1993) undertook an experiment in which they fed athletes a liquid meal of "Metabolol", which consisted of 13.0 g protein, 31.9 g carbohydrate and 2.6 g fat per 100 ml and provided 825 kJ of energy. These researchers demonstrated that it is possible with such intermittent feeding during intense weight training to maintain a person's blood glucose at or above resting levels and at the same time, significantly increase insulin levels for the duration of the workout. This suggests a potentially effective and safe non-drug method for achieving a sustained elevation of blood insulin levels. l evels. The authors of this research commented that "theoretically, this could provide a biochemical environment conducive to accelerating the rate of muscle hypertrophy and inhibiting protein degradation." However, the writer knows of no scientific studies which support this theory. It is also relevant to note that muscle repair and growth begins in the hours and days following heavy exercise. It is doubtful that the use of insulin just prior to a workout will have any anabolic effects over and above natural processes, at this time. However, use of insulin prior to a workout will certainly expose you to much greater risk of serious harm. If you believe it is beneficial to have a higher insulin blood level during workouts, use the natural method outlined here. Level of Risk Associated with Insulin Use: The use of all drugs carries some risk along with potential or perceived benefits, whether used for legitimate medical reasons or for other purposes. Insulin carries some risk even when used by an insulin dependent diabetic, as demonstrated by the observation that some diabetics run into difficulties with their treatment from time to time and often require assistance to restabilize their medical condition and insulin requirements. If used by a healthy non diabetic person in whom there is no natural deficiency i n insulin production or reduced insulin sensitivity and in the absence of medical advice and monitoring, the risks may be substantially increased. The major risk associated with insulin is a physical state known as hypoglycemia or "low blood sugar". This occurs when the level of glucose in the blood falls below a certain level required for normal body function. If the blood glucose level is substantially reduced below this normal level and if this is not quickly corrected, there is a risk of disorientation, collapse, coma, permanent brain damage and even death. Exercise and reduced food intake decreases the body's need for insulin and increases the risk of hypoglycemia associated with non-medical use of insulin. It is difficult to provide a quantitative estimate of risk for any drug but on a scale of risk i n relation to other non-medical and unsanctioned drug use, the use of insulin in this manner would rank towards the higher end of the scale. If zero equals "no risk" of harm to a person's health and ten equals "extreme risk", the use of anabolic steroids in a non-medical context might rate towards the middle of the scale of risk (particularly in the medium to long term) whilst insulin would rate higher. This level of risk associated with insulin use will depend on a number of factors: © 2012 Thatotherguy


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Whether the person is a diabetic or not: non-diabetics and lean healthy people are more sensitive to the blood glucose lowering effects of insulin than diabetics; Type of insulin: short acting insulin preparations are considerably safer than long acting preparations because with short acting types, it is much easier to avoid hypoglycemia with adequate food intake. With the non-medical use of longer acting insulin preparations, a person is at real risk of experiencing hypoglycemia late in the day, particularly in between meals, during or after exercise and when asleep. Regardless of this advice, some people are in reality using a mixture of short and long acting insulin preparations and exposing themselves to unnecessary increased risk. Food intake: the type and timing of food consumed, its glycemic i ndex (the glucose elevating effect) and the amount consumed, Body weight, Timing of insulin administration in relation to food intake and exercise. Individual variation: two different people can respond in a very different way to a given dose of insulin, even if they are of a similar height, weight and other personal characteristics. The fact that a certain dose does not seem to cause a problem for one person does not mean this will be so for another. In addition, the response to insulin will also vary greatly within any one i ndividual over time, according to changes in one or more of the above noted factors. 5-10 Units of a short acting preparation may have little or no observable impact on someone who eats a meal soon before or after but this dose could cause hypoglycemia and collapse in a person who has not consumed adequate food in close proximity to the time when the insulin begins to take effect (insulin starts to take effect within 5-10 minutes if injected by intra-muscular route and in 30-60 minutes if injected by subcutaneous route). Foods with a high glycemic index will maintain the blood glucose level for a short period of time, perhaps an hour or so whilst those with a low glycemic index will provide for more sustained glucose levels. Risk Reduction Advice: Given the risks of using insulin for non medical purposes, the best advice one can give is not use i t in this way. Even the body building magazines such as "Muscle Media 2000" advise: "If you're thinking about using insulin, think twice - it's really risky!"(3) However, if you are not persuaded by this advice and are determined to pursue its use in the hope of achieving some additional anabolic or other gains, you should take the following precautions: Consider using the natural method of raising your blood insulin level during workouts by consuming glucose containing fluids at intervals during exercise. These fluids may have a protein sparing effect and at the same time, will help maintain keep your blood glucose and blood insulin levels. However, if you decide to use insulin, you should consider the following advice: Always use insulin in the presence of someone someone else who knows about about and understands the exact risks of using insulin in this manner, so they are able to act quickly and appropriately should something go wrong; Always use a sterile needle and syringe every time and a clean injecting technique technique (e.g. don't touch the needle or the skin where you are going to inject, with your fingers and don't breathe on or cough over the injection site before or after injecting.) Be aware that 1.0 ml of insulin contains one hundred International Units (100 IU), 0.1 ml of insulin contains ten (10) IU and 0.01 ml contains one (1.0) IU. So take care in measuring out your insulin, It is very concentrated! Note that 0.01 ml is the volume contained in the space between the smallest graduated markings on a 1.0 ml Terumo diabetic syringe; Inject by the subcutaneous route (injecting just under the skin and preferably in the abdominal area or outer part of the upper thigh), not intramuscularly or intravenously as using the latter routes can lead to a rapid rise in blood insulin level and a sudden hypoglycemic episode; © 2012 Thatotherguy

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Alternate your injection sites in order to minimize tissue damage ("lipoatrophy" ("lipoatrophy" or "lipohypertrophy"; "lipohypertrophy"; Always use a short short acting, "regular" insulin (e.g. Actrapid, Insulin Neutral, Humulin R, Hypurin Neutral) Neutral) rather than a longer acting insulin preparation (e.g. Semilente, Lente or Ultralente); Use a human insulin rather than an animal insulin preparation if possible (there is little animal insulin available now); Start with no more than 5 IU (0.05 ml) of this short acting/ regular insulin preparation and increase the dose gradually over a period of one week, to a dose no higher than 20 IU (0.20 ml) per day. Doses above this will expose you to progressively greater risk and most body builders who use insulin believe there is no advantage in taking doses higher than this. Anecdotal evidence amongst bodybuilders suggests increased doses leads to excess bodyfat accumulation. The writer would caution against users falling into the trap of thinking: "If 20 units is good, 40 units will be twice as good" or "Joe says he injected 20 units and it didn't affect him, so it will be safe for me to inject 30 or 40 units". All drugs have a therapeutic dose range and above this, may be toxic or even lethal. If you are not diabetic, your body does not require additional i nsulin and there is no therapeutic range for you. In addition, people are different and often respond differently to drugs. An individual may also respond differently to the same drug in the same dose at different times, depending on a wide range of factors such as their general health, alcohol or other drugs taken, food eaten, exercise undertaken before, during or after drug administration and so on. Don't use a medium or long acting insulin in the middle or latter part of the day, as you may very well experience a hypoglycemic attack whilst you are asleep. If this happens, neither you nor anyone else will be aware of or able to respond to your urgent need for glucose, in order to prevent possible serious harm. Dietary Guidelines: Close attention to diet is extremely important in people using insulin, whether this is for legitimate medical purposes or for other reasons. You can reduce your risk by consuming an adequate amount and mixture of high and low G.I. carbohydrate foods and drinks immediately after using i nsulin and at regular intervals (every 2-3 hours) throughout the day. High G.I. carbohydrates (e.g. sweets, soft drinks and ice-cream) will raise your blood sugar quickly and prevent early hypoglycemia. Low G.I. carbohydrates (e.g. white pasta, high amylose rice, softened whole grain breads and instant noodles) are metabolized more slowly and will keep your blood glucose level up over a more extended period of time, when the medium acting insulin preparations begin to take effect; 55-65% of your total daily energy intake should be in the form of carbohydrates, 15-20% as protein and ~20% as fat. You should seek advice from a dietitian about your daily requirements but most heavy training athletes need to consume between 3,000 and 5,500 Calories per day (depending on the sport and level of training) and between 450 and 800 grams of carbohydrate each day. If you are a body builder who weighs 100 kg and your total energy requirements are calculated to be 4,000 calories/ day, you should aim to eat approximately 570 grams of carbohydrate each day. If your total energy requirements are calculated to be 5,000 calories/ day, you should aim to eat approximately 720 grams of carbohydrate each day. Divide up your calculated total daily carbohydrate requirements over the course of your waking hours and consume frequent carbohydrate meals throughout the day. For example, if you require 4,000 calories per day, you might eat six meals of 650-700 Calories at 2-3 hour intervals. This would mean eating approximately 90-100 grams of carbohydrate each meal, which for example you will obtain from 7 slices of bread alone or 4-5 slices of bread with 1 ½ tablespoons of honey or 500 © 2012 Thatotherguy


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ml of Sustagen or 3 slices of bread eaten with a 450 gram can of baked beans. You can refer to the attached food tables to work out your own requirements according to your own food preferences. You will need to choose a mixture foods from this table with a high, medium or low G.I., according to the nature and level of the training you are doing. Once again, the writer would strongly recommend that you consult a dietitian who has an interest and experience in sports nutrition, in order to assist you design a dietary program which is best suited to your training goals and needs and to your food preferences. It is equally important that you find a dietitian with whom you feel comfortable telling about your insulin or other performance enhancing substance use, as their advice may otherwise be less than useful to you. If your dietitian does not know about and does not take such substance use into account, their advice may even add to the dangers associated with this substance use. Always have a source source of glucose or other high G.I. food ready at hand, in case you should should begin to experience the symptoms of hypoglycemia. If this does occur, you should take this glucose or food without delay. You should eat or drink 15-20 grams of carbohydrate to begin with, which is contained in ~ 2 slices of white or brown bread, two glasses of milk, a half glass of soft drink, a tablespoon of honey or six jelly beans. Other examples of glucose or other high Glycemic index carbohydrate preparations which you can use include: glucose tablets, glucose powder mixed in a small volume of water, barley sugar, or other sweets or if these are not immediately available, a sugar containing cordial, soft drink or plain sugar dissolved in water. This should be followed by an adequate low Glycemic index carbohydrate meal to prevent further hypoglycemia since the insulin levels are likely to remain high for some hours after the high Glycemic index carbohydrates are used up (metabolized) in the body. The Crucial Role of the Friend or Peer Observer: If you are going to use insulin, it is essential that you have a friend or peer observer remain with you in case you experience problems. This person really needs to be with you for the whole time while the insulin preparation used is working. Be aware that the risk of hypoglycemia occurs not at the time of insulin injection but rather, when the insulin starts to take effect. The risk will be greatest when your insulin blood level nears or reaches its highest level, usually 30-60 minutes afterwards if a short acting insulin preparation is used (by subcutaneous injection) and up to 20 hours later if a long acting insulin is used. Consider giving this paper to the person who is going to be with you when you use insulin, so they are aware of the things to look out for and what to do if you should experience a hypoglycemic reaction. The following instructions are for a peer observer or other person who may find you experiencing difficulty as a result of overdosing on insulin or any other drug or combination of drugs: Instructions for the Peer Observer Assisting an Insulin User: If the person who has used insulin states that they are beginning to feel any of the following symptoms: faintness, dizziness, thirst, hunger, nausea, weakness, sweating, or if you observe that they have become: confused, disorientated, sweaty, drowsy, you should immediately give them glucose or a sugar containing drink or food as mentioned above. However, you should not try to give a person food or fluids if they are so drowsy that they are unable to swallow it, since they will be at risk of accidentally breathing in (aspirating) this food or fluid. If they cannot readily respond to your questions or your commands, you should assume they are unable to swallow anything safely. If the person loses consciousness, you should place them in either a "lateral" or "coma" position, tilting the head fully back and jaw forward, in order to ensure an open airway and protect them from possible aspiration. Keep them in this position while medical assistance is being sought. You should then immediately call an ambulance by dialing "911", to get them to a hospital without any delay whatsoever. When the ambulance arrives, you should tell the ambulance officers exactly what the person has taken and what you have observed so the correct treatment can be provided promptly. This is essential as the person's life may be at stake. © 2012 Thatotherguy

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Severe hypoglycemia or a combination of alcohol and other drugs, particularly drugs which suppress the central nervous system, can cause a person to stop breathing and their heart to stop beating. Remember, it only takes a few minutes for someone to suffer permanent brain damage or to die, once they stop breathing. There are several common signs which may be apparent in someone who has overdosed from one or a combination of drugs. These include: very slow or shallow breathing or no breathing at all (listen close to the person's mouth and nose for breath sounds and l ook for movement of their chest wall); snoring or gurgling breathing in someone who is asleep; blue lips and fingernails (caused by lack of oxygen); no response to shaking, calling their name or pain (try pinching their earlobe and pressing down hard on one of their fingernails with a pen); very slow, faint pulse or no pulse at all. What To Do in the Event of an Overdose: stay calm; squeeze earlobe/ press on fingernail of person in an effort to arouse them; if person responds, try to walk them around; if no response, check person's breathing and pulse; if unconscious but breathing, place in lateral or coma position; call an ambulance by dialing 911, they will give you advice on what to do, which might include: if there is a pulse but the person is not breathing, start artificial respiration, otherwise known as Expired Airways Resuscitation (EAR), without delay; if no pulse, start cardio-pulmonary resuscitation (CPR); stay with the person, continuing to administer artificial respiration or CPR until the ambulance arrives. Keep them i n the lateral or coma position if they are breathing on their own; tell the ambulance officers exactly what they may have taken and what you have observed. The writer would like to emphasize once more that this paper should in no way be construed as an encouragement to people to use insulin in an effort to increase muscle mass, sports performance or appearance. Rather, it represents a pragmatic attempt at providing harm reduction advice to people who choose to take the risk of using insulin in this way, despite their knowledge of those risks.

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How How To Use Use Insu Insuli lin n Wit Witho hout ut Gai Gaini ning ng Fat Fat Since Insulin is such a new subject for most of you the way I am going to do this post is going to be a little different. I am going to write a few sections on it then give links to a lot of different articles on the subject. I do not want to post a 10 page post that will just confuse you. My suggestion is to read this post and all the l inks then print out this post as instructions for your cycle. If you still have questions on this topic after reading it, let me know. Insulin Rating: 1-5 (Five being the highest) 4 Bulking 4 Cutting 2 Strength n/a Testosterone Stimulation n/a Use as an Anti-Estrogen 5 Side Effects 5 Ability to Keep Gains Basic effects: Increased workout Pumps Increase in appetite Increase the transport of nutrients into the muscle cells. Side Effects: Fat Gain Hypoglycemia Death Stacking: © 2012 Thatotherguy


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Creatine Any roid HGH My first experience with Insulin: About 2 years ago I tried insulin for the first time. I started using it 2weeks before my cycle to get use to it and figure out the best dosage for me. I worked up to using it at 10 units in the morning, 10 before I lift and 10 units after. I had a bout with Hypoglycemia only once but I felt pretty shitty for a few days after. Anyway I stacked it with 40grams/day Creatine 750mg/week Sust 300mg/week EQ The cycle lasted 10 weeks and I put on 40lbs, keeping 30 of i t. This is what you can expect from you first bout with slin. Section 1 - The right insulin to use and why: There are various types of insulin available but as bodybuilders we are only interested in the short acting types. The only two types that should be used are Humalog and the R (Regular) Types. The difference between the two is the time it takes them to peak and the time to leave your system. In my opinion Humalog is the better choice for new users. There are a few reasons for this. 1. Humalog starts to work within 15 minutes after taking it 2. Humalog more closely matches the action curves of the insulin produced in your body then the R type. 3. Humalog does not last as long as the R type All of these effects effects make Humalog easier easier to control then then the R type. The The only problem with Humalog Humalog is some states that sell R type OTC require a script for Humalog…. So ask about Humalog when you call. If you cant get Humalog then use the R type but remember that there are differences…. See below: Humalog Regular Onset of action within 15 minutes 30 minutes Peak effect 30-90 minutes 2-4 hours Duration less than 5 hours 6-8 hours Section 2 - How to obtain Insulin: Insulin is over the counter in many states. The best was to obtain it is directly from a pharmacy. This way you know that it has been kept cold and did not lose potency. If you do not know if Insulin is OTC in your state then try this: 1. Call a pharmacy and tell them that you are from Florida and you are going to be coming to their area for a business trip for about 1 month. Tell them that you are a diabetic and you need to know if Insulin is sold with out a script their. Explain that since you live in FL you do not have a script since it is OTC. Also ask if insulin syringes syringes are also sold OTC OTC since some time one is but not the the other. Also try try this in any bordering state that is in driving distance. The next way to get insulin is from an online pharmacy. You can usually order it and pins with out a problem. Hear is a list of sites that sell insulin and insulin syringes: Syringe site: Removed Section 3 How to use Insulin for Beginners. (Everything I will talk about will be using the R type since it is more available. If you can get Humalog email me if you have any questions on how to change your usage) Now that you have your insulin let say you bought Humulin R. You need to make sure you have the right syringes. Insulin syringes are marked for units not CCs. 1 CC OF INSULIN WILL KILL YOU. So make sure you have the right type of syringes. You can order them from the sites above. Every CC of insulin has 100 units in it. When you Inject you can either Inject SubQ or Intra-muscular. IntraIntramuscular injections take effect about twice as quick. Some basic rules: © 2012 Thatotherguy

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1. Eat as much protein as you can plus 10grams of carbs per unit of insulin immediately after shooting the insulin. 5 units = 50 carbs 2. Keep some kind of simple carb on you at all times just i ncase you become hypoglycemic. A chocolate bar works well 3. Eat more protein and carbs about 2 hours after using the insulin. Around 5 grams of carbs per unit used of insulin. 4. Continually snack through out the rest of the day. 5. Try not to eat any fat for at least 4 hours after taking the insulin. 6. Try not to use i nsulin too late at night. You want most of it out of your system before you go to sleep 7 ***** Important ***** Be aware of the signs of Hypoglycemia: ? Shaking ? Vomiting ? headaches ? concentration problems ? visual disturbances ? muscle pain ? Weakness ? mood swings ? passing out ? Death 8. If you notice any of these signs immediately eat as many simple carbs as you can 9. Do not use any stimulants until you are use to how insulin effects you or you may mistake the signs of hypoglycemia for the effects of the stimulants. When to take insulin: As a beginner you should start by just taking it after after working out. Start with 4 units and work up from there. Once you reach 10 units after working out try throwing in another 10 units when you wake up in the morning. I see no need to go much over 10 units at a time. I worked my way up to 20 units and all that did was make me hypoglycemic. Hear is what your day should look l ook like once you reach this point: 6am wake up 6:30 am Inject 10 units of Humulin R 6:31 am Eat a 12 egg white omelet and 3 waffles with enough syrup to = 100 carbs 8:30 am Drink a protein shake with at least 50 carbs i n it 10:30 am an apple and a protein bar 12:30 pm Big lunch 2:30 pm Drink a protein shake (no carbs needed) 4:30 pm Snack 5:00pm workout 6:00 pm Inject 10 units of Humulin R (Assuming this i s the end of your workout) 6:01pm Tuna salad with pasta and fat free mayo. (At least 100 carbs) 8:00 Drink a protein shake with at least 50 carbs in it 10:00 snack with some carbs Before bed You should eat a good amount of carbs (50 or so) just to be safe Insulin for Dieting: Insulin can be used to get you into ketosis in 1 day. This really helps when doing any low carb diet. You will probably have to play around with the dosage to see what you need to get into ketosis. This is what I do: Eliminate carbs from your diet Day 1 of the diet take 4 shots of insulin spaced 3 hours apart. 8am 2units of Humulin R 11am 2units of Humulin R 1pm 2units of Humulin R 3pm 2units of Humulin R By the next morning I am deep into ketosis.



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Why Insulin works: Androgen/Insulin Synergy By Michalovich Greutstein Should anabolics be used with insulin or is it best to use insulin while off steroids in order to hold onto muscle mass? We are going to demonstrate that they have to be used together. We will also try to provide some clues about their respective contribution to the synergy both hormones create. This will help us to handle both drugs better. Here are some general observations: It is safe to conclude something else is needed to uncover the full anabolic effect of steroids. The hormone which is the most affected by a high calorie or by a low calorie diet is insulin. Also, heavy steroid users know that past a certain amount of steroids, adding insulin will make a big difference as far as muscle gains are concerned. Insulin is thus a strong candidate as a potentiator of anabolic steroids (which we will indiscriminately refer to as androgens, steroids or anabolics). Furthermore, studies performed in trained dogs have shown a lack of insulin completely negates the anabolic effects of steroids on protein synthesis. There are some easy hypotheses such as a possible androgen receptor up regulation, a stimulation of androgen secretion, an antiaromatase effect arising from insulin. But, there is still something missing. Using anabolics plus insulin will wil l not make you much bigger unless you weight train. The synergy can only be realized if insulin + steroids + training are present. What is the link between those three factors? A very likely candidate candidate is an enzyme enzyme called insulinase. As its name implies, it is an enzyme responsible responsible for the destruction of insulin. But we are going to see it does much more than that. It is found inside many tissues of the body, particularly in muscle. What science is telling us is that insulinase is essential for insulin to provide its anti-catabolic effect on our muscles. It is also likely that insulinase is able to multiply the anabolic effects of androgens. It's worth repeating: insulin cannot stop protein catabolism without insulinase and the effects of steroids are potentiated by insulinase. It sure looks good. Androgens are very very powerful stimulators stimulators of the muscle muscle protein synthesis synthesis rate. On the other hand, the muscle gains provided by androgens do not match this elevation in synthesis. steroids promote anabolism to a much higher rate than they make our muscles grow. The reason for this discrepancy is that they also stimulate protein degradation. I know many people think they are anti-catabolic, but it is not the case. Anabolics stimulate protein turnover. This means they increase both synthesis and degradation of proteins. They are simply more effective at stimulating synthesis than degradation, which is why they make our muscles grow but not at a super fast rate. Look at how long it takes to grow huge muscles. If androgens were stimulating synthesis while inhibiting degradation, one would grow very, very quickly. This is where insulin comes in. As we said, it mostly reduces protein degradation rate. It might stimulate protein synthesis right after training, but this effect is very limited in duration. Ideally, using insulin along with steroids would allow us to accelerate synthesis (thanks to anabolics) and reduce degradation (thanks to insulin). This is the best way to grow muscle fast. Unfortunately, as both insulin and anabolics need insulinase to work better, they will compete against each other for this enzyme. For natural athletes, the supply of muscle insulinase should roughly meet the demand. Now if you add anabolics, there will be less insulinase for insulin. If you do not take too high a dose of steroids, the level of insulinase should still be sufficient to allow a fair insulin-induced anti-catabolism. But as you take more steroids, the insulinase available for insulin will be lower and lower. Insulin will lose its anti-catabolic effect. As it wi ll still bind some insulinase, the enzyme availability for steroids will not be optimal either. Anabolics will lose some of their potency. What is important to understand is that past a certain dose, anabolics will provide their own antidote © 2012 Thatotherguy

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against muscle growth. The only solution (beside using less steroids) is to increase i ncrease insulinase level. At least two factors factors can accomplish this feat: feat: The first one is insulin itself. The higher the insulin level is in a target organ (muscle for example) the higher the insulinase level will be. You would expect that the body would detect the shortage of insulinase for insulin and so produce more insulin (or more insulinase). Unfortunately, this does not seem to be the case. While insulinase is crucial for the anti-catabolic effect of insulin, it does not seem as important for glucose disposal. Insulin's main function is not to assist in muscle growth but to control glucose homeostasis. As a result, it is likely our body does not really care about a relative shortage of insulinase. In any case, we are left with a less than optimal equilibrium. It is up to the bodybuilder to react to this imbalance. One way of increasing insulin secretion is to eat more, but you can only do so up to a point. You cannot increase your carb intake in parallel with the amount of steroids without getting too fat. Another solution is to use drugs to add or to stimulate insulin secretion. This way you get the insulin without the excess of calories. In any case you now understand why steroids work better while on a high calorie diet while they lose their potency during a diet or a shortage of insulin. Here is a way of "artificially increasing insulin level": One dose of long acting insulin first thing in the morning (this is the only injection). Before each meal (except the pre-workout one), take a sulfonylurea (an oral anti-diabetic drug which will boost food induced insulin secretion ). I like Glipizide because of its short half-life. In case you experience hypoglycemia, you know it will not last. This is the main problem with the long acting sulfonylureas. When you are hypoglycemic, you try to compensate by absorbing carbs. But the drug will make your pancreas secrete even more insulin before the carbs can hit the blood. It makes the hypoglycemia worse - not better. In case of problems, make sure you get some ready-to-inject Glucagon (sold as "insulin emergency kits" in drugstores). An additional benefit of the Glipizide is that it induces the release of GH on top of insulin which is beneficial for non diabetics. This is a nice way to fix the reduced anticatabolic property of insulin. Unfortunately, this will not yet provide the optimal amount of insulinase to have steroids work better. We said that training was the third key ingredient in this synergy. This is because training can stimulate insulinase activity. Not any exercise will do. The traumatic ones inducing muscle soreness are the most effective. It is the factors inducing soreness which will trigger this increase in insulinase. On the other hand, you do not want to create too much soreness as it will temporarily reduce the effects of insulin and androgens by impairing their effects at the level of their respective receptors. What you want is mild but frequent soreness along with some very frequent pumping sessions. Do not forget both androgens and insulin circulate in the blood. The more blood you get into the muscles (and the longer it stays), the more your muscles will be "drenched" in those two hormones. Please note that insulinase is produced locally in the trained muscles only. It does not circulate into the blood. From GUY at Canadian Juice Monsters

12.10 12.10 Acnema Acnemans ns Insuli Insulin n FAQ FAQ Warning: Taking this drug can and and will kill you if you do not use it properly. This article article is only meant to inform you. This should not be be used instead of your doctor's doctor's consultation.. Never under any circumstances take this or any other drug without your doctors approval. Consult your doctor first! What is insulin? Insulin is a hormone secreted by the beta cells of the pancreas that controls the metabolism and cellular uptake of sugars, proteins, and fats. As a drug, it is used principally to control diabetes. Insulin is not a steroid. What type of insulin should I use for bodybuilding? Humulin R and Humalog are the only insulin's I recommend because they act fast and are out of the © 2012 Thatotherguy


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body fastest (this makes them the safest). I have never used Humalog but understand that aside from quicker onset and half-life it is essentially the same. Why do I want to use insulin? Insulin has been called "Anabolicus Maximus" by some gurus of the bodybuilding world. Insulin can give you greater gains than you have ever had using anabolic's alone. Insulin, in combination with androgens and resistance exercise, may trigger maturation of satellite muscle cells (small, more or less useless cells that are held in reserve, which do not contribute to muscular strength) into mature mature muscle cells that do contribute to muscular size and strength. How freakin cool is that. Hyperinsulinemia has been shown to stimulate protein synthesis in isolated limb infusion experiments , these anabolic properties seem to be the result of insulin binding to IGF-1 receptors. If insulin is so great why aren't all diabetics huge? Diabetics have a disease and use insulin to replace endogenous insulin that they cannot produce. Bodybuilders use insulin in a totally different way. Some diabetic bodybuilders manipulate their insulin use to use insulin for muscle growth and get good results but changing dosages and times of i njection of insulin for diabetics can be dangerous. Isn't taking insulin dangerous? Ummm YES! Before deciding to take insulin here is what you have to do to be safe. Insulin safety

1. Do not use slin alone have a training partner or girlfriend who's not using slin hang around with you from the time you take the slin to about 2.5/4 hrs after. 2. Tell you're partner to look for anything out of the norm for your personality and have a list of questions like your ssn or address etc that they can ask you. Don't joke around, and answer them without shit, because if you cant answer or refuse to answer it could be a sign of hypoglycemia (low blood sugar). Symptoms of hypoglycemia include disorientation, headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. 3. If you cant/wont answer or are feeling the symptoms of hypoglycemia they should be prepared to feed you carbs like pancake syrup, coke, sugary stuff. stuff. I bought glucose tablets at Walmart. Walmart. kind of like candy but gets in the blood faster and dissolve quickly. these are for diabetics ask at the pharmacy. 4. Have your partner know that if they suspect low blood sugar and cant convince or force you to consume carbs until your better. CALL 911 and ask for an ambulance and tell the truth to the operator... that they suspect you are in insulin shock and explain when they get there (the ambulance guys not the cops) that you are not di abetic but using insulin for anabolic purposes. Have the type of slin, the dosage and carbs consumed recorded to give the paramedic. They will save your life. Then you refuse transport to the hospital and eat. It might be a good idea to make sure your house is "clean" before every workout just in case the bad thing happens and the cops ask a lot of questions. 5. Why so much preparation for the possible problem?? insulin can kill you i n minutes if you go down!! 6. Take the carbs and protein together immediately after injecting the slin (dont take chances trying to time out 15 min after injection). Take the protein with the carbs because the protein is pushed into the muscles with the slin also (creatine too). 7. Before an hour passes you should eat a normal balanced meal (high protein low fat with carbs). 8. Consume another small high protein medium carb low fat meal at 2.5 hours after the injection. Congrats you lived. (keep some Gatorade on hand just to make sure because your not going to have a © 2012 Thatotherguy

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lifeline) 9. YAWN... Don't go to sleep within 4/6 hours of using insulin since you can develop hypoglycemia while asleep and not have warning signs. Ok I'm not scared I still want to use insulin... Where do i get it? Humulin R is over the counter (OTC) just about everywhere. Humulog is new and is still a prescription drug is some places. BUT... Insulin is NOT a controlled substance and will not be confiscated by customs or postal inspectors so order it online if you cant get it locally. Its legal. Where do I keep it? (STORAGE) The FDA requires that all preparations of insulin contain instructions to keep in a cold place and to avoid freezing. The refrigerator is a good spot. Unrefridgerated insulin can be kept of 28 days as long as it stays in a cool and dark place. Where/how do I inject insulin? The best sites for insulin injection are in the subcutaneous tissue of the abdomen (avoid the area close to bellybutton) .Usually, you should not inject wi thin 1 inch of the same site within 1 month. The arms and legs can also be used, but insulin i nsulin uptake from these sites is less uniform. Insulin should be injected subcutaneously only with a U-100 insulin syringe. "B-D ultra-fine" insulin syringes are good. Insulin syringes are available without a prescription in many states. If you cant purchase the syringes at a pharmacy, you can mail order them. Using a syringe other than a specific insulin syringe is dangerous since it will be difficult to measure out the correct dosage. How much insulin should I take? I recommend never using over 10IU. 10IU is enough to make you grow. In general Dosages used are usually 1 IU per 20 pounds of lean bodyweight. So a 220lb bodybuilder with 9% body-fat would use 10iu of insulin(aprox200lb lean mass/20 = 10iu). But even experienced insulin users shouldn't use max dosage at the beginning of an insulin cycle. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout until you reach your calculated dose or determine a maximum personal dose (some people are more sensitive to insulin sides like hypoglycemia). This will allow the athlete to determine a dosage he can safely use. Insulin dosages can vary significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone and thyroid might have higher insulin requirements. When do I take insulin? It is my opinion that you should only take insulin after a work out, never before or when not working out, because before a work out you could crash and die during the workout and when your not working out it makes you fat. Some people disagree with this. IF you want, get some info from them and try it. But remember I told ya so. When do i eat after using insulin? Immediately!!! DO NOT TRY TO TIME YOUR CONSUMPTION OF CARBS!! You should immediately take a carbohydrate AND protein drink after taking you're insulin. I've stated this twice because it is very important. Even experienced insulin users can get a surprise now and then. Eat a meal at about an hour after using insulin. Consume another small high protein medium carb low fat meal at 2.5 hours after the injection. keep some Gatorade on hand just to make sure. Remember that insulin can still work much later so be careful and eat if you feel hypoglycemia symptoms. What do I eat after using insulin? Some people recommend a zero fat intake for 4 hours after taking insulin. I do not disagree with this. But if your bulking you can be a little relaxed on this. But high fat intake after taking insulin can lead to © 2012 Thatotherguy


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high body fat. The carb/protein drink taken after the insulin shot should contain AT LEAST 10 grams of carbs and 5 grams of quality protein per IU of insulin injected with little or no fat (creatine taken in this drink i s optional but works great). Before an hour passes you should eat a normal balanced meal (high protein low fat with carbs). At 2.5 hours after the injection you should Consume a small meal. keep some Gatorade on hand just to make sure. Remember that insulin can still work much later so be careful and eat if you feel hypoglycemia symptoms. Once again i've stated this twice because it is important. ***Some insulin users recommend far less carbs than I have stated above. This is a personal decision you will have to make since it could be very dangerous...Even deadly! My opinion is to take the carbs and learn to diet after bulking if you gain too much fat.*** How long should/can I take insulin? Short cycles please because you could have side effects. It is suspected that you could become an insulin dependant diabetic but I have never seen proof, but is it worth the risk? I would only use it a few times a week (maximum 4 on 3 off) for no more than 3/4 weeks. What should I avoid while using insulin? Do not use alcohol. It lowers blood sugar, and you may experience dangerously low blood sugar levels. Do not change your workout in the middle of a cycle of insulin. Changes in how much you exercise can change the amount of insulin you can tolerate and maintain blood sugar levels. Do not take any recreational drugs at the same time as insulin since they could mask symptoms of hypoglycemia. Do not change the brand of insulin or syringe that you are using without first talking to a doctor or pharmacist. Some brands of insulin and syringes are interchangeable, while others are not. Do not use insulin if you are sick with a cold, flu, or fever. These illnesses may change your insulin requirements.. Do not use any insulin that is discolored, looks thick, has particles in it, or looks different from the way it looked when you bought it. Do not use OTC drugs that will cause drowsiness within 6 hours of using insulin. Do not go to sleep within 4/6 hours of using insulin since you can develop hypoglycemia while asleep and not have warning signs. What are the possible side effects of insulin besides hypoglycemia? Rarely, people have allergic reactions to insulin. Seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives). Hypothetically, one could become an insulin dependent diabetic if insulin is used too long.

references http://www.meso-rx.com/steroid-profiles/insulin.htm "Taber's Cyclopedic Medical Dictionary," Copyright © 2001 by F. A. Davis Co., Phil., PA © 2012 Thatotherguy

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http://www.getbulky.com/Info http://www.getbulky.com/Info/Steroid_Info/insu /Steroid_Info/insulin.html lin.html http://www.bodybuilding.com/fun/ http://www.bodybuilding.com/fun/catinsulin.htm catinsulin.htm Elisabeth R. Barton-Davis, Daria I. Shoturma, Antonio Musaro, Nadia Rosenthal, and H. Lee Sweeney. Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proc Natl Acad Sci U S A 22;95(26):15603-7, 1998 http://www.subscriberx.com/.SRX?Ser...Dialect=English http://www.rxlist.com/frame/ http://www.rxlist.com/frame/display.cgi?drug=HUMULI display.cgi?drug=HUMULIN N http://www.lillydiabetes.com/Prod http://www.lillydiabetes.com/Produc...ityProfiles. uc...ityProfiles.cfm cfm Anabolic Diabetic



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Chapter 11: Peptides Peptide cycles and Profiles

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Reco Recons nsti titu tuti ting ng and and Mea Measu suri ring ng Pep Pepti tide des s Most peptide's (HGH, MGF, GHRP, HCG) can be reconstituted with sterile water or more commonly with Bacteriostatic Water (BW) which is sterile water with 0.9% Benzyl Alcohol added and maximizes shelf life. BW is readily available and preferred. Some HGH comes with water provided but best to discard this and use BW as generally the supplied water is intended for single use application only.. One important exclusion to the above is IGF. IGF requires reconstituting with 0.6% Acetic Acid (AA) or 10 mM HCl. 0.6% AA provides the maximum shelf li fe for the product and is preferred. Firstly it's a good idea to use an alcohol swab to clean the nipples of both your vial of peptide and diluent before reconstituting Before reconstituting we need to determine how much diluent to add to the peptide. This will vary upon your own preference for measuring the amount for injection of the reconstituted hormone. I will add at the bottom of this post a guide for this purpose. So we now have our peptide in a lyophilized powder form and our intended diluent so let's reconstitute it. Using a regular 3cc pin with 23-25 gauge needle draw up your required diluent amount and proceed to add it to the vial with your lyophilized powder. This process needs to be done with care as the peptide are relatively unstable. I suggest tilting the vial on a roughly 45 degree angle and very gently adding in the diluent allowing it to slowly trickle down the side of the vial and then reaching the lyophilized powder at which time it should dissolve into the diluent. DO NOT squirt your diluent directly into the vial or onto the lyophilized powder. It might not fully dissolve so again very gently swirl the vial in one direction only until you have a good mix. DO NOT shake the vial or agitate it violently in any way during this process as again this could conceivably degrade your peptide. Most peptide injections are done using an insulin syringe. Measurements on these are in International Units (iu's). This is a measurement of the biological effect and applied to your hormone as a standard accepted "Internationally" but don't get too hung up on that excepting to know it can be applied with surety to your peptide. So if your using a U100 insulin syringe this means 1iu is 1/100th of a ml or 1ml = 100iu's. Peptides are generally packaged and labeled in terms of micrograms (mcg's) which is 1/1000 of a milligram. So 1mg = 1000mcg's. Let's use an example where you have 1mg of peptide which is reasonably common. This then means you have 1000mcgs of that peptide. If you add 1ml of diluent to that you now have a solution that will provide you with 10mcg's per IU. If you add 2mls of diluent your solution becomes 5mcgs per 1iu and so on. Here is a chart for quick reference: 1000mcg/1mL = 10 mcg per IU 1000mcg/2mL = 5.0 mcg per IU 1000mcg/3mL = 3.3 mcg per IU 1000mcg/4mL = 2.5 mcg per IU Going from above if you have a 2mg vial of lyophilized powder then the equations changes by a multiple of 2 as below: 2000mcg/1mL = 20 mcg per IU 2000mcg/2mL = 10 mcg per IU 2000mcg/3mL = 6.6 mcg per IU © 2012 Thatotherguy

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2000mcg/4mL = 5 mcg per IU A simple reference to refer back to is the following: Peptide amount in mcgs / diluent volume in ml/100 = mcg per IU Should probably add in here with HGH specifically it is often shipped in kits/vials labeled as 5 or 10iu's per vial rather than in micrograms. The calculations are the same but to expand on this if you have a 10iu vial of HGH and add 1ml of BW to it you now have in solution with 10iu's per 1ml. We know from our previous calculations that a U100 insulin syringe holds 1ml of liquid. So to measure your HGH in this example divide the total amount of diluent by the total IU's of HGH and what we get is 1iu of HGH each 10 tick on the insulin syringe. Chart again below for easier reference: 1ml = 100 IU's 100 IU (amount of dilutent) / 10 IU (amount of HGH) = 10 for each IU of HGH If adding 2mls BW: 200 IU / 10 IU = 20 Most peptide injections are done subcutaneously (sub-q) but can also be done intra muscularly (IM). IGF is again the exception here as this peptide should be inj ected IM otherwise I prefer sub-q for most others. All peptide should be stored stored in the refrigerator refrigerator once reconstituted reconstituted to ensure maximum maximum shelf life and this does vary. HGH and HCG are typically good for up to 30 days whereas IGF is good for up to 2 years. Keep them away from direct sunlight at all times. by Access

13.2 13.2

HGH HGH + IGFIGF-1 1 + Insu Insuli lin n - A bas basic ic guid guide e There are volumes of information and studies available about using HGH, IGF-1, and Insulin, but for the most part coming up with a good cycle including all of these is a tedious process and requires more reading than most people wish to do or have the time to do. The following is meant to a quick and simple reference to what a cycle including all three might look like and a brief description of the action of each component. THE CYCLE Weeks 1- (20-30) - HGH - On 5/ off 2 2 - 2.5 IU's first thing in the morning 2 - 2.5 IU's early afternoon injected Sub-C into abdomen, obliques, fronts of the thighs, upper triceps Weeks 1-5, 11-15, (21-25) - Long R3 IGF-1 - Every day 60mcg's intramuscular post work out on workout days, first thing in the morning on non workout days Weeks 6-10, 16-20, (26-30) - Humalog - Workout days only 8IU's immediately post workout, intramuscular *** alternatively, you could run the Humalog on 1-5, 11-15, (21-25) with your LR3 if you prefer, depending on your cycle goal***


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Immediately after Humalog injection - do the following Injection + 5 minutes - drink shake with 10g glutamine / 10g creatine / 55g dextrose Injection + 15 minutes - drink shake with 80g of whey protein in water Injection + 60 - 75 minutes - eat a protein / carb meal with 40-50g of protein, 40-50g of carbs, NO FATS Avoid fats for 2-3 hours hours for Humalog IM, 3-4 hours for Humalog Humalog sub-q, 4-5 hours for for Humulin-R. **keep some glucose tablets or other simple carbs on hand for the active window of your insulin. Hypo symptoms can and will hit hard and fast and you will have little time to react. This is the main danger of insulin use. Be ready.*** OPTIONAL T3 - 12.5mcg per day (or 12.5mcgs ->100-150mcgs ->12.5mcgs if used for fat loss instead of protein synthesis assist) HGH HGH should ideally be used for 20-30 week cycles (or longer). The dosage should be between 2-3IU per day if you are using GH primarily for fat loss, 4-5 IU's a day for both fat loss and muscle growth, and approximately 1.0 - 2.0 IU's a day for females. It is best to split your injections 1/2 first thing in the morning, 1/2 early afternoon if your dose is above 2.0IU's per day. Your pituitary will naturally produce about 10 pulses of GH per day. Each injection you take will create a negative feedback loop that will suppress these pulses for about 4 hours. By taking your injections first thing in the morning and early afternoon you will still allow your body to release i ts biggest pulse, which normally occurs shortly after going to sleep at night. When starting out with your HGH cycle, for most people people it is wise to begin you dose at 1.5 - 2.0IU per day for the first couple of weeks, and then begin increasing your dose by 0.5 to 1.0 units every week or two until you reach your desired level. While it isn't an absolute necessity to do this, if you are sensitive to the type of sides HGH present you will often times avoid these sides of joint pain/swelling, and bloating/water retention by slowly acclimating to your ultimate 4-5 IU's /day goal. You should use an U100 insulin syringe for injecting HGH, and inject it Sub-C into your abdomen, obliques, top of thighs, triceps. Rotate injection sites. HGH can have a small localized fat loss benefit, so keep this in mind when choosing your injection sites. IGF-1 When HGH makes it pass through the liver, a release of IGF-1 is a result. IGF-1 appears to be the key player in muscle growth. It stimulates both the differentiation and proliferation of myoblast. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. While HGH will cause an increase in your IGF-1 level over the course of a few months, HGH has a cumulative effect, so the addition of IGF-1 will greatly speed up the time to results. There are two types of IGF-1 that will typically be used by bodybuilders. One is bio-identical HuIGF-1, a 70 amino acid string. The other is Long R3 IGF-1, which is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long). Which of these you use depends on your goal. HuIGF-1 is very short lived in the body (half life of probably around 10 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth. Use a U100 insulin syringe, and inject 80mcg's bilaterally into the desired muscle immediately post workout. For this type of IGF-1, I would use it workout days only or if desired you could inject on non-workout days first thing in the morning into a muscle group worked the previous day. For Long R3 IGF-1, it isn't as critical that you inject into a local site as long R3 has a active window of © 2012 Thatotherguy


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many hours, and is designed specifically to resist being bound. Since it is common to reconstitute this type of IGF-1 with Benzyl Alcohol, Acetic Acid, or Hydrochloric Acid I would still recommend that you inject intra-muscular. It can and probably will leave a nice red irritated spot if you inject Sub-C. I still inject into a muscle just worked to take advantage of increased IGF-1 receptors, but because of the long activity window of this type of IGF-1 any muscle will work well and give you good results,. I would suggest that you inject between 40-80mcg's per day everyday immediately post workout on workout days, and first thing in the morning on non-workout days. Use a U-100 insulin syringe with 1/2" needle to inject IGF-1 intramuscular (bilaterally for HuIGF-1, bilaterally optional for Long R3) Insulin Working out causes us to end up in a catabolic state. It is important to back in a positive nitrogen balance as soon as possible. When not using insulin, we drink some dextrose with our protein to cause an insulin spike immediately post workout to help shuttle the protein and sugars to the muscles. Insulin is very good at shuttling nutrients to the muscles, and works in a very complimentary manner with GH in the types of things that they shuttle. Also, HGH can cause an amount of insulin resistance, so adding some insulin to your cycle will offset any potential resistance that might occur during your HGH cycle. For the purposes that we are using insulin, a dosage of 4-10IU's is adequate and should be used immediately post workout. I personally prefer using Humalog intramuscular as it will cause a rapid spike and clear out of your system quickly. You can use it sub-q or use Humulin-R instead, but each of these will result in a longer active window, thus a longer time to avoid eating any fats and watching your carb intake. Any fats or over abundance of carbs will end up being stored as fat during insulin's active window. The approximate windows are: Humalog Intramuscular ---- 2-3 hours subcutaneous --- 3-4 hours hours Humulin R Intramuscular ---- 3-4 hours subcutaneous --- 4-5 hours hours Use a U-100 insulin syringe with 1/2" needle to inject IM immediately post workout. Alternatively, you can inject Sub-C if desired or if you wish a longer active window for some reason. Begin with a dose of 2IU's or so, and increase the dose each workout day until you reach your 8IU's. If for some reason you wish to avoid insulin, I would still suggest that immediately post workout you spike you own endogenous insulin by drinking 80 grams of dextrose / 40 grams of whey isolate protein. While this certainly won't do the work of 8-10 IU's of Humalog, it will most certainly assist getting your muscle back in a nitrogen positive environment in a short amount of time. T3 HGH can have a slight inhibitory effect on your thyroid. For most people this is minimal and does not require any additional thyroid be taken, but if you wish to augment protein synthesis as well as give yourself a slight boost in thyroid without shutting down your own production, you can add 12.5mcg of T3 daily to your HGH, IGF-1, Insulin cycle. This will aid both in bulking and cutting. If you add this, you should also consider taking some thyroid support supplements such as t-100x, bladder wrack, coleus forskolin. You should check and make sure your i ntake of trace minerals (selenium, zinc, copper) is sufficient to aid in the conversion of T4 to T3. If you are going to take more than 12.5 mcg of T3, you will need to cycle the dose both up and down to avoid a rebound effect when going off cycle, but for our use with an HGH cycle and use in assisting with protein synthesis, 12.5mcg will be sufficient. If you wish to use T3 in conjunction with the above for heavy cutting, begin with 12.5mcgs, ramp up to 100-150mcgs, then slowly back down tapering back to 12.5 mcgs for a time before discontinuing use. This will minimize the chance for rebound while your © 2012 Thatotherguy

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own thyroid gets back in gear. Well, I think that about covers it. add a cycle or two of your favorite testosterone and you have a great combination for bulking or cutting. By RED BARON

13.3 13.3

A basi basic c IGFIGF-1 1 cyc cycle le guid guide e Author: Mr Sparkle Sparkle What is it? And why is the difference between huIGF-1 and LR3 IGF-1? IGF-1 stands for insulin like growth factor. IGF-I is the primary protein involved in responses of cells to growth hormone (GH): that is, IGF-1 is produced in response to GH and then induces cellular activities. One such example is muscle growth or hyperbolas This compound also makes the human body more sensitive to insulin. It is the most potent growth factor found in the human body. IGF-1 causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells, this is a good thing. LR3 IGF-1 Long Recumbent 3 IGF-1, which is an 83 amino acid analog of human IGF-1 sequence with the substitution of an arg for the glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long). HuIGF-1 It has a 70 amino acid string. It is very short lived in the body (half life of probably around 10-15 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth. This coupled with PGF2a and TNE would do wonders for site specific growth IMO. Usage It needs to be shot PWO. Most shoot bilaterally into the muscle that was worked. Stacking- because LR3 increases hyperplasia it is best when used in conjunction of other AAS. The ideal situation would be to inject twice ED due to the life of LR3. If this isnt feasible PWO will suffice, and suffice well. If you are on your off day, in the AM is best. It will help fight catabolism. If you add insulin to your LR3, be careful. LR3 will make you more sensitive to the effects that insulin has on you. So raise your PWO carb intake to accommodate the added LR3. If you have never ran insulin before, DO NOT add it with LR3. What can I expect? First off you can expect to drop a little BF if your diet is good. LR3 seems to burn off fat. You can expect an increase in hunger, this is awesome when bulking. That though can be controlled while cutting. Another thing to remember remember is hyperplaisa, hyperplaisa, once again the forming forming of new muscle muscle cells, thus more size. Strength will go up along with the new muscle mass. You can expect great pumps. For some people so bad it hurts... you be the judge. I for one have never got pumps that hurt like that... for me personally I feel more pumps with insulin. Dosing For LR3 The general consensus for dosing LR3 seems to be 40mcg to 60mcg. For no longer than 5 weeks. Do not exceed 100mcg. The average user should have no reason to ever come close to that dose. Some people shoot everyday, some just PWO. So on the days you do not work out the best thing to do is shoot whenever you wake up this helps maintain constant blood levels and helps fight of catabolism. © 2012 Thatotherguy


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The first time user should just use 40mcg on PWO days only. This way you can use 40mcg for 5 weeks assuming you have just one MG of LR3. It is a great starting dose that will get you results. But if you have used 40mcg in the past and didnt see the results you wanted, try 60mcg. A great way to run a cycle that includes IGF would be thisWeeks 1-12 test enanthate E3D 500-750mg a week Weeks 1-4, 15-19* 40mcg of LR3 ED PCT 14-18 *IMO I do not feel that its needed the first week of PCT, if my weight falls off it does in weeks 2-3, so I want to alleviate that problem. Dosing For huIGF This is about the same as LR3, this is strictly my opinion based on what I have gathered and read. As there is next to no information on this. So from what I know about it, this is how Id/do/will use it. PWO with 30-40mcg into each muscle that was worked. 20-30 min l ater, repeat. Do this for 4 times. for a total of 120-160mcg And if I were using this Id use it with humalog. The The insulin will remain active for over and hour after the the IGF was injected. So this will get all the possible gains from it that you could. How to figure out dosing Ok I get, I should use 40mcg.... but how do I figure that out? 1mg = 1000mcg... assuming there is 1ml of liquid we can say that 1ml = 1000mcg and also = 100units... So 2 units = 20 mcg The best way to measure this is to use an insulin syringe. You can get away with a 1cc syringe but I prefer to use the .5cc or even the .33cc ones. They measure out each unit, so when you are measuring two units it is much easier on the smaller pi n. While the 1cc syringe is fine, it is measured out by two IU at a time. So one "tick" on the 1cc is 2iu, the .5cc each "tick" is one IU. Wow so you mean you’re telling me I shoot 4iu of this stuff? What if I do not get it all out of there ? I thought you would never ask. I have found the best way to get it and even measure my LR3 is like this. First draw out 30iu of B12 or BW (bacteriostatic water) on the dot. Then draw your LR3 out for a total of 34iu. This means you have 4iu of LR3 in the end of your syringe. Shoot out all of it and that way you can be sure all of the LR3 is out and into your desired muscle of choice. Reconstitution. But just about always you do not have to worry about reconstituting it yourself. All of the manufacturers usually suspend their LR3 in either BA or AA for you. Storage, Taken from MR The stability of a liquid solution of LR3IGF-I was monitored for a period of two years at storage conditions of -20 C, +4 C, +22 C, and +37 C. The final concentration of LR3IGF-I was in acetic acid. At various time points, samples were taken and compared to a lyophilized control (stored at 4 C). Listed below are the stability results for each respective storage condition. Storage Condition: -20 C (-4 F) Biological Potency No Change up to 2 years Immunological Activity No Change up to 2 years Mobility of Protein No Change up to 2 years Elution Profile by reversed phased HPLC No Change up to 2 years


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Storage Condition: +4 C (39.2 F) Biological Potency No Change up to 2 years Immunological Activity No Change up to 2 years Mobility of Protein No Change up to 2 years Elution Profile by reversed phased HPLC No Change up to 2 years Storage Condition: +22 C (71.6 F) Biological Potency No Change up to 2 years Immunological Activity No Change up to 2 years Mobility of Protein No Change up to 2 years Elution Profile by reversed phased HPLC No Change up to 2 years Storage Condition: +37 C (98.6 F) Biological Potency No Change up to 1 year Immunological Activity No Change up to 1 year Mobility of Protein No Change up to 1 year Elution Profile by reversed phased HPLC No Change up to 1 year In conclusion There is no significant di fference in the potency of LR3IGF-I associated with the storage of the liquid formulation when stored at this range of temperatures. There is no evidence for loss of biological activity at any of the tested temperatures when stored as a liquid product. As you can see IGF can be quite stable for even a year at room temp, but if you want to keep it around for a while stick it into the fridge. So IMO the best way to store LR3 that is suspended in BA is in the freezer. The BA wont allow it to freeze. And if you have it suspended in AA, store it in the fridge.

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Pept Peptid ide e Po Powd wder er Reco Recons nsti titu tuti ting ng So you now have a peptide in the form of lyophilized (freeze dried) powder. The amount of this powder should be indicated on the vial somewhere. It will likely be stated in International Units (IU's) or in Milligrams (mg). What we need to do with this lyophilized powder is add the proper dilutent. What is a proper dilutent you ask? For Melanotan (I & II), PT141, CJC1295 & GHRPs, HGH, MGF, GH fragments, etc use Bacteriostatic Water

For IGF you use an acetic acid solution. If one was not made available to you you can make the solution using 7 parts distilled water and 1 part vinegar from the grocery store. You must filter this through a sterile syringe filter before use. © 2012 Thatotherguy


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RECONSTITUTING 1.) Take an alcohol swab to the stopper of both your peptide vial and the vial of the dilutent. 2.) With a 1cc syringe and draw your preferred dilutent. Choose an amount that will make measuring the final product simple. 1ml(cc) per 10mg vial of Melanotan would mean each 10 mark on a U100 slin syringe would equal 1mg of Melanotan 1ml(cc) per 10 IU vial of HGH would mean each 10 mark on a U100 slin syringe would equal 1 IU of HGH 2ml(cc) per 10mg vial of Melanotan would mean each 10 mark on a U100 slin syringe would equal 1mg of Melanotan 2ml(cc) added to a 10 IU vial of HGH would mean that the 20 mark on a U100 syringe would equal 1 IU of HGH 3.) Take the syringe with the dilutent and push it into the vial of lyophilized powder letting the dil utent dissolve the peptide. 4.) After all of the dilutent has been added to the vial, gentling swirl (do NOT agitate or violently shake the vial) until the lyophilized powder has dissolved and you are left with a clear liquid. The peptide is now ready for use. Store your now reconstituted peptide in the refrigerator. MEASURING After you have have successfully reconstituted reconstituted your peptide, now you you need to know know how to measure measure the desired amount out for injection. You will want to use a U100 insulin syringe to draw out and inject your product. Here is the way to figure out how much to draw out. Since you know the amount of IU's/MG's in your vial, we divide this out as follows: You will need to know the following to be successful 1ml = 1cc = 100 IU's We take our dose from the label of the dry lyophilized powder and we divide that into the amount of dilutent used. example- We used 1cc(ml) of water. We have a 10 IU vial of HGH. From our formula above we know that 1cc = 100 IU's, so we have 100 IU's of water. We now divide the 100 IU's (the amount of our water) by 10 IU's (the amount of our HGH) 100 IU / 10 IU = 10 This 10 will perfectly correspond with the markings on a U100 insulin syringe. In our example every 10 mark on our syringe will equal 1 IU of HGH. Want to draw out 2 IU's of GH? ....draw out to the 20 mark on the syringe. Say you have a 1mg vial and you add 1ML you get 1000mcg/1mL: 10 mcg per IU © 2012 Thatotherguy

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1000mcg/2mL: 5 mcg per IU Say you have a 10mg vial and you add 1ML you get 10mg/1mL: 1 mg per 10 IU 10mg/2mL: .5 mg per 10 IU Say you have a 20mg vial and you add 1ML you get 20mg/1mL: 2 mg per 10 IU 20mg/2mL: 1 mg per 10 IU Say you have a 10iu (HGH for example) vial and you add 1ML you get 10iu/1mL: 1 iu per 10 IU (on the syringe - 1/10th the product) 10iu/2mL: 1 iu per 20 IU (on the syringe - still 1/10th the product) Say you have a 5000iu vial and you add 1ML you get 5000iu/1mL: 500iu per 10 IU 5000iu/2mL: 250iu per 10 IU To recap, just keep straight: 1.) How much actual product you are dealing with (MG or IU) 2.) How much water (dilutent) you are using to add to powder 3.) Divide the amount of water in units by the amount MG/IU. 4.) This result will equal the measurement on your U100 Insulin syringe per unit 5.) multiply the number you get it step 4 by how many units you want to inject. This is the number to draw to on your syringe You may still have lots of questions. None of this is set in stone, hope this is helpful. Video demonstration of how to reconstitute and draw up a powdered medication below. Note that the video is just a rough example of what to expect and how to to preform. Best of luck!

13.5 13.5

AICA AICAR, R, GW15 GW1516 16 - Exe Exerc rcis ise e In A Pil Pilll AICAR and GW1516 experiments experiments suggest that that these two drugs, drugs, also called exercise in a pill, might protect against gaining weight on a high-fat diet, which might make it useful for treating obesity. Researchers have identified two drugs, AICAR and GW1516, that mimic many of the physiological effects of exercise. The drugs increase the ability of cells to burn fat and are the first compounds that have been shown to enhance exercise endurance. Both AICAR and GW1516 can be given orally and work by genetically reprogramming muscle fibers so they use energy better and contract repeatedly without fatigue. In laboratory experiments, mice taking the drugs ran faster and longer than normal mice on treadmill tests. Animals that were given AICAR, one of the two drugs, ran 44 percent longer than untreated animals. The second compound, GW1516, had a more dramatic impact on endurance, but only when combined with exercise. Ronald M. Evans, the Howard Hughes Medical Institute investigator who led the study, said drugs that mimic exercise could offer potent protection against obesity and related metabolic disorders. They could also help counter the effects of devastating muscle-wasting diseases like muscular dystrophy. Evans and his colleagues, who are at the Salk Institute for Biological Studies, published their findings on July 31, 2008, in an advance online publication in the journal Cell. Concerned about the potential for abuse of the two performance-enhancing drugs AICAR and GW1516, Evans has also developed a test to detect the substances in the blood and urine of athletes who may be looking for way to gain an edge on the competition. In 2004, Evans and his colleagues genetically engineered mice that had altered muscle composition © 2012 Thatotherguy


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and enough physical endurance to run twice as far as normal mice. These “marathon mice” had an innate resistance to weight gain, even when fed a high-fat diet. “We made these mice and they had low blood sugar, they resisted weight gain, they had low fats in their blood. They were much healthier animals,” Evans said. “And when we put them on a treadmill, the engineered mice ran twice as far than normal mice - they transformed into remarkable runners.” The scientists achieved these effects by modifying a gene called PPAR-delta, a master regulator of numerous genes. Evans and his colleagues showed that by enhancing PPAR-delta's activity, they had shifted the genetic network in muscle cells to favor burning fat over sugar as their energy source. But the effects seen in the marathon mice were caused by a genetic manipulation that was present in their bodies as their muscles were developing. Evans's group began to wonder whether they could duplicate these effects by turning on PPAR-delta in adult mice.

“We had shown that we could pre-program muscle using genetic engineering. If you express this gene while the muscle is being formed, you can increase the amount of non-fatiguing muscle fibers,” Evans says. “But what about reprogramming in an adult? When all the muscles are in place, can you give a drug that washes over the muscle for a few hours at a time and reprograms existing muscle fibers? That's a very different question.” PPAR-delta has long been an attractive drug target because of its central role in metabolism, so Evans and his colleagues had no shortage of chemical compounds available to test. They began by testing a compound called GW1516. They treated young adult mice with the drug for five weeks. “We measured gene changes and the muscles looked like they were responding, so we knew the drug was working.” Thus, while fully expecting the drug to dramatically increase endurance - Evans says, “There was no change at all in running performance. Nothing — not even a percent.” Surprised by this spectacular failure, Evans and his colleagues decided to try a different approach, based on real-life experience. “If you're out of shape - and most of us are - and you want to change, you have to do some exercise. The way we reprogram muscle in adults is by training.” So the scientists subjected two groups of mice — one that received the drug and one that did not — to interval training. The mice ran for 30 minutes on a slow treadmill five days a week for a total of four weeks. At the end of the training period, all of the mice - regardless of whether they had received GW1516 - had improved their performance. Those that had received GW1516, however, ran 68 percent longer than those that had only done the exercise training. “The dramatic effect of the drug was stunning,” Evans said. The scientists were intrigued by this synergistic interaction and wanted to know how exercise allowed the drug to work. One possibility was an enzyme called AMP kinase (AMPK). During exercise, cells burn ATP as their primary source of energy. In the process, they create a by-product called AMP. When cells sense the presence of AMP, they activate AMPK. Activation of AMPK creates more ATP for the cell to burn. AMPK also triggers changes that lower blood sugar, sensitize cells to insulin, enable cells to burn more fat, suppress inflammation, and otherwise influence metabolic pathways. This is one reason that exercise is so beneficial. Evans's team found that in addition to replenishing the cell's energy stores, AMPK also assists PPARdelta in activating its gene targets. “It hops onto PPAR-delta in the nucleus and turbo-charges its transcriptional activity,” Evans explained. “We think AMPK activity is the secret to allowing PPAR-delta drugs to work.” The critical question was whether chemical activation of AMPK is sufficient to trick the muscle into thinking it has been exercised. The second drug, called AICAR, enabled them to answer that question. AICAR mimics AMP, Evans said, “so muscle thinks it's burning fat.” The researchers researchers were encouraged encouraged when they found that when they gave the drug to mice, they activated many of the genes in muscle © 2012 Thatotherguy

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that are turned on by exercise. After four weeks weeks of treatment treatment with AICAR, Evans and his colleagues once again challenged sedentary sedentary mice to run on the treadmill. They found that mice that had received AICAR were able to run 44 percent longer than untreated mice. “This is a drug that is like pharmacological exercise,” Evans says. “After four weeks of receiving the drug, the mice were behaving as if they'd been exercised.” In fact, he says, those that got the drug actually ran longer and further than animals that received exercise training. The animals receiving AICAR improved i mproved their running performance and their ability to burn fat. None of these effects, however, were as strong as they were in the animals that received both exercise and activation of PPAR-delta via GW1516. Evans said this indicates that the benefits are li kely due to collaboration between cells' AMPK and PPAR-delta signaling pathways. The team's genetic analyses supported this hypothesis; they found that AICAR and GW1516 alone activated a subset of exercise-induced genes, but activating both pathways (by combining GW1516 with exercise) activated a larger group of genes. Many of those genes regulate metabolism and muscle remodeling. Evans and his colleagues called this the “endurance gene signature.” Like exercise, AICAR and GW1516 trigger a variety of changes that contribute to muscles cells' improved endurance and ability to burn fat. These changes include an increase in mitochondria, the structures responsible for producing energy; a shift in metabolism that takes advantage of lipids as an energy source; and an increase in blood flow, which enables the steady delivery of fat to burn. While the scientists only examined the drugs' effects on muscle cells in this study, Evans says it is likely that they confer benefits on other systems impacted by exercise, such as the heart and lungs. Based on his group's findings, Evans is optimistic about using small molecules that mimic exercise to treat and prevent a variety of common conditions. For example, the way in which AICAR and GW1516 transformed the muscle fibers of mice suggests they might help reverse the muscle frailty associated with aging or diseases l ike muscular dystrophy. “We have now created the potential for a really simple intervention in an area of major health problems for which there is no intervention,” he says. More broadly, AICAR and GW1516 could offer the benefits of exercise to people who do not get enough. “Almost no one gets the recommended 40 minutes to an hour per day of exercise,” he says. “For this group of people, if there was a way to mimic exercise, it would make the quality of exercise that they do much more efficient. This might be enough to move people out of the `danger zone' toward a lower risk, healthier set point. By intervening early, you may forestall the emergence of more serious problems.”

Evans expects these types of drugs will be attractive to a variety of individuals. “If you like exercise, you like the idea of getting more bang for your buck,” he says of GW1516. “If you don't like exercise, you love the idea of getting the benefits from a pill,” as with AICAR. So, while Evans sees tremendous opportunities for health benefits from drugs that mimic exercise, he also sees serious potential for abuse. “Drugs that improve health are not only going to be used by people who have medical problems. They may also be used by people who are healthy - or by athletes who want an edge,” said Evans. He noted that the sports world has long been aware of his lab's work demonstrating a link between PPAR-delta and endurance. What's more, GW1516 has a relatively simple chemical structure and can be synthesized easily. Evans anticipates that athletes will seek their own sources of the drug - if they haven't already. Concerned about the potential for abuse, Evans thought it was important to develop a test that could detect whether the drug was being used as a performance-enhancing substance. With HHMI support, his group has created a highly sensitive test that uses mass spectrometry to detect the two drugs and © 2012 Thatotherguy


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their metabolic by-products in the blood or urine. While the test is very reliable in mice, Evans says that further analyses are needed to ensure that it is accurate in humans. Evans, HHMI and the World AntiDoping Agency are now working to certify the detection system and make it available in time to retroactively test athletes who compete in the 2008 Olympics Submitted by Armen Hareyan

13.6 13.6

CJCCJC-12 1295 95 Sh Show ows s Pro Promi mise se HGH HGH Rel Relea ease se If you have used CJC-1295 please post your results below. What dose did you use? CJC-1295 is a peptide analogue of GHRH. Because of the way CJC-1295 is engineered its half life has been extended from ~7 minutes to greater than 7 days! Due to the extremely long half life of CJC-1295 it is plausible to use this peptide once per week with outstanding results. It would be wiser to use ½ dosages twice per week to keep serum levels high and to get maximal. Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.53 fold for 9-11 days after a single injection. Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group. Another very positive benefit of CJC-1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS are decreased significantly in older adults and also with people who tend to exercise later in the evening. This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy. Quotes: CJC 1295 is expensive whereas the GRF 1 – 29 & GHRP 6 are not, so I use GRF 1- 29 & GHRP 6 at doses of 100 mcg’s each morning. Before bedtime I inj ect 150 mcg’s of CJC 1295 & 100 mcg’s of GHRP 6. This seems to provide a good sleep & I wake in the morning feeling quite fresh & ready for another day at the uni. The most popular dosage used by body builders seems to be 100 mcg injections of both CJC 1295 & GHRP 6 * 3 times each day. It really depends on a person’s goals, because some people use what I consider to be massive doses once or twice each week. The general opinion, however, seems to be that regular small doses are healthier & more effective. I’ve found that better sleep, & better digestion are the obvious results of using these products. GHRP-6 is great for appetite stimulation and works very well taken with CJC-1295 and testosterone, Especially for those who have difficulty in gaining weight. My vote goes to real hgh,lots of chinese brands have popped up these days.And like Sly Stallone said, hgh and testosterone should really be over the counter.

your best way to go is to take 100mcg of GRF1-29 and 100mcgs GHRP6 in the morning upon waking up, post workout and pre-bed. The 2 peptides has a synergistic effect without the other i t would be not 100% effective. A GRF1-29 only wont do such… A GHRP6 only will will be a better choice… But both will increase GH release 100%… © 2012 Thatotherguy

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Try not to eat for about 30 minutes after administering the following peptides as fat affects the GH pulsations Chris White

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GRF - GHRP GHRP - GH GH a com compre prehen hensiv sive e dosi dosing ng protoc protocol ol In effort to list a protocol for the use of GHRP / GRF / and in combo with GH if desired I thought I would post my current protocol based upon the research I have done within the last year or so. Obviously the information I gathered is not based on medical studies completed by me but I do use the following protocol myself and have been pretty damed impressed with the results. Recovery from injury is very impressive to me (any kind of injury). Example, 5 days ago I was lifted by the butt of a tree I cut down (long story). I had bruising and some serious raspberry on my under arm, left quad and my abs ( the but of the tree ran right up the front of my once it got under my arm it lifted me and tossed me about 10 feet through the air). Its been 5 days and all that is left of the raspberries are some faint red marks......amazing marks......amazing IMO. Also: I encourage others to do their own research. research. Don't think all that I have written below is gospel gospel or the only / best way to run these peptides. This is nothing more than my interpretation of what I have read and what I perceive as the best way to use peptides. Best Choices for GHRP's. GHRP-6 Good GH spike when used with a GRF, large increase in hunger. Elevates prolactin and cortisol levels GHRP-2 Good GH spike, when used with wi th a GRF, on par with GHRP-6 without the hunger. Elevates prolactin and cortisol levels Ipamorelin good GH spike when used with a GRF. GH spike is not as high as GHRP-2 or 6 but it i t does not elevate prolactin or cortisol. Note: in order for a GHRP to have a positive affect and create a GH spike alone one as to be very lucky in the timing and hope it is injected at time when Somatostatin is low in the body. Somatostatin blunts GH release in the presence of just GHRP. Using GRF will override the signal presented by Somatostatin so you will get a very dramatic GH pulse. GRF's (GHRH) Two choices Mod GRF 1-29, higher GH peaks, short half life (30 minutes) most closely mimics your bodies own GH pulses but far greater amplitude CJC 1295 long half life (7days). Lower GH amplitude when used wi th GHRP, raises the troughs in the bodies GH level profile, the downside is it creates GH bleed. Think of the GH as being stored in a jar until someone (thing) opens up the faucet. It is best if the jar is full and then dumps. CJC does not allow the jar to fill. Current recommendations are to avoid CJC Saturation dose for any of the GHRH's or GHRP's including Ipamorelin is 100mcg (or 1mcg / kg of bodyweight) so this is all based on a 100mcg dose. As you may know, know, it is best to pin 1.5 to to 2 hours after after eating any fats or carbs and then after you pin don't eat any fats or carbs for 20-30 minutes as they will blunt the GH release. Pure protein is OK but I try to avoid all foods. Also, pure protein is OK anytime prior to pinning. Dosings should be 3 hours apart or more. Mornings upon waking pre cardio (if you are doing any), afternoon (or PWO) and before bed pin mod GRF 1-29 / GHRP (or Ipamorelin) @ 100mcg / 100mcg. (2 pinnings per day are also adaquate for improvements in recovery, better sleep etc. 3 will make you a bit more anabolic than 2 and you can even go 4 if the pocket book allows. If you include GH in this protocol it should be 10 minutes after the peptides. So, first pin the peptides, wait 10-15 minutes and then pin your GH. Reason being is that Exogenous GH administration can also © 2012 Thatotherguy


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blunt GH release. Wait 20-30 minutes after pinning the peptides and you are free to eat. When you recon your peptides use as little BW as you can. I don't go as low as some people because I figure I don't want to leave a drop of highly concentrated peptide in the vial that I can not get out. The less BW used for recon the less the degradation of the peptide over time. If you premix a shot ahead of time, don't let it sit mixed for more than 8 hours or so. When mixed they will exchange ions and who know what the final compound would be called :-). I actually have a way to preload without mixing the peptides until I am ready to pin it. Do not pin IGF within 1 hour of pinning your peptides. IGF has a feedback loop that inhibits GH release. With the above for pinning around workouts to get the most of your investment.... Pin insulin (humalin R) immediately PWO wait 10 minutes pin peptides If using GH wait 10 more minutes and pin the GH (see above for reasoning) If using IGF wait approx. 1 hour PWO and pin the IGF. IGF blunts GH release. another reason to wait is in effort to keep the IGF local you want to wait until you lose your pump. Blood flow is reduced in teh area of injection. if you pin IGF immediately PWO blood flow is still very high so the IGF get transported away too quickly..

For convenience... Pin insulin Pre work out.... Humalin R is active for 4-5 hours PWO pin peptides (or if you want to pin slin and peps at the same time PWO) 10 minutes after peps pin GH if you are using GH 30-60 minutes PWO pin IGF if using IGF by: Bilter

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GHRP GHRP-2 -2 grow growth th horm hormon one e relea releasi sing ng-h -hor ormo mone ne GHRP-2 is a synthetic ghrelin analogue. Like ghrelin, it stimulates release of endogenous growth hormone from somatotropes in the anterior pituitary; also like ghrelin, it is synergistic with endogenous growth hormone releasing-hormone (GHRH) as well as with synthetic GHRH analogues such as Sermorelin or GRF(1-29). [3] Whereas GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means.[1] Unlike ghrelin, GHRP-2 is not lipogenic meaning it does not induce fat storage. While ghrelin has a very important role in hunger, GHRP-2 as an analog of ghrelin does not increase i ncrease appetite significantly.[1] GHRP-2 is synergistic with GHRH due to secondary actions on hypothalamic neurons. [2] The quantity of GH released by a living mammal to which GHRP-2 and GHRH are administered exceeds the combined release of each compound when measured when taken alone. [2] The neuronal excitation in the hypothalamus lasts for an hour or so with GHRP-2 dosing, quickly causing a high-amplitude pulsation of GH which tapers back to baseline by the third hour after application.[4] This pulse closely resembles natural or endogenous GH release, and for many purposes is likely superior in application to the synthetic GH circulation period of eight hours. Cellular desensitization to the effects of GH is more likely to occur with a longer, shallower pulse.[5] Age-related GH decline, decline, as well as other other potential issues that might be treated with GHRP-2, GHRP-2, is not a


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result of inability to produce GH but rather is due to a reduction in signaling. The aged pituitary of humans can still produce the same amount of GH with the same frequency, but the signaling compounds ghrelin and endogenous GHRH are released in different patterns creating a loss in GH production relative to youthful states or healthful states.[5] In humans, a dose of 1mcg/kg (100mg for a 100kg male) of GHRP-2 when combined with a GHRH of equal dosage creates a three-hour pulse of GH that is double the amplitude of an 8 IU synthetic (e.coli derived) growth hormone dose.[4] IV, intramuscular and subcutaneous routes lead to different onset times but roughly similar peaks and declines. Due to ease of synthesis (as opposed to the complicated process of creating GH from e. coli), safety, and lower cost, GHRP-2 as part of comprehensive therapy may soon supplant conventional exogenous GH therapy.

References: [1] Bercu, B.B., Yang, S-W., Masuda, R. and Walker, R.F. (1992) Role of selected endogenous peptides in growth hormone releasing hexapeptide (GHRP) activity: analysis of GHRH, TRH and GnRH. Endocrinology 130, 2579–2586. [2] Chen, C., Wu, D. and Clarke, I.J. (1996) Signal transduction systems employed by synthetic GHreleasing peptides in somatotrophs. J. Endocrinol. 148, 381–386 [3] Frohman, L.A., Downs, T.R. and Chomczynski, P. (1992) Regulation of growth hormone secretion. Front. Neuroendocrinol. 13, 344–40 [4] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205 [5]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464.

13.9 13.9

Growth Growth Hormo Hormone ne Rele Releasi asing ng Horm Hormon one e (GHRH (GHRH)/C )/CJCJC-129 1295 5 It increases protein synthesis and stimulates the growth of new muscle tissue. - Allows for normal growth in short children with GH deficiency. - Increases muscle mass (and physical strength if combined with moderate exercise). - Reduces wrinkling of the skin and some other effects of skin aging. - Re-grows internal organs that have atrophied with age. - Causes hyperplasia, the increase of more muscle cells. - It increases muscle mass through the creation of new muscle cells (which differs from hypertrophy). - It promotes lipolysis, which results in the reduction of adipose tissue (body fat). - Increased bone density. - Faster recovery from exercise, exertion, and i njuries. - Strengthen the immune system. It is important to begin the discussion of CJC-1295 with a discussion of the parent of the Growth Hormone Releasing Factors which is somatocrinin., this peptide ultimately gave birth to the newer generations of Growth-hormone-releasing hormone peptides (CJC-1295). Growth-hormone-releasing Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus. GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary gland where it stimulates growth hormone secretion. GHRH stimulates the production of growth hormone. GHRH gave birth to a more compact growth hormone releasing factor known as Sermorelin which is a © 2012 Thatotherguy


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synthetic analogue of growth hormone releasing hormone, which is produced by the hypothalamus. Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues. The free base of sermorelin has the empirical formula C 149 H 246 N 44 O 42 S and a molecular weight of 3,358 daltons. Sermorelin stimulates the secretion of growth hormone by acting directly on the pituitary gland, in the brain. In contrast to GHRH which is a 44 amino acid sequence Sermorelin is a 29 amino acid peptide hormone and is also known as (GRF 1-29 NH2). Sermorelin was sold in the United States with the brand name GEREF by Serono Biotechnologies, which later was sold to Merck, they stopped production of Sermorelin in November 2002. So, what was the problem with Sermorelin, or GHRH for that matter? The clinical use of growth hormone-releasing hormone (GHRH) is limited by its short half-life. Also it follows that Sermorelin faced the same difficulties and thus is limited by its short half life (approximately 12 min following intravenous injection in humans), mainly due to its susceptibility to rapid enzymatic degradation. Thus, the product quickly dissipated in the body and the peptide could not stay in the body long enough to have a medicinal impact. A Munafo, T X Q Nguyen, O Papasouliotis, H L?cuelle, A Priestley and M O Thorner (2005). There were attempts to resolve some of the short half-life issues with Sermorelin, in fact a PEGylated GHRH was developed. Even though PEGylated GHRH solved some of the degradation issues, the much more potent CJC 1295, rendered PEGylated GHRH obsolete. Instead of using a PEGylated technology, the technology of bioconjugation was employed. In vivo bioconjugation to serum albumin is a useful tool to increase the half-life of small molecules or peptides in plasma. In vivo bioconjugation occurs when a strategically placed reactive group on a bioactive peptide reacts with a nucleophilic entity found in blood or in sc interstitium to form a stable bond. The foremost nucleophile is the thiol, and its most abundant source in these fluids is Cys34 on albumin. The thiol on Cys34 reacts with a Michael acceptor, such as a maleimido derivative, leading to a new bioactive protein construct that will adopt an extended half-life due to stabilization from enzymatic degradation) or reduced elimination through the kidney. It therefore became logical to combine the long-lasting effect of bioconjugation with the proper GRF analog. Lucie Jett?, Roger L?ger, Karen Thibaudeau, Corinne Benquet, Martin Robitaille, Isabelle Pellerin, V?ronique Paradis, Pieter van Wyk, Khan Pham and Dominique P. Bridon (2005). CJC-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days. Bioconjugation takes a reactive group and attaches it to a peptide, which in turn reacts with a nucleophilic (usually a partially negative molecule) entity found in the blood to form a more stable bond. Albumin, one of the most abundant substances in the human body is chosen as the nucelophile by this particular peptide thanks to a Cys34 thiol group that attracts it. By combining the tetrasubstituted GHRH analogue with maleimodoproprionic acid using a Lys linker, you create a GHRH peptide with a high binding affinity for albumin. So how effective is bioconjugation? How long will CJC-1295 stay in ones system? How wi ll CJC-1295 impact IGF-1 levels? This is the exact question researchers asked and a study was conducted to determine the efficacy of CJC-1295. The objective of this study was to examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog. The study design was two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 days. Healthy subjects, ages 21-61 years old were studied. After a single injection of CJC1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 days or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 days. The estimated half-life of CJC-1295 was 5.8-8.1 days. After multiple CJC-1295 doses, mean IGF-I levels remained © 2012 Thatotherguy

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above baseline for up to 28 days. No serious adverse reactions were reported. Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne and Lawrence A. Frohman (2006). What was the research dose used in i n the study? A particularly important question, the dosage was 3060 micrograms per kilogram of bodyweight. This bears repetition, GH remained elevated for up to six days! IGF-1 concentrations were up 1.5 to 3 fold for 9-11 days! And the estimated half-life of CJC-1295 is 5.8-8.1 days! IGF-1 levels were elevated up to 28 days! At a dosage of 30-60 micrograms per kilogram of bodyweight, with no significant side effects. Excuse all he emphasis but this is a truly remarkable research product, its ability for efficacy is self-evident. So in sum, what is CJC-1295? CJC-1295 is a long-acting analog of GH-releasing hormone. CJC-1295 exhibits the same effects of Human Growth Hormone, it has the ability to promote muscle mass, increase bone density, improve protein synthesis, increase IGF-1 levels potently, strengthen immune systems, stimulate the production of bone marrow cells that produce red blood cells, and of course reduce excess body fat, especially abdominal fat. (The reduction of abdominal fat is the single most profound effect of HGH replacement.) Peptide should be administered at least twice a week (so divide the research dose into two administrations on your research subject) this will help to keep blood levels consistent in your research subject, or in cellular culture, or in vitro. Figure 1 Chemical structure of the CJC-1295 (DAC-GRF). The core therapeutic moiety is a tetrasubstituted GHRH-(1вЂ“29)NH2. The substituted amino acids are shown in italics. The linker is lysine, and the

reactive chemical is maleimidoproprionic acid that binds covalently to the single unpaired cysteine (cysteine 34) in serum albumin. Figure 2

Plasma disappearance curves of CJC-1295 after a single sc injection. Shown are the mean В± SD half-life. Drug concentrations were generally measurable for at least 12вЂ“14 d after injection.

Figure 3 GH responses to a single sc injection of CJC-1295. A, Serum GH concentrations (mean В± SD) are shown and suggest that pulsatile hormone secretion is maintained. B, Mean GH AUC0вЂ“7 d, expressed as a percent increase over placebo. *, P < 0.05 vs. placebo. Shown ar e the mean В± SD.

Mean maximum concentrations of GH were 6.6, 9.6, 9.9, and 13.3 ng/ml in the 30, 60, 125, and 250 Вµg/kg groups; mean AUC were 758, 969, 977, and 1370 ng/mlВ·h, respectively.

Figure 4 IGF-I responses to a single sc injection of CJC-1295. A, Serum IGF-I concentrations (mean В± SD) are shown. B, Mean IGF-I AUC0вЂ“7 d, expressed as a percent increase over placebo. *, P < 0.05 vs. placebo. Shown are the mean В± SD. The shaded area marked is the upper limit of normal (U.L.N.)

for age- and gender-matched cohorts. Mean maximum concentrations of IGF-I were 232, 319, 328, and 435 ng/ml in the 30, 60, 125, and 250 Вµg/kg groups; mean AUC were 91, 127, 119, and 172 Вµg/mlВ·h, respectively.

Figure 5



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IGF-I responses to multiple sc injections of CJC-1295. Serum IGF-I concentrations (mean В± SE) are

shown. Arrows indicate days of injection. A, Changes in serum IGF-I levels after three weekly injections of CJC-1295 or placebo. B, Changes in serum IGF-I levels after two biweekly injections of

CJC-1295 or placebo. In both A and B, for d 0вЂ“7 and 14вЂ“21, the entire pooled placebo group (n =

4) is plotted, because all these subjects received placebo injections on d 0 and 14. In A, for the period from d 7вЂ“14, only the two subjects who received placebo injections on d 7 are plotted (i.e. three weekly injections). In B, for the period from d 7вЂ“14, only the two subjects who received placebo

injections on d 0 and 14 are plotted (i.e. two biweekly injections). RESEARCH DOSAGE: 30-60 mcg per kilogram of bodyweight.

Peptide should be administered at least twice a week (so divide the research dose into two administrations on your research subject) this will help to keep blood levels consistent in your research subject, or in cellular culture, or in vitro. STORAGE: REFRGIRATE UPON RECEIPT. KEEP REFRIGERATED AFTER RECONSTITUTION ALLOW 24 HOURS FOR THE PEPTIDE TO SETTLE BEFORE BEGINNING YOUR RESEARCH. Academic References & Further Information Information A Munafo, T X Q Nguyen, O Papasouliotis, H L?cuelle, A Priestley and M O Thorner (2005). (2005). Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjects. European Journal of Endocrinology, Vol 153, Issue 2, 249-256. Lucie Jett?, Roger L?ger, Karen Thibaudeau, Corinne Benquet, Martin Robitaille, Isabelle Pellerin, V? ronique Paradis, Pieter van Wyk, Khan Pham and Dominique P. Bridon (2005). Human Growth Hormone-Releasing Factor (hGRF)1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification Identification of CJC-1295 CJC-1295 as a Long-Lasting Long-Lasting GRF Analog. Endocrinology Vol. 146, No. 7 3052-3058. Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne and Lawrence A. Frohman (2006). Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults. The Journal Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 3 799-805 799-805

13.10 13.10 Mechan Mechano o Growth Growth Fact Factor or - MGF MGF Loss of muscle mass in old age and in certain diseases is associated with an impaired ability to express MGF. - The ability to produce MGF declines with age, and this is commensurate with the decline in circulating GH levels. - MGF has been shown to boost muscle mass by improving the ability of wasted tissue to grow. - MGF has been shown to improve the ability of wasted tissue to grow. - MGF has been shown to activate muscle stem cells. - MGF has been shown to increase the upregulation of protein synthesis. - MGF induces rapid muscle hypertrophy. - MGF has considerable potential as a generic means of treating muscle cachexia. - Mechano Growth Factor (MGF) targets skeletal tissue, and promotes muscle growth by repairing the damaged tissue and upregulating protein synthesis. © 2012 Thatotherguy

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The sequencing of the human genome showed that there are only about 40,000 genes. However, there are many more proteins. This is because some genes are spliced to produce different protein/ peptides which usually have different biological functions. Combining physiological and molecular biology methods made it possible to identify and characterize a local muscle growth/repair factor (MGF). After resistance exercise, the IGF-I gene is spliced towards MGF which? kick starts? hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as anabolic processes. Interestingly, loss of muscle mass in old age and in certain diseases is associated with an impaired ability to express MGF. Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue. MGF has been shown to boost muscle mass by improving the ability of wasted tissue to grow and improve itself by activating muscle stem cells and increasing the upregulation of protein synthesis. MGF is a part of the IGF family, but, in the case of MGF, this part of the peptide acts as a separate growth factor involved in initiating muscle satellite (stem) cell activation in addition to its IGF-Ireceptor domain which increases protein synthesis, and hence improves muscle mass. (Adams GR 2002). Mechano Growth Factor (MGF) is derived from the insulin-like growth factor (IGF-I) but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in i n the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibers that are required for repair and for the hypertrophy processes which may have similar regulatory mechanisms. Hence, Mechano growth Factor (MGF) appears to be more anabolic than IGF because MGF responds to the signals produced by damaged muscle tissue induced by exercise and actually repairs the tissue and prevents cell death. Loss of muscle mass (sarcopenia) is one of the main problems associated with ageing as it has major health care as well as socioeconomic implications. The growth hormone (GH)/IGF-I axis is regarded as an important regulator of muscle mass. However, it is now appreciated that other tissues in addition to the liver express IGF-I and that there are local as well as systemic forms of IGF-I which have different functions. At least two different different kinds of IGF-I that are expressed expressed by skeletal muscle are derived from the IGF-I gene by alternative splicing, one of which is expressed in response to physical activity which has now been called? mechano growth factor? (MGF). The other is similar to the systemic or liver type (IGFIEa) and is important as the provider of mature IGF-I required for upregulating protein synthesis. MGF differs from systemic IGF-IEa in that it has a different peptide sequence which is responsible for replenishing the satellite (stem) cells in skeletal muscle, in other words it is more anabolic. In vivo experiments in which muscles of the rat were subjected to mechanical damage or injection of a myotoxic agent also demonstrated (Hill &Goldspink, 2003) that MGF precedes muscle satellite (stem) cell activation. This is in accord with the finding that when skeletal muscle cells in culture, were either transfected with the MGF cDNA or were treated with the MGF carboxy peptide they increased in number but stayed as monocleated myoblasts (Yang & Goldspink, 2002). It appears that MGF plays a dual role in inducing satellite cell activation as well as protein synthesis and this is probably why it is much more potent than the liver type or IGF-IEa for inducing rapid muscle hypertrophy. The ability to produce MGF declines with age, and this is commensurate with the decline in circulating GH levels. GH treatment up regulates the level of IGF-I gene expression in older people and when combined with resistance exercise more is spliced towards MGF and hence should improve the ability of muscle to respond to physical activity.(Goldspink and Harridge 2004). The characterization of a local tissue repair factor (mechano growth factor, MGF) that is produced by exercised and/or damaged muscle by differential splicing of the IGF-I gene provides understanding of how muscle is maintained in the young normal individual. Mechano Growth Factor, or MGF, is different to the systemic IGF-I as it has an insert of 49 base pairs i n exon 5 that introduces a reading frame shift resulting in a C terminal peptide with unique properties.



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Muscle is a post-mitotic tissue and as cell replacement is not a means of tissue repair there has to be an efficient local repair mechanism otherwise the damaged cells undergo cell death. The extra nuclei for muscle repair and hypertrophy are provided by the muscle satellite (stem) cells. The pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following a mechanical challenge. Unfortunately, the production of MGF is deficient in certain diseases such as in the muscular dystrophies in which the mechanotransduction mechanism, mechanism, which may involve the dystrophin complex, is defective. In elderly muscles, decreased levels of growth hormone apparently mean that there is less primary RNA transcript of the IGF-I gene to be spliced towards MGF. Consequently, there is an increasing inability to maintain muscle mass during ageing. Delivery of MGF and cDNA or peptide produces marked increases in the strength of normal as well as diseased muscle and, therefore, MGF has considerable potential as a generic means of treating muscle cachexia. (Goldspink 2006). Skeletal muscle is one of the few tissues with the capacity for rapid and widespread repair. The source of this regenerative ability lies in precursor stem-cell reserves that are harbored by the myofibers. The myofibers (muscle fibers) that comprise skeletal muscle are muscle cells packed with contractile machinery (myofibrils), rechargeable energy sources (mitochondria), many nuclei (myonuclei), and a cytoplasmic unit (sarcoplasm, over two-thirds of which is water), each competing in a sense for space inside the cell. (Linstedt SL 1998). Mechano Growth Factor targets skeletal tissue, and promotes muscle growth by repairing the damaged tissue and upregulating protein synthesis.

RESEARCH DOSAGE: 100-200mcg every day. Peptide is best administered at least twice daily, bi-lateral doses (so divide the research dose into two administrations on your research subject) this will help to keep blood levels consistent in your research subject, in cellular culture, or in vitro.

13.1 13.11 1 Pept Peptid ide e Profi Profile les s

Protein peptides profile Peptides are short polymers of amino acids l inked by peptide bonds. They have the same peptide bonds as those in proteins, but are commonly shorter in length. The shortest peptides are dipeptides, consisting of two amino acids joined by a single peptide bond. There can also be tripeptides, tetrapeptides, pentapeptides, etc. Peptides have an amino end and a carboxyl end, unless they are cyclic peptides. A polypeptide is a single linear chain of amino acids bonded together by peptide bonds. Protein molecules consist of one or more polypeptides put together typically in a biologically functional way and sometimes have non-peptide groups attached, which can be called prosthetic groups or cofactors. Protein peptides are the preferred method for the body to absorb nitrogen into the muscles because the proteins can be absorbed intact. In fact, peptides are absorbed over 200 percent faster than freeform amino acids or whole protein molecules. The faster protein is absorbed in the body, the more it promotes protein synthesis – a key component in muscle development. When the body breaks down proteins, it breaks them down into peptides, which in turn creates nitrogen in the bloodstream. Over 70 percent of nitrogen found in the bloodstream is in peptide form. Also, protein peptides made from whey are over 65 percent better at retaining nitrogen than regular whey. Other valuable characteristics of peptides are that it helps weight loss by stimulating the brain center that tells the body that it is full. Peptides stimulate Insulin Growth MGF © 2012 Thatotherguy

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MGH is a protein peptide that activates the process that repairs muscle damage. When muscles are worked out, or damaged, MGH triggers the metabolic agents in the body such as IGF-1 to repair and replace damaged muscles. Natural MGH declines with age and is a major cause of muscle tissue decreases as we grow older. MGH in clinical doses has shown remarkable results for not only muscle repair but new muscle growth as well. CJC-1295 CJC-1295 is a tetrapeptide that was developed to aid in weight loss. It is a growth hormone releasing hormone (GHRH) that has a longer half-life in the body than other GRHRs. PT-141 (Bremelanotide) PT-141 is a heptapeptide developed from Melantonan II. It has been studied for a variety of applications, including cosmetically as a sunless tanning agent and as a sexual dysfunction drug that could treat erectile dysfunction in men and arousal dysfunction in women. PT-141 was found to have some unwanted side effects on the circulatory system (high blood pressure) and further testing has been delayed. Hexarelin Hexarelin is a hexapeptide that is injected and stimulates the pituitary gland to produce growth hormone (GH). It also stimulates IGF-1 response, making it ideal for muscle mass and strength increases as well as fat loss. Because Hexarelin stimulates natural GH, it is often used after a cycle of HGH to avoid shutdown of natural GH production. ALCAR (Acetyl-L-carnitine) (Acetyl-L-carnitine) ALCAR is an experimental experimental acetylating agent that modifies protein protein structures. It is being tested tested for its unique quality of improving brain function and as a possible cure to diseases such as Alzheimer’s and dementia. IGF-DES IGF DES is a potent Insulin Growth Factor peptide that is fast-acting and has the ability to act with IGF receptors even after they’ve become damaged by lactic acid during workouts. It also seems to have a longer half-life than its counterparts like IGF-1 or IGF-LR3. Follistatin 344 Follistatin 344 is a peptide that inhibits myostatin, the chemical in the body that regulates muscle growth. When the body produces myostatin, it tells the muscles to stop growing, which is why i nhibitors like Follistatin allow bodybuilders to grow larger muscles. Reports on this peptide vary and there are complaints that it adversely affects the tendons. Triptorelin Triptorelin (aka Decapeptyl, Diphereline, Gonapeptyl, Trelstar and Variopeptyl) is a decapeptide that was developed to help treat prostate cancer. It is in a class of drugs called gonadotropin-releasing hormone agonists (GnRH agonists). The result from taking Triptorelin is a gradual reduction of testosterone in the body, which is why the best use for this peptide is part of a post-cycle therapy where you need to reduce testosterone before it aromatizes into estrogen. PEG-MGF (PEGylated Mechano Growth Factor) PEG-MGF is a peptide hormone that increases the stem cell count in muscle tissue. Stem cells allow the muscle to heal and to grow in number and size. The PEG, or polyethylene glycol, is attached to the MGF to make the peptide last longer in the body by increasing its half-life. This allows the MGF molecule to act more consistently on the muscle tissues, providing greater results. Melanotan II Malanotan II is a synthetic analog of the body’s natural melanocortin peptide hormone – the alphamelanocyte stimulating hormone (a-MSH). (a-MSH). It is being developed as a tanning agent for skin and as a drug to treat sexual dysfunction in both men and women. GHRP-2 (Growth Hormone Releasing Peptide-2) © 2012 Thatotherguy


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GHRP-2 is a hexapeptide that acts on the pituitary gland to release Human Growth Hormone (HGH). This peptide has a strong anabolic effect and creates strong muscle gains and weight loss. Besides boosting HGH levels, it also has a strong effect in boosting IGF-1 levels. This peptide works best in conjunction with HGH because it stimulates the natural HGH levels making it less l ess likely that synthetic HGH will shut down the pituitary gland’s natural production. Ipamorelin Ipamorelin is a pentapeptide that acts on the pituitary gland to produce Human Growth Hormone. An increase of HGH levels builds muscles and burns fat at incredible rates. Studies have shown that there is little long-term effect that Ipamorelin has on the pituitary gland’s ability to naturally produce growth hormones. IGF-1 Long R3 IGF- 1 Long R3 s an insulin-growth factor peptide that increases amino acid transport to cells, increases glucose transport, increases protein synthesis, decreases protein degradation and improves RNA synthesis. Unlike regular IGF-1, the the Long R3 version doesn’t easily bind to the IGF binding proteins that inhibit the biological actions of IGFs. GHRP-6 Growth Hormone Releasing Peptide-6 (GHRP-6) is an amino-acid peptide that triggers the body to release growth hormone. Growth Hormone burns fat and increases muscle strength and mass. GHRP-6 has the distinct characteristic of being a Ghrelin antagonist. Ghrelin is a chemical i n the body that helps store fat, which makes GHRP-6 a great peptide to take to get lean. HGH Human Growth Hormone (HGH) is a synthetic version of the natural growth hormones produced by the pituitary gland. Growth hormones tell the body to build muscle and burn fat in people during their puberty years. Growth hormone production slows as we age and is a major cause of how the body looses strength in old age. There are many types of HGH on the market today and is available by prescription and on the black market. HGH Fragment 176-191 HGH Fragment 176-191 is a piece of the Growth Hormone chain of amino acids – the part of the chain from amino acid number 176 through the amino acid number 191. It is believed by the developers of this peptide that the fragment of amino acids is responsible for the fat burning properties of HGH. They were attempting to isolate a stronger formula that targeted only fat burning to market as a weight loss drug. Adapotide Adapotide is a new research research drug used to to treat cancer but has shown remarkable remarkable results for weight loss. It is in a class of drugs called angiogenesis inhibitors that work to block bl ood flow to various parts of the body, in this case, fat cells. Clinical trials involving primates have shown remarkable results in cutting belly fat and overall weight loss

13.11.1 13.11.1 AICAR AICAR The Salk Institute discovered that AICAR significantly improves the performance of mice in endurancetype exercise by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, fat-burning, slowtwitch type. They also found that AICAR and GW1516, when given to "sedentary" mice, activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. As a result a publicity storm about "exercise pills" and "exercise in a pill" ensued. The World Anti-Doping Agency now lists both compounds on their prohibited list (since 2009), and the lead researcher of the breakthrough study cooperated in providing data to make possible a urinalysis test to detect AICAR.[4] [5] AICAR, aminoimidazole carboxamide ribonucleotide, ribonucleotide, acts as an agonist to AMP-activated AMP-activated protein kinase; AMP-activated protein kinase, also known as AMPK, is an enzyme with an important role in cellular homeostasis and energy regulation.[1] AMPK acts through a variety of means to ultimately © 2012 Thatotherguy

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stimulate liver fatty oxidation, ketogenesis, beta-cell modulation of insulin secretion, and other functions within the body. AICAR has been shown to stimulate glucose uptake and reduce apoptosis by reducing reactive oxygen compounds within cells.[2][3] AICAR has a number of of other experimental/clinical experimental/clinical and research chemical chemical uses as it is expressed expressed in a variety of tissue types. Bai et al found that "data demonstrate that AICAR-initiated AMPK activation may represent a promising alternative to our current approaches to suppressing intestinal inflammation in IBD."[6] Guo et al found "results suggest[ing] a mechanism by which AICAR inhibits the proliferation of EGFRvIII expressing glioblastomas and point toward a potential therapeutic strategy for targeting EGFR-activated cancers."[7] An original study by by Pold et al offers offers additional hope that AICAR could offer important important treatment potential for humans: Five-week-old, pre-diabetic ZDF rats underwent daily treadmill running or AICAR treatment over an 8week period and were compared with an untreated group. In contrast to the untreated, both the exercised and AICAR-treated rats did not develop hyperglycemia during the intervention period. Whole-body insulin sensitivity, as assessed by a hyperinsulinemic-euglycemic clamp at the end of the intervention period, was markedly increased in the exercised and AICAR-treated animals compared with the untreated ZDF rats (P < 0.01). In addition, pancreatic beta-cell morphology was almost normal in the exercised and AICAR-treated animals, indicating that chronic AMPK activation i n vivo might preserve beta-cell function. Our results suggest that activation of AMPK may represent a therapeutic approach to improve insulin action and prevent a decrease in beta-cell function associated with type 2 diabetes.[8]

References: [1]Corton JM, Gillespie JG, Hawley SA, Hardie DG. "5-aminoimidazole-4-carb "5-aminoimidazole-4-carboxamide oxamide ribonucleoside. A specific method for activating AMP-activated AMP-activated protein kinase kinase in intact cells?". Eur. Eur. J. Biochem. 229 229 (2): 558–65. 1995. [2]Lemieux K, Konrad D, Klip A, Marette A. "The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogenactivated protein kinases alpha and beta in skeletal muscle". Faseb J. 17 (12): 1658–65. 2003. [3]Kim JE, Kim YW, Lee IK, Kim JY, Kang YJ, Park SY. "AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside 5-aminoimidazole-4-carboxamide-1-beta-D-ribof uranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression". J. Pharmacol. Sci. 106 (3): 394–403. 2008. [4]Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. "AMPK and PPARdelta agonists are exercise mimetics". Cell 134 (3): 405–15. 2008. [5]WADA 2009 Prohibited List: WADA PROHIBITED LIST PDF (PDF Document). [6]Bai A, Yong M, Ma Y, Ma A, Weiss C, Guan Q, Bernstein C, Peng Z. Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide ribonucleoside with protective effect in DSS-induced acute and chronic colitis. J Pharmacol Exp Ther. 2010 Mar 17. © 2012 Thatotherguy


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[7]Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. The AMPK agonist AICAR inhibits i nhibits the growth of EGFRvIII-expressing EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12932-7. [8]Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, Fujii N, Goodyear LJ, Gotfredsen CF, Brand CL, Lund S. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes. 2005 Apr;54(4):928-34.

13.11.2 Bremelanotide PT-141 Bremelanotide or PT-141, a research chemical and peptide, belongs to the classification known as melanocyte stimulating hormones (MSH). It is a hexapeptide analog of alpha-MSH, and was originally developed from the MSH Melanotan II, a peptide agent that was reviewed in trials for sunless tanning but, unexpectedly, resulted in sexual arousal and sexual spontaneous erections in nine of ten test subjects. [1] Bremelanotide was developed as an agent to stimulate sexual arousal with the tanning “side effect;” it activates the melanocortin receptors MC1R and MC4R.[1] Bremelanotide is effective in its potential to treat sexual desire disorders as well as disorders that affect physical arousal. Bremelanotide induces lordosis in animal subjects, a sign of physical preparation for copulation.[2] In males, it does not stimulate the vascular aspect of the penis, but instead acts to stimulate the central nervous system primarily via dopamine receptor activity to increase sexual desire and also demonstrates functionality in treating purely physical manifestations of ED/SAD, likely through improved signalling. There are plans by the developer, Palatin Technologies, for a novel subcutaneous delivery system for the drug that makes the side effects more rare. In a double-blind placebo controlled study of 54 volunteers bremelanotide delivered with the novel system did not evoke hypertensive side effects as the nasal delivery system used in previous studies did, leading researchers to conclude "variability of uptake" due to intranasal administration of the research chemical resulted in "increases in blood pressure and gastrointestinal events...primarily events...primarily related to high plasma levels in [only] a subset of patients."[3] Palatin Technologies is now in discussion with the FDA to resume Phase II (human) studies utilizing subcutaneous administration exclusively.[3] The research chemical also holds promise for treatment of acute hemmoraghic shock.[3] The activity at the M1CR and M4CR receptors has been demonstrated to specifically modulate inflammation and to limit ischemia (blood flow restriction). Of course, the blood pressure/hypertension "side effects" are not a concern in this patient population.[4] The similarity in mechanisms-of-action mechanisms-of-action of currently available (FDA-approved) medical treatments for ED means medical practitioners are often limited in treating patients who do not respond well to that class (PDE5 inhibitor) of drug. As Hellstrom writes: Currently available agents for erectile dysfunction (ED) share the same mechanism of action and pharmacologic properties. Therefore, they share the same limitations, including a principal focus on erection as an end-organ process. One of the relatively unexplored areas of research has been the potential for centrally acting agents to improve male sexual response. A variety of neurohormones and neurotransmitter systems systems are involved in the male sexual response, including testosterone, dopamine, serotonin and the melanocortin systems. Investigations to determine the utility of centrally acting agents as monotherapy or adjunctive therapy in men with ED or other forms of sexual dysfunction are © 2012 Thatotherguy

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underway. Bremelanotide, a melanocortin agonist, has been tested in men with ED and may prove to be one of the first centrally acting agents to have clinical utility in male sexual dysfunction.[5] Safarinejad and Hosseini explore the efficacy of bremelanotide where sildenafil (commercial name Viagra) fails: A total of 342 married men (28 (28 to 59 years years old) with erectile erectile dysfunction who did not respond to sildenafil were randomly assigned to receive 10 mg bremelanotide as an intranasal spray (group 1, 172) 45 minutes to 2 hours prior to sexual stimulation, or a similar regimen of placebo (group 2, 170). Patients were asked to use at least 16 doses/attempts at home. They underwent preliminary assessment, including medical and sexual history, and self-administered International Index of Erectile Function. The efficacy of 2 treatments was assessed every 4 attempts during treatment and at the end of study, using responses to International Index of Erectile Function, and evaluation of mean intercourse satisfaction domain, mean weekly coitus episodes and adverse drug effects. RESULTS: Positive clinical results were seen in 51 (33.5%) patients in the bremelanotide group compared with 13 (8.5%) patients in the placebo group (p = 0.03). Patients in the bremelanotide group reported significantly greater intercourse satisfaction than those in placebo group (p = 0.03).[6] Bremelanotide also offers potential as a low-dose concurrent treatment with low-dose sildenafil: The erectile response induced by co-administration of PT-141 and sil denafil was significantly greater than the response elicited by administration of sil denafil alone. Co-administration of PT-141 and sildenafil was safe and well-tolerated and did not result in new adverse events or adverse events that were increased in frequency or severity compared with monotherapy. CONCLUSIONS: Coadministration of intranasal PT-141 and a phosphodiesterase type 5 inhibitor may constitute a treatment alternative for patients in whom higher doses of a single therapy are not effective or well tolerated.[7] In conclusion, bremelanotide is a novel treatment that could potentially change the face of treating sexual disorders, not only because of its effectiveness due to a unique mode of action, but also due to its safety and the fact it works synergistically with other ED/SAD treatments: Based on bremelanotide clinical experience, administration of a melanocortin agonist is well tolerated and not associated the hypotension observed with phosphodiesterase-5 inhibitors currently used to treat erectile dysfunction. This review discusses investigations of melanocortin agonists for the treatment of sexual dysfunction with emphasis on proposed sites and mechanisms of action in the central nervous system that appear to be involved in melanocortinergic modulation of sexual function. Current research validates use of melanocortinergic agents for the treatment of both male and female sexual dysfunction.[8]

Cititations: [1]US 6,794,489 bremelanotide (PT-141) patent (Appl. No.:040547). (Available online:http://www. google.com/patents?q=6794489). [2]Pfaus JG, Shadiack A, Van Soest T, Tse M, Molinoff P (July 2004). Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10201–4. [3]Press release: "Palatin Technologies Announces New Strategic Objectives and Reports Third Quarter 2008 Financial Results" 5/13/2008. (Available online: http://palatin.com/news/news.asp? http://palatin.com/news/news.asp? ID=202). © 2012 Thatotherguy


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[4] Palatin Technologies: Bremelanotide Overview. (Available online:http://www.palatin. online:http://www.palatin.com/products/ com/products/ bremelanotide/overview.asp). [5]Hellstrom WJ. Clinical applications of centrally acting agents in male sexual dysfunction. Int J Impot Res. 2008 Jul;20 Suppl 1:S17-23. [6]Safarinejad MR, Hosseini SY. Salvage of sildenafil failures wi th bremelanotide: a randomized, double-blind, placebo controlled study. J Urol. 2008 Mar;179(3):1066-71. [7]Diamond LE, Earle DC, Garcia WD, Spana C. Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology. 2005 Apr;65(4):755-9. [8] Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ. Melanocortins in the treatment of male and female sexual dysfunction. Curr Top Med Chem. 2007;7(11):1137-44.

13.11.3 13.11.3 CJC-1295 CJC-1295 CJC-1295 is a Long acting GHRH analog. Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the hypothalamus by the arcuate nucleus. GHRH stimulates growth hormone (GH) secretion from the pituitary. GHRH is released in a pulsatile manner, stimulating pulsatile release of GH respectively. In addition, GHRH also promotes slow-wave sleep . The active portion of this GRF or GHRH peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment. Despite the effectiveness of GHRH to stimulate growth hormone release there are a number of problems associated with using it in vivo. The most noteworthy problem is the half life of the peptide, which has been shown to be ~7 minutes using advanced HPLC technologies that have proven to be very accurate. The reason for this relatively short half life is due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV), which has a high affinity for the amino acids Ala and Pro and in the case of GHRH GHRH it cleaves the 1 and 2 positions that consist of Tyr-Ala, creating GHRH3-29, an inactive form of the peptide. To prevent the problems associated with natural GHRH, pharmaceutical companies looked at new ways to increase the half life and bioavailability of these smaller peptides with technologies that work far different than other technologies, such as PEGylation. CJC-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days! Bioconjugation is a relatively newer technology that takes a reactive group and attaches it to a peptide, which in turn reacts with a nucleophilic (usually a partially negative molecule) entity found in the blood to form a more stable bond. Albumin, one of the most abundant substances in the human body is chosen as the nucelophile by this particular peptide thanks to a Cys34 thiol group that attracts it. By combining the tetrasubstituted GHRH analogue with maleimodoproprionic acid using a Lys linker, you create a GHRH peptide with a high binding affinity for albumin. Once the CJC-1295 molecule has attached itself to albumin, it is given an extended half life and bioavailability thanks to the albumin preventing enzymatic degredation and kidney excretion. In fact, bioconjugation is so effective that there was less than 1% of CJC-1295 left unreacted in vivo and © 2012 Thatotherguy

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over 90% was stabilized after subcutaneous injection. This means that you get more of what you paid for working for you. There was no DPP-IV degredation observed on CJC-1295 in any of the various experiments conducted. Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.53 fold for 9-11 days after a single injection! (from the same study) Subcutaneous administration of CJC-1295 resulted i n sustained, dosedependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 µg/kg. There was evidence of a cumulative effect after multiple doses Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group. Because of the long half-life and stability of the CJC-1295 analog it may only need to be taken 1-2 times per week. However research on GHRH knockout mice showed that e/d injections where superior in increasing GH vs every 48 or 72 hours. “GHRHKO animals receiving daily doses of CJC-1295 exhibited normal body weight and length. Mice treated every 48h and 72h reached higher body weight and length than placebo-treated animals, without full growth normalization.” These mice were treated for 5 weeks. However the flaw in this study appears to be that the mice treated e/d were receiving a larger dose, so at minimum cjc-1295 is dose dependent. Whether or not a more frequent injection would prove to be beneficial is yet to be determined.

13.11.4 13.11.4 GHRP-6 GHRP-6 GHRP-6, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog. GHRP-6 is from the first generation of GHRPs and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary.[1] The cells that produce and release GH are known as somatotropes.[2] somatotropes.[2] Like GHRP-2, GHRP-6 does not have ghrelin’s lipogenic properties. Unlike GHRP-2, GHRP-6 induces hunger consistently in mammals. GHRP-6 acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1] The synergy comes both due to the suppression of somatostatin and the fact that GHRP-6 increases GH release per-somatotrope, per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2] There is also a secondary effect of neuronal excitation in the hypothalamus caused by GHRP-6, which lasts for approximately 3 hours after application, similar to GHRP-2. Because they increase GH release to a degree dependent on their application, any GH secretagogue used at an effective dose offers the benefits of GH. Increased collagen production, better cellular repair of internal organs, increased healing capability, increased energy, improved sleep, increased lean body mass, and reduced body fat are all documented effects of GH. However, unli ke the exogenous synthetic e. coli-derived 22kDa growth hormone in application, the resultant GH pulse from GHRP-6 lasts about three hours instead of eight. Overexposure to GH – that is, GH release that does not adhere to normal pulsatile rhythms of the body (a steeper curve, with a sharp peak and rapid decline) but instead lasts longer and does not reach the same amplitude (a shallow curve, with a slow rise and descent over eight hours) – results in cellular desensitization to the effects of GH. GH secretagogues do not result in cellular desensitization to GH in any quantity; the pituitary may stop responding to the signal the compounds indicate i f they are used in extreme quantities, but when administered up to every three hours GHRP-6 can result in supraphysiological levels of GH that are nonetheless reasonably safe, unlike exogenous GH.



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Each GH secretagogue – GHRP-2, GHRP-6, ipamorelin, hexarelin, etc – has unique properties beyond release of GH. As demonstrated in the rat, GHRP-6 does have some lipogenic properties that are additive but are dependent on insulin/glucose states. Granado et al find that “GHRP-6 and insulin exert an additive effect on weight gain and visceral fat mass accrual in diabetic rats, indicating that some of GHRP-6's metabolic effects depend on the insulin/glucose status.” [3] The rats who were administered GHRP-6 when insulin was quiet did not experience the same effects on adiposity and weight gain when compared to either group (insulin or insulin with GHRP-6). Delagado et al document that the most important unique effect of GHRP-6 could be a neuroprotective effect that is independent of the established IGF-1 pathway: Treatment of the fetal hypothalamic neuronal cell line RCA-6 with growth hormone-releasing peptide 6, an agonist of the ghrelin receptor, or insulin-like growth factor I activates intracellular signalling cascades associated with anti-apoptotic actions. Abnormally high concentrations of glutamate provoke over-excitation of neurons leading to cell damage and apoptosis. Thus, the aim of this study was to investigate whether the administration of growth hormone-releasing peptide 6 and insulin-like growth factor I attenuates monosodium glutamate-induced apoptosis in RCA-6 neurons and the mechanisms involved. Two different mechanisms are involved in glutamate-induced cell death, one by means of caspase activation and the second through activation of a caspase-independent pathway of apoptosis mediated by the translocation of apoptosis-inducing factor. Growth hormone-releasing peptide 6 partially reversed glutamate-induced cell death but not the activation of caspases, suggesting blockage of the caspase-independent cell death pathway, which included interference with the translocation of apoptosis-inducing factor to the nucleus associated with the induction of Bcl-2. In contrast, the addition of insulin-like growth factor I to RCA-6 neurons abolished glutamate-induced caspase activation and cell death. These data demonstrate for the first time a neuroprotective role for growth hormone secretagogues in the caspase-independent cell death pathway and indicate that these peptides have neuroprotective effects independent of its induction of insulin-like growth factor I.[4]

Referances: [1] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205. [2]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464. [3]Granado M, García-Cáceres C, Frago LM, Argente J, Chowen JA. The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status. Endocrinology. 2010 May;151(5):2008-18. May;151(5):2008-18. [4] Delgado-Rubín A, Chowen JA, Argente J, Frago LM. Growth hormone-releasing peptide 6 protection of hypothalamic neurons from glutamate excitotoxicity is caspase independent and not mediated by insulin-like growth factor I. Eur J Neurosci. 2009 Jun;29(11):2115-24.

13.11.5 13.11.5 Hexarelin Hexarelin Hexarelin belongs to a class of growth hormone secretagogues specifically known and referred to as Ghrelin mimetics or GHRPs. As opposed to GHRHs (growth hormone releasing hormones such as Sermorelin, Modified GRF 1-29, and CJC-1295), which are a separate class of growth hormone secretagogues, Ghrelin mimetics primarily increase growth hormone release in the somatotrophs within the pituitary. GHRHs, on the other hand, slighty increase somatotroph output while concurrently causing more somatrophs overall to release growth hormone. © 2012 Thatotherguy

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Ghrelin mimetics have been demonstrated in clinical environments to release more growth hormone than GHRHs in comparison studies. [2] Ghrelin mimetics are less susceptible to environmental, hormonal, and physiological factors that inhibit GHRH-induced GH release, such as somatostatin, fatty acids circulating in plasma, and timing of the natural rhythmic growth hormone pulse in the human body. [1] The most-studied Ghrelin mimetic peptides are GHRP-2, GHRP-6, hexarelin, and ipamorelin. Of these, ipamorelin is the least potent GH releasing compound but the compound that also has the least effect on cortisol and prolactin release. GHRP-6 is more potent with slightly more cortisol and prolactin release; GHRP-2 is more potent still; and hexarelin is the most potent of the four, with the most release of cortisol and prolactin as well. [3] Each of the Ghrelin mimetics has unique properties largely unrelated, in most cases, to effecting the release of growth hormone from the pituitary. Hexarelin "reduces i njury of cerebral cortex and hippocampus after brain hypoxia-ischemia in neonatal rats" according to one study; this effect may possibly be achieved with ghrelin, as well. [4] The ghrelin mimetics (GHRPs) are believed, as a whole, to potentially exert an antioxidant benefit on the testis by action involving the GHS-R type 1a present in Sertoli and Leydig cells; it may have antioxidant and anti-inflammatory effect through reduction of lipid peroxidation as well as increasing the activity of the body's three main antioxidant systems (superoxidate dismutase, glutathione peroxidase, and catalase), and may additionally protect spermatozoa from free radicals. [5] Pang et al found, regarding hexarelin's potential cardioprotective effects, that: GHS-R mRNA was abundantly expressed in cardiomyocytes and was unregulated after administration of hexarelin. These results suggest that hexarelin abates cardiomyocytes from ANG II-induced apoptosis possibly via inhibiting the increased caspase-3 activity and Bax expression induced by ANG II and by increasing the expression of Bcl-2, which is depressed by ANG II. [6] In a separate study, Pang et al found data leading them to believe that hexarelin may have potential benefits in humans for treating atherosclerosis: Hexarelin suppressed the formation of atherosclerotic plaques and neointima, partially reversed serum HDL-c/LDL-c ratio and increased the levels of serum NO and aortic mRNAs of eNOS, GHSR and CD36 in As rats. Hexarelin also decreased [(3)H]-TdR incorporation in cultured vascular smooth muscle cell (VSMC) and calcium sedimentation in aortic wall. Furthermore, foam cell formation induced by ox-LDL was decreased by hexarelin. In conclusion, hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in rats, possibly through up regulating HDL-c/LDL-c ratio, vascular NO production and downregulating the VSMC proliferation, aortic calcium sedimentation and foam cell formation. These novel anti-atherosclerotic actions of hexarelin suggest that the peptide might have a clinical potential in treating atherosclerosis. [7] Bresciani et al concluded, due to findings that hexarelin induces hunger in rats even with chronic use, that "hexarelin is endowed with long-lasting orexigenic activity and might represent a potential therapeutic approach for pathological conditions characterized by a decline in food intake." [8]

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[1]Penalva, A., Carballo, A., Pombo, M., Casanueva, F.F. and Dieguez, C. (1993) Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine pyridostigmine or hypoglycemia on GHRP- 6induced GH secretion in man. J. Clin. Endocrinol. Metab. 76, 168–171 [2]Bowers CY, Reynolds GA, Chang D, Hong A, Chang K, Momany F. A study on the regulation of GH release from the pituitary of rats, in vitro. Endocrinology 1981;108(3):1070–1079. [3]Ghigo, E., Arvat, E., Muccioli, G. and Camanni, F. (1997) Growth hormone releasing peptides. Eur. J. Endocrinol. 136, 445–460 [4]Liu Y, Wang PS, Xie D, Liu K, Chen L. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin J Physiol. 2006 Oct 31;49(5):244-50. [5]Kheradmand. Antioxidant enzyme enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia, Nov 2008, Volume 41, Issue 6, Pages 335-340 [6]Pang JJ, Xu RK, Xu XB, Cao JM, Ni C, Zhu WL, Asotra K, Chen MC, Chen C. Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis apoptosis in vitro. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1063-9. Mar;286(3):H1063-9. Epub 2003 Nov 13. [7]Pang J, Xu Q, Xu X, Yin H, Xu R, Guo S, Hao W, Wang L, Chen C, Cao JM. Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat. Peptides. 2010 Apr;31(4):630-8. Epub 2009 Nov 30. [8] Bresciani E, Pitsikas N, Tamiazzo L, Luoni M, Bulgarelli I, Cocchi D, Locatelli V, Torsello A. Feeding behavior during long-term hexarelin administration in young and old rats. J Endocrinol Invest. 2008 Jul;31(7):647-52. author -Unknown

13.11.6 13.11.6 Ipamoreli Ipamorelin n Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analog developed by Novo Nordisk[3]. Ipamorelin belongs to the most recent generation of GHRPs from the mid 1990s and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides).[1] The cells that produce and release GH are known as somatotropes. [2] Like GHRP-2 and GHRP-6, ipamorelin does not have ghrelin’s lipogenic properties. Like GHRP-2 and unlike GHRP-6 ipamorelin never induces hunger in mammals. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1] The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2] There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6. Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Raun et al demonstrated the selectiveness of ipamorelin for GH release only in a study: The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth © 2012 Thatotherguy

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hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.[3] Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose. Further, a mega-dose of ipamorelin results in a concomitant mega-release of GH (up to the entire amount present in the pituitary), whereas GHRP-2 and GHRP-6 have limits of approximately 1mcg/kg in humans for their maximal GH release.[4,5]

References: [1] Bowers CY, Momany F, Reynolds GA. In vitro and in vivo activity of a small synthetic peptide with potent GH releasing activity. 64th Annual Meeting of the Endocrine Society, San Francisco, 1982, p. 205. [2]Bowers CY, Momany F, Reynolds GA, Sartor O. Multiple receptors mediate GH release. 7th International Congress of Endocrinology, Quebec, Canada, 1984, p. 464. [3] Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):55261. [4] Brosnan-Cook, M. et al. (1998) Iontophoretic delivery of ipamorelin, a growth hormone secretagogue. Proceedings of 80th Annual Meeting Endocrine Society, New Orleans, USA. Abstract Pp1-186. [5] Jogarao V S Gobburu; Henrik Agerso; William J Jusko . Pharmacokinetic-Pharmacodynamic Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide in Human Volunteers. Lars Ynddal Pharmaceutical Research: Sep 1999; 16, 9; ProQuest Nursing & All ied Health Source p. 1412.

13.11.7 13.11.7 Melanota Melanotan n II Melanotan II belongs to a group of peptides called the melanotropin peptides. Other peptides belonging to this group are ACTH (adrenocortropic hormone) and the melanocyte-stimulating hormones (MSH). Classification, Actions, Mechanisms:



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The MSHs contribute to pigmentation and also play a role as a hypothalamic satiety signal [1]. Melanocortins also have been demonstrated to play a role in lipolysis of adipocytes, thermal control, sexual function, and cognition [1, 2]. Further, leptin exerts its action partly by activation of the melanocortin system in the brain [3]. Further, the MCR (melanocortin receptors), to which MTII binds, play a key role in eating behavior in humans [3]; Perboni et al write: MC4R activity affects meal size and meal choice but not meal frequency, with the type of diet affecting the efficacy of MC4R agonists to reduce food intake [3]. Dorr, et al, demonstrated in a pilot trial study using human subjects that significant change in pigmentation (specifically, darkening) occurred after just five applications of MTII (applied every other day via subcutaneous injection) as measured by visual perception as well as by quantitative reflection [5]. They also noted that penile erection consistently occurred concomitantly with " stretching and yawning" between one and five hours after application of MTII in males via subcutaneous injection [5]. Mild nausea was observed at most MTII dosage levels, although no treatment was required and all subjects opted to continue the trials for the duration of the two-week study [5]. Wessells et al concluded that "Melanotan-II is a potent initiator of erections in men with psychogenic erections in men with psychogenic erectile dysfunctions and has manageable side effects at a dose of 0.025mg/kg" based on the findings of their study that: In 8 of 10 men treated with Melanotan-II clinically apparent erections developed. Mean duration of tip rigidity greater than 80% was 38.0 minutes with Melanotan-II and 3.0 with placebo (p=0.0045). Transient side effects of nausea, stretching and yawning, and decreased appetite were reported more frequently after injections of Melanotan-II than placebo but none required treatment" [6]. The unique combination of effects, i.e. penile erection in addition to the hunger/satiety modulation properties, of Melanotan II as demonstrated in clinical trials renders it "complicate[d]" in applied treatment of obesity [3]. The CNS/MCR system plays a role in controlling adiposity through nutrient partitioning as well as cellular lipid metabolism independent of nutrient intake [3]. Pharmacologically inhibiting MCR in rats, and genetically di srupting MCR4 expression in mice, has resulted in lipid uptake, triglyceride synthesis, and fat accumulation in white adipose tissue "directly and potently." Conversely, increased CNS-MCR signalling increases lipid mobilization [3]. On the topic of MTII as a potential obesity treatment agent, Perboni et al write: MC3R has been suggested to play a role in nutrient partitioning. Although agonists of the MC3R would not be expected to produce dramatic weight l oss, they may favor a more beneficial partitioning of nutrients ... development of dual MC4 and MC3 receptor agonists has been addressed in order to reduce weight dramatically, as well as improve the metabolic co-morbidities of obesity significantly [3]. Melanotan II binds to both of these receptors. Of a study performed on rats, Banno summarizes: ...data showed that food intake and body weight were decreased by chronic administration of MTII and that insulin sensitivity as well as glucose tolerance was improved by MTII in those rats. The serum TG [triglyceride] levels were also decreased by MTII, and these effects persisted for at l east 25 days. Thus, our data demonstrated that melanocortin agonists administered peripherally ameliorated obesity, insulin resistance and hypertriglyceridemia in OLETF rats [4]. Banno et al also refer to other data, and synthesize these data with their own to conclude, similarly to Perboni, that "melanocortin agonists [such as MTII] could well be a promising treatment for obesity in humans": ...[in a study on humans,] there was not full compensation in food intake, and body weight remained significantly lower for about a month i n the present study. These data suggest that melanocortin agonists could well be a promising treatment for obesity in humans...administration humans...administration of MSH/ACTH410, a MC4R agonist, was shown to decrease body weight and body fat in healthy and normal weight humans without apparent side effects [4].


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Conclusion: Trends in current research suggest that Melanotan II and other MSHs will likely be implemented in various capacities for treatment of obesity, metabolic syndrome, and comorbid disorders. While trials for various delivery systems are underway for MTII and similar peptides to be used for treatment of erectile dysfunction and for aesthetic purposes (harnessing the well-known pigmentation properties of the MSHs), FDA approval for treatment of more serious issues such as the abovementioned is more likely. The MSH are unique in their disparate and broad actions in the body.

references: [1] Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, et al. Cyclic lactam alphamelanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating alpha-melanocyte-stimulating hormone-(4–10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J Med Chem 1995;38(18):3454–61. [2] Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY. PT- 141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci 2003;994:96–102. [3] PEPTIDES IN ENERGY BALANCE AND OBESITY (Book), Gema Frühbeck (ed.), CAB International 2009, Subsection: Anorexigenic Peptides, Perboni, S., Ueno, G., Mantovani, and Inui, A. pp. 45-47 [4]Banno R. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides Volume 25, Issue 8, August 2004, pp. 1279-1286 [5]Dorr R.T., Lines R, Levine N., Brooks C., Xiang L., Hruby V.J., Hadley M.E. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci, 1996;58(20), pp.1777-84. [6] Wessells H., Fuciarelli K., Hansen J., Hadley M.E., Hruby V.J., Dorr R., Levine N. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J Urol. 1998 Aug;160(2): pp. 389-93.

13.11.8 13.11.8 Modified Modified GRF 1-29 In the healthy human body, large amounts of growth hormone are stored in the pituitary. The cells within the pituitary release growth hormone in response to signaling by GHRH (Growth Hormone Releasing Hormone), Ghrelin (of which GHRPs - Growth Hormone Releasing Peptides - are mimetics), and are inhibited from releasing these stores by Somatostatin. GHRH and Ghrelin act on different populations of somatotropes (GH releasing cells). GHRP/Ghrelin increases the number of somatotropes releasing GH but not the amount released by each cell; GHRH affects both the number of secreting cells and - more so - the amount they each secrete. [1] GHRH and Ghrelin are released in specific patterns that vary depending on event and environment: post-exercise, in response to slow wave sleep, in certain stages of life l ife and physical development, and so on. Most people (even the diseased) continue to possess the ability to make GH in the pituitary. The problem is in the signalling of the pituitary to release it and make more. Even most people with diseases that affect growth hormone secretion retain the ability to continue to make GH in their pituitaries. The disease states and symptoms result, most typically, in altered (dysfunctional) GH release signaling and this also affects the ability of the pituitary to continue to make more GH. [2] Endogenous-type GHRH, which has a forty-four amino acid long chain (and a specific shape - thus © 2012 Thatotherguy


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making it a peptide as well as a hormone), has been marketed for the longest as Sermorelin in comparison to the other GHRH-type peptides. However, Sermorelin has been demonstrated to be degraded rapidly in the body and is cost-inefficient. But because most patients in need of GH therapy do retain the ability to produce and secrete their own GH, treatment with a GHRH-type analog remained hypothetically preferable to exogenous GH treatment. GH itself when administered exogenously results not only in "unnatural" release patterns, it results universally in down regulation of endogenous GH production - as do many hormones when applied exogenously.[3] Sermorelin's limitations naturally resulted in a variety of formulations of GHRH analogs for therapeutic usage. CJC-1295, discussed in another article, is a GHRH analogue with attached MPA (aka DAC), binds to albumin in the bloodstream and circulates for a week or longer. Modified GRF 1-29, which is also called D-Ala2-GHRH-(1-29), [Nle27]-hGHRH(1-29)-NH2, GHRH (1-29)NH2, or ModGRF1-29, is the bioactive portion of GHRH(1-44) with fifteen amino acids subtracted and four amino acids replaced at the weakest points in the peptide structure. Soule et al write that "D-Ala2 substitution contributes to the enhancement of biological activity by reducing metabolic clearance." [3] In a comparison study with synthetic exogenous GH for treating prepubertal GH deficiency, Lanes and Carillo concluded that "GHRH (1-29) at the dose and schedule used is generally effective in the treatment of GH deficiency." [4] Campbell et al explain both GHRH(1-44)'s shortcomings in treatment as well as advantages offered by Modified GRF (1-29) and specific structural differences: Native human GRF(1-44)-NH2(hGRF44) is subject to biological inactivation by both enzymatic and chemical routes. In plasma, hGRF44 is rapidly degraded via dipeptidylpeptidase IV (DPP-IV) cleavage between residues Ala2 and Asp3. The hGRF44 is also subject to chemical rearrangement (Asn8->Asp8, beta-Asp8 via aminosuccinimide formation) and oxidation [Met27-->Met(O)27] in aqueous environments, greatly reducing its bioactivity. It is therefore advantageous to develop long-acting GRF analogues using specific amino acid replacements at the amino-terminus (to prevent enzymatic degradation): residue 8 (to reduce isomerization) and residue 27 (to prevent oxidation). Inclusion of Ala15 substitution (for Gly15), previously demonstrated demonstrated to enhance enhance receptor binding affinity, would would be predicted to improve GRF analogue potency. Substitution of [His1,Val2]-(from the mouse GRF sequence) for [Tyr1,Ala2]-(human sequence) in [Ala15,Leu27]hGRF(1-32)-OH [Ala15,Leu27]hGRF(1-32)-OH analogues completely inhibited (24-h incubation) DPP-IV cleavage and greatly increased plasma stability in vitro. Additional substitution of Thr8 (mouse GRF sequence), Ser8 (rat GRF sequence), or Gln8 (not naturally occurring) for Asn8 (human GRF sequence) resulted in analogues with enhanced aqueous stability in vitro (i.e., decreased rate of isomerization). These three highly stable and enzymatically resistant hGRF(1-32)-OH analogues, containing His1, Val2, Thr/Gln8, Ala15, and Leu27 replacements, were then bioassay for growth hormone (GH)-releasing activity in vitro (rat pituitary cell culture) and in vivo (SC injection into pigs). Enhanced bioactivity was observed with all three hGRF(1-32)-OH analogues. In vitro, these analogues were approximately threefold more potent than hGRF44, whereas in vivo they were eleven- to thirteen fold more potent.[5] Just as GHRH and Ghrelin work in conjunction through different means for maximal GH release within the body, exogenous GHRH such as Modified GRF (1-29) results in a synergistic effect when used with a Ghrelin mimetic, such as the hexapeptide known as GHRP-6. [6] Pandya et al also conclude that "GHRH is necessary for most of the GH response to GHRP-6 in humans." [6] Massoud et al conclude that "Hexarelin and GHRH-(1-29)-NH2 are synergistic" [7] (Ed note: Hexarelin is another Ghrelin mimetic). Sawada writes that "findings suggest that the KP-102-induced GH secretion largely depends on GRF and the secretagogue potentiates the GRF effect by antagonizing the SS action at the level of somatotropes. It is concluded that KP-102 alone or in combination with GRF provides a means of © 2012 Thatotherguy

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stimulating GH secretion in the face of elevated inhibitory tone mediated by SS." [8] (Ed note: KP-102 is the Ghrelin mimetic GHRP-2) An abstract of a review by Hamilton touches on the main main advantage of GRF(1-29) GRF(1-29) over, for for example, CJC-1295 or synthetic GH: Growth hormone secretion occurs in a rhythmic pattern regulated by intricate interactions between two neurohormones: growth hormone-releasing hormone (GHRH) and somatotropin release-inhibiting factor (SRIF).[...] research also indicates that there are sexual differences in the pattern of growth hormone release and that growth hormone regulates its own secretion by means of a negative feedback system. [9]

By mimicking natural release patterns with properly dosed and timed GHRPs (Ghrelin mimetics) and GHRH-analogues, negative feedback and undesirable side effects that are typically seen in synthetic GH therapy or even with past forms of GHRH administration (such as constant low-dose administration via pump) can be avoided. For achieving ends other than restoring natural GH release in diseased patients, optimized rhythmic or pulsatile dosing of GHRH with or without a GHRP may be useful, as Vittone et al write about their findings on GHRH applied to healthy elderly men: Data suggest that single nightly doses of GHRH are less effective than multiple daily doses of GHRH in eliciting GH- and/or IGF-I-mediated effects. GHRH treatment may increase muscle strength, and it alters baseline relationships between muscle strength and muscle bioenergetics in a manner consistent with a reduced need for anaerobic metabolism during exercise. Thus, an optimized regimen of GHRH administration might attenuate some of the effects of aging on skeletal muscle function in older persons.[10]

references: [1] Lewis UJ. Growth hormone: what is it and what does it do? Trends Endocrinol Metab 1992;3:117– 121 [2] J Izdebski, J Pinski, JE Horvath, G Halmos, K Groot and AV Schally. Synthesis and Biological Evaluation of Superactive Agonists of Growth Hormone-Releasing Hormone. Proceedings of the National Academy of Sciences, Vol 92, 4872-4876. [3] Soule S, King JA, Millar RP. Incorporation of D-Ala2 i n growth hormone-releasing hormone-(1-29)NH2 increases the half-life and decreases metabolic clearance in normal men. J Clin Endocrinol Metab. 1994 Oct;79(4):1208-11. Oct;79(4):1208-11. [4]Lanes R, Carrillo E. Long-term therapy with a single daily subcutaneous dose of growth hormone releasing hormone (1-29) in prepubertal growth hormone deficient children. J Pediatr Endocrinol. 1994 Oct-Dec;7(4):303-8. [5] Campbell RM, Stricker P, Miller R, Bongers J, Liu W, Lambros T, Ahmad M, Felix AM, Heimer EP. Enhanced stability and potency of novel growth hormone-releasing factor (GRF) analogues derived from rodent and human GRF sequences. Peptides. 1994;15(3):489-95. [6]Pandya N, DeMott-Friberg R, Bowers CY, Barkan AL, Jaffe CA. Growth hormone (GH)-releasing © 2012 Thatotherguy


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peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation. J Clin Endocrinol Metab. 1998 Apr;83(4):1186-9. [7]Massoud AF, Hindmarsh PC, Matthews DR, Brook. The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity. Clin Endocrinol (Oxf). 1996 May;44(5):555-62. [8] Sawada H. Effect of newly developed analogue of growth hormone releasing peptide [D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102)] on growth hormone secretion in adult male rats (Trans. from Japanese). Nippon Ika Daigaku Zasshi. 1995 Apr;62(2):142-9. [9] Hamilton J. A question of rhythm: recent advances in growth hormone research. CMAJ. 1995 Sep 1;153(5):585-8. [10] Vittone J, Blackman MR, Busby-Whitehead J, Tsiao C, Stewart KJ, Tobin J, Stevens T, Bellantoni MF, Rogers MA, Baumann G, Roth J, Harman SM, Spencer RG. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 1997 Jan;46 (1):89-96.

13.11.9 Sermorelin - synthetic synthetic version of the peptide peptide hormone GHRH Sermorelin is a synthetic version of the peptide hormone GHRH and can be considered interchangeable where acute effects of either are studied. Sermorelin is also referred to as GHRH (129) or GRF 1-29 because the peptide chain contains 29 aminos as opposed to the 44 in native GHRH. Native GHRH is produced in and released from the hypothalamus. GHRH causes the anterior pituitary’s somatotropes to release growth hormone, and also directly (by other mechanisms) promoted slow-wave sleep.[1] GHRH is released in pulses in the body that alternate with corresponding pulses of somatostatin or growth-hormone inhibiting-hormone. Somatostatin causes the pituitary to cease release of growth hormone. Ghrelin, released from the gut which circulates and acts as a hunger hormone, has synergistic activity in the body with GHRH and also suppresses somatostatin to make way for the GHRH pulse. If exogenous GHRH (sermorelin) is administered when somatostatin is active, it has no effect. Another difference between GHRH and sermorelin is that while an acute dose of either has the same effect, the pulse pattern of native GHRH – longitudinal release or release over time – is different from a single administration of sermorelin. To compensate for this difference in studies and in clinical uses, multiple injections of sermorelin are used, or sometimes sermorelin is administered from an intravenous pump device. The effectiveness of peptides such as sermorelin for GH replacement therapy is generally greater than that of exogenous synthetic 22kDa growth hormone, attributable primarily to the pulsatility of the GH release induced (3 hour duration as opposed to 8 hour duration), or “spontaneity” as Lebl’s Czech study refers to it: BACKGROUND: Treatment with growth hormone (GH) restores the natural growth rate in children with growth hormone deficiency (GHD). This is, however, achieved only after daily injections extending over many years and therefore daily short-term hypersomatotropinaemia. hypersomatotropinaemia. Stimulation of endogenous secretion of GH e.g. by oral administration of growth hormone-releasing peptide (GHRP) may help in future to eliminate these adverse aspects. This treatment could be beneficial in patients with a stimulable endogenous GH secretion. METHODS AND RESULTS: In order to find potential candidates for spontaneous secretion of GH the authors examined, using a test with sermoreline (GHRH129NH2), 31 children (21 boys) aged 5.8-16.5 years suffering from idiopathic (GHD), previously treated by daily GH injections. GH rose after stimulation with sermoreline to more than 14 mIU/l in 18/31 children (responders). The ratio of "responders" was higher in the sub-group of children with isolated GHD, as compared with multiple pituitary deficiency (p = 0.05) and insignificantly higher in the subgroup of children born by breech delivery (p = 0.13). CONCLUSIONS: More than half the children treated nowadays with GH could profit in future from the method of spontaneous GH secretions. The © 2012 Thatotherguy

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success of this procedure is more likely in children with isolated GHD and in breech delivered children. [2] Because GH release varies greatly from person to person and in different life stages, and because different persons have different levels of cellular sensitivity to GH, one test used by practitioners to test for GH deficiency in short-stature children is to measure plasma blood levels and then administer GHRH and retest, in order to compare the “baseline” to an optimized release pattern for that particular individual: Sermorelin is a well tolerated analogue of GHRH which is suitable for use as a provocative test of growth hormone deficiency when given as a single intravenous 1 microg/kg bodyweight dose in conjunction with conventional tests. Limited data suggest that once daily subcutaneous sermorelin 30 microg/kg bodyweight is effective in promoting growth in some prepubertal children with idiopathic growth hormone deficiency.[3] Future therapies will likely include combined use of one of several GHRPs as well as sermorelin or a similar analog due to the necessity of inhibiting somatostatin for GHRH to work, as well as due to the overall synergy and efficacy as demonstrated in the following study by Pandya et al (note that endogenous GHRH is somewhat interchangeable with exogenous, if one adjusts to mimic release patterns in regards to administration of the synthetic version): GH-releasing peptide-6 (GHRP-6) is a potent GH secretagogue that releases GH by uncertain mechanisms. To assess whether GHRH is required for GH release by GHRP-6 in humans, we used the specific antagonist to GHRH (N-Ac-Tyr1,D-Arg2)GHRH(1-29)NH2 (N-Ac-Tyr1,D-Arg2)GHRH(1-29)NH2 (GHRH Ant). We have previously shown that GHRH-Ant (400 microg/kg) blocked the GH response to 0.33 and 3.3 microg/kg boluses of GHRH by 95% and 81%, respectively. Nine healthy men between the ages of 20 and 30 yr were studied on two occasions. They received either saline or GHRH-Ant (400 microg/kg, i.v.) at 0840 h, followed by GHRP-6 (1 microg/kg, i.v. bolus) at 0900 h. Blood was sampled every 10 min from 0800-1100 h. GH responses were measured as the maximal increase over the baseline GH concentration and as the area under the curve. GHRH-Ant eliminated most of the GH response to GHRP-6 [maximal increase over the baseline GH concentration, 33.8 +/- 4.8 vs. 6.2 +/- 1.8 microg/L (mean +/- SEM; P < 0.0001); area under the curve, 1701 +/- 278 vs. 376 +/- 113 microg/min x L (P < 0.001)]. These data show that endogenous GHRH is necessary for most of the GH response to GHRP-6 in humans.[4]

References: [1] Obál F, Krueger J (2001). "The somatotropic axis and sleep.". Rev Neurol (Paris) 157 (11 Pt 2): S12–5. [2] Lebl J, Pechová M. [Stimulation of endogenous secretion of the growth hormone. Today in diagnosis, tomorrow in therapy?] Cas Lek Cesk. 1995 Jun 14;134(12):371-3. [3] Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. [4] Pandya N, DeMott-Friberg R, Bowers CY, Barkan AL, Jaffe CA. Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation. J Clin Endocrinol Metab. 1998 Apr;83(4):1186-9. Author unknown



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Chapter 12: Profiles Reference information.

14.1

Anti-Estrogens

14.1.1 14.1.1 Anti-E Anti-Estr stroge ogen n produc products ts When talking about all the benefits of anabolic steroids I think it is important to take a moment to talk about side effects and how to prevent them. The biggest source of steroid related side effects comes from the impact anabolic steroids have on your body's production of estrogen. So, here is a quick biochemical over-view of estrogen. Estrogens regulate the growth, differentiation, and functioning of diverse target tissues, both within and outside of the reproductive system. Most of the actions of estrogens appear to be exerted via the estrogen receptor (ER) of target cells, an intracellular receptor that is a member of a large super family of proteins that function as ligand-activated transcription factors, regulating the synthesis of specific RNAs and proteins. This process is almost identical to the action by which anabolic steroids affect protein synthesis. Estrogen is also a steroid hormone, although not used for athletic enhancement. However, estrogen plays a key role in i n the use of AAS. Certain steroids, at high enough dosages, can convert via the enzyme aromatase into other hormones; in the case of testosterone-based steroids this other hormone is usually estrogen. Steroids with a dihydrotestosterone (DHT) base are not subject to aromatization; as a metabolite of testosterone its structure is not affected by the aromatase. Steroids with 17-alkylated structures generally convert into weaker estrogens. Some steroids, such as nandrolone (deca-durabolin) or trenbolone convert into progesterone. High dosages of steroids for prolonged periods also shut down the body's natural production of certain hormones (particularly testosterone) when steroid therapy is stopped the body attempts to establish homeostasis by adjusting hormonal levels. The average ratio of testosterone to estrogen in a healthy male is 100:1. When drugs increase the testosterone in the body, the body will respond by increasing the estrogen in the body. Additionally, estrogen circulates in the body bound to the protein SHBG (sex hormone binding globulin) as does the testosterone. SHBG is produced in the liver and use of steroids increases the production of this protein; which has a very high receptor affinity for testosterone. With more SHBG in the body, more testosterone is bound, becoming inactive as only free testosterone can activate an androgen receptor. SHBG, however, has poorer receptor affinity for estrogen and more active free estrogen circulates in the body, further altering the hormonal balance. These effects of steroids (i.e. the potential for conversion into estrogen, as well as the disruption of the hormonal balance in the body) can cause serious side effects in male users. So, steroid users seek ways to block this estrogen from affecting them. That is all a very nice and formal way of saying that you need to be taking anti-estrogens when you are using steroids. See, without the anti-estrogens you get all sorts of pleasant side effects, not limited to a nice pair of breasts (with oh -so tender nipples) and extra body fat! This article will explore how to effectively use anti-estrogens to prevent many of the side effects that accompany anabolic steroid use. These Drugs Are Your Friends Oral clomiphene citrate (Clomid) is an ovulation stimulant used to treat ovulatory failure in women. Oral tamoxifen citrate (Nolvadex) belongs to a class of antineoplastics called antiestrogens. It is used to treat breast cancer. Body builders use both of these drugs. Why on earth would they do that? The answer is that both of these drugs are anti-estrogens. The term anti-estrogen is a little inaccurate. This class of pharmaceutical does not engage in some sort of matter/anti-matter matter/anti-matter reaction, annihilating estrogen in a blinding burst of anabolic goodness. Rather, let us think of the classical anti-estrogen drugs (such as nolvadex and clomid) as estrogen receptor antagonists (ERA). These ERAs are chemicals that are close enough in i n structure to estrogen to fit into the estrogen receptor site; however © 2012 Thatotherguy

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these chemicals do not have the same chemical effect as estrogen. The result is that any estrogen produced by the body or exogenous estrogen cannot find an open receptor site to attach to. The freefloating estrogen then presents far less problems to homeostasis. There is a lot of conflict over using nolvadex, clomid and other ERAs. The regulation of estrogeninduced cellular effects is a multi-step molecular process. The diversity of estrogen and anti-estrogen effects on cellular functions is also modulated by tissue and gene specificity. This diversity of reaction may be explained by different levels of molecular regulation, including the presence of two distinct estrogen receptor isoforms (ER alpha and ER beta), their binding to activator or co-repressor transcriptional proteins, and their affinity to different DNA binding domains of target genes (estrogen responsive element or API). These mechanisms may account for the specific responses to estrogens or anti-estrogens according to tissue, cell or gene level. Therefore, in English, a drug like nolvadex, which targets breast tissues, is going to do a better job of preventing gynecomastia than is clomid. However clomid has the benefit of boosting the levels of follicle stimulating hormone, which helps restore the bodies natural testosterone levels and protects against testicular atrophy. Many people stop using their ERA drugs when they end the cycle. That is a terrible idea. Clomid, as we have already discussed, helps immensely with your recovery processes. But remember, there is almost always an estrogen backlash to having been using testosterone drugs for so long. Therefore, many symptoms of high estrogen levels appear after the cycle. I would continue to use both Clomid and Nolvadex for up to 3 weeks after the last of the drugs have left your body. Remember, if on Friday you take 500 mg of a longer acting drug like Sustanon, then don't consider the following few weeks as truly off time. That is why it is important to know how long the drugs are effective in your body and yet another reason to switch to faster acting drugs in the last few weeks of a cycle. Effective dosages of these two drugs are debated. I personally would use the two drugs be used together, Nolvadex at 20 mg per day, and clomid at 50 mg per day. If Nolvadex is used by itself, 20-40 mg are sufficient. 50-100 mg of clomid can be used if clomid is the only ERA drug. Clomid should be used for two weeks after the last l ast steroid injection to help return your body to its natural hormonal state. Nolvadex and Clomid are not expensive, but very available because they are not scheduled drugs and can be legally imported. There is a second class of drug used to combat estrogen side effects from what is grandly called steroid therapy; there are aromatase inhibitors. As mentioned previously in this chapter, the body can convert testosterone into estrogen using the enzyme aromatase. This second group of drugs, which I will call the inhibitors, prevents this process from occurring at all. This class of medication is generally only prescribed for severe conditions and is generally more expensive then any of the ERA. Teslac, (testolactone), has fallen out of favor for several reasons. First of all, almost one gram daily is needed to achieve sufficient estrogen synthesis inhibition. This makes this a very expensive drug to use. Also, it is currently a scheduled drug because it is a testosterone derivate. Cytadren (aminoglutethimide) is a better choice, requiring dosages of between 250-500 mg per day to suppress estrogen synthesis. 250mg cytadren doesn't cause significant desmolase inhibition, so there would still be cortisol and other steroids, while estrogen is minimized! Cytadren is used therapeutically to combat Cushing's syndrome because it also interferes with the body's ability to synthesis cortisol. Sounds like fun, huh ... no cortisol, no estrogen. Perfect you say, well not really remember Andreas Munzer! Cytadren can cause cysts as well as effect things like blood clotting. It is reported that Munzer used 1-2g(!) of cytadren/day! Therefore cytadren use should be done with precision. Arimidex (anastrozole) is a drug designed to to combat second stage breast cancer. cancer. It is an extremely extremely potent drug; one pill per day is i s sufficient to almost entirely inhibit estrogen in the body. Its costs have come down thanks to the production of this product in many underground pharmacies. The final conclusion about inhibitors is that these are far more powerful drugs then the ERA. All the © 2012 Thatotherguy

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drugs listed above effect a much wider hormonal spread then the anti-estrogens and they are also going to cost you a lot more. Of all the drugs mentioned, I think that Arimidex is the most useful drug for the body builder. Cytraden was promoted particularly because of its anti-catabolic ability to suppress cortisol. But, this product is a double-edged sword. Too little cortisol is painful to the joints and in the end, extremely dangerous. I would not recommend the use of cytadren, but I have mentioned moderate dosage schemes which have been used by friends with no ill effect. Clomid - Taken daily during a cycle as an anti-estrogen, dosages range between 50-100 mg per day if used exclusively. If combined with Nolvadex, 50 mg per day is sufficient. Nolvadex - If used alone then 20-40 mg are needed. Some athletes, because of evidence that it negatively impacts various growth factors in the body, dislike this drug. If combined with clomid, 10-20 mg are sufficient. Proviron - This drug binds to androgen receptors but is also helps prevent excess testosterone from converting into estrogen. I consider this effective when stacked with either clomid or nolvadex. 1 pill will do if combined with either 50 mg of clomid or 20 mg or nolvadex. On its own, I suggest at least 2 pills. Arimidex - This is a very potent drug that prevents prevents the body from from converting testosterone into estrogen. The drawback is that is very expensive. The minimum effective dosage is around between a quarter and a half of a milligram/day. This drug does not need to be combined with any other during the cycle; however I recommend you begin using arimidex two weeks prior to commencing your cycle so that the drug can effectively eliminate the enzyme that permits conversion of testosterone to estrogen. Now the bad part! - The scientific evidence that gave rise to this whole dispute is that in addition to its anti-estrogenic action requiring estrogen receptors (ER) and leading to growth arrest of breast cancers, studies have previously shown that the anti-hormone tamoxifen (nolvadex) is able to block EGF, insulin and IGF-I mitogenic activities in total absence of estrogens. Thus the excessive use of anti-estrogens will actually result in a loss of some of the most anabolic of hormones (insulin and insulin-like growth factor 1). Steroid antagonists can inhibit not only the action of agonist ligands of the receptors they are binding to, but can al so modulate the action of growth factors by decreasing their receptor concentrations or altering their functionality. Bottom line is: Yes, you are probably compromising your anabolic state a bit by using ERA. But does that mean they shouldn't be used? I've heard statements so ridiculous as "Don't use anti-estrogens, they cut into your gains and cost too much." Lovely, just brilliant, like needing surgery to remove the tumors from your pecs isn't going to cut into your workouts or your gains and possibly ruin the look of your chest in the process with scarring and possibly muscle tissue removal too.

14.2

Steroid Profiles More Profiles to come in next version.

14.2 14.2.1 .1 1-Te 1-Test stos oste tero rone ne Pharmaceutical Name: Dihydroboldenone Chemical Names: 17beta-hydroxyandrost-1-en-3-one, 17beta-hydroxyandrost-1-en-3-one, 5alpha-androst-1-en-3-one, 5alpha-androst-1-en-3-one, 17beta-ol Active Life: depends depends on the ester utilized Anabolic/Androgenic Ratio: Ratio: 200/100

Dihydroboldenone, most commonly known as 1-testosterone, is a 5alpha reduced form of the steroid boldenone. This lack of 5alpha reduction with the compound allows users to administer it without © 2012 Thatotherguy


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suffering the negative side effects associated with this chemical reaction but also eliminates the benefits as well. Boldenone is not the only steroid that shares similarities with dihydroboldenone. In fact dihydroboldenone is chemically identical to the drug methenolone except for the 1-methylation that is apart of methenolone (1). 1-methylation was of course added to methenolone to make it more available when taken orally and thus dihydroboldenone is not efficiently utilized when administered orally, although it was once sold over the counter in tablet and pill form. Some of these over the counter preparations of the drug were done utilizing a delivery system similar to Andriol, i.e. producing an oil-solubilized product with dihydroboldenone. This would still not be a relatively worthwhile system of delivery to use however if one wanted to maximize the potential of the compound. Intramuscular injection is by far the most efficient method of administration to use as with most anabolic steroids. As mentioned above, above, dihydroboldenone is structurally similar to methenolone methenolone and boldenone and less so to testosterone despite the commonly used name for it, 1-testosterone. For this reason some female athletes may be inclined to use the drug as well. The potential for development of symptoms of virilization still remain but are not as severe as with synthetic testosterone or other harsher drugs. This is not to say however that dihydroboldenone is a mild drug. To simplify the explanation of exactly what the drug is, it is to boldenone as dihydrotestosterone (DHT) is to testosterone. This would explain why the effects of the drug, both positive and negative, are so dissimilar to those of boldenone. Like testosterone and dihydrotestosterone, dihydrotestosterone, a portion of the boldenone that a user administers converts to dihydroboldenone. Also similarly, dihydroboldenone like dihydrotestosterone dihydrotestosterone does not convert to anything else past that compound. Dihydroboldenone, while not overly androgenic, is a potent anabolic. It has been demonstrated that the drug binds extremely well and selectively to the androgen receptor and stimulates androgen receptor transactivation of dependent reporter genes (2, 3). This equates to a drug that possesses the ability to stimulate significant muscle growth while not producing androgenic side effects. It has been shown to be by far more anabolic then such compounds as boldenone, nandrolone, and even testosterone itself. Obviously this is of great benefit to many athletes. Anecdotally some users have indicated indicated that post-injection post-injection pain with dihydroboldenone can become an issue for some. Diluting the drug with either another injectable drug or some other type of sterile oil seems to alleviate at least some of this discomfort. The type of ester used does not appear to negate this pain for the users that experience it however. Indeed dihydroboldenone is available in numerous different esters. Cypionate, Ethyl Carbonate, Propyl Carbonate, and Propionate, among others, are all available for use wi th the drug. As always each does not offer any real advantages over one another other then the obvious differing active lives that each presents and the amount of time that it takes for the body to completely eliminate the drug from it (4). For the most part users will want to have their choice dictated by the i njection frequency with which they want to deal with when using the compound, but of course they will also likely be limited by those that are made available to them. Use/Dosing As for the duration with which dihydroboldenone can be run, due to the mild nature of the drug extended use of the compound can be completed with little in the way of serious complications arising. There are no major issues with hepatoxicity or severe kidney stress and the effect it has on other vital health markers such as blood pressure is slight in the majority of users. As for specific dosages used with this this drug, the low end is primarily thought thought to be three three hundred to four hundred milligrams per week for male users. Like all drugs this number will vary from user to user and also depends on how much of a dramatic effect a user will want to achieve with the drug. As for the highest doses that would be worthwhile for users to attempt, this again depends on a number of variables. Doses of one gram per week are not uncommon for some users with others attempting doses in excess of this. It will always come back to how much one is willing to administer and at what point do the positives of increasing your doses begin to be outweighed by the negatives. © 2012 Thatotherguy

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For females the usual rules apply with dihydroboldenone as they do with other drugs. These are namely starting out with short esters if possible so that if side effects begin to become too severe discontinuation of the drug can begin immediately and low doses should be administered at the beginning of the cycle and can be increased once the tolerance of the user is gauged. Anywhere from twenty five to one hundred milligrams per week would be a good starting point for the majority of female users who have little to moderate experience with anabolic drugs. As stated earlier, earlier, for the frequency of dosing dosing with dihydroboldenone it of course depends on the ester used with the compound. Seemingly the most popular current ester to produce the drug with is cypionate. No matter what ester utilized however the same rules would apply as with any other drug in terms of the frequency of administration needed to maintain relatively stable blood levels of the compound. Risks/Side Effects As previously indicated indicated dihydroboldenone does does not aromatize aromatize and therefore therefore estrogenic side effects such as gynecomastia and water retention are not a concern for users. This is partly due to the drug being incapable of 5alpha reduction. Also, androgenic side effects would also be extremely infrequent for most users as there is little in the way, in terms of attributes of the drug, to produce these. These include such things as acne and hair loss, although it appears to have the potential to cause prostate enlargement. This potential for prostate growth is actually similar in frequency and severity as with that of testosterone propionate (2). With the positive aspects of the lack of aromatization associated with dihydroboldenone also come the negative ones. Fortunately these are primarily limited to such symptoms as lethargy, malaise and possibly a reduction in sex drive. These are caused by a lower ratio of estrogen in comparison to androgens in the body. For the most part however this effect is relatively slight and can be avoided with the use of steroids that do aromatize in conjunction with dihydroboldenone and thus restore a better balance in terms of androgens versus estrogen. It also appears that the administration of dihydroboldenone may result in an increase in liver weight (2). This effect occurred when administering the drug orally but should also be true of the drug when administered via intramuscular injection. There is no research to indicate this however. Other common negative side effects associated with the use of anabolic/androgenic steroids are still relatively mild with the use of dihydroboldenone. Of course suppression of the natural testosterone production of users will occur like with all steroids, however other side effects such as an increase in blood pressure, acne and others are comparably mild and often times non-existent in users, at least as they are directly related to the administration of this drug. In terms of side effects for women, at moderate to heavy doses symptoms of virilization are likely. These can include such symptoms as clitoral enlargement, body hair growth and deepening of the voice. At lower doses however these side effects should not be a concern for the majority of potential female users.

References 1. Llewellyn, William, Anabolics 2004, 2003-4, Molecular Nutrition, pp. 66-7. 2. Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schanzer W, Thevis M, Vollmer G, Zierau O, Diel P. 17beta-hydroxy-5alpha-androst-1-en-3-one 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) (1-testosterone) is a potent androgen with anabolic properties. Toxicol Lett. 2006 Aug 20;165(2):149-55. 3. Jadrijevic D, Girardi S, Iglesias R, Lipschutz A. Antifibromatogenic and antihysterotrophic activities © 2012 Thatotherguy


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of synthetic androgens (19-nor-methyltestosterone, (19-nor-methyltestosterone, 19-nor-testosterone phenylpropionate, delta 1testosterone and delta 1-androstenedione). Proc Soc Exp Biol Med. 1957 Oct;96(1):259-61. Oct;96(1):259-61. 4. Choi MH, Chung BC, Lee W, Lee UC, Kim Y. Determination of anabolic steroids by gas chromatography/negative-ion chromatography/negative-ion chemical ionization mass spectrometry and gas chromatography/ negative-ion chemical ionization tandem mass spectrometry with heptafluorobutyric anhydride derivatization. Rapid Commun Mass Spectrom. 1999;13(5):376-80.

14.2.2 14.2.2 Anadro Anadroll (Oxym (Oxymeth etholo olone) ne)

Anadrol (commonly called by athletes "A50" or "A-bombs") "A-bombs") was initially developed developed as a compound compound to help people with anemia, and has since been used very successfully to aid people who are suffering from many other diseases where weight loss is a concern. Thus, it is clearly an effective agent for promoting weight gain, increasing appetite, gaining strength, and increasing Red Blood Cell count. And, as with most Anabolic/Androgenic Anabolic/Androgenic Steroids (AAS), it has its downsides downsides as well. Anadrol Anadrol 50 will inhibit your body's natural production of hormones (testosterone, etc ), will negatively affect your blood lipid profile, can cause water retention, is notorious for causing headaches, and is also highly liver toxic (in fact, it has the worst reputation for hepatoxicity out of all steroids). Paradoxically, although one the benefits touted by its original manufacturer (Syntex) is that it can be used to stimulate weight gain through increasing appetite, taking too much may actually inhibit your appetite! Anadrol Effects on Body I think, in order to gain a complete understanding of the Anadrol 50 effects on body, we need to take a look at its advantages contrasted with its disadvantages. Anadrol is a DHT-derived compound, and i s 17-Alpha-Alkylated steroid, meaning that it has been altered at the 17th carbon position to survive oral ingestion. Most oral steroids are 17aa, and this helps them make it through your liver in a useful form. Sounds great, right? Lets 17alpha-alkylate everything! Well as you can imagine, there's a down side. Anadrol Side Effects This 17aa alteration, which makes it possible for Anadrol to survive its first pass through your liver, also makes it very taxing on your liver. How taxing is A50 and how much weight can you gain from its use? Well, there was a 30 week study done on A50 and, as you can expect, a reasonable amount of side effects were noted. The fact that A50 causes some side effects has really never been in debate. But how effective was the drug? Well, first it should be mentioned that this study was done on people with AIDS related wasting, and they actually gained weight (8+kg) while the control group lost weight, and had increased mortality rates. (1). I suppose, if you're in a study because you have a wasting disease which is also a terminal illness, you don't want to end up in the control group. Anyway, weight gain in this study peaked at 19-20 weeks, though, so the last 10 weeks weren't very productive in this respect. Clearly, you wouldn't want to run Anadrol 50 for 20 weeks, gi ven its toxicity, but after that, any effect in terms of weight and strength gains would be negligible. So, with regards to sides from Anadrol, and the sheer fact that this study study lasted so long (30 weeks), it should be apparent that they can be kept under control and the drug can be used safely. People are commonly told to limit their intake of A50 to 4 weeks or less I'm a bit less conservative and think you can easily run A50 for 6 weeks or more. From personal experience, however, I can tell you that gains from Anadrol are quite dramatic for the first 3 weeks and then quickly level off. Unfortunately, I find that the side effects experienced from Anadrol (which include a headache, bloating, elevated blood pressure, and a general general "unwell" feeling for me) remain for the entire duration of use. But I find as usual, side effects for this drug are pretty much half legend and half truth. Since Anadrol 50 is derived from DHT, it cant actually convert to estrogen (via the aromatase enzyme), and its not a progestin or a compound with progestenic activity so the estrogenic (?) side effects produced by it are of a very mysterious nature. It has been speculated that perhaps it can stimulate the estrogen receptor without actually being converted to estrogen and that's that's about as plausible an explanation as Ive heard. heard. However, things really get © 2012 Thatotherguy

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strange, when Oxymetholone has been used in studies to alter the female reproductive/menstrual cycle; in those cases, it has lowered plasma progesterone levels! (7)One would expect that an AI (aromatase inhibitor) wouldn't be of much use with this drug, but many have found that Letrozole (which has, in some cases been shown to reduce estrogen in the body to an undetectable amount)(6) can greatly reduce or even eliminate many of the more noticeable side effects of Anadrol, such as the bloating. As I've stated, however, the sides sides from this drug are certainly certainly no joke, but are easily preventable, preventable, and controllable. One study even showed very few sides for subjects using up to 100mgs of Oxymetholone (2). In the original UnderGround Steroid Hand Book, Dan Duchaine states that he used it at doses up to 150mgs/day. Clearly, Anadrol's hepatoxicity has been a bit exaggerated, in some circles. Be that as it may, my suggestion is still to limit Anadrol's use to 6 weeks, at a maximum even if just to err on the side of caution. Of course, I have personally run this drug for much longer.. How should we use Anadrol? Id probably be wil ling to include Anadrol in a cycle including injectable steroids, but not other 17aa compounds. Id make any 6-week-run of this compound begin at the start of a cycle, as a form of "jumpstart" towards seeing gains quickly. The quick gains you wi ll get from Anadrol (up to a pound per day for the first first 2 weeks are not uncommon in Steroid.com Steroid.com members) are are also just as quick to disappear upon cessation of use .unless you are simply using it as a kickstarter, while waiting for your other compounds to kick-in. Ill go out on a limb here and say that utilizing Anadrol as a "Jumpstart" "Jumpstart" is the most popular use of this drug for athletes and bodybuilders today. Ill also say that this drug is immensely i mmensely popular with strength athletes who dont have to worry about weight classes (Field athletes and strongmen), and with powerlifters in the heavier weight brackets. Its also important to note that in one study by Schroder et. Al (2) Anadrol showed that it has the ability to lower serum SHBG (Sex Hormone Binding Globulin which binds to your free test and makes it no longer useful for anabolism, among other things) concentrations by 54.9 25.8 and 45 16.2 nmol/l in the 50- and 100-mg treatment groups. This means there will be more free test circulating around your body when you take this drug and clearly, this would produce some synergy when stacked with other steroids. Given the large amounts of weight and strength which can be gained in a relatively short time span on this drug, I'm sure this comes as no surprise to many. Another important and often understated understated characteristic of this compound is that Oxymetholone doesn't bind well to the androgen receptor (Relative Binding Affinity = too low to be determined) (3) which is the lowest Ive ever read about. Basically, what this tells me is that there are a lot of non-receptor mediated effects from this steroid, making it a very potent addition to ANY BULKING stack, because it wont be competing for the receptor sites with the other steroids you're using. Its also, as you may have guessed a very poor choice for a cutting stack. Anadrol Cycles What is an Anadrol Cycle? How much should you use? Well, this is actually one of the most interesting facts about Anadrol 50. You see, most steroids produce what we call a "dose respondent curve" which is a fancy way of saying "the more you use, the more you gain." Anadrol is one of the few steroids where the dose respondent respondent curve flattens flattens out very quickly. When you take 50mgs of Anadrol, you'll make some very good gains. When you take 100mgs of Anadrol, you'll make even more gains. However, it has been found that 100mgs/day is as effective for weight gain as 150mgs/day but produces less side effects and was less toxic (4). I feel that the jump from 50mgs to 100mgs constitutes an acceptable rise in benefit vs. cost, but this is not the case as dosages get over 100mgs. Now, lets see how 50mgs and 100mgs of Oxymetholone actually effect strength, when compared with each other: Relative (%) changes in strength are shown for the groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and 100 mg/day oxymetholone (gray bars). Nos. above bars represent relative change (%) from baseline to week 12 for the 1-repetition maximum tests of strength. Error bars represent 1 SE from the mean. * Significant difference from placebo, P < 0.05; significant difference from placebo by Wilcoxon test, P < 0.02. See text for additional statistical analyses. As you can see, see, in this study, study, doubling the dose of Anadrol 50 nearly doubled the strength gains of the © 2012 Thatotherguy


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test subjects. Now, when we look l ook at changes in body composition from Oxymetholone (chart below) we can see that although the guys taking the 100mgs (vs. the 50mgs group) had more fat lost and more Lean Body Mass gained, it wasn't as dramatic as the differences in strength gains between the two groups: Changes in body composition are shown for the groups receiving placebo (filled bars), 50 mg of oxymetholone per day (open bars), and 100 mg per day (gray bars). Numbers above the bars represent the mean absolute changes and the error bars are 1 SE. For total lean body mass (LBM) and total fat, differences among the 3 groups were significant (P < 0.0001, one-way ANOVA). * Significant differences from placebo, P 0.001. Although I am usually not inclined to to posit speculations on why a particular particular drug does does or doesn't do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound profound effect on on your body's natural hormonal system, on par with most other oral steroids, but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are Anadrol Body Building (2). As an interesting side note, some of the medical literature on this compound suggests a dose of 15mgs per kg of bodyweight. Ill pause a second here for you to figure out how absurdly high of a dose that would translate to for the average bodybuilder! To Buy Anadrol Liquiad Anadrol and others This steroid is very available on the black market in the form of capsules, tablets (some are even 75mgs!), liquid, and even paper. Prices will vary, and be indicative of many different factors including the form you buy this compound in (paper wil l usually be the most expensive, and liquid the least), and where you live. In any case, you shouldnt be paying more than $2.50-3.00 per 50mgs. What is Anadrol? (Oxymetholone) [17 beta-hydroxy-2-hydroxymethylene-17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one] alpha-androstan-3-one] Molecular Weight: 332.482 Molecular Formula: C 21 H 32 O 3 Melting Point: 178-180C Manufacturer: Syntex (Originally) Release Date: 1960 Effective Dose: 100mgs (optimal) Active Life: <16hours <16hours Detection Time: up to 8 weeks Androgenic: Anabolic Ratio: 45:320 Anadrol References: Charts from reference 2: Am J Physiol Endocrinol Endocrinol Metab 284: E120-E128, 2003. First published September September 24, 2002; 2002; doi:10.1152/ajpendo.00363.2002 doi:10.1152/ajpendo.00363. 2002 0193-1849/03 Br J Nutr. 1996 Jan;75(1):129-38. Schroeder et al. Am J Physiol Endocrinol Metab 284:E 120-28 Endocrinology. 1984 Jun;114(6):2100-6. HIV Clin Trials. 2003 May-Jun;4(3):150-63. J Clin Endocrinol Metab. 1981 Nov;53(5):905-8 Epilepsy Behav. 2004 Apr;5(2):260-3 Am J Obstet Gynecol. 1973 Sep 1;117(1):121-5.


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14.2.3 Anadur

Anadur Profile Anadur is one of several anabolic androgenic androgenic steroids that contain the drug nandrolone. Its most defining characteristic is that it is the longest lasting nandrolone, because of i ts large ester. Users report that Anadur gives them slow, steady muscle and strength gains with few side effects.As with any anabolic drug, a high protein intake is required for muscle buildup. Anadur has been reported as causing an increase in appetite so this shouldn’t be much of a problem, but it should be noted that without an increase of protein intake, muscle damage might occur. Anadur dosage A solid dose of Anadur Anadur for good gains gains is a 200 mg injection every 10 days. days. For women, a dose of between 50 to 100 mgs every 10 days has shown to be a reasonably safe dosage to avoid irreversible virilization. Anadur side effects There is some debate as to whether Anadur aromatizes less than its nandrolone cousin DecaDurabolin. Some argue that it is only because the drug works slower than Deca that the effects of aromatization are less recognized. Either way, Anadur has mild side effects but i f you take any testosterone-based testosterone-based drug, be aware that large doses or prolonged use can lead to aromatization and gynocomastia. There is some water retention that might need to be countered when taking Anadur. Some users report that the water relieves pain in their joints, but body builders may want to avoid water retention before a competition. Women taking Anadur will have less l ess to worry about when it comes to virilization, although acne, hoarseness, a deepened voice and hirsutism have been reported by women who use Anadur for several weeks. Drugs such as Winstrol or Primobolan will need to be used to avoid irreversible virilization in women. Anadur availability Anadur can only be found found on the black market market in the US and there are no US manufacturers of the drug. A 50 mg ampule of Anadur costs around $15. Anadur research Besides its use as an anabolic agent for muscle growth, Anbadur is being researched for other applications as well, including male contraception contraception drugs, increased immunities during acute acute pneumonia and help with osteoperosis. Nandrolone base + Hexyloxyphenylpropionate ester. Molecular Weight(base):274.4022 Weight(base):274.4022 Formula (base): C18 H26 O2 Melting Point (base): 122-124C Manufacturer: Various Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight) Effective Dose (Women): 50-100mgs/week © 2012 Thatotherguy


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Active life: 15 15 days Detection Time: Up to 18 months Anabolic/Androgenic ratio: ratio: 125:37 Reference: http://www.ncbi.nlm.nih.gov/p http://www.nc bi.nlm.nih.gov/pubmed?term=Ana ubmed?term=Anadur%20(nandrolon dur%20(nandrolone%20hexylphenylprop e%20hexylphenylpropionate)%20% ionate)%20% 20

14.2 14.2.4 .4 Anav Anavar ar (Oxan (Oxandr drol olon one) e) Anavar (oxandrolone) (oxandrolone) is not very toxic, not very androgenic, androgenic, mildly anabolic, anabolic, and pretty pretty mild on the the bodys HPTA (Hypothalamic-Testicular-Pituitary-Axis). (Hypothalamic-Testicular-Pituitary-Axis). Those are its 4 major points, and Id like to examine each one a bit further; as usual, gym-rumors and internet conjecture has made this steroid the subject of many misconceptions. Anavar (Oxandrolone) Side Effects First of all, and this will come as no surprise to many people, Anavar (oxandrolone) is quite mild on your liver. Its probably the mildest oral steroid available today. Dosages of up to 80mgs/day are easily tolerated by most men, and most side effects often found with other steroids are not common with var (1). For this reason, Anavar is frequently the steroid of choice for many top level female bodybuilders and other athletes. Anavar Dosage Due to its being a mild steroid in every sense of the word, high amounts of Anavar dosage are needed. It binds reasonably well to the AR, but pretty high doses are still needed and I would never suggest doing less than 20mgs/day. In fact, 20-80mgs are needed to start halting AIDS related wasting(1) and recovering weight for burn victims (2) so thats the range Id recommend keeping your dosages in concerning this compound. Personally, Id use 100mgs/day if I were ever going to try this stuff. Any less than this amount (20-100mgs) would be a waste. For women, however, I think 2.5-10mgs/day would suffice. Virilation is not a concern with this compound, as it is only very mildly androgenic (3). Water retention is also virtually nil with it. Although Anavar is an oral steroid, steroid, and has been been alpha-alkylated to survive oral ingestion and the first pass through the liver, its still relatively mild in that respect too..., the unique chemical configuration of anavar both confers a resistance to liver metabolism as well as noticable anabolic activity. It would also appear that Anavar appears not to exhibit the serious hepatotoxic effects (jaundice, cholestatic hepatitis, peliosis hepatis, hyperplasias and neoplasms) typically attributed to the C17alpha-alkylated AASs. (17) Anavar has even been used used successfully in some some studies to heal heal cutaneous wounds (7), (7), or to improve respiratory function (18). Both of these novel properties could make it a good choice for inseason use for boxers, Mixed Martial Arts competitors, and other such athletes. Anavar and Fat Loss Now heres some interesting stuff for anyone interested primarily in the fat loss properties of this stuff: Anavar may be what wed call a "fat-burning steroid". steroid". Abdominal and visceral visceral fat were both reduced in one study when subjects in the low/normal natural testosterone range used anavar (4). In another study, appendicular, total, and trunk fat were all reduced with a relatively small dose of 20mgs/day (8), and no exercise. In addition, weight gained with var may be nearly permanent too. It might not be much, but youll stand a good chance of keeping most of it. In one study, subjects maintained their weight (re)gains from anavar for at least 6 months after cessation (2)! Concomitantly, in another study, Twelve weeks after discontinuing anavar, 83% of the reductions in total, trunk, and extremity fat were also sustained (8)! If youre regaining weight, Anavar will give you nearly permanent gains, and if you are trying to lose fat (and you keep your diet in check), the fat lost with Anavar is basically looks to be nearly permanent. Check this chart out: Absolute change in total total fat mass (A) (A) and trunk fat fat (B) by dual-energy dual-energy X-ray absorptiometry absorptiometry from baseline to study week 12 (solid bars) and from baseline to study week 24 (open bars) in the placebo © 2012 Thatotherguy

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(n = 12) and the oxandrolone (n = 20) study groups. Values are means SE. *Significant decrease from baseline, P < 0.001. Significant difference between study groups for change in fat mass from 0 to 12 wk, P < 0.001. (15)(8) Anavar Cycles Keep in mind this is all without any Post-Cycle-Therapy, and without any change in diet or training! And although many of the studies done on anavar use elderly men or young boys as the test subjects, some evidence suggests that many of the effects of anavar are not age dependant (11). If you are following the typical "time on = time off" protocol, this means you can lose a bunch of fat during your time on, then keep most (if not all) of it off until your next cycle. That makes it a great drug for athletes who are drug tested and need to be clean for their season, yet need to keep the fat/weight they lost on their cycle off& Im thinking about wrestlers and other weight-class athletes. Anavar is also the clear choice for a "spring-cutting" cycle, to look great at the beach and you can use it up until the summer starts, and then keep the fat off during the entire beach season! Anavar is great for strength and and cutting purposes, but not for bulking bulking or a lot of weight gain. In other other words, what Im saying is that everything you gain will be soli d. Personally I am leaning towards a theory which basically purports that the more solid your gains are, the more youll keep (percentagewise). It makes sense, when you think about it; people make a lot of weight gains on the highly waterretentive steroids (Dbol, A50, long estered testosteones, etc. ), but lose the greatest percentage of their gains afterwards. The same seems to be opposite for the steroids which cause less (or no) water retention (Anavar, Primo, Winstrol, etc& ). So why else may you keep such a high proportion of what you gained on var? Well, I think it may be due to its relatively light impact on the HPTA, which brings me to my final point; Anavar will not totally shut down your HPTA, especially at lower doses (unlike testosterone, which will eventually do this even at a 100mg dose, or deca which will do it with a single 100mg dose). This could be due, at least partly, to the fact that Anavar doesnt aromatize (convert to estrogen). Serum testosterone, SHBG (Sex Hormone Binding Globulin), and LH (Leutinizing Hormone) will be slightly suppressed with low doses of Anavar, but less than with other compounds. FSH (Follicle Stimulating Hormone) , IGF1 (Insulin Like Growth Factor 1) and GH (Growth Hormone) will not be suppressed with a low dose of Anavar, but will actually be raised significantly (12)(13)(14) as you may have guessed, and LH will even experience a "rebound" effect when you stop using anavar (3) If your endocrine system and HPTA are functioning normally, you should be able to use anavar with minimal insult to it, and can even keep most of your values within the normal range (5). Thus, Anavar may even be ideal for use in bridges between cycles, (at very low doses under 10mgs perhaps), or as previously mentioned, for cutting/strength cycles at 50-100mgs. How to Buy Anavar Its relatively high cost is its only major drawback when you buy Anavar. Tablets can typically sell in Mexico or on the black market for up to a dollar (1USD) per 10mgs. Many black market dealers or Underground Labs, however offer capsules, liquid form (or in some cases, even their own brand of tabs) for substantially less money than the legit pharmaceutical versions, or even veterinary versions found overseas. Anavar Profile [17b-hydroxy-17a-methyl-2-ox [17b-hydroxy-17a-methyl-2-oxa-5a-androstanea-5a-androstane-3-one] 3-one] Molecular Weight: 306.4442 Formula: C19H30O3 Melting Point: 235 238 Celcius Manufacturer: BTG, SPA, Originally Searle (1964) Effective dose: (Men)20-100mgs/day (Men)20-100mgs/day (or .125mg/kg~bdywt); (Women) 2.5-20mgs.day Active Life: 8-12 hours Detection Time: 3 weeks Anabolic/Androgenic Ratio (Range): 322-630:24 322-630:24 Anavar References: Proj Inf Perspect. 1997 Nov;(23):19. © 2012 Thatotherguy


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Burns. 2003 Dec;29(8):793-7 Clin Endocrinol (Oxf). 1993 Apr;38(4):393-8. Int J Obes Relat Metab Disord 1995 Sep;19(9):614-24 jcem.endojournals.org/cgi/content/full/84/8/ jcem.endojournals.org/cgi/content/full/84/8/2705 2705 Segal S, Cooper J, Bolognia J., Treatment of lipodermatosclerosis with oxandrolone in a patient with stanozolol-induced hepatotoxicity., J Am Acad Dermatol 2000 Sep;43(3):558-9 Demling RH., Oxandrolone, an anabolic steroid, enhances the healing of a cutaneous wound in the rat., Wound Repair Regen 2000 Mar-Apr;8(2):97-102 Mar-Apr;8(2):97-102 J Clin Endocrinol Metab. 2004 Oct;89(10):4863-72. Demling RH, Orgill DP., The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury., J Crit Care 2000 Mar;15(1):12-7 Hart DW, Wolf SE, Ramzy PI, Chinkes DL, Beauford RB, Ferrando AA, Wolfe RR, Herndon DN., Anabolic effects of oxandrolone after severe burn., Ann Surg 2001 Apr;233(4):556-64 Apr;233(4):556-64 Demling RH, DeSanti L., The rate of restoration of body weight after burn injury, using the anabolic agent oxandrolone, is not age dependent., Burns 2001 Feb;27(1):46-51 Demling RH, DeSanti L., Oxandrolone, an anabolic steroid, significantly increases the rate of weight gain in the recovery phase after major burns., J Trauma 1997 Jul;43(1):47-51 Papadimitriou A, Preece MA, Rolland-Cachera MF, Stanhope R., The anabolic steroid oxandrolone increases muscle mass in prepubertal boys with constitutional delay of growth., J Pediatr Endocrinol Metab 2001 Jun;14(6):725-7 Doeker B, Muller-Michaels J, Andler W, Induction of early puberty in a boy after treatment with oxandrolone? Horm Res 1998;50(1):46-8 J Appl Physiol 96: 1055-1062, 2004. First published October 24, 2003; doi:10.1152/ japplphysiol.00808.2003 8750-7587/04 James JS., Wasting syndrome: oral oxandrolone re-released in U.S., AIDS Treat News 1995 Dec 22; (no 237):3-4 Drugs. 2004;64(7):725-50. Mt Sinai J Med. 1999 May;66(3):201-5.

14.2.5 14.2.5 Dynabol Dynabol (Dianabol (Dianabol)) (nandr (nandrolone olone undecanoat undecanoate) e)

Dynabol (Dianabol) profile Like other nandrolones, Dynabol has many distinct and positive characteristics. It is a good drug for gaining weight and strength in the muscles and because it binds well to the androgen receptors, it is also good for burning fat from the muscle. Compared to nandrolone decanoate, Dynabol is much slower acting, however users can depend on this drug for high quality results. One of Dynabol’s qualities is that it soothes sore joints and muscles, allowing users to push themselves harder in the gym, which in turn develops even more muscle, mass. Dynabol doesn’t contain testosterone, but instead reduces the amount of Luteinizing Hormone present in the body, which i ncreases the amount of natural testosterone. This will also i ncrease the level of estrogen in the body and also cause a measurable amount of water retention in the muscles. Dynabol also promotes protein synthesis, allowing the mass of the muscle tissue to grow. Dynabol dosage and usage © 2012 Thatotherguy

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Dynabol works in the body for only one to two weeks, which is why athletes usually inject the drug twice a week. A minimum dosage of 2 ml/week will achieve some results, although 4 ml/week is preferred for serious athletes looking for real gains. This translates to two 2 ml injections per week. At this level, Dynabol doesn’t strongly aromatize but any higher doses to achieve even better results will most likely require the addition of anti-estrogens to a stack to avoid water retention and gynocomastia. Dynabol side effects Side effects are rare and short lived in men who take Dynabol at 4 ml/week or under. At higher doses, the usual side effects associated with aromatization are present such as water retention, acne and gynocomastia, although these effects usually wear off once the user stops taking the drug. Dynabol availability Dynabol is a widely available drug, due to its popularity and its relatively low level of side effects. Ampules of Dynabol range from $15 to $20 on on the black market. Dynabol research Research into alternative uses of Dynabol include weight loss for older, obese women and as drug to combat muscle tissue deterioration for victims of nerve trauma. http://www.ncbi.nlm.nih.gov/pubme http://www.ncbi. nlm.nih.gov/pubmed?term=nandrolone% d?term=nandrolone%20undecanoate 20undecanoate Nandrolone Base + Cypionate Ester Molecular Weight: 274.4022 Formula: C18 H26 O2 Melting Point: 122-124C Manufacturer: Multiple Effective Dose (Men): 200-400 mg/week (2mg/lb of Bodyweight) Effective Dose (Women): 50-100 mg/week Active Life: 10-14 10-14 Days Detection Time: Up to 12 Months Anabolic/ Androgenic Ratio: 125:37

14.2.6 14.2.6 Equipo Equipois ise e (Bolde (Boldenon none e Undec Undecyle ylenat nate) e) Equipoise was actually created while attempting to make a product which would be be a long acting injectable d-bol (Methandrostenolone). What was actually created was a product which, in the real world acts nothing like D-bol, despite its similarity to it chemically. A simple way to think of Equipoise, chemically at least, is simply as Dianabol without the 17-alpha-methyl group (thats the thing which makes D-bol able to be ingested orally and not be destroyed by your liver). However, having had first hand experience with both Equipoise as well as D-bol, I can tell you that the results from each are vastly different. To make Equipoise, a double bond was added between carbon atoms 1 and 2 of the Steran Nucleus of Testosterone. What does this mean? Well, first of all, since Equipoise was created by one simple modification in the testosterone molecule, you could rightly suspect that it shares many similarities with it. Equipoise is just as anabolic as testosterone (as you can tell by its anabolic rating above), but only half as androgenic. Those ratings can be quite deceiving though, as I don't know anyone who would claim that you can gain as much weight on Equipoise as you can gain on an equal amount of testosterone (even though strength gains from the two compounds are very similar). Its not very common to compare Equipoise to testosterone; however a far more common comparison is between Equipoise and Deca. I suspect this is because when Dan Duchaine introduced this compound to the steroid using community, he made an immediate comparison to Deca, speculating that it would act similarly to Deca but like a much stronger version of it. Equipoise doesn't actually act much like deca at all; Deca is actually a progestin and a 19-nor derived steroid whereas Equipoise is more closely related to testosterone (being only one double bond differ rent). Duchaine later rescinded his original statement on Equipoise and said that it was disappointing as a mass builder when compared with deca, but a far better drug than for both strength gains and vascularity. Unfortunately, the myth that Equipoises action is similar to Deca's has persisted for nearly 2 decades after he revised his opinion; this is most evident on internet message boards today, where many will advise against © 2012 Thatotherguy


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including both of them in a cycle because "they act the same way." The 1-2 double bond that Equipoise has is responsible for many of its characteristics. First of all, it acts to slow aromatization (conversion into estrogen). The best estimate is that it does so at roughly half the rate of testosterone (1). This is the best number Ive found in studies. Athletes almost never report estrogenic side effects with Equipoise, even when the dose is up to a gram per week. Side effects caused by estrogen include oily skin, acne, and gynocomastia, and as I said, those are usually not found from Equipoise. Virilization (development of male sexual characteristics in women) is almost never seen with this compound, when reasonable doses are used by female athletes. This is one of the few injectable compounds which could be successfully be used by female athletes and bodybuilders, and isn't often faked. Clinical Equipoise and Athletes That double bond is also responsible for Equipoises resistance for being changed by the 5- 5-Alphareductase enzyme (2)(3). This enzyme converts a small amount of Boldenone into Dihydroboldenone, which is a very potent androgen (7x as anabolic as testosterone)(4). testosterone)(4). As I said though, such a small amount of it is converted that its really of no concern to most athletes taking Equipoise. This factor, plus its low aromatization rate mean athletes don't need to consider using ancillaries with Equipoise. Athletes taking Equipoise Equipoise often report report a slow and constant buildup of of quality muscle, and certainly this has been my experience with the drug. I would speculate that this slow buildup of muscle is due to the very long ester attached to the Boldenone; Undeclynate is a longer ester than the decanoate ester by one carbon. Thus, we could expect the accumulation of muscle from Equipoise to actually occur at a slightly slower rate than that found with Deca (nandrolone decanoate). This leads me to advise that if you are considering the use of Equipoise, you should consider using it for no less than 12 weeks. Equipoise, like Deca, is also detectable in your system for a long time (although i t is substantially less than Deca's detection time). Strangely, shorter estered versions of Boldenone are available as well. Anecdotally, many people (and manufacturers) claim that this produces less water retention...but water retention from Equipoise is virtually unheard of, so I consider this to be a silly idea. An informal poll I took took on Steroid.com (as well as with my friends) seems to to put the ideal dose of Equipoise at 600mgs/week. Most people I asked about their Equipoise experience with Equipoise seemed to think that using over 600mgs/week produced no additional results, but the jump from 400mgs/week to 600mgs/week produced noticeable additional gains, and thus was warranted. I have personally found very nice results from 400mgs-600mgs/week myself. Equipoise Side Effects One of the most pronounced effects in Equipoise is its ability to raise your RBCs (red blood cells). This is very typical of anabolic steroids; however, Equipoise would appear to do it to a slightly greater degree than most. One of the other effects most Equipoise users report is an increased appetite. I can say that this is true of me, also; this factor makes it impossible for me to diet on it. Its because of this ability to increase appetite that many will include Equipoise in a mass cycle, and its for the quality of muscle gained on it that many will include it in a cutting cycle. Its probably the most versatile injectable compound, next to testosterone. People even use a low dosed version of Equipoise to blend with irritating injectable drugs suck as testosterone suspension or Propionate. Im thinking of the old Ganabol version which was dosed at 50mgs/ml, here... its not that Equipoise is especially good to cut other steroids with, but the low dose and cost of Ganabol made it ideal to do this with, when sterile oil wasn't available or desirable. This low dosed version was also very popular with women, who were comfortable shooting 1cc of this stuff every few days or every week. Equipoise will cause a suppression of your hormones, such as endogenous testosterone, so I would also recommend using injectable testosterone in any cycle containing i t. Failure to do so could result in possible sexual dysfunction and other sides. Buy Equipoise Finally, when you buy equipoise, one of the best parts of Equipoise is its low price and high availability. © 2012 Thatotherguy

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Equipoise is produced by most Underground Labs at very reasonable prices. You shouldn't be paying more than $50 for a 10cc bottle dosed at 200mgs/ml, and that price is true of Mexican veterinary products and underground labs alike. Id have to say that due to its incredible versatility, availability, and low price, Equipoise is going to be a staple in many cycles for a long time. Equipoise Steroid Profile Boldenone Undeclynate (1,4-androstadiene-3-one,1 (1,4-androstadiene-3-one,1 7b-ol) Molecular Weight(base): 286.4132 Molecular Weight (ester): 186.2936 Formula (base): C19H26O2 Manufacturer: Various Effective Dose (Men): 200-600mgs/week Effective Dose (Women): 50-100mgs/week Active life: 15 15 days Detection Time: Up to 5 months Anabolic/ Androgenic ratio: 100:50 Equipoise References: Endocrinology 71 (1962) 920-25 Metabolism of boldenone in man: gas chromatographic/mass spectrometric identification of urinary excreted metabolites and determination of excretion rates. Biol Mass Spectrom. 1992 Jan;21(1):3-16. Gas chromatographic/mass spectrometric spectrometric analysis of boldenone urinary metabolites in man. Yao Xue Xue Bao. 1991;26(5):362-6. Chinese. Erratum in: Yao Hsueh Hsueh Pao 1991;26(9):687. Counsel et al., "Anabolic Agents. Derivatives of 5alpha-Androst-1-ene", J. Org. Chem., 27 (1962), 248251

14.2.7 14.2.7 Halote Halotesti stin n (Fluox (Fluoxyme ymeste steron rone) e) Halotestin (Fluoxymesteron) is legendary among powerlifters and strength athletes. The mere word conjures up images of little mint colored pills that turn Dr. Jeckyl instantly into Mr.Hyde. Since Im generally Mr.Hyde 24/7 this isnt of much concern to me.. but lets see what else Halotestin can do for us. If youre anything like me, the first thing youll notice is Halotestins absurd Anabolic and Androgenic rating. This stuff is 19x as anabolic as testosterone and 8.5x as androgenic! Whoa! I have to admit, those numbers are a bit deceiving, and through personal experience, I can say that Halotestin will not put anywhere near as much muscle on you as testosterone. Lets take a closer look at Halo and see what kind of realistic effects we can expect from it, and what kind of side effects well be dealing with. Firstly, I have to admit that I love Halotestin, and generally its use in athletics and powerlifting is far more pronounced than its use in bodybuilding, where it is basically a one-trick-wonder used in the final weeks before a contest to harden up an already lean physique and give the user some added aggression during the final calorie depleted workouts before a contest. Halo has no estrogenic activity, and thus will not cause any kind of water retention or most of the bad effects associated with estrogen. It is however hepatoxic (liver toxic) (13) and I recommend keeping doses at or around 40mgs/day for a maximum of 4-6 weeks. If you are using Halotestin for its pronounced effect on aggression, you can simply use 10mgs prior to a workout, I personally prefer 10mgs upon rising and 10mgs prior to a workout, during the most intense weeks of a bulking or cutting cycle. This (as you will see later) can be used with minimum HPTA inhibition. Effects of Halotestin Halotestin also has a volumizing effect on the physique, and for those with low a body fat percentage, this will cause an immediately more contest ready appearance. This is due, at least in part, to Halos ability to increase mean hematocrit with and hemoglobin level as well as red cell mass (4)(5)(6). Halotestin also appears to act through cells already committed to respond to erythropoietin (11), which is good news for athletes, of course. As you can see, Halo has quite a profound effect on red blood cell © 2012 Thatotherguy


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production, and this action is clearly one of the most obvious mechanisms by which it is thought to exert its effects with regards to increasing strength and energy levels. It also points to the possibility of using it for athletics and sports where a high VO2 max is needed, such as Rugby, Mixed Martial Arts, etc.. Halotestin also exerts its effects on strength and fat loss by both regulation of fatty acid oxidation in the liver and fast-twitch muscle mitochondria (2). Oddly, for a drug which exerts such a nice anabolic effect, and promotes such good strength gains, Halotestin has a pretty low Androgen Receptor Binding affinity (14).. I suppose, in this respect it can be compared to Winstrol (Stanozolol). As far as strength strength and agression agression goes, Halo is a great drug. Halotestin Halotestin is especially useful useful on a cutting or strength cycle. Its use for mass and weight gains have been pretty disappointing for most users, however. Fluoxymesterone administration is (unfortunately) accompanied by a reduction in thyroid binding globulin which causes associated decreases in T3, while the free T4 index remained totally unaltered; thus implying that thyroid function was unchanged. Remember, many anabolic steroids (notably Trenbolone) lower your T3 levels. In addition, during fluoxymesterone administration, administration, there was a reduction in testosterone, gonadotropins and LH response to LHRH. Basal TSH did not vary, but there was a reduction in the peak and integrated TSH response to TRH. PRL levels tend to remain unchanged during fluoxymesterone use (8). Halo is of course suppressive to your HPTA, but Ive found that in some studies where measurements were made of serum FSH, LH, testosterone, up to 20mgs per day of Halo did not suppress them measurably (9). This could possibly indicate the use of up to 20mgs/day of Halotestin without being in any great danger of suppressing endogenous hormones. Halotestin a Steroid? Anyway, Halotestin is a testosterone testosterone derived steroid, steroid, and has has an 11-beta group attached to it to inhibit aromatization, although it is particularly prone to being 5-alpha-reduced and may thus cause DHT related side effects, such as acne and hair l oss. It is metabolized primarily by 6 beta-hydroxylation, 4ene-reduction, 3-keto-reduction, 3-keto-reduction, and 11-hydroxy-oxidation. We know this by the identification of 4 particular metabolites and the tentative identification of at least 3 other metabolites. Detection of Halo in urine is possible for at least 5 days after a single 10 mg oral dose to previously untreated adult males, by monitoring the presence of 2 metabolites, since the parent drug i s not detectable more than 1 day after the dose(12). However, the moral-compass of the athletic world, the IOC, has developed a test for fluoxymesterone metabolites that will detect them for up to 2 months after cessation of use. Halotestin is not in high demand in bodybuilding except for as a pre-contest drug, and would more likely be found circulating in Athletic and Powerlifting circles, where it is more commonly used in a cycle. Halotestin (Fluoxymesteron) Profile [9-alpha-fluoro-11-beta-hydroxy [9-alpha-fluoro-11-beta-hydroxy-17-alpha-methy -17-alpha-methyl-4-androstene-3 l-4-androstene-3-one,17b-ol] -one,17b-ol] Molecular Weight: 336.4457 Formula: C20 H29 F O3 Melting Point: 240C Manufacturer: Upjohn, Various Date Released: 1957 Effective Dose:10-40mgs/day Active life:6-8 hours hours Detection Time: 2 months Anabolic/Androgenic ratio:1,900/850 Halotestin References: Treatment with anabolic steroids increases the activity of the mitochondrial outer carnitine palmitoyltransferase in rat liver and fast-twitch muscle. Biochem Pharmacol. 1991 Mar 1;41(5):833-5. Effects of synthetic androgen fluoxymesterone on triglyceride secretion rates in the rat.Proc Soc Exp Biol Med. 1975 Jun;149(2):452-4. Metabolism of anabolic steroids in humans: synthesis of 6 beta-hydroxy metabolites of 4-chloro-1,2dehydro-17 alpha-methyltestosterone, alpha-methyltestosterone, fluoxymesterone, and metandienone. Steroids. 1995 Apr;60 © 2012 Thatotherguy

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(4):353-66. Influence of fluoxymesterone on in vitro erythropoiesis affected by leukemic cells.Exp Hematol. 1984 Mar;12(3):171-6. [Erythropoietin in serum and urine in healthy persons and patients with chronic renal disease upon hypoxic stimulation and hypoxic stimulation after pretreatment with fluoxymesterone (authors transl)] Fluoxymesterone therapy in anemia of patients on maintenance hemodialysis: comparison between patients with kidneys and anephric patients. J Dial. 1977;1(4):357-66 Combination hormonal therapy with tamoxifen plus fluoxymesterone versus tamoxifen alone in postmenopausal women with metastatic breast cancer. An updated analysis.Cancer. 1991 Feb 15;67 (4):886-91. Effect of non aromatizable androgens on LHRH and TRH responses in primary testicular failure.Horm Metab Res. 1984 Sep;16(9):492-7. The effect of synthetic androgens on the hypothalamic-pituitary-gonadal axis in boys with constitutionally delayed growth. J Pediatr. 1979 Apr;94(4):657-62. The effect of synthetic androgens on the hypothalamic-pituitary-gonadal axis in boys with constitutionally delayed growth. J Pediatr. 1979 Apr;94(4):657-62. Steroids and hematopoiesis. II. The effect of steroids on in vitro erythroid colony growth: evidence for different target cells for different classes of steroids. J Cell Physiol. 1976 Jun;88(2):135-43. Testing for fluoxymesterone (Halotestin) administration to man: identification of urinary metabolites by gas chromatography-mass spectrometry. J Steroid Biochem. 1990 Aug 28;36(6):659-66. Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures. J Pharmacol Toxicol Methods. 1995 Aug;33(4):187-95. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology. 1984 Jun;114(6):2100-6. The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men. J Clin Endocrinol Metab. 1981 Feb;52(2):173-6.

14.2.8 14.2.8 Master Masteron on (Drost (Drostano anolon lone e Propio Propionat nate) e) Masteron is, to be honest, my favorite Anabolic/Androgenic Steroid (AAS). For many years, this compound was unavailable to the average athlete; it was frequently counterfeited, often very expensive, and almost never available on the black market. The most common form of this product, as manufactured by major pharmaceutical houses, is 50mg/ml ampules with either 1-2mls per amp (or vial). Needless to say, these products used to be the only game in town, and since this drug was a particularly sought-after compound for bodybuilding contest preparation, its price made it prohibitive for all but the highest level bodybuilders Masteron is a derivative of DHT (as you can tell from its chemical name: 2a-methyl-dihydrotestosterone propionate), but what they fail to tell you is that DHT and its derivatives are commonly used in treatment of certain forms of breast cancer (see the etymology here: MASTectomy, gynocoMASTia, MASTeron, get it?). Masteron is not clinically used for wei ght gain (as is common with most steroids), so this makes it a very unique steroid from that perspective. Unfortunately, much of the information on Masteron available in medical journals doesnt focus on weight or strength gain or even fat loss, for those reasons. Most information on Masteron focuses on its use in treating certain forms of breast cancer, and it does this reasonably well.(4)(5) To give you an idea, Masteron + Tamoxifen actually fared better than Chemotherapy for immediate objective responses from patients (8).So? What does this tell us? Well, this makes it a very exciting drug for a lot of reasons. Clearly it wont aromatize at all nor will it have progesteronic sides, remember, Nolvadex (and most ancillaries) are used to reduce estrogen for breast cancer patients, so a drug used to treat breast cancer obviously wouldnt convert to estrogen...and in fact Masteron may interact with the aromatase enzymes to inhibit aromatization of other steroids into estrogen, and may additionally interact with estrogen (as a "blocker" of sorts) at the receptor site. (4)(5) This is how it helps to combat breast cancer, obviously, but this could also be part of the reason that Masteron is considered a "cutting" or "Pre-contest" drug. Masteron may actually be very useful for combating estrogenic/progesteronic estrogenic/progesteronic side effects yes, you read that right, if you include Masteron in your cycle, you may not need other "ancillary" drugs like Arimidex or Letrozole). Hence, much like Proviron, Masteron could be used as an © 2012 Thatotherguy


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anti-side-effect-drug anti-side-effect-drug (remember, most ancillary drugs we use to combat estrogenic sides, like nolvadex, letrozole, and arimidex were originally developed to combat breast cancer...and that's exactly what Masteron was developed and used for). Along a similar line, being a DHT (DiHydroTestosterone) derivative, derivative, its got a very nice ability abil ity to add muscle hardness to an already lean physique, remember, Masteron has a deceivingly low anabolic/androgenic ratio, but since DHT i s 5x as androgenic as testosterone and has a 3-4x higher affinity to receptor sites, Masteron provides a l ot of "bang for the Buck" when examined on a Mg for Mg basis. In my experience, as well as many others, Masteron is a stronger androgen than it appears on paper, and and this could cause increased aggression. As we know, higher androgens also produce that "hard" look prized by competitive BBers and as we all know, androgens also promote lypolysis (fat loss). The effects of Masteron, in that way are consistent with the documented effects of (somewhat heavier) androgens to decrease lipoprotein lipase and upregulate -adrenergic receptors on adipocytes, which would inhibit the accumulation of lipid (fat) and enhance the efflux of lipid from these cells in response to catecholamines (1)(2)(3). So, like I said previously, dont let Masterons deceptively low Anabolic:Androgenic ratio fool you, it helps eliminate fat as well (if not better) than much more highly scored androgens, in part due to its being a derivative of DHT. This reduction in fat and rise in aggression (making workouts more effective) could be beneficial for people competing in a sport or who are on a reduced calorie diet. Sounds pretty good, right? Unfortunately, being a DHT derivative means that it can have certain undesirable sides as well (acne, hairloss, prostate enlargement, etc& you may want to consider using Finasteride with this drug). Water retention (and increased danger of high Blood Pressure) with this compound is virtually nil, and liver toxicity is not much of an issue either. Really, you can take heaps of this stuff...the maximum therapeutic dose is pretty high: 167mgs/kgbdywt/day. So thats 167mgs per day, every day of the week, for a 220lb person...and that's not considered excessive by the FDA...who hasnt been very traditionally liberal on dosing protocols. So clearly, up to that dose i s very safe for almost anyone. DHT has a bad reputation for causing prostate hypertrophy, acne, and hairloss& but most people Ive talked to find that reputation to be mostly undeserved at least in the case of Masteron. Remember that year that the Chinese National Swimming Team (womens) were kicking everyones ass? Or the year that the German National Swimming Team (again, Im talking about women) were taking all those Gold medals? They were all using a form of DHT or a derivative, possibly Masteron. The German Women had very deep voices, which leads me to believe that Masterons virilizing effects on women could be very bad (there was a famous/funny interview where the interviewer implied that they all had deep voices, and one of them replied "Ve came here to svim, not to sing."). Hence, I feel Masteron is a great drug for any type of athlete, but possibly not for women (at least not at high doses... perhaps 50mgs/E3D is appropriate). Sorry girls...you can have a go with this drug, but keep the doses low. Stacking Masteron? Well, Id say that your best bet is with test, of course but really, due to Masterons reasonable binding to the Androgen Receptors and its hi gh androgenic properties, almost any cutting drug (Tren, Anavar, etc... ) could be included in a cycle with it for an efficient stack. I have a feeling that due to Stanozolols (Winstrol) non-AR mediated effects, and its ability to reduce SHBG, a stack including both of these drugs would be very synergistic. However, don't forget the Testosterone, as Masteron will reduce your own natural testosterone levels (9), and since you are going to have to inject Masteron Every Other Day at least (100mgs EOD is the lowest dose of this stuff Id consider using), you might as well stack it with Testosterone Propionate, and possibly injectable Winstrol (and/or maybe Tren Acetate, if you're inclined to use a lot of compounds in the same cycle& and I know I am& ). Eq is another popular choice to stack with Masteron. Id say that optimum effects of this stuff are found with 4-500mgs/week (based on conversations Ive had with people who have used Masteron, as well as my own results). I happen to have a friend who has gone up to 600mgs/week with Masteron and didn't feel that it provided significantly better results than 400-500mgs per week. I think, for maximum cost effectiveness, 400mgs per week is ideal. Its also important to remember to spread those shots out on an every other day basis, as the Masteron I'm talking about here is the Propionate version, and as such, requires more frequent dosing. Of course I know there is a version of Masteron with an enanthenate ester dosed at 200mg/ml being produced by a very good Underground Lab (I personally used the "alpha" version, as a sort of Human © 2012 Thatotherguy

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Guinea Pig almost a year ago), but that's not the version of Masteron Im talking about in this profile. In addition, there is another form of Masteron out there: Drostanolone (base), yeah, that's right, Masteron without an ester. Its called Dromostan and its made by the Xelox Company. Ive never tried this version, and don't know anyone who has, but its my suspicion that it would be a very potent product, but would need to be injected every day. Buying Masteron If you are looking for this drug from a major pharmaceutical company, Id caution you to reconsider that route, and go with an Underground Lab instead. There are many very reputable underground labs operating out there, with no known counterfits. On the other hand, genuine Masteron is one of the most difficult drugs to find on the black market, when you're looking for a "Human-grade" product made by a major pharmaceutical house. In addition, UGLabs commonly offer this product for a very reasonable $50-75 for a 10ml bottle dosed at 100mg/ml. Trying to find the Syntex (or comparable Human-Grade) version of this product will bring a mg for mg cost of 2-5x that amount. To recap: Masteron is derived from DHT, could be used as an anti-estrogenic drug, clearly it doesn't convert to estrogen and actually works to reduce it in your body, can possibly cause hair loss and other DHT-related sides, is great for all types of athletes and BBers, but not women in high doses, it stacks well with almost anything, is very androgenic, awesome for losing fat and getting "hard", and should be used at around 400-500mgs/week. Its no surprise that its many peoples favorite steroid, mine included. Masteron profile (Drostanolone Propionate) [17beta-Hydroxy-2alpha-methyl-5alpha-andros [17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one tan-3-one propionate] Molecular Weight: 360.5356 Formula: C23H36O3 Melting Point:N/A Manufacturer:Syntex, Manufacturer:Syntex, Various Underground Labs Effective Dose (men):350mgs/week (*100mgs Every other day) to 500mgs/week Effective Dose (women): 25-50mgs Every other Day to Every Third Day Active Life:2-3 days Detection time: 3 weeks Anabolic/Androgenic Ratio:62:25 Masteron References: Marin P, Oden B, and Bjorntorp P. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. J Clin Endocrinol Metab 80: 239-243, 1995 Rebuffe-Scrive M, Marin P, and Bjorntpor P. Effect of testosterone on abdominal adipose tissue in men. Int J Obes 15: 791-795, 1991. Xu XF, De Pergola G, and Bjorntorp P.Testosterone increases lipolysis and the number of betaadrenoceptors in male rat adipocytes. Endocrinology 128: 379-382, 1991. Eur J Cancer Clin Oncol. 1983 Sep;19(9):1231-7. Cancer Res. 1982 Nov;42(11):4408-12. Gan No Rinsho. 1986 Apr;32(4):345-8. Japanese. Khirurgiia (Sofiia). 1987;40(6):80-6. Bulgarian. Sem Hop. 1982 Sep 23;58(34):1919-23. J Clin Endocrinol Metab. 1965 Apr;25:476-9.

14.2 14.2.9 .9 Oxan Oxandr drol olon one e Searle Company introduced the substance Oxandrolone to the U.S. market in 1964 under the name Anavar and Oxandrolone Oxandrolone enjoyed great popularity for over two decades until, until, on July 1, 1, 1989, the production of Anavar was phased out. Today Anavar is manufactured under its various generic names in only a few countries (see above). The compound with the generic name Oxandrolone SPA by S.p.A. Milano Company (Societ? Prodotti Antibiotica) from Italy is the only original anabolic steroid available in Europe, which contains the substance oxandrolone. There are 30 tablets in one box with two push through strips of 15 tablets each. Oxandrolone is a weak steroid with only a slight androgenic © 2012 Thatotherguy


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component. It has been shown that Oxandrolone, when taken in reasonable dosages, rarely has any side effects. This is appreciated since Oxandrolone was developed mostly for women and children. Oxandrolone is one of the few steroids, which does not cause an early stunting of growth in children since it does not prematurely close the epiphysial growth plates. For this reason Oxandrolone is mostly used in children to stimulate growth and in women to prevent osteoporosis. Oxandrolone causes very light virilization symptoms, if at all. This characteristic makes Oxandrolone a favored remedy for female athletes since, at a daily dose of 10-15 mg, masculinizing symptoms are observed only rarely. Bodybuilders and power lifters, in particular, like Oxandrolone for three reasons. First, Oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing liquid (water) in the joints and the muscles. Power lifters and weightlifters who do not want to end up in a higher weight class take advantage of this since it allows them to get stronger without gaining body weight at the same time. The combination of Oxandrolone and 20 - 30 mg Halotestin daily has proven to be very effective since the muscles also look harder. Similarly good results can be achieved by a simultaneous intake of Oxandrolone and 120-140 mcg Clenbuterol per day. Although Oxandrolone itself does not cause a noticeable muscle growth it can clearly improve the muscledeveloping effect of many steroids. Deca-Durabolin, Dianabol, and the various testosterone compounds, in particular, combine well with Oxandrolone to achieve a "mass buildup" because the strength gain caused by the intake of these highly tissue-developing and li quid retaining substances results in an additional muscle mass. A stack of 200 mg Deca-Durabolin/week, 500 mg Testosterone Enanthate (e.g. Testoviron Depot 250)/week, and 25 mg Oxandrolone/day leads to a good gain in strength and mass in most athletes. Deca-Durabolin has a distinct anabolic effect and stimulates the synthesis of protein; Oxandrolone improves the strength by a higher phosphocreatine synthesis and Testosterone Enanthate increases the aggressiveness for the workout and accelerates regeneration. The second reason why Oxandrolone is so popular is that this compound does not aromatize in any dosage. As already mentioned, a certain part of the testosterone present in the body is converted into estrogen. This aromatization process, depending on the predisposition, can vary distinctly from one athlete to another. Oxandrolone is one of the few steroids, which cannot aromatize to estrogen. This characteristic has various advantages for the athlete. With Oxandrolone the muscle system does not get the typical watery appearance as with many steroids, thus making it very interesting during the preparation for a competition. In this phase it is especially important to keep the estrogen level as low as possible since estrogen programs the body to store water even if the diet is calorie reduced. In combination with a diet, Oxandrolone helps to make the muscles hard and ripped. Although Oxandrolone itself does not break down fat, it plays an indirect role in this process because the substance often suppresses the athlete's appetite. Oxandrolone can also cause some bloating, which in several athletes, results in nausea and vomiting when the tablets are taken with meals. The package insert of the Italian Oxandrolone notes its effect on the activity of the gastrointestinal tract. Some athletes thus report continued diarrhea. Although these symptoms are not very pleasant they still help the athlete break down fat and become harder. Those who work out for a competition or are interested in gaining quality muscles should combine Oxandrolone with steroids such as Winstrol, Parabolan, Masteron, Primobolan, and Testosterone Propionat. A stack of 50 mg Winstrol every two days, 50 mg Testosterone Propionate every two days, and 25 mg Oxandrolone every day has proven effective. Another advantage of Oxandrolone's non-aromatization is that athletes who suffer from high blood pressure or develop gynecomastia of the thymus glands when taking stronger androgenic steroids will not have these side effects with this compound. The. Oxandrolone/Deca-Durabolin stack is a welcome alternative for this group of athletes or for athletes showing signs of poor health during mass buildup with testosterone, Dianabol, or Anadrol 50. Athletes over forty should predominantly use Oxandrolone. The third reason which speaks well for an intake of Oxandrolone is that even in a very high dosage this compound does not influence the body's own testosterone production. To make this clear: Oxandrolone does not suppress the body's own hormone production. The reason is that it does not have a negative feedback mechanism on the hypothalamohypophysial testicular axis, meaning that during the intake of Oxandrolone, unlike during the intake of most anabolic steroids, the testes signal the hypothalamus not to reduce or to stop the release of GnRH (gonadotropin releasing hormone) and LHRH Luteinizing hormone releasing hormone). This special feature of Oxandrolone can be explained by the fact that the substance is not converted into estrogen Oxandrolone (Anavar), when given to © 2012 Thatotherguy

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normal men in high doses does not reduce the seminal volume or count, nor can it be converted (aromatized) into estrogen. Oxandrolone combines very well with Andriol, since Andriol does not aromatize in a dosage of up to 240 mg daily and has only slight influence on the hormone production. The daily intake of 280 mg Andriol and 25 mg Oxandrolone results results in a good gain in strength and, in steroid novices, also in muscle mass without excessive water retention and without a significant influence on testosterone production. As for the dos-age of Oxandrolone, 8-12 tablets in men and 5-6 tablets in women seem to bring the best results. The rule of thumb to take 0.125 mg/pound of body weight daily has proven successful in clinical tests. The tablets are normally taken two to three times daily after meals thus assuring an optimal absorption of the substance. Those who get the already discussed gastrointestinal pain when taking Oxandrolone are better off taking the tablets one to two hours after a meal or switching to another compound. Since Oxandrolone is only slightly toxic and usually shows few side effects, several athletes use it over a prolonged period of time. However Oxandrolone should not be taken for several consecutive months, since, as with almost all oral steroids it is 1 7-alpha alkylated and thus liver toxic. Oxandrolone is an all purpose remedy, which depending on the athlete's goal is very versatile. Women who react sensitively to the intake of anabolic steroids achieve good results when combining Oxandrolone/ Primobolan Tabs and/or Clenbuterol, without suffering from the usual virilization symptoms. Women, however, should not take more than 6 tablets daily otherwise, androgenic-caused side effects such as acne, deep voice, clitorial hypertrophy or increased growth of body hair can occur. Probably the largest disadvantages that come along with Oxandrolone are its high price and poor availability on the black market. Original Oxandrolone costs about $1 - 2 per tablet on the black market and is rarely available, if at all.

14.2.10 Pituitary Growth Hormone (pGH) Pituitary Growth Hormone is a protein hormone that is synthesized and secreted by cells call ed somatotrophs in the pituitary. Pituitary Growth Hormone controls and/or effects many physiologic processes, including muscle growth and fat metabolism. metabolism. When Pituitary Growth Hormone Hormone is generated within the body, Pituitary Growth Hormone is called endogenous and when it is administered from an outside source it is called exogenous. Growth Hormone, like many other hormones has both direct effects (acting directly on tissues and cells) and indirect effects (stimulating the release or synthesis of a hormone, like IGF-1, which will then in turn effect tissues and cells on its own). Muscle cells have both Growth Hormone receptors as well as IGF-1 receptors. When growth hormone or IGF-1 is introduced into muscle cells, more cells are created and existing cells are enlarged. These responses are known as hyperplasia and hypertrophy, and are the processes that contribute to the growth of additional muscle tissue. Growth Hormone also has the ability to directly influence Fat-Loss, as fat cells have Growth Hormone receptors. When Growth Hormone is introduced into a fat cell, the result is that the fat cell is then more readily used as energy. This process is known as lipolysis, typically called burning fat, which Pituitary Growth Hormone does simply, the conversion of fat into energy. However, while muscle cells possess both Growth Hormone as well as IGF1 receptors, allowing Growth Hormone to have a direct as well as indirect effect, fat cells do not have an IGF-1 receptor. IGF-1, which is stimulated by Growth Hormone production, works in a totally independent manner to burn fat in the body by enhancing protein, fat, and carbohydrate metabolism. Thus, Pituitary Growth Hormone has both direct as well as indirect effects on promoting muscle growth, and fat loss. Finally, based on anecdotal reports from people experienced with Pituitary Growth Hormone , results © 2012 Thatotherguy


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often take 6-8 weeks to manifest. At the 6-week point, athletes typically report that results are beginning to show, but by week 12 (and beyond), the increase increase in muscle mass and fat loss are are nothing short of amazing. This is why athletes often stay on this compound for a minimum of two months, but usually closer to three or four months at a time.

14.2.11 Primobolan (methenolone acetate) Primobolan is one of those anabolic steroids which has a cult following not unlike the old original version of Masteron. Actually, as you can easily see from its anabolic:androgenic ratio below in the profile, its a pretty weak steroid but actually stronger(!) than Masteron in both regards. I dont know anyone who has run both compounds at the same dose. We are probably justified in speculating that youd probably get similar results from either of them, when you consider the fact that you are getting quite a bit less actual drug and more ester when you choose injectable Primobolan (which has the very long Enanthate ester attached to it) over Masteron (which has the very short propionate ester attached to it). In truth, I think part of the reason many Primobolan users have been disappointed is that they failed to use enough of it, for long enough. From its chemical structure and anabolic:androgenic rating, we can assume it is at least as effective as Masteron, on an equal Mg for mg basis. However, due to its ester (in the injectable version), it needs to be run for at l east 12 weeks to see the full benefits from it. When you consider a measly dose of 400mgs of this stuff for 12 weeks will probably cost you around $500. Its easy to see why many people have tried to use less...and have been disappointed with their results. On the other hand, many competitive bodybuilders consider Primobolan indespensible to their precontest drud routine, and wouldnt consider dieting without it. Anyway...I think the comparison to Masteron (another great precontest drug) is the best one we can make, with reference to expected gains and results. I happen to be one of the few people who have used Drostanolone Enanthate (Masteron with the Enanthate ester attached) as well as Methenolone Enanthate (injectable Primobolan). I can tell you that the results from these two compounds, when ester and mg potency are the same, are in fact very similar. Effects of Primobolan Lets flesh out some of the various general effects of Primobolan, before we get into the differences between the oral and injectable versions... One study performed on sheep involved administering 100mgs of Methenolone, and electronically stimulating their lats (electronic stimulation was used because they kept falling off the chin-up bars). Anyway, when compared with the lat muscles of sheep who didnt receive Methenolone, the receiving group gained significantly more muscle mass as well as strength (1)(2). Its also has a relatively high affinity for binding to the AR, actually binding better than testosterone (3). This ability to strongly bind to the AR may be why Primobolan is such a good "fat burner." Strong AR binding has been positively correlated with lypolysis (fat-burning) (8). In addition, as this steroid can actually aid in reducing breast tumors, no ancillary products need be considered for use with Primobolan, and in fact, it may actually be a useful ancillary agent in its own right, similar to Masteron. Also, just like Masteron, Primobolan has no propensity to aromatize (convert to estrogen). Since it doesnt aromatize, alot of the side effects commonly associated with estrogen will not be of concern. This means water retention, acne, and gyno will be non-existent more or less. this lack of water retention combined with the slow and steady gains provided by Primo may help to explain why it has earned a reputation for creating quality muscle gains. This also helps to explain why it is so expensive. Although estrogenic sides are not a concern, hair loss still, remains a very real concern with Primobolan, as with many DHT-Derived steroids. Many primobolan fans always include Finasteride and Ketoconazole (shampoo) in cycles containing Primobolan. Although nobody would ever suggest to use Primobolan as a bulking agent, agent, its been studied as an agent to halt wasting and possibly reverse many of the adverse effects of anemia. It is a shocking failure in both areas, according to some of the case studies Ive read, (5)(6) and this should come to no © 2012 Thatotherguy

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surprise to anyone. Anadrol reigns supreme in this area, and nobody in the athletic community would ever compare those two drugs. However, Michael Mooney and many other respected doctors who work with AIDS patients have found sufficient evidence to claim that Primobolan is an immune enhancer and as such is very useful for AIDS patients (not that the FDA cares...Primobolan is still not approved for sale in the United States). AIDS patients arent really in need of Bulking Drugs, so an immune enhancer like Primo which will add small, quality gains in muscle is perfect for them. And since we arent even going to vaguely consider the use of Primobolan as a bulking agent, clearly this leaves us with considering it primarily for use in gaining and maintaining lean tissue. Its a great choice for this purpose, and many competitors have used it very successfully to retain muscle while on a calorie reduced diet. The reason Primo is so useful for this purpose is that one of its primary functions is to help your body retain nitrogen (7) at a greatly enhanced rate. The greater your nitrogen retention is, the more muscle you will build. In the case of using primo as a pre-contest drug, this nitrogen retention will help you retain muscle and ensure that your dieting preferentially favors fat loss over muscle loss. Primobolan is a very unique steroid, as it is one of the few that comes in both an oral as well as an injectable version. I suppose Winstrol does also, but Primobolan actually has a different ester on the oral (acetate ) and injectable (Enanthate) versions. The oral version is one of the more interesting oral compounds Ive looked into. For starters, its one of the few compounds available to athletes and bodybuilders which is both oral as well as non-17-alpha-alkylation. This alteration is (as Im sure you remember from other stuff Ive written) what generally makes oral steroids survive their first pass through your liver, but also makes them Hepatoxic (Liver toxic). Well... oral Primo doesnt have this feature, so it is very mild on your liver (actually it basically isnt liver toxic at all), but also is largely destroyed by it, since 17 beta estrification and 1 alkylation is the method used to make this stuff orally available. Youll need to take a lot of this stuff for it to be effective... 100mgs/day 100mgs/day of the oral version is a safe estimate for reasonable gains& for women, you could get away with less; perhaps 25mgs/day. Even though the acetate ester has a 2-3 day active life, your liver will do some damage to oral primo, so every day dosing will still be necessary. When men were given a 30-45mg dose of the oral version of Primo, they experienced a 15-65% decrease in gonadotropin levels (9). Remember, I said 100mgs is a good dose for gains... well, youll also reduce your gonadotropin levels considerably. I have personally never understood why people recommend either oral or injectable Primobolan as a possible bridging compound for this reason... maybe at a too-low-to-do-anything dose of 10mgs it could be used as a bridge. And forget about using injectable Primo to bridge& Hey... speaking about injectable Primo... Ive used this stuff at 200mgs/week and wasnt very impressed with it. Generally, I think injectable primo needs to be used at a dose of at least l east 350mgs/week (100mgs/Every other Day), and preferably at a dose of 400-600mgs/week. I happen to like running it with testosterone propionate, but for convenience I would imagine most people would run it with Testosterone Enanthate, to keep dosing times the same (shooting it twice per week, in most cases). Buying Primobolan The unfortunate truth about injectable Primo is that i ts a very expensive chemical to obtain, and that price is reflected in the cost to the average consumer. Ten dollars per 1ml/100mg ampule is not unheard of, and Ive seen it go for more. This is, of course, absurd. As if thats not enough, this is also the most commonly counterfeited steroids on the black market. I recommend buying Primobolan (either the oral or injectable) from a respected Underground lab instead of trying to play a game of "spot the fake steroid" in Mexico or Europe. The underground versions should cost between $5-7 for 100mgs of Methenolone and I wouldnt really consider paying more for it, although I have seen the British Dragon version of this product priced up to $20/ml. Primobolan Profile (Methenolone) (Oral Version is + Acetate Ester) (Injectable Version is + Enanthate Ester) [17beta-Hydroxy-1-methyl-5alpha-androst-1-en-3-one] © 2012 Thatotherguy


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Molecular weight of base: 302.4558 Molecular weight of Acetate ester: 60.0524 Molecular weight of Enanthate ester: 130.1864 Formula: C20H30O2 Melting Point: Manufacturer: Schering Effective dose(oral): (Men)50-100mgs/day; (Women) 10-25mgs/day Effective dose (injectable): (Men) 350-600mgs/week; (Women) 100mgs/week Active Life: 10-14 days (injectable); 4-6hrs (oral) Detection Time: 4-5 weeks Anabolic/Androgenic Ratio (Range): 88:44-57 References: Anabolic steroids (metenolone) (metenolone) improve muscle performance performance and hemodynamic characteristics characteristics in cardiomyoplasty. Ann Thorac Surg. 1995 Apr;59(4):961-9; discussion 969-70. Effect of an anabolic steroid (Metenolon) on contractile performance of the chronically stimulated latissimus dorsi in sheep. Eur J Cardiothorac Surg. 1994;8(4):214-9. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology. 1984 Jun;114(6):2100-6. [Anabolic therapy in metastatic breast cancer] Med Klin. 1981 Nov 20;76(24):689-91. German. German. Partial remission and severe adverse effect caused by metenolone acetate in a male patient with aplastic anem. Eur J Haematol. 1995 Jul;55(1):57-8. Fatal outcome of a patient with wi th severe aplastic anemia after treatment with metenolone acetate. Ann Hematol. 1993 Jul;67(1):41-3. Metabolic effects of anabolic steroids. Wien Med Wochenschr. 1993;143(14-15):368-75. Biochim Biophys Acta. 1995 May 11;1244(1):117-20. Comparative Studies about the influence of MetenoloneAcetate and Mesterolone on hypophysis and male gonads. Arzneimittelforshung. 1970 20(4) 545-7

14.2.12 14.2.12 Primotest Primoteston on Primoteston is a popular anabolic androgenic steroid made by one of the premier pharmaceutical compounding companies Schering. Schering is a German based pharmaceutical company founded in 1851 that would eventually merge with Plough and then be absorbed by Merk & co. but the area known as Schering AG would be later absorbed into Bayer and still produces compounds today. Of course, the compound were concerned with is Primoteston Depot; one of the most popular TestosteroneEnanthate compounds on earth. Interestingly enough, Schering AG also manufactures Testoviron Depot; a Testosterone-Enanthate compound that is for all intense purposes identical; this should not be confused with its Testoviron product which is actually an Enanthate and Propionate mixture. While merely a Testosterone-Enanthate Testosterone-Enanthate compound, what separates Primoteston from the rest is simply that it is Primoteston. First and foremost, Testosterone-Enanthate Testosterone-Enanthate is not only one of the most popular testosterone compounds on the market, its one of the most popular anabolic steroids; further, for the healthy adult male it carries not only extreme power and effectiveness, but a high level of toleration. As for Primoteston, of all brands and compounds of this nature, this is one of the best; infact, you will not find testosterone products like Primoteston on the market that are any better; this is truly top of the line. Schering Primoteston Depot will always be clean and pure, it will always be accurately dosed and every last thing Testosterone-Enanthate is supposed to be; in a world where counterfeits and contaminated products often run wild, this is a more than welcomed product. A truly remarkable remarkable testosterone compound, compound, Primoteston carries carries properties that that are of both a therapeutic and performance nature; in-fact, in-fact, there is a strong crossover in some cases. For a low testosterone patient, this can be the remedy, and for the individual suffering from Andropause it is often an essential part of the remedying plan. Then we have performance, and as we will see this is one of the most versatile anabolic steroids we have at our disposal. Perfect for bulking and cutting cycles, fantastic for enhancing athletic performance, this is a steroid that holds the majority of the © 2012 Thatotherguy

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primary steroidal traits, and will serve most any healthy adult male quite well. This leads us to an important note; anabolic steroids like Primoteston are typically not advised to women; the virilization rating is much too high. Women need testosterone too; however, they do not need nearly as much, and if they suffer from low levels transdermal applications or implant pellets are often the best routes. Make no mistake, Primoteston can be used to treat a low level condition in women, but if it is used, while it can be tremendously effective it must be done so with tremendously low doses. Further, as with all anabolic steroids, Primoteston should not be used by adolescents due to the severe and often irreversible damage it can cause to their developing androgen system. With all of this in mind, lets take a look at Primoteston; we want to look at its nature and traits, the benefits held within, and of course, the possible adverse side-effects. In doing so, for the healthy adult male and we will only focus on the healthy adult male, we will wil l find safe and successful Primoteston supplementation to be more than a possibility. Primoteston 101: Primoteston Depot is a single large ester based testosterone compound attached to the large Enanthate ester. As all testosterone compounds, Primoteston carries an anabolic and androgenic rating of 100 in both categories, and more importantly, its translating action is in accordance with such ratings; this is important to note as it is not the case with all anabolic steroids. As a l arge ester based compound, Primoteston carries an active half-life of approximately 10.5 days making therapeutic injections necessary every seven to eight days, with most performance based schedules falling in the two injections per week range. Large performance doses can be an exception; even though it carries a fairly long active half-life, large doses are often best in every other day to every three day range. The reason for this is due to this steroids strong aromatizing nature, and when smaller doses are applied, this appears to make it easier to control the aromatizing nature of this steroid; more on aromatization in the side-effects section. As a pure testosterone testosterone compound, this is not a substance substance our body is unfamiliar with; it is merely testosterone. As you understand, testosterone is the primary androgen and one of the most essential hormones all human beings produce; it affects our physical and sexual function and health, and even our mental function to a degree. In-order to understand the importance of this hormone, the best path to take is to understand what happens when our levels fall below satisfactory ranges; thankfully, when this occurs Primoteston can remedy the situation. Those who suffer from low testosterone, and there are more than 30-million men in the U.S. alone who suffer from a low level due to low testosterone or as part of a larger Andropause condition the following symptoms can occur: Loss of Libido: may refer to a partial or total loss Erectile Dysfunction: may refer to the inability to maintain or obtain Loss of Strength: often despite diet and exercise Loss of Muscle Mass: often despite diet and exercise Increased Body-Fat: often despite diet and exercise Loss of Energy: testosterone is essential to recovery recover goes down and energy levels decrease Depression: see all symptoms Lethargy: see energy Loss of Mental Clarity: testosterone keeps is part of what fuels the brain Loss of Focus: see clarity A Weakened Immune System: System: see recovery Insomnia: when our hormone levels are below adequate ranges, our most basic functions often falter Irritability: see all of the above As you can see, see, none of the the above is all that that exciting, and such symptoms symptoms can severely diminish your overall quality of life. Unfortunately, in most cases, once you suffer from low testosterone you will always suffer from low testosterone; however, once again Primoteston can remedy every last symptom. Further, while the above symptoms are not directly life-threatening, when low testosterone levels are ignored it can open the door to many far more serious conditions; some of which are l ifethreatening indeed. Low testosterone has been linked to diabetes, osteoporosis, Alzheimers disease and polyuria as well as a contributing factor to many more possible conditions. Of course, by the nature of testosterone, its quite easy to see how Primoteston can aid in treating a low testosterone condition; however, this doesnt tell us a lot about direct performance enhancement. Even © 2012 Thatotherguy


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so, a reversal of tissue and strength loss as well as body-fat gain should already tell you quite a bit, but when it comes to performance we want to know more; specifically, we want to understand this hormones nature as it pertains to supraphysiological doses. With Primoteston supplementation, the following steroidal traits are greatly enhanced; these are some of the most common anabolic steroidal traits of all, and Primoteston will enhance each of them massively; they include: Increased Red Blood Cell Count: the body needs oxygen, and it is the bloods responsibility to carry oxygen through the body and the red blood cells are what carry oxygen to and through the blood an increased count results in greater oxygenation largely promoting recovery, endurance and even some visual conditioning effects Enhanced Protein Synthesis: one of the primary anabolic factors protein is the building block of muscle, and protein synthesis refers to the rate by-which cells build proteins as synthesis is enhanced, this building rate is enhanced this also dramatically affects tissue preservation Enhanced Nitrogen Retention: the more nitrogen we retain, the greater our anabolic atmosphere the less nitrogen we retain, the less anabolic we remain when nitrogen levels fall too low, we can easily slip into a catabolic state Decreased Glucocorticoid Production: - the most commonly known glucocorticoid is cortisol glucocorticoid hormones are often referred to as stress hormones, and these hormones promote fat gain and destroy muscle tissue glucocorticoid hormones can also make fat-loss and tissue building extremely difficult to do if the levels are too high Enhanced Metabolism: the metabolism refers to the rate by-which we process all our body intakes, performs, produces, heals, rejuvenates and functions The Benefits of Primoteston: By now, it shouldnt be too hard to see the benefits of Primoteston; in a therapeutic sense the benefits are simply the reversal of low level symptoms. You suffer from low testosterone, as a result you suffer from some of the symptoms of the condition, but with Primoteston supplementation the problems go away; that may sound simple, but its not a complicated matter. Then we have performance enhancement, and once again the benefits should be easy to see, but as Primoteston can be used for numerous performance enhancing purposes lets put the benefits i nto a more real life understanding. For the off-season athlete, the individual looking to gain mass and strength there is nothing better than testosterone, and as Primoteston Depot is a pure and high quality testosterone compound it is the perfect solution. For such an individual, mass and strength will greatly increase, but more importantly it will do so with less body-fat accumulation that often comes with off-season periods of growth. This isnt a license to eat like a cow; do this and youll gain body-fat just as you would without supplementation, and while youll still need excess calories to grow, youll be able to grow at a more efficient and cleaner rate. Then we have cutting cycle use; this i s the period when we are trying to lose body-fat, but, unfortunately, cutting often comes with severe muscle tissue and energy loss. In-order to lose body-fat, we must be in a caloric deficit, and as we continue to lose fat our body will begin to fight this process; the body does not want to change even when change is in its best interest. As the body fights this change, as its survival instinct is to hold onto stored body-fat it will begin to take what it needs from your muscle tissue, and as you lose muscle tissue this even slows down your metabolism. Fortunately, Primoteston supplementation will prevent all of this; youll be able to lose body-fat while preserving your hard earned lean tissue, and just as important, due to the increased metabolic rate youll be able to burn fat at a higher and more efficient rate. Those are some fantastic benefits, but if thats not good enough its only going to get better. Regardless of your purpose of use, Primoteston will as mentioned above greatly enhance your muscular endurance and promote healing and rejuvenation of the body at a more efficient rate; by any definition, that is performance enhancement. You wont tire out as fast, you will heal faster and be able to perform at a higher rate more often, and all in all, youll simply be a more effective you. Your energy levels will have increased, and just as the low level patient, your sense of well-being will be increased, and as this results in a happier you it simply once again results in a better you. The Side-Effects of Primoteston: © 2012 Thatotherguy

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As with all anabolic androgenic androgenic steroids, the side-effects of Primoteston Depot are very real, and they will be the same as all testosterone compounds. By its nature, Primoteston carries a strong aromatizing nature; aromatization referring to the conversion of testosterone into estrogen. As estrogen levels increase, this can lead to some of the most common anabolic steroidal side-effects known to man, and while they are a concern there is hope. As we mentioned early on, Primoteston carries an extremely high level of toleration for the healthy adult male; so high, with responsible use most healthy adult males can avoid every last side-effect. As excess estrogen is the primary concern concern due to the aromatizing nature of this compound, the primary side-effects of Primoteston include gynecomastia, high blood pressure and water retention. Inorder to prevent such conditions, your first line of defense will be an Aromatase Inhibitor (AI) such as Anastrozole (Arimidex) (Arimidex) or Letrozole Letrozole (Femara). AIs do exactly exactly what they sound like they do; they inhibit the aromatase process from occurring, and they even lower the bodys total estrogen levels. Of course, it must be noted; AIs can have a negative impact on cholesterol levels, and testosterone supplementation, especially at a supraphysiological level can also have a negative impact on cholesterol; both HDL and LDL levels. For this reason, responsible doses of Primoteston and AI use are imperative, but just as important and perhaps more important is your overall lifestyle. First and foremost, you should not supplement with Primoteston or any anabolic steroid if you already suffer from high blood pressure of cholesterol, but if your levels are healthy you should continue to live in a way that promotes the continuation of such healthy levels. Including plenty of omega fatty acids in your diet is a great place to start; omega fatty acids will increase your HDL cholesterol, the good cholesterol, and as HDL cholesterol largely regulates LDL cholesterol, the bad cholesterol this will improve your total cholesterol levels. Beyond these effects, there are two side-effects of Primoteston use that are guaranteed in all men who supplement, and they are completely dependent on one another; testosterone suppression and testicular atrophy. When we supplement with Primoteston, our body no longer has a need to manufacture its own testosterone, and as testosterone is manufactured in the testicles, as a result they will atrophy. This atrophy does not mean they vanish or disappear, but they will lose a good bit of fullness. Even so, during supplementation, this is of very little concern; after all, while testosterone is essential to our health and natural production has been suppressed we are still providing all our body needs through exogenous use. Then we have the issue of discontinuing use, and once we discontinue use our natural production will return, but theres still more to say. When it comes to a natural recovery, first and foremost, this is assuming you did not suffer from a low testosterone condition prior to supplementation, and more i mportantly, you did not severely damage your HPTA during supplementation with improper practices. Further, for the low level patient, as you will need continuous therapy, coming off supplementation isnt an issue for you. Where this can be an issue is for the performance enhancer, and once use is di scontinued its going to take some time for your natural production to fully recover. For this reason, a Post Cycle Therapy (PCT) plan is often advised; a PCT plan should consist of one Selective Estrogen Receptor Modulator (SERM) such as Tamoxifen Citrate (Nolvadex) or Clomiphene Citrate (Clomid) with the possible inclusion of short-term Human Chorionic Gonadotropin (hCG) use. No, this will not return your levels back to their prime all on its own, theres no PCT plan on earth that can do this; however, it will stimulate your natural testosterone production, and more importantly, ensure you have enough of this essential hormone for proper function while your levels continue to naturally rise. It should al so be noted; as natural testosterone production comes back online, your testicles will return to their normal size.

14.2.13 14.2.13 Sustanon Sustanon Sustanon is without question the most popular testosterone mixture on the planet. Where most testosterone compounds are single ester compounds, Sustanon 250 is comprised of four distinct esters; four distinct testosterone compounds conjoined into one. Developed by Organon for the purpose of infrequent Testosterone Replacement Therapy (TRT) treatment, while effective it would soon be held as vital to many performance enhancing athletes; after all, Organon has for years © 2012 Thatotherguy


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manufactured some of the best anabolic steroids on earth. When it comes to Sustanon's original intent, the idea was to create a testosterone compound comprised of varying sized esters that would allow for instant testosterone benefits that would be long lasting. Of course, this hope would prove to be successful; in-fact, a TRT patient could actually remedy his low testosterone condition with only one injection of Sustanon 250 every three to four weeks. Even so, due to a mixture of small and large esters, a problem was later discovered; while low testosterone would be remedied, total testosterone levels would rise and fall beyond appropriate or satisfactory means. For this reason, if levels are to be maintained at a more stable level, one injection every teen to fourteen days is probably more efficient, and for this reason, many U.S. physicians often opt for large single ester testosterone compounds like Testosterone Cypionate. While the original intent of Sustanon was for TRT, this can be an excellent choice for performance enhancing athletes; after all, Sustanon 250 is merely testosterone. Even so, due to the mixture of four varying esters, if levels are to remain not only stable but also peaked at all times, despite large esters being a part of the compound every other day injections are normally recommended. You might be able to get by with three injections per week, but an every other day schedule wil l prove far more efficient. With all of this in mind, we want to look at Sustanon , what it is precisely, what it has to offer, the side effects associated, and of course, what you can do about them in-order to achieve successful supplementation. Sustanon Traits & Nature: As stated above, Sustanon is a four part testosterone testosterone mixture; specifically specifically it is comprised of Testosterone Propionate, Testosterone Phenylpropionate, Testosterone Isocaproate and Testosterone Decanoate. Through this mixture, the Propionate and Phenylpropionate esters represent the small esters and will provide fast acting testosterone benefits while the Decanoate ester, a truly massive ester will ensure the benefits are long lasting; the Isocaproate ester fills the role in the middle. Of course, its not enough for these esters to be conjoined together, in-order for Sustanon 250 to exist they must be conjoined together in a precise manner; otherwise, it is not Sustanon 250. The precise composition of Sustanon is as follows: 30mg/ml Testosterone Propionate 60mg/ml Testosterone Phenylpropionate 60mg/ml Testosterone Isocaproate 100mg/ml Testosterone Decanoate If you come across a product claiming to be Sustanon, if it is not comprised exactly as listed above, if i t carries varying esters or even the same esters at different doses it is not Sustanon 250; the above is what defines and separates this testosterone form. As a testosterone compound, in many ways everything that can be said of all single ester testosterone compounds can be said of Sustanon; in the end, it all comes down to personal preference. At any rate, as a pure testosterone compound, Sustanon carries an anabolic and androgenic rating of 100 in both categories, and is a highly versatile steroidal hormone. Identical to the testosterone you naturally produce, Sustanon 250 carries all the sexually related traits and plays intrinsic roles on our sexual and physical health and to a degree even our general state of mind and overall well-being. A compound that has the ability to greatly enhance enhance protein synthesis, synthesis, this is important important as protein protein is the building block of muscle tissue and synthesis represent the rate by-which cells build proteins. Further, Sust as its often called will enhance nitrogen retention in the muscle tissue; all lean muscle tissue is comprised of 16% nitrogen, and the more we retain the more anabolic we remain; our anabolic atmosphere is enhanced. While these two factors are primary and important traits, Sust is not done yet. Often ignored but truly valuable is this hormones ability to increase the production and release of Insulin-Like Growth Factor-1 (IGF-1). IGF-1 IGF-1 is highly anabolic, a peptide hormone produced by all human beings and it plays important roles revolving around our total recovery; in-fact, IGF-1 will affect nearly every cell in the human body. Enhanced protein synthesis, nitrogen retention and IGF-1 are all important factors, but Sustanon continues to not disappoint. Through supplementation, red blood cell count is increased, and as red © 2012 Thatotherguy

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blood cells carry oxygen to and through the blood this results in greater blood oxygenation. Then we have glucocorticoid suppression; simply put, the suppression and reduction of stress hormones. These nasty hormones, cortisol being the most well-known are in many ways the opposite of anabolic hormones in that they destroy muscle tissue and promote fat gain; Sustanon will see such hormones suppressed. A hormone that aromatizes heavily, like all testosterone compounds Sustanon Sustanon 250 can lead to to adverse estrogen effects. Further, due to its heavy androgenic activity, this is a steroid that cannot be recommended to women or virilization will occur. Absolutely, women need testosterone, and they can suffer from low testosterone, but if therapeutic treatment is needed a single ester compound is easier to control. As for performance enhancement, the doses necessary to promote such performance will always lead to some level of virilization and on this basis other steroids must be chosen; specifically steroids that possess low androgenic activity and low virilization ratings. Testosterone ReplacementTherapy Benefits of Sustanon: When it comes to Testosterone Replacement Therapy, the benefits of Sustanon are fairly straightforward; your testosterone levels are low, Sust is pure testosterone, and through administration the problem is solved. Through supplementation, each and every last symptom of low testosterone can and will be reversed, and as a result, your overall quality of life enhanced. Those who suffer from low testosterone often find their libido is severely diminished and often erectile dysfunction becomes a problem, but these are hardly the only symptoms. A loss of muscle mass and strength is often common as is increased body-fat, and this can all occur despite proper exercise and dieting habits. Further, those who suffer often find their energy levels drained, they become depressed, suffer from insomnia and their immune system weakens; not to mention they suffer from a lack of mental clarity and open the door to many far more serious conditions. When low testosterone is ignored, it has been shown to be a contributor to leading l eading to diabetes, osteoporosis and even Alzheimers disease. Thankfully, if you suffer from low levels, Sustanon 250 can ensure you suffer no more, and the odds of you falling prey to the more serious conditions will be greatly improved. Performance Benefits of Sustanon: In many ways, there is a lot of crossover as it pertains to TRT and performance based supplementation of Sustanon, but in this case, were referring to supraphysiological doses. In a TRT plan, we are supplementing with testosterone in-order to bring our levels back to normal, but with performance the idea is to increase i ncrease them beyond what can normally be achieved in-order for more testosterone to be available to do what testosterone does best. In any case, when it comes to the performance benefits of Sustanon 250, they can largely be broken down into three categories, bulking, cutting and overall enhancement. Bulking: with supplementation and adequate calories present, you will be able to gain more lean mass as well as see your strength increase. Further, due to the metabolic enhancing properties of testosterone, you will be able to do so with less body-fat accumulation that normally accompanies mass gaining phases. Cutting: when it comes to the cutting cycle, many often think of other steroids before they think of Sustanon or any testosterone compound, but exogenous testosterone can be essential to a successful plan. Through use, you will ensure you preserve as much lean tissue as possible while calories are restricted, and this is invaluable. When we diet, in-order to lose body-fat our caloric intake must be at a deficit level; we must burn more calories than we consume in-order to burn body-fat. As a result, lean tissue is often lost, but Sust will protect it, and the more lean tissue you hold onto the more fat you'll burn. Couple this with testosterones metabolic enhancing properties and you're a fat burning machine. Overall Enhancement: regardless of your purpose of use, bulking, cutting or to simply enhance athletic performance, you will find Sustanon is one of the most versatile steroidal compounds on earth. Regardless of your purpose of use, your muscular endurance will be enhanced as will your overall rate of recovery, and those two traits alone make this a steroid worthy of consideration. When we look at all these benefits and how testosterone affects the body in its every day functional sense, the benefits of Sustanon 250 as you can see are truly vast. The Side Effects of Sustanon: As a heavily aromatizing aromatizing steroid, the the primary side-effects side-effects of Sustanon 250 will be those of an © 2012 Thatotherguy


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estrogenic nature as the aromatase process refers to the conversion of testosterone into estrogen. As estrogen levels increase, this can lead to gynecomastia and excess water retention, which can in-turn promote high blood pressure. For this reason, its often advised that the use of an Aromatase Inhibitor (AI) be present with the use of any testosterone compound; Anastrozole (Arimidex) and Letrozole (Femara) are always your best choices. By their natural mode of action, AIs will inhibit the aromatase process from occurring and even lower the bodys total estrogen levels; problem solved. It should be noted; Selective Estrogen Receptor Modulators (SERMs) can also protect against gynecomastia by binding to the receptors in the place of estrogen; however, they will not inhibit aromatase or reduce estrogen levels. This means SERMs cannot offer protection beyond gynecomastia, and depending on your dosing and overall sensitivity they may not be enough to protect you from that; AIs are the only true answer. While AIs can offer a lot of protection, and with supraphysiological doses of testosterone they're often recommended, they can have a negative impact on your lipid profiles as can supraphysiological doses of testosterone to a degree. Its not uncommon to see LDL levels increase and HDL levels decrease, but all hope is not lost. For this reason, it is imperative you do not supplement if you have high cholesterol, but if healthy you should give extra effort into ensuring the continuation of such healthy levels. A great place to start is with the consumption of plenty of omega fatty acids as they will increase your HDL levels, which will in-turn regulate your LDL levels. Notes on Sustanon Side-Effects: You should not supplement if you have hi gh blood pressure. You should not supplement it you have high cholesterol. You should not supplement if i f you suffer from prostate enlargement. You should not supplement if youre not a healthy adult male. Weve already looked at blood pressure and cholesterol, and while prostate enlargement is unlikely with testosterone use, it is possible, and the problem could be exasperated if you already suffer. The testosterone hormone has the ability to convert into dihydrotestosterone (DHT), the androgen that causes prostate enlargement, but it takes a massive DHT buildup for a healthy prostate to fall prey. Further, DHT buildups of a massive nature can induce hair-loss in men who are predisposed to malepattern baldness; however, if you are predisposed you were going to lose your hair anyway. It must be noted; when it comes to the side effects of Sustanon 250, TRT patients rarely have a large concern; after all, theyre merely replacing, they are not enhancing. With TRT level doses, we are not presenting a hormone we are unfamiliar wi th or surpassing levels our body is unaccustomed to; once again, we are merely replacing what we are lacking with a hormone we are very familiar with. Then we have adolescent use, and in no way can such use be recommended unless under severe therapeutic need due to the damage it i t could cause to a fragile and underdeveloped androgen system. Making a Purchase of Sustanon: If you decide to buy Sustanon for the purpose of performance enhancement, in many cases, especially if you live in the U.S. youll be doing so on the black market, and this compound comes with a cost with such a purchase. First and foremost, this is one of if not the most expensive testosterone compounds youll ever find; this is largely due to is extreme popularity. Further, this is without question the most commonly counterfeited testosterone testosterone compound youll ever find. In most cases, when counterfeited its still testosterone, but its normally a single large ester testosterone compound and not the precise four ester mixture as described above. For these reasons, if you decide to buy Sustanon 250, youll need to put in a little extra effort if youre going to find a good price, and more importantly, if youre going to find a quality product. Make no mistake, theres plenty of high quality product at a reasonable and fair rate, but you may need to do a little digging. Sustanon Profile 17b-hydroxy-4-androsten-3-one Testosterone base + 4 different esters Propionate , Phenylpropionate, Isocaproate, Decanoate Formula (base): C27 H40 O3 Molecular Weight (base): 288.429 Molecular Weight, Esters: © 2012 Thatotherguy

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Propionate: 362.5082 Phenylpropionate: 438.6058 Isocaproate: 404.5886 Decanoate: 460.6958 Formula (base): C19 H28 O2 Melting Point (base): 155 Manufacturer: Organon Effective Dose (Men): 500-2000mg/ week Effective Dose (Women): Not recommended Active life: Up to 3 weeks Detection Time: 3+ months Anabolic/Androgenic ratio:100/100 Sustanon References: J Lab Clin Med. 1995 Mar;125(3):326-33. Mar;125(3):326-33. Anat Histol Embryol. Embryol. 2003 Apr;32(2):70-9. Apr;32(2):70-9. Health Psychol. 1990;9(6):774-91. Zhonghua Nan Ke Xue. 2003;9(4):248-51 Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7. May;7(3):271-7. J Appl Physiol. 2001 Mar;90(3):850-6. Can J Physiol Pharmacol. 1999 Apr;77(4):300-4. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E222-E227. Jan;288(1):E222-E227. Epub 2004 Sep 14. J Clin Endocrinol Metab. 2004 Dec 21 Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81. Dec;281(6):E1172-81.

14.2.14 14.2.14 Testoste Testosterone rone While there are numerous hormones we may aptly label important in-terms of proper function and health, for men the hormone testosterone is of great importance. Both men and women require testosterone for a well-functioning body but men do so in far higher amounts then their female counterparts. While a very important hormone and largely misunderstood, testosterone is easily one of the most exciting hormones we can discuss, especially as it pertains to performance enhancing; infact, we can confidently say it is the most important hormone in the performance enhancing game. Without adequate levels of testosterone our goals will largely not be met and without wi thout increased levels you can in many cases wave goodbye to the idea of surpassing these goals to a great degree. As a very important hormone, in order to make the most of exogenous use, meaning in this case testosterone introduced beyond our natural production, we are best served to first have a general understanding the hormone itself and then how best to maximize its use regarding its various forms. What is Testosterone? Testosterone belongs to a class of hormones known as androgens; in-fact this is the primary androgenic hormone. A very powerful hormone in its own right, testosterone is largely responsible for testicular and prostate development, as well as the development of muscle tissue, bone density and strength. Beyond these basic functions, testosterone is by-in-large imperative for our overall general health and well-being; low levels of testosterone can not only negatively affect muscle and bone strength but can negatively affect our state of mind. While a member of the androgenic class of steroidal hormones, testosterone is also highly anabolic. As both androgenic and and anabolic, like all steroidal hormones testosterone testosterone is derived from from cholesterol and is largely regulated in terms of production by luteinizing hormones (LH) and follicle stimulating hormones (FSH). Being regulated by LH and FSH, in order for these hormones to be released the pituitary gland must first be stimulated in order to achieve this purpose; once achieved and LH and FSH are released, testicular stimulation is achieved thereby causing the production of testosterone. As you can easily see, as important as the testicles are in testosterone production, the pituitary gland is of equal importance; without adequate pituitary function natural testosterone production cannot occur. The Birth of Exogenous Testosterone: While a hormone we naturally produce and for centuries athletes of all types have experimented with © 2012 Thatotherguy


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testicular extract but true synthetic testosterone intended for human use first made its way to the scene in 1935, largely thanks to chemists Adolf Butenandt and Leopold Ruzicka who both received a Nobel Prize for their work. With the testosterone hormone now being isolated and synthesized the first successful injections of testosterone were available in the form of Testosterone-Propionate. Testosterone-Propionate. Once the first batches of testosterone were made available, soon after many other forms would be introduced and made ready for human use but there is something important you need to understand. All testosterone in a general sense is the same; it is the ester attached attached that gives it its own unique function regarding time release and duration of activity but by-in-large all exogenous testosterone is simply the same testosterone. We will explain as we go along and get into understanding half-lives. - Click on the following link for more info on the [History of Steroids] The Benefits of Exogenous Testosterone Use: There are many benefits to testosterone use and while they are generally the same for anyone who uses they can be largely dose dependent in-terms of the overall effect. Many men who use testosterone simply do so as part of a hormone replacement therapy plan; the idea i s to raise testosterone levels to a normal range after they have fallen short. Many other men use testosterone for an entirely different purpose; to increase levels far beyond normal in order to enhance performance. Regardless of your purpose you can expect to receive the following benefits to one degree or another: Increased Recovery Abilities: The most apt example revolves around training/exercise. The act of training is not when muscle is built but rather torn down; it is through the recovery process in-which muscle tissue is built. Testosterone will increase the rate of recovery, improve the efficiency of recovery in-turn leading to a more efficient and capable physique. Stronger Anti-Catabolic Protection: some hormones have a negative effect on muscle tissue and can promote body fat; most notable is the hormone cortisol. Testosterone can aid in blocking and reducing this negative hormone reaction ensuring your muscle tissue is protected and body fat is not accumulated. Increase Red Blood Cell Count: Testosterone can greatly increase your endurance; the higher the endurance will result in the ability abili ty to do more work, i.e. train. By this increase in red blood cells we are able to increase the amount of oxygen entering the blood which increases working capabilities and can lead to greater muscle tissue efficiency. Increased Protein Efficiency: By supplementing with testosterone we increase protein synthesis, thereby increasing the level and rate in-which we build muscle tissue or protect it in a calorie restricted diet. Further, we are able to maintain a higher level of protein storage in-part due to an increase in nitrogen production due to higher levels of testosterone. These are all positive attributes to supplemental or exogenous testosterone use and the same effects can be achieved regardless of the form of testosterone we use. While these are not the only positive traits these are the most fundamental to our process and essential to our goals revolving around testosterone use. Testosterone Forms: There are many forms in-which testosterone can be found, as well as application methods. The most common form of application is by way of injection but there are transdermal gels and patches that may be used as well and even orally administered gel caps and tablets. While injectable testosterone is by far the most effective, all forms can be largely found in a hormone replacement plan but for the performance enhancer the injectable administration will prove to be far more efficient and desirable. Beyond application, ester attachment is the largest difference most testosterones will display and this will be the most important aspect regarding the various types as it pertains to interest and understanding. While there are many types of testosterone, in the grand scheme there are six common forms worth discussing in detail; beyond these six there are other forms included as we will see but the following six will wi ll be of the greatest importance to you and they include: Testosterone-Propionate Testosterone-Enanthate Testosterone-Cypionate © 2012 Thatotherguy

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Testosterone-Suspension Sustanon-250 Omnadren Testosterone-Propionate: The original testosterone; Testosterone-Propionate is one of the most popularly used forms the world over. This type of testosterone is defined by the fast-acting short ester it has attached known as the Propionate ester. The results and effects caused by this testosterone will largely be identical to all other forms but it is in the half-life it possesses where it differs to the highest degree. TestosteronePropionate carries with it a half-life of approximately 48 hours; due to this short half-life most users will need to administer the hormone quite frequently; most performance enhancing athletes will inject this testosterone on an every other day schedule in order to maintain stable blood levels. Milligram for milligram Testosterone-Propionate has been reported to be slightly more potent than many other testosterone forms; however, this difference is very negligible. There is another effect/ benefit that is noted by many Test-Prop users as it is commonly called and it revolves around water retention. All testosterones have the ability to cause excess water retention; although very diet dependent, however, many Test-Prop users report less water retention with use as compared to other forms. Theres no doubt about it; Testosterone-Propionate while a very simple hormonal compound is very effective and a more than solid choice in testosterone for most any athlete. Even so, some users will find this particular form difficult to use; some, the majority will not. Some individuals will find they are very sensitive to the Propionate ester and wil l find they experience a level of discomfort from the medication. If you fall into this category all hope is not lost; those who experience degrees of pain from Testosterone-Propionate Testosterone-Propionate in most all cases will not experience it from other common forms.

- For more info see: Testosterone-Propionate Testosterone-Enanthate:

Testosterone-Enanthate Testosterone-Enanthate is a pure testosterone with a slow-acting long ester attached and is a testosterone of high popularity. Like the Propionate version it is one of the most common forms used the world over by performance enhancing athletes. As for the functional properties of TestosteroneEnanthate, the same exact results will generally be obtained i n comparison to the Propionate version assuming doses are similar. As a long ester testosterone, testosterone, commonly commonly known as Test-E, this steroid carries with it a half-life of approximately 15 days. Due to the long half-life, injections will not need to be of a frequent nature, especially if it is used in a hormone replacement plan. However, for the athlete an administration schedule of 2 injections per week is common place and generally accepted as the best form of application. Most athletes will find 2 injections of equal doses to provide them wi th the results they are looking for. As this protocol is very effective, increasingly many competitive bodybuilders will opt for a more frequent injection schedule, as often as once every other day. Although this is not necessary when we consider the long half-life and duration of drug activity many bodybuilders report more stable blood levels and a general better feeling by keeping testosterone levels at maximum peak levels. There are many quality brands you may choose from when using Testosterone-Enanthate but there is one brand that is universally accepted as the premier form and that is Testoviron Depot. While there are many other quality pharmaceutical grade brands available, many just as good, Testoviron Depot has for whatever reason developed a grand mystique behind its name, so much so that it may indeed be the most popular brand of Testosterone-Enanthate or any testosterone of all time.



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- For more info see: Testosterone-Enanthate Testosterone-Cypionate: Virtually identical in almost every way to Testosterone-Enanthate, Testosterone-Cypionate Testosterone-Cypionate is another slow-acting long ester testosterone of high popularity. Absolutely everything that can be said of Testosterone-Enanthate Testosterone-Enanthate can be said of Testosterone-Cypionate with one minor difference. While generally structurally the same as the Enanthate ester, Test-Cyp or simply Cyp as its commonly known possesses a half-life of approximately 24 hours longer. The very slightly longer half-life is of negligible mention when we consider the total half-life time span, so much so that injection frequency schedules will be the same with Cypionate as they were with Enanthate. There is however a more or less urban legend regarding Testosterone-Cypionate; for one reason or another this legend has really taken hold in the United States. The common story goes and is believed by many that Testosterone-Cypionate is stronger than Testosterone-Enanthate; Testosterone-Enanthate; the truth is thats a lie. You may absolutely find a more powerful Cyp if youre basing your experience on underground versions but as Human Grade pharmaceutical testosterone goes both Test-E and Cyp are virtually twins and this includes the kick they provide.

- For more info see: Testosterone-Cypionate Testosterone-Suspension: While Test-E and Cyp are virtually identical and Test-Prop is close to the same except for the shorter ester, while Testosterone-Suspension is simply testosterone too it has perhaps the most notable differences of all; two of importance. Unlike most forms, Testosterone-Suspension does not have an ester attached. Because of the lack of ester the conversion rate or actual usable and absorbed testosterone from each injection is 100% while other common forms carry with them absorption rates of approximately 75%. Another important aspect regarding Testosterone-Suspension Testosterone-Suspension revolving revolving around its lack of an ester is the frequency in-which it must be administered. As you may or may not understand, the ester attached to a steroid will determine its duration of activity; for example, if we inject 100mg of TestosteronePropionate with a half-life of 48 hours, at the 24 hour mark after injection we now have 50mg of active testosterone left; after another 48 hours we now have 25mg of active testosterone left and so on until there is none left at all. From one 100mg injection of Testosterone-Suspension Testosterone-Suspension in less than 24 hours we will have no active testosterone left. For this reason very frequent injections of this steroid must be administered to have any desired effect; athletes will inject this steroid at minimum once per day and often at least twice. Testosterone-Suspension Testosterone-Suspension further carries the trait of being suspended in water; while almost all testosterones are suspended in oil this gives Testosterone-Suspension an even more potent and fast acting effect. It is important to note, as a water based steroid this testosterone can be very painful to inject; so much so that most athletes cannot tolerate the pain. As this pain can be very intense, it is largely an individualistic type of thing; much of steroid use is largely trial and error and while it may be painful to inject this steroid for you, for another there may be no pain at all.

- For more info see: Testosterone-Suspension Testosterone-Suspension Sustanon-250: © 2012 Thatotherguy

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Sustanon-250 is not a testosterone in of itself but a mixture of four different testosterones. Like all testosterone, the four various forms mixed together here are simply testosterone; in that there is no difference. However, each form mixed to comprise Sustanon-250 has a different ester attached to it thereby giving a slow steady release of testosterone for an extended amount of time. The composition of Sustanon-250 is as follows: Testosterone-Propionate: Testosterone-Propionate: 30mg Testosterone- Phenylpropionate: 60mg Testosterone-Isocaproate: Testosterone-Isocaproate: 60mg Testosterone-Decanoate: Testosterone-Decanoate: 100mg While we are familiar with the Propionate ester the remaining three esters that create Sustanon-250 are almost always found as part of a mixture or compounded anabolic androgenic steroid. Developed by Organon, the original idea behind Sustanon-250 was to provide a testosterone form well-suited for hormone replacement therapy that would only needed to be administered once every few weeks and for all intense purposes the idea was a success. For the performance enhancing athlete Sustanon-250 can be a fine choice but the idea of injecting only once or twice a month is not applicable here. As a performance enhancer this testosterone like all forms will need to be administered on a more frequent basis. This mixture carries with it two fast, short esters, Propionate and Pheylpropionate, a longer more moderate ester Isocaproate and the very slow and long Decanoate ester. In order to keep testosterone levels stable and at their peak most athletes will inject Sustanon-250 at a minimum of every 3 days and more commonly every other day for optimal results.

For more info see: Sustanon-250 Omnadren:

Everything that can be said of Sustanon-250 can identically be said of Omnadren. While virtually identical the only difference worth noting i s the four esters attached. Like Sustanon-250, Omnadren is comprised of 4 various testosterones each with its own ester, the difference here is in the last ester or longest ester. While the longest ester in Sustanon-250 is that of Decanoate, Omnadrens final ester is Caproate dosed identically at 100mg; beyond this very slight difference there is nothing worth noting regarding Omnadren.

For more info see: Omnadren Side-Effects of Testosterone Use: Testosterone use carries with it the possibility of negative side-effects as do all anabolic steroids. As this may sound unpleasant and any side-effect is, keep in mind, all medications, steroidal and nonsteroidal alike carry with them the possibility of adverse reactions. The most common possible sideeffects include: Testicular Atrophy Water Retention Gynecomastia High Blood Pressure Acne Adverse Cholesterol Reactions © 2012 Thatotherguy


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Of these side-effects only one is certain and it is testicular atrophy; yes, if you are a male and you use exogenous testosterone your testicles will shrink; however, once you discontinue use they will return to their normal size. There is a very simple explanation for this occurrence; our natural testosterone is produced in the testicles, once outside testosterone is introduced into the body our testicles no longer have a need to produce any testosterone and therefore shrink. Once use is discontinued and natural testosterone production begins again our testicles will return to their previous state. As for the remainder remainder of the side-effects, these these are largely avoidable avoidable or reversible if they do occur; a simple breakdown would be as follows: Water Retention: Testosterone use can cause us to hold more water than we would otherwise, this much is true but in most cases this is highly exaggerated. In most all cases and we will see this to be true with most possible side-effects, ones diet will largely affect this outcome. Diets that are too high in carbohydrates will cause you to bloat or hold more water; add in excess testosterone and this will be more pronounced. While some individuals will be far more sensitive than others the use of a good Aromatase Inhibitor Inhibitor (A.I.) will largely eliminate this problem. Gynecomastia: AKA Gyno or Bitch Tits can occur due to testosterones aromatizing effect. While this is a side-effect no man wants, if we supplement with adequate aromatase inhibitors such as Anastrozole (Arimidex) or Femara (Letrozole) we will largely eliminate any Gyno occurrence. However, some individuals will find they are extremely sensitive to testosterone use and even a good aromatase inhibitor will not save them; while a minority, these individuals will have to have their Gyno surgically removed if they desire to supplement. Blood Pressure & Cholesterol: Testosterone use can have a negative effect on both of these issues. Keep in mind, if you are already al ready susceptible to either the chances of you being negatively affected will increase. If you already have issues you are highly advised to get them under control before you begin use; for the remainder of you there are things we can do to prevent them from happening. As with so many things regarding anabolic androgenic steroid use, diet and nutritional intake is of the utmost importance. Supplementing with healthy Omega Fatty Acids in many cases can eliminate these sideeffects from occurring. Acne: It is a dreaded side-effect for one simple reason; reason; whats the point of a well-tuned well-tuned physique if its covered in pimples? While most all forms of anabolic androgenic steroids present this risk, by-in-large it is highly exaggerated. In most cases, not all but most, acne is caused by using gear you shouldnt be using in the first place; were talking about the plethora of underground gear that is nothing short of garbage. Use human grade testosterone and most of you will never see this problem occur. Testosterone Doses & Cycles: For the individual who undergoes hormone replacement therapy your doctor will determine your appropriate dose but for the athlete looking for a boost this dose will always be a great deal higher. There is no question, a mere 250mg per week of testosterone can provide a fantastic edge but in most circles 500mg per week is considered the gold standard for optimal results. Yes, doses can range much higher than 500mg per week; it is not uncommon for many athletes to use as much as 1,000mg per week and while less common but certainly not rare even as high as 1,500mg per week. It is important to note, there is a risk to reward ratio highly in effect as it pertains the our testosterone use; the higher the dose the potential for a higher reward but the higher the dose the greater increase of risk in-terms of negative side-effects and risk to our overall health. Most all beginners are advised to never go beyond 500mg per week and many veteran users will find this is all they ever need. If you do desire to chance a higher dose that is a call only you can make but understand the increase in risk is very real. As for cycles, in this instance were referring to the duration of use, use, a common minimum minimum length of time is 8 weeks, with 12 weeks being far more optimal for quality results. While a majority of veterans will use at minimum for 16 weeks, although not as common many will use for far extended periods of time; again, greatly increasing the risk to reward ratio. For most athletes, regardless of their level of experience with testosterone use, cycles of 12 weeks to 16 weeks in length will be their best bet and best suited for their long-term overall health.


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* This product is not to be used by anyone 18 years of age or younger. Use under a doctors supervision. This product is not a drug and should be used correctly. Use in conjunction with a well balanced diet and an intense bodybuilding or exercise program.

14.2.15 Testosterone Cypionate

Cypionate profile: Cypionate is a powerful anabolic drug that increases muscle mass in the user. It has a perfect anabolic androgenic rating, which means it will convert to estrogen in the body at very high levels. Also, muscle mass gained when using Cypionate will be lost relatively quickly after discontinuing use. Testosterone Cypionate is an endogenous androgen, which means it wi ll cause the development of masculine characteristics such as deepening of the vocal chords and body and facial hair growth. In the muscle tissue, Cypionate will improve nitrogen retention, causing the muscles to grow by allowing the tissue to store more protein. Cypionate dosage and usage Cypionate is best used in short cycles to avoid the effects of its conversion to estrogen. Users often stack Cypionate with other drugs at the beginning of a cycle to bulk up and continue with other drugs once the muscles have developed. A range of 250 to 1000 mg/week is the most common dosage taken, however, some athletes have been known to take much larger doses of the drug Cypionate side effects Because Cypionate converts rather easily into estrogen, the usual estrogenic side effects are present – gynocomastia, water retention, reduction of the the testicles. Also, Cypionate, if taken taken over long periods periods of time will alter the way the body stores fat and can lead to clogged arteries. For this reason, it is not recommended to use Cypionate regularly. Cypionate availability Cypionate is mostly used as an injectible. However, it can also be found in pill form or as a skin patch. There are also many fakes that are sold on the black market. Avoid products made by Lemmon, Goldline and in-ternational Pharmecutical. Real Cypionate is relatively easy to find on the black market and costs $10 to $15 for a 200 or 250 ml vial. Cypionate research Testosterone Cypionate has been researched for several applications besides just bulking up. It has been tested for its effects on hair loss, helping with prostrate function, hormone replacement therapies for men with dysthymia and to help with recovery from spinal cord injury among others. http://www.ncbi.nlm.nih.gov/pubm http://www.ncb i.nlm.nih.gov/pubmed?term=testo ed?term=testosterone%20cypionat sterone%20cypionate e Testosterone base + cypionate ester Formula: C27 H40 O3 Molecular Weight: 412.6112 © 2012 Thatotherguy


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Molecular Weight (base): 288.429 Molecular Weight (ester): 132.1184 Formula (base): C19 H28 O2 Formula (ester): C8 H14 O2 Melting Point (base): 155 Melting Point (ester): 98 – 104 C Manufacturer: Various Effective Dose (Men): 300-2000mg+ week Effective Dose (Women): Not recommended Active life: 15-16 15-16 days Detection Time: 3 months Anabolic/Androgenic ratio:100/100.

14.2.16 Testosterone Enanthate Testosterone Enanthate Testosterone Enanthate is probably the most commonly used form of testosterone by both athletes and bodybuilders alike. Further, in the United States, it is one of the most commonly prescribed testosterone compounds for the treatment of low testosterone or andropause conditions; however, Testosterone Cypionate is the most commonly prescribed when an injectable form is offered. Extremely effective for building muscle and enhancing strength, Testosterone Enanthate can also help with losing fat and it comes with wi th some great news; its very cheap and widely available. In-order to understand exactly how Testosterone Enanthate (commonly referred to as "test-e") builds muscle and burns fat, first well take a look at androgens and what they do in the body. You see, hormones are substances secreted by one cell that has an effect on the functions of another cell. Testosterone is manufactured in the Leydigs cells of the testes (in men) and the adult male produces between 2.5 and 11mgs of Test per day. Testosterone induces changes in shape, size and also can change the appearance and the number of muscle fibers(7). Androgens like testosterone, which is exactly what Testosterone Enanthate is can protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones(8), thus inhibiting their ability to send a message to muscle cells to release stored protein. Remember, testosterone sends a message to muscle cells to store more contractile protein (called actin and myosin); glucocorticoid hormones send the opposite message. In addition, Testosterone Enanthate has the ability to increase erythropoiesis (red blood cell production) in your kidneys(9), and a hi gher Red Blood Cell (RBC) count will improve endurance via better oxygenated blood. More RBCs can also improve recovery from strenuous physical activity. Of course, aggression levels can rise dramatically with the use of exogenous testosterone (15); however, its important to remember aggression in of itself is not a bad thing; what we do with it is what makes it right or wrong. At any rate, Testosterone Enanthate holds no mind altering traits or nature whatsoever. All of these great great benefits are to be had with the use of Testosterone Enanthate Enanthate alone, but realistically, it will in most cases be part of a cycle containing one or more other steroids. People who are bulking will probably choose Deca Durabolin or Trenbolone compounds, and of course the possibility of powerful oral steroids like Anadrol or Dianabol. Then we have those who are cutting, and they wil l probably steer towards Equipoise and once again Trenbolone, along side compounds such as Anavar, Masteron, Winstrol and perhaps Primobolan; all are solid options. Very often users will administer Testosterone Enanthate once or twice a week, but blood levels are still above baseline with this steroid at around day eight (16).Common wisdom holds that the testosterone portion of any such cycle should be equal to or greater than any other injectable steroids portion (on a mg basis); however, this isnt always needed, but its a good rule of thumb to ensure no low testosterone condition exists. As you may have have suspected, Testosterone Testosterone Enanthates anabolic/androgenic effects effects are dose dependent; the higher the dose the higher the muscle building effect(10). Lets take a look at exactly what kind of results we can expect from administration of Testosterone Enanthate: Effects of 20 weeks of GnRH agonist plus Testosterone Enanthate administration on relative changes (mean SEM) in total LBM (A), appendicular LBM (B), and trunk LBM (C) (percent change from © 2012 Thatotherguy

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baseline) measured by DEXA. P values are results for ANOVA: *, P < 0.05 vs. all other dose groups for the multiple comparison tests using Student-Newman-Keuls; a, P < 0.05 vs. zero change.(11)

This chart shows that the subjects in this test made a roughly 15% gain in Lean Body Mass from 20 weeks of 600mgs/week of Testosterone Enanthate. That's pretty impressive, but the following set of charts is even more telling:



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Change in fat-free mass (A), fat mass (B), leg press strength (C), thigh muscle volume (D), quadriceps muscle volume (E), sexual function (F), insulin-like growth factor I (G), and prostate-specific antigen (H). Data are means SE. *Significant differences from all other groups (P < 0.05); significant difference from 25-, 50-, and 125-mg doses (P < 0.05); +significant difference from 25- and 50-mg doses (P < 0.05); and significant difference from 25-mg dose (P < 0.05). (14) Now this is very interesting. You'll note that the most fat was lost by the group in this study who used the highest dose of Testosterone Enanthate (600mgs/week), and the most Fat Free mass, Strength and Muscle Volume was gained, when compared to any of the lower doses studied (14). Basically, the more Testosterone Enanthate you use (and this holds true for almost all steroids), the more gains you'll get! Of course, that the previous statement will ruffle some feathers in the "less is more" club, but that's simply too bad; more Testosterone Enanthate = more muscle, more strength, more size, and less fat. Did the men in this study experience side effects at the 600mg dose? Well, HDL cholesterol was lowered (but not total cholesterol or triglyceride levels), and two guys got Acne. Not exactly cause for a Senate Investigation. (14) Of course, the usual nasty side effects you can get from any form of injectable testosterone are possible with Testosterone Enanthate; gynecomastia, water retention and high blood pressure are all possible, but they are very overstated or controllable in many instances. A large percentage of those side effects effects occur from from the body's ability ability to turn Testosterone Testosterone Enanthate, which is again simply a testosterone hormone into estrogen via a metabolic pathway mediated by the aromatase enzyme. This process, known as aromatization causes a portion of testosterone to be converted to estrogen. Aromatase Inhibitors, Anastrozole (Arimidex) and Letrozole (Femara) can © 2012 Thatotherguy

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combat this very effectively, and are usually necessary with doses over a gram per week, and often recommended with lower performance doses. Now that we understand Testosterone Enanthate, lets talk about cost. You should be paying no more than $75 for a 10cc bottle of Testosterone Enanthate, dosed at 250mgs/ml. Of course, as usual, prices fluctuate depending on the brand or supplier, but $75 is a standard underground label range. Even so, you can easily obtain Testosterone Enanthate in high quality form from an underground lab for even less, as little as $40 per 10ml, but youll need to do some digging. As for human grade forms, $100+ for 10ml is quite common, especially if its purchased directly from the pharmacy; however, with the right large supplier you can easily find $60 pricing; even Testoviron Depot, considered one of the best Testosterone Enanthate compounds on earth has been found for as little as $5 to $7 per ampule. Testosterone Enanthate Steroid Profile 17b-hydroxy-4-androsten-3-one Testosterone base + Enanthate ester Molecular Weight: 412.6112 Molecular Weight (base): 288.429 Molecular Weight (ester): 130.1864 Formula (base): C19 H28 O2 Formula (ester):C7 H12 O Melting Point (base): 155 Manufacturer: Various Effective Dose (Men): 300-2000mg+ week Effective Dose (Women): Not recommended Active life: 10.5 days Detection Time: 3 months Anabolic/Androgenic ratio:100/100. Testosterone Enanthate References: Am J Physiol. 1998 Nov;275(5 Pt 1):E864-712 J Clin Endocrinol Metab. 1997 Feb;82(2):407-13 Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7. Mar;282(3):E601-7. Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7. May;7(3):271-7. Curr Pharm Biotechnol. 2004 Oct;5(5):459-70. Oct;5(5):459-70. J Clin Endocrinol Metab. 2004 Oct;89(10):5245-55. Anat Histol Embryol. Embryol. 2003 Apr;32(2):70-9. Apr;32(2):70-9. J Lab Clin Med. 1995 Mar;125(3):326-33. Mar;125(3):326-33. Zhonghua Nan Ke Xue. 2003;9(4):248-51 J Clin Endocrinol Metab. 2003 Apr;88(4):1478-85 J Clin Endocrinol Metab. 2004 Feb;89(2):718-26. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52. Biochim Biophys Acta. 1995 May 11;1244(1):117-20. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81. Dec;281(6):E1172-81. Health Psychol. 1990;9(6):774-91. Fertility and Sterility 33.



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14.2.17 Testosterone Heptylate

Testosterone Heptylate has been on the market since the 1950s. It is know to have a strong anabolic effect and a distinct androgenic effect as well, which causes a quick buildup of muscle strength and mass. Testosterone Heptylate also causes strong protein synthesis which will increase appetite as the user builds muscle mass. Diets that are high in protein are strongly recommended while using this drug for maximum gains. Water retention is also lower with Testosterone Heptylate than with other testosterone compounds, making muscle gains solid and less puffy looking. Teststeron Heptylate usage and dosage Testosterone Heptylate lasts in the body for up to 20 days, making injections less frequent for users. Men can inject 250 mg/week, but women should be aware that doses over 50 to 100 mg/week can lead to virilization. Doses of up to 750 mgs/week for men will show quick, intense gains of solid muscle mass. Testosterone Heptylate is often stacked during a buildup stage of a cycle with Deca-Durabolin and Dianabol. For example, a man would take 500 mgs/week of Testosterone Heptylate with 200 mgs/ week of Deca-Durabolin and 30 mgs/day of Dianabol. A woman would stack 50 mgs/week of Testosterone Heptylate with 50 mgs/week of Deca-Durabolin and 15 mg/day of Oxandrolone. Testosterone Heptylate side effects Because Teststerone Heptylate readily aromatizes into estrogen in the body, it is recommended to take anti-estrogen pills while taking this steroid. Testosterone Heptylate will also shut down the body’s own testosterone production so taking a stimulant such as HCG, Clornifen or Cyclofenil is highly hi ghly recommended during post cycle therapy. Virilzation in women taking high doses of Testosterone Heptylate is common, so it is not an ideal drug for female athletes. Testosterone Heptylate availability Other than in France where it is readily available in pharmacies, Testosterone Heptylate is not a commonly found drug. In French pharmacies, it costs around $2 for a 50 mg package containing two ampules; $2.50 for a 100 mg package containing two ampules; and $4.50 for a 250 mgs package containing two ampules. On the US black market, 250 mg packs cost around $12 to $15. Testosteron Heptylate research Resarch in to other uses for Testosteron Heptylate include therapies for children with chromosome damage, supplemental drugs for AIDS patients and anemia. http://www.ncbi.nlm.nih.gov/pubm http://www.ncbi.nlm.nih.gov/pubmed?term=test ed?term=testosterone%20hept osterone%20heptylate ylate


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14.2.18 Testosterone Propionate

Propionate is a widely used steroid that shows good results with few side effects. It is effective because it acts like the body’s natural testosterone, which is responsible for growing muscles in men and women. Propionate works because it is androgenic with an anabolic effect. It allows the muscles to retain more protein, thus giving them more bulk. A diet high in protein and a strong workout program are absolutely necessary for gains to occur when using propionate. Propionate also helps the body heal by i ncreasing red blood cells in the body and reducing lactic acids in the muscles, the cause of the “burn” experienced when lifting weights. Propionate usage and dosage Propionate is safest when used at doses less than 4 ml/week. Using propionate is only good for 1 to 2 weeks, which makes frequent injections the best way to go when using the drug. Athletes, or people who workout heavily, inject propionate twice a week. Two injections of 2 ml is a good dose for bodybuilders and half that amount is the minimum amount to see any effective gains. Propionate side effects Propionate has very fe3w side effects when taken at doses of 4 ml/week or less. However, prolonged use or taking propionate at high doses can cause high blood pressure, gynocomastia and high cholesterol. Propionate availability Propionate is available in 1 ml ampules. Ampules cost around $15 to $20 each and are available on the black market. Be sure to check the ampule for a red brand in the glass that cannot be scratched off to avoid buying fake product. Propionate research Propionate (testosterone enanthate) has been researched for a variety of uses, from treating muscle wasting to its effects Klinefelter syndrome. Other research has included its effect on urinary tract infection in patients with hypogonadism and its use in transsexual patients. http://www.ncbi.nlm.nih.gov/pubmed http://www.ncbi.nlm.nih.gov/pubmed?term=testoste ?term=testosterone%20enanthate rone%20enanthate 14.2.18.1 Testosterone Propionate

As we all know, Testosterone Testosterone was the first steroid steroid to be synthesized, synthesized, and now it remains the gold standard of all steroids. First, we will discuss Testosterone in general, and in depth, then well examine exactly how and what the propionate ester is (together, Testosterone Propionate is often referred to as just "prop" test-p or "test prop"). © 2012 Thatotherguy


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Testosterones anabolic/androgenic ratio is 1:1 meaning it is exactly as anabolic as it is androgenic. Actually, testosterone testosterone is the steroid steroid that all anabolic/androgenic anabolic/androgenic ratios are based on. If a steroid steroid is 2:1, then it is, compared with testosterones ratio, doubly as anabolic as it is androgenic. Hence, we see from testosterones ratio, ratio, it is both quite anabolic as well as androgenic. It should be noted; as Testosterone Propionate is merely testosterone, this anabolic/androgenic rating holds the same. So how exactly does Testosterone Propionate build muscle? Testosterone Propionate promotes nitrogen retention in the muscle (6), and the more nitrogen the muscles hold the more protein the muscles store, and the bigger the muscles get. Testosterone Propionate can also increase the levels of another anabolic hormone, IGF-1, in muscle tissue (7). IGF-1 is alone highly anabolic and can promote muscle growth. It is responsible for much of the anabolic activity of Growth Hormone (GH). IGF-1 is also one of the few hormones positively correlated with both muscle cell hyperplasia and hyperphasia (this means it both creates more muscle fibers as well as bigger fibers). All of this might lead one to speculate that for pure mass, IGF-1, HGH, and Testosterone Propionate would be a very effective combination. Testosterone Propionate also has the amazing ability to increase the activity of satellite cells(8). These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor (A.R.) to promote all of the A.R dependent mechanisms for muscle gain and fat loss (9), but clearly, as we've seen, this isnt the only mechanism by which it promotes growth. Testosterone Propionate has a profound ability to protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones (11), and increase red blood cell production (12), and as you may know, a higher RBC count will improve endurance via better oxygenated blood. The former trait increases nitrogen retention and muscle building while the latter can improve recovery from strenuous physical activity, as well as increase endurance and tolerance to strenuous exercise. Testosterone occurs naturally in both the male and female body, as insofar as drug testing for it, typical tests dont work (i.e. testing for metabolites). Testosterone can be tested for on a testosterone/ epitestosterone ratio, a failing result usually being anything over 6 to 1, but there are other more effective tests currently in use as well as being developed by the usual party-poopers in the IOC and FDA. Noteworthy is that if you are using low doses of Testosterone Propionate and stop taking it 36-48 hours before a testosterone/epitestosterone analysis, you can still pass! Testosterone, once in the body can be converted to both estrogen (via a process known as aromatization) as well as dihydrotestosterone (DHT). Estrogen is the main culprit for many side effects such as gynecomastia, water retention, and as a result high blood pressure while DHT is often blamed for hair loss and prostate enlargement. Naturally there are ways to combat this, such as using an antiestrogenic compound along with your Testosterone Propionate, or even an estrogen blocker. DHT can be combated (on the scalp, to prevent hair loss) with compounds such as Ketoconazole shampoo (sold under the trade name Nizoral) as well as Finasteride (sold as Proscar in the 5mg version and as Propecia as 1mg tablets). Interestingly, this shampoo can also be used topically to combat acne on the face (or even the back if youre really flexible). Both of these methods for preventing hair loss and acne are reasonably effective; however, if you are not predisposed to male pattern baldness they will be wholly unnecessary. Male Pattern Baldness (MPB) is carried by the X chromosome, so if your mothers family boasts men with full heads of hair, then you are probably safe (unless those full heads of hair are all mullets). Naturally, as with most other steroids, your lipid profile is going to suffer a bit while supplementing with Testosterone Propionate. This, of course is nothing that cant be controlled by watching your diet and doing your cardio, at least for the duration of the typical cycle (which for arguments sake, Ill assume is +/- 12-16weeks). Lets be totally honest, here, even a modest amount of exercise will improve your blood pressure and lipid profile (10). In-order to combat the aromatization of testosterone, you can simply take an aromatase inhibitor such as Arimidex. This and other anti-estrogenic compounds are generally considered a must with testosterone doses over a gram per week (1,000mgs), and often recommended with even less. Also among side effects (as if acne and going bald arent enough) is increased aggression. This is a hotly debated issue in steroid-culture. Generally the consensus is that if you are prone to being a jerk, you'll be a bigger jerk, and if you aren't, then your temper will not get much worse (this is supported by © 2012 Thatotherguy

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research as well.) Interestingly enough, high l evels of testosterone are generally only associated with improper aggression and anti-social behavior in males with lower intelligence (1)(2). Guess what? Dumb people shouldn't use steroids at all, especially testosterone! For many, the increased aggression found from increased testosterone testosterone levels is often a bonus in the weight room as well as on the playing field. Lets not get started on its benefits in the bedroom! Testosterone Propionate is also a relatively safe steroid to use, with some studies showing no adverse effects from 20weeks at 600mgs/week! (3) Testosterone is usually attached to an ester (i.e. when you buy Testosterone Propionate, the subject of this profile, you are buying testosterone with a Propionate ester attached). The ester determines how long it takes your body to dispose of the steroid in question, and Propionate is the shortest ester available with a testosterone base (of course, Testosterone Suspension has no ester). There are enzymes, called esterases, in your body that have the function of removing the ester from steroids, and leaving you with just the steroid molecule with the ester cleaved off. Depending on how heavy the ester chain is, that determines how long it takes the esterase to remove it, and that amount of time determines how long the steroid stays active in your body. Great, right? No, not t really; the ester takes up space in the injection. Check out this chart: Chemical = Formula = Molecular Weight = Mg of Testosterone Testosterone (no ester) = C19 H28 O2 = 288.4mg = 100mg Propionate = C3 H4 O = 56.1mg = 83.72mg Cypionate = C8 H4 O = 124.2mg = 69.90mg Here, were comparing Testosterone with no ester (suspension) with Testosterone Propionate and Testosterone Cypionate (basically the longest vs. shortest esters available with testosterone). So you see, the longer the ester on the testosterone hormone is, the longer the steroid is active in your body, and the less actual testosterone you get. This is because, for every 100mgs of Testosterone Cypionate you inject, only 69.90mgs of it is actually testosterone, the rest is the Cypionate ester, which must be removed. On the other hand, wi th the Propionate ester youll get 83.72mgs of testosterone! The advantage to longer esters is that they need to be injected less frequently (Testosterone Propionate needs to be injected every other day while you can shoot Testosterone Cypionate once per week). The disadvantage to long estered steroids is that they contain less actual steroid. Anecdotally, however, most people from Steroid.com and other discussion boards who have tried differing esters on their various cycles agree: Testosterone Propionate causes the least side effects and the least bloating. For this reason, its often the testosterone of choice in cutting cycles. Testosterone levels when youre using injectable Testosterone Propionate begin to decline sharply after the second day of use(5). Obviously this is not the steroid of choice for those who are squeamish about injections, youll be shooting this stuff every other day at least. Also, as with most most steroids, injected testosterone testosterone will inhibit your natural natural testosterone testosterone levels and HPTA (Hypothalamic Pituitary Testicular Axis). A mere 100 mgs of Testosterone Propionate per week takes about 5-6 weeks to shut down the HPTA, and 250-500mgs shuts you down by week 2 (4). Realistically, every cycle should contain testosterone. Go back and read that sentence again. A beginners dose of testosterone (i.e. someone on their first or second cycle of AAS) would be in the 250-500mgs ranges. Though, realistically, we wouldnt recommend much less than 400mgs of testosterone per cycle for anybody, beginner or not who is supplementing for the purpose of performance, and guess what? The more you use the more results you get, and frequently, the more side effects too (3). Testosterone Propionate Stack What stacks well with Testosterone Propionate? Everything! Many peoples favorites are Equipoise © 2012 Thatotherguy


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(Boldenone Undeclyenate) or Deca Durabolin (Nandrolone Decanoate), but really, anything will stack well with Testosterone Propionate. Trenbolone (Trenbolone Acetate), Masteron (Drostanolone), and Winstrol (Stanozolol) are also favorites for many on a cutting cycle. Its important to remember that since Testosterone Propionate has such a short ester, most people stack it with other short estered drugs, the rational being that they need to endure frequent injections for the Testosterone Propionate to be effective, so they may as well be using other drugs requiring the same dosing protocol. Finally, its worth noting that sometimes a strategy known as "frontloading" is employed with Testosterone Propionate, this is where double or triple the intended dose for the cycle is injected for the first two weeks, then the user switches to a longer ester. The reasoning behind this is presumably to get the blood levels of the hormone up quickly in the hopes of seeing results more rapidly. Buy Testosterone Propionate Of all testosterones available on the market today, Testosterone Propionate is the most expensive. This is both because it is in high demand (due to its ability to avoid bloating the user as other testosterones tend to do) and because the actual chemical is expensive compared to other testosterones. Expect to pay roughly $40-60 for a 10-20ml bottle dosed at 100mgs/ml, when buying from a reputable Underground Lab, expect to pay double (or more than) that amount if you are buying Human grade ampules or bottles from a major pharmaceutical company. Facts About Testosterone-Propionate Testosterone-Propionate Testosterone-Propionate Testosterone-Propionate is a short ester based anabolic steroid of the testosterone family and is one of the oldest forms available since the inception of synthetic anabolic steroids. As a short ester based testosterone Testosterone-Propionate Testosterone-Propionate is very easy to control in-terms i n-terms of maintaining stable blood levels; an important factor in testosterone administration and therapy; however, in order to achieve this end frequent injections of the medication will prove to be of an absolute necessity. Nevertheless, those who supplement with Test-Prop as it is commonly known will find all the benefits of testosterone supplementation to be achievable via this particular form. Understanding Testosterone-Propionate Testosterone-Propionate Testosterone-Propionate Testosterone-Propionate is simply testosterone; compared to other forms there is no difference interms of mode of action as the nature of the testosterone hormone is the same in each form in-terms of benefits and function. Like all testosterone forms, Testosterone-Propionate is defined by the ester that is attached, as is the case with all forms or in some cases defined by the lack of ester attached, as can be the case in certain instances. To fully understand the compound we need only understand two things; the active hormone itself and then the ester and how it affects its mode of action in-terms of time release and active duration. Testosterone-Propionate Testosterone-Propionate is a highly anabolic and androgenic hormone, equal in both parts. As a testosterone based hormone it is generally well-tolerated by all who supplement with it as testosterone is naturally produced in the body and is not a foreign hormone to natural human function. Not only is testosterone naturally produced by all human beings it is essential for proper endocrine function; those who suffer from low levels of testosterone will find they suffer from a host of issues from decreases in strength and muscle tissue, decreased libido, insufficient immune system function, depression, lack of mental clarity and increases in body-fat to name a few. Conversely, those who exceed their natural testosterone levels will find each category diminished when levels are low enhanced when levels are of a higher nature. While all testosterone forms can provide the same benefits, Testosterone-Propionate Testosterone-Propionate functions based on the ester attached; in this case the Propionate ester. A very short ester, as such milligram for milligram Testosterone-Propionate is more powerful than many other common forms. For example, another common form of testosterone is that of Testosterone-Cypionate; 100mg of TestosteroneCypionate will yield approximately 70mg of active testosterone; however, as the Propionate ester takes up less mass in the compound 100mg of Testosterone-Propionate will yield approximately 83mg of testosterone. As a short ester based testosterone testosterone Testosterone-Propionate Testosterone-Propionate carries a half-life half-life of approximately 4 days; the shortest half-life of all common ester based testosterones. As such, once administered the © 2012 Thatotherguy

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active hormone enters the blood stream and becomes active in full capacity very quickly but it i t also dissipates just as fast. For example, 100mg of Testosterone-Propionate administered on day one will fall to 50mg by day 4 and 25mg by day 8 and so on. Conversely, so that you may understand the significance, 100mg of Testosterone-Cypionate administered on day one will fall to 50mg but not until day 12 post injection. For this reason, in order to maintain stable and peak levels of the hormone in the body we must necessarily administer the hormone once every 3 days with every other day being optimal. Benefits of Using Testosterone Propionate As a testosterone testosterone based anabolic steroid steroid the benefits of Testosterone-Propionate Testosterone-Propionate supplementation are are nothing short of amazing and truly encompass almost every benefit one who uses anabolic steroids would desire. As a testosterone such benefits will include but are not limited to: Increased Strength: Increased Muscle Mass Reduced Body-Fat Increased Recovery Increased Levels of IGF-1 Increased Sex Drive A Greater Sense of Well-Being Increased Energy Greater Athletic Performance As you can easily see the benefits are truly great and largely understood understood by a simple brief overview overview of testosterone. Testosterone greatly increases nitrogen retention thereby allowing more protein to be stored in the muscles of the body thereby increasing protein synthesis. Further, as by its nature, testosterone greatly blocks and reduces the glucocorticoid hormones in the body; the muscle wasting hormones that not only destroy muscle tissue but promote body-fat gains as well. Equally as important, as powerfully anabolic and androgenic testosterone promotes recovery and regeneration; the faster we recover the faster and greater our growth; further, the greater our regeneration the greater our athletic performance. When you couple this with its ability to increase the potent naturally occurring anabolic hormone IGF 1 you truly have a remarkable anabolic steroid in Testosterone-Propionate. Side-Effects of Testosterone Propionate All anabolic steroids carry carry with them possible negative and adverse adverse side-effects; side-effects; in that TestosteroneTestosteronePropionate makes no exception. However, often the effects are highly exaggerated and it is important to note that through responsible use in healthy adult men such side-effects can largely be controlled and often of little concern at all. The most common side-effects of Testosterone-Propionate Testosterone-Propionate use will be estrogenic related due to the aromatase process. As testosterone will convert to estrogen via the aromatase enzyme common side-effects include but are not limited to: Gynecomastia Water Retention High Blood Pressure High Cholesterol These are the most common side-effects but all hope is not lost. We can greatly reduce these sideeffects by taking two precautions; ensuring our diets are full of healthy omega fatty acids and through the use of quality aromatase inhibitors such as Arimidex or Letrozole. However, there is one side-effect that will occur in al l men who supplement with Testosterone-Propionate and that is testicular atrophy. Exogenous testosterone use will suppress your natural production; however, once use is discontinued normal production will begin again and testicular size will return to normal. Testosterone Propionate Profile (Testosterone) 4-androstene-3-one, 17beta-ol Testosterone base + Propionate ester Molecular Weight (base): 288.429 Molecular Weight (ester): 74.0792 Formula (base): C19 H28 O2 Formula (ester): C3H6O2 © 2012 Thatotherguy


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Melting Point (base): 155 Melting Point (ester): 21C Manufacturer: Various Effective Dose (Men): 350-2000mg+ week. Effective Dose (Women): 50-100mgs/week Active life: 2-3 days Detection Time: 2-3 weeks Anabolic/Androgenic ratio:100/100. References: Pope, H.G, Kouri, E.M., & Hudson, J.I. (2000). Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: A randomized controlled trial. Archives of General Psychiatry, 57, 133-140 Chance, S.E., Brown, R.T., Dabbs, J.M., & Casey, R. (2000). Testosterone, intelligence and behavior disorders among young boys. Personality and Individual Differences, 28, 437-445 Am J Physiol Endocrinol Endocrinol Metab 2003 Jan 7; [epub ahead of print] Related Articles, Links Links "Development of Models to Predict Anabolic Response to Testosterone Administration in Healthy Young Men." J Investig Med. 1997 Oct;45(8):441-7 Oct;45(8):441-7 J Clin Endocrinol Metab. 1986 Dec;63(6):1361-4. J Clin Endocrinol Metab. 1997 Feb;82(2):407-13. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7. Mar;282(3):E601-7. Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7. May;7(3):271-7. Curr Pharm Biotechnol. 2004 Oct;5(5):459-70. Oct;5(5):459-70. Metabolism. 1991 Apr;40(4):368-77. J Lab Clin Med. 1995 Mar;125(3):326-33. Mar;125(3):326-33. Zhonghua Nan Ke Xue. 2003;9(4):248-51. Effect of androgen on erythropoientin in patients with hypogonadism] [Article in Chinese]

14.2.1 14.2.19 9 Tren Tren Tren is one of the most popular steroids of all time as it is one of the most powerful and most effective. Officially known as Trenbolone, Tren can come in many forms with the small ester version Trenbolone-Acetate and the large ester version Trenbolone-Enanthate being the most common. Originally developed for the purpose of beefing up livestock Tren became very popular during the golden age of bodybuilding as it was discovered whats good for the cow is just as good for the athlete. During this time the Acetate version was all that was available in the form of an implant pellet known as Finaplix; these subcutaneous pellets were easily transformed into an injectable solution. However, as the years went by many other Tren forms would hit the shelf from the original Finaject and Parabolan but in the end the Acetate version remains king. Understanding Tren: Tren is a 19-nor anabolic androgenic steroid of i mmense power; so powerful Tren is 500 times more anabolic and 500 times more androgenic than testosterone and whats more those are not made up numbers. By its very nature the Tren hormone can cause several reactions and actions within the body which include but are not limited to: Increase IGF-1 Output Increase Nitrogen Retention Increase Protein Synthesis Increase Red Blood Cell Count Decrease & Block Glucocorticoid Steroids Increase Nutrient Efficiency Several of these affects you may notice are similar to many other anabolic steroids with the exception of Nutrient Efficiency. While many other steroids do similar things Tren simply does them better; sure, any working car will get you down the road but whats better a new Ferrari or a 1972 Gremlin? Do we need to answer that question? Of course then there is the advent of increased nutrient efficiency and this is one of the factors that truly make Tren stand along. When this hormone is in our system each and every nutrient that enters our body becomes far more valuable, our body is able to use each and every gram of food to a higher and more efficient degree and as food is the most anabolic substance © 2012 Thatotherguy

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on earth this trait is invaluable. The Benefits of Tren: The benefits of Tren are vast and they include nearly every benefit and trait any performance enhancer could ever be after. You will find several of these traits to be similar to many other anabolic steroids but it cannot be stressed enough, the level of efficiency within each effect is so much stronger and efficient with Tren its almost not even fair to compare it to other steroids and this is often true even when Tren is taken at a very low dose. The solid benefits of Tren include: Increase Muscle Mass Increased Strength Decreased Body-Fat Increased Recovery Increased Tissue Preservation A Harder Physique Increased Vascularity As you noticed the the benefits of Tren include both bulking and cutting traits traits and the good news is it is just as efficient in either case. This anabolic hormone can truly add lean tissue tissue with more efficiency efficiency than most steroids; it is also the best tissue preserver when calories are restricted on earth. Further, by its very nature Trenbolone is one of the very few anabolic steroids that directly promotes fat loss and will harden a physique more so than any single steroid available; in-fact, the Trenbolone hormone will harden a lean physique more so than just about any stack of other hardening agents. The Downside of Tren: Unfortunately Tren is not without its faults as it can be a very harsh anabolic steroid indeed. Many of the side-effects due to Trenbolone use are very easily controlled but there are others that are more of a tossup and for many men will prove to simply be too much to handle. Luckily Tren does not aromatize making many aromatase based side-effects little concern; it also means any weight gained through Tren use will be pure lean tissue since water weight is of no concern. However, a common based aromatase effect in Gynecomastia is still very possible due to this steroids progestin nature and quality aromatase inhibitors are advised. Other possible side-effects may include hair-loss in men who are predisposed to male pattern baldness, acne in some and high blood pressure in predisposed men or in men who take the dose beyond responsible levels. The above side-effects of Tren are largely controllable and with responsible use most men will have no problems at all but there are other potential negative reactions that truly make this a harsh steroid. Remember, responsible use will always prove to be your best friend and responsible use will improve your odds but the harsh side-effects of this steroid do exist and include: Anxiety Decreased Libido Erectile Dysfunction Insomnia Night Sweats Rapid Heart Rate The bad news is twofold; if such side-effects occur they will normally do so in a very pronounced manner, often far beyond what is imaginable; further, while responsible use is an important factor individual sensitivity will always prove to be the most important factor. There are some men who will fall prey to these effects even with responsible use and that is unfortunate but there is simply not a lot they can do about it. The Bottom Line: Tren is one of the best anabolic steroids to ever exist; a truly unique steroid in many ways of enormous power that will provide nearly every trait imaginable. Conversely, as a powerful steroid it is also very harsh and for this reason responsibility must be held to with even more respect than in comparison to other anabolic steroids; while responsibility is always i mportant it is simply more so with Tren. For those who use responsibly, who tolerate the hormone well and who are ready for such a powerful hormone you will be hard pressed to find one any better than simple Trenbolone. © 2012 Thatotherguy


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14.2.20 Trenbolone (Trenbolone Acetate) The drug Trenbolone is, without a doubt, the most powerful injectable anabolic steroid used by Steroid. com members to gain muscle. However the full properties of the drug are not always fully understood. This profile will separate fact from fiction and help steroid.com members decide if Trenbolone is right for them. Trenbolone is similar to the highly popular steroid Nandrolone, in that they are both 19-nor steroids, meaning that a testosterone molecule has been altered at the 19th position to give us a new compound. Unlike Nandrolone however Trenbolone is an excellent mass and hardening drug with the majority of gains being muscle fiber, wi th minimal water retention (1) It has an unbelievable anabolic (muscle building) score of 500. When you compare that to Testosterone, which itself is a powerful mass builder, and has an anabolic score of 100 you can begin to fathom the muscle building potential of Trenbolone. What makes Trenbolone so anabolic? Numerous factors come into play. Trenbolone greatly increases the level of the extremely anabolic hormone IGF-1 within muscle tissue (2). And, its worth noting that not only does it increase the levels of IGF-1 in muscle over two fold, it also causes muscle satellite cells (cells that repair damaged muscle) to be more sensitive to IGF-1 and other growth factors(3). The amount of DNA per muscle cell may also be significantly increased (3). Trenbolone also has a very strong binding affinity to the androgen receptor (A.R), binding much more strongly than testosterone (4). This is important, because the stronger a steroid binds to the androgen receptor the better that steroid works at activating A.R dependent mechanisms of muscle growth. There is also strong supporting evidence that compounds which bind very tightly to the androgen receptor also aid in fat loss. Think as the receptors as locks and androgen's as different keys, with some keys (androgen's) opening (binding) the locks (receptors) much better than others. This is not to say that AR-binding is the final word on a steroids effectiveness. Anadrol doesnt have any measurable binding to the AR& and we all know how potent Anadrol is for mass-building. Trenbolone increases nitrogen retention in muscle tissue (5). This is of note because nitrogen retention is a strong indicator of how anabolic a substance is. However, it's incredible mass building effects do not end there. Trenbolone has the abili ty to bind with the receptors of the anti-anabolic (muscle destroying) glucocorticoid hormones (6). This may also has the effect of inhibiting the catabolic (muscle destroying) hormone cortisol (7). Yet another amazing trait that must be noted is its ability to improve feed efficiency and mineral absorption in animals given the drug (8). To help you understand what this means for you, feed efficiency is a measurement of how much of an animals diet is converted into meat, and the more food it takes to produce this meat, the lower the efficiency. Conversely, the less food it takes to produce meat the, higher the efficiency& well you get the idea. Animals given Trenbolone gained high quality weight without having their diet adjusted, thus improving feed efficiency. Finding new compounds which can improve feed efficiency is a bill ion dollar industry, and has spawned many nutritional advances in the bodybuilding world over the last few decades (CLA, Whey Protein, and HMB are compounds which spring to mind as having first been introduced by the livestock industry). What does this translate to for the hard training athlete? The food you eat will be better utilized for buil ding lean muscle, and vitamins and minerals are also better absorbed which may keep you healthier during cycle.

Trenbolone is also a highly androgenic hormone, when compared with Testosterone, which has an androgenic ratio of 100; Trenbolone's androgenic ratio is an astonishing 500. Highly androgenic steroids are appreciated for the effects they have on strength as well as changing the estrogen/ androgen ratio, thus reducing water and under the skin. As if the report on Trenbolone was not good enough, it gets better; Trenbolone is extraordinarily good as a fat loss agent. One reason for this is its powerful effect on nutrient partitioning (9). It is a little known fact is that androgen receptors are found © 2012 Thatotherguy

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in fat cells as well as muscle cells(10), androgens act directly on the A.R in fat cells to affect fat burning.(11) the stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose tissue (fat)(11). Since some steroids even increase the numbers of A.R in muscle and fat (11, 12) this fat loss effect would be amplified with the concurrent use of other compounds, such as Testosterone. Trenbolone promotes red blood cell production and increases the rate of glycogen replenishment, significantly improving recovery (13). Like almost all steroids, it's effects are dose dependant with higher dosages having the greatest effects on body composition and strength. Mental changes are a notorious side effect of Trenbolone use (15), androgens increase chemicals in the brain that promote aggressive behavior(16), which can be beneficial for some athletes wanting to improve speed and power. Trenbolone's chemical structure makes it resistant to the aromatize enzyme (conversion to estrogen) thus absolutely no percentage of Trenbolone will convert to estrogen. Trenbolone administration would not promote estrogenic side effects such as breast tissue growth in men (gynecomastia, bitch tits) accelerated fat gain, decline in fat break down and water retention. Trenbolone is also resistant to the 5- alpha-reductase enzyme, this enzyme reduces some steroid hormones into a more androgenic form, in this case however this does not matter. Trenbolone boasts an androgenic ratio of 500. It can easily cause adverse androgenic side effects in people who are prone to hair loss, prostate enlargement, oily skin and acne. Unfortunately Trenbolone's potential negative side effects do not end there. Trenbolone is also a noted progestin: it binds to the receptor of the female sex hormone progesterone (with about 60% of the actual strength progesterone) (17). In sensitive people this can lead to bloat and breast growth worse still, Trenbolone's active metabolite 17beta-trenbolone has a binding affinity to the progesterone receptor (PgR) that is actually greater than progesterone itself (18). No need to panic though, the anti-estrogens letrzole or fulvestrant can lower progesterone levels, and combat any progestenic sides. The use of a 19-nor compound like trenbolone also increases prolactin & . bromocriptine or cabergoline are often recommended to lower prolatin levels (20). Testicular atrophy (shrunken balls) may also occur; HCG used intermittently throughout a cycle can prevent this. (21) It is also wise for Tren users to closely monitor their cholesterol levels, as well as kidney function and liver enzymes, as Tren has the potential to negatively affect all of those functions. Finaplix, being a powerful progestin, will also shut down natural testosterone production which even a relatively small dose and keep the testosterone level suppressed for an extended period of time, this can lower libido and cause erectile dysfunction (fina dick). It is essential that you always stack Finaplix with testosterone. The acetate ester is a very short-chain ester attached to the Finaplix molecule. It has an active life of 2-3 days but to keep blood levels of trenbolone elevated and steady, daily injections are often recommended. The acetate ester provides a rapid and high concentration of the hormone which is beneficial to those seeking quick gains, coupled with a rapid clearing time the acetate ester can be discontinued on the onset of adverse side effects. Now that the properties of Trenbolone Acetate have been explained we can better understand how to use it in order to maximize its advantages. Evidence suggests that Finaplix when stacked with estrogen promotes more weight gain that Trenbolone alone(22), now Im not telling you to go pop some birth control with your Tren but the addition of aromatizing orals such as Dianabol and a long estered testosterone such as Cypionate or Enanthate would produce great gains in a bulking cycle. For a cutting cycle Finaplix is the best choice you have; Trenbolone's powerful effect on nutrient shuttling allows a user to restrict calories and remain in a state of positive nitrogen balance (remember what that means?). The cortisol reducing effect and binding to the glucocorticoid receptor will greatly reduce the catabolic effects of harsh dieting and excessive amounts of cardio and not to mention that Finaplix itself may burn fat (due to its strong AR-binding). A good choice to stack with Tren in a cutting cycle is Winstrol. Winstrol has a low binding affinity to the AR and thus will act in your body in vastly different ways than the Tren (i.e. in non-receptor mediated action). In addition, Winstrol is a DHT-based drug and Tren is a 19-nor& throw in some Testosterone (prop), and you'll have a cutting cycle which takes advantage of all 3 major families of Anabolic Steroids (Testosterone, 19-nor, and DHT), as well as vastly different AR-binding affinities and mechanisms of action.



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Ironically, even though Trenbolone ( Tren ) is an excellent contest prep drug, it lowers your thyroid level(23), and this raises prolactin. I recommend taking T3 (25mcgs/day) along with your Tren to avoid elevating your prolactin too high via this route. Also, this drug is a poor choice for athletes who who rely on cardiovascular cardiovascular fitness to play a sport. Trenbolone ( Tren ), anecdotally at least, reduces many athletes ability to sustain high levels of endurance. Unfortunately, this makes Tren a poor choice for many. As of now the main source of Trenbolone is from implants for for cattle being converted converted into an injectable or transdermal compound, from powder, and of course Underground Labs. "Home brewing" powder or cattle implants seems to be the preferred method of obtaining injectable Trenbolone Acetate, because the user would have much more control over the potency and sterility of the drug. Trenbolone is much more expensive than other anabolic steroids ranging from 15 U.S dollars per gram of powder or 150 U. S for a single 10 ml bottle. The cost of Trenbolone should not matter, it is worth every penny. Trenbolone Acetate Profile (17beta-Hydroxyestra-4,9,11(17beta-Hydroxyestra-4,9,11-trien-3-one) trien-3-one) (Trenbolone Base + Acetate Ester) Formula: C20 H24 O3 Molecular Weight: 312.4078 Molecular Weight (base): 270.3706 Molecular Weight (ester):60.0524 Formula (base): C18 H22 O2 Formula (ester): C2 H4 O2 Melting Point (base): 183-186C Melting Point (ester):16.6C Manufacturer: Cattle implants, British Dragon, Various Effective Dose (Men):50-150mg ED Effective Dose (Women): Not recommended Active life: 2-3 2-3 days Detection Time: 5 months Anabolic/Androgenic ratio: ratio: 500/500 References: Br J Nutr. 1978 Nov;40(3):563-72. J Cell Physiol. 2004 Nov;201(2):181-9. Endocrinology. 1989 May;124(5):2110-7. Toxicol Sci. 2002 Dec;70(2):202-11.15 J Anim Sci. 1994 Feb;72(2):515-22. APMIS. 2001 Jan;109(1):1-8. J Anim Sci. 1990 Sep;68(9):2682-9. APMIS. 2001 Jan;109(1):1-8. J Anim Sci. 1992 Nov;70(11):3381-90. Nov;70(11):3381-90. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52. Biochim Biophys Acta. 1995 May 11;1244(1):117-20. J Appl. Physiol.94 1153-61 2003 J Vet Med A Physiol Pathol Clin Med. 2001 Aug; 48(6):343-52 Toxicol Sci. 2002 Dec;70(2):202-11.15 Steroid.com forums. Med Sci Sports Exerc. 2003 Jan; 35(1):32-8 Cancer Res 1978 Nov; 38(11 Pt 2):4186-98 APMIS. 2000 Dec;108(12):838-46. Curr Med Res Opin. 2001;16(4):276-84 2003 drug handbook. Pharmacol Biochem Behav. 1988 Mar; 29(3):489-93. J Anim Sci. 1997 May;75(5):1256-65. Res Vet Sci. 1981 Jan;30(1):7-13.


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14.2.21 Winstrol (Stanozolol)

Winstrol - Stanozolol is a very commonly used anabolic steroid for cutting cycles. While many people will attempt to use Dianabol or even Anadrol for cutting cycles, Ive really never heard of anyone using Stanozolol for anything except a cutting cycle. Its a bit of a one-trick-pony in this respect. Let me repeat that: Stanozolol is a cutting drug. Not many people wi ll argue for its use in a bulking cycle. Its certainly not a very effective compound for treating anemia (1) and thus, one could rightly assume that its role in bulking cycles is very limited. One novel use for Winstrol in any cycle (perhaps even bulking) would be to use it at a very limited dose, in order to lower SHBG. (2) One of the properties of Winstrol is its profound ability to lower SHBG much more than other steroids. A dose of .2mg/kg lowered SHBG significantly, which would in turn, raise the amount of free testosterone circulating in the body. As with 99% of steroids, however, its important to note that suppression of your natural hormonal levels will occur (though perhaps not to the extent that it wil l with many other steroids).(10) As with running virtually any compound, testosterone supplementation (i.e. running test in a cycle containing Winstrol) is warranted to avoid possible sexual dysfunction. Winstrol & Stanozolol Side Effects Adding it to a heavy bulking cycle could be problematic, problematic, as Stanozolol is a 17aa compound, compound, meaning that its been altered to endure the first pass through your liver without being destroyed. This makes it an orally active compound; so many people choose to take the pills which are available from both legitimate pharmaceutical companies as well as Underground Labs. Unfortunately, since it is 17aa, it is is also liver toxic& in fact; Stanozolol has one of the worst hepatoxicity (mg for mg) of any steroid. This is the reason its addition to a bulking cycle could be problematic; generally a bulking cycle will be very heavy, dosage wise as well as toxicity-wise. It also has undesirable results on Cholesterol, and a mere 6mgs/day of Stanozolol can lower HDL by 33% and raise LDL by 29% (3). Cardiac Hypertrophy, even at lower doses could be a concern with Winstrol as well (4) Thus, many people limit their intake of Stanozolol to precontest or Summer-cutting types of cycles. Its generally accepted that due to the toxicity issues of Stanozolol, its use should be limited to 6 weeks& as with anything though, many people have run it for up to 12 weeks with no problems. Winstrol & Stanozolol Use Effects I ran Winstrol for about 3 months (12 weeks) at a dose of 100mgs Every Other Day (along with Test prop at 125mgs, every other day) and I suffered no ill-effects. My joints felt fine, and I can say that the only thing which was undesirable about that cycle was the injection pain. Generally, people report a "dry" and less lubricated feeling in their joints when on this drug (fluid retention is nil with Stanozolol), and also a "dry" overall look as regards contest prep. This could be due to a sort of "reverse-osmotic" effect...of course this is speculation, but people do look "dryer" on Winnie, and some even look dryer in the site they inject (more on this later). There are many conflicting reports on tendon strength and Stanozolol, even in medical journals. Some reports state that it weakens tendons, others that it strengthens them (and some speculation on the i nternet among many "gurus" is that it strengthens them unevenly, leading to possible injury). For this reason, it may be best for athletes in explosive or high-impact sports to stay away from this drug. It has certainly been shown to be beneficial in some bone ailments induced by glucocorticoid induced stress (5) as wel l as having collagen producing properties (11), but with all of the anecdotal problems athletes have suffered with their joints while on Stanozolol, I simply can not recommend it with confidence to strength/speed athletes. I can say that personally, it was an effective compound for me and did not cause joint duress, but I can do without the discomfort of the shots, and have found other DHT based compounds to be far more effective (Masteron springs to mind). As previously stated, stated, this compound is unique, as it is available in both an oral form as well as an injectable form. Both forms contain the exact same compound, but injecting this compound (and yes, you can drink the injectable version, and no you shouldn't) is superior to ingesting it orally in terms of nitrogen retention (6), and thus one would also imagine, for overall anabolism. Injecting it also has the advantage of avoiding the "first pass" through your liver, and thus places your liver under less stress.



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Stanozolol (Winstrol) and Women Stanozolol is also one of the few compounds that women can take safely, as its anabolic:androgenic ratio is quite skewed towards anabolism. Its generally accepted that women can tolerate around 510mgs a day of this compound. Men, on the other hand can dose themselves in the .5-1.5mg/kg range. I find 100mgs injected every other Day to be sufficient, but of course, even with the injectable form, every day dosing is optimal. I tend to favor DHT based compounds, and have enjoyed great success with a Winstrol/Masteron/Testosterone cycle, but I suspect that replacing the Masteron in that cycle with Trenbolone would prove more beneficial for most bodybuilders seeking to get ripped. Although the anabolic ratio of this product is very high as compared to its androgenic actions, not many people report huge weight gains off of Stanozolol. Also, interestingly, it has a relatively weak AR binding ability (7), which is quite unusual for a "cutting" steroid. Many of the effects of this drug, as relates to building muscle, are probably from its very high protein synthesizing ability (6) (8). In addition, since this compound is derived from DHT, it tends to promote a very nice, "quality" look to the users muscles, with little or no water retention. Winstrol does not aromatize at any rate and has even been speculated to have anti-progestenic properties (in at least some cases, where it may "block" that receptor) (9). If one were to run ancillary compounds with Stanozolol, perhaps Tamoxifen would be appropriate for its beneficial effects on blood lipids, but an anti-estrogen (in its classic sense) would be unwarranted; proper post cycle therapy is still needed, though. Most underground labs produce Winstrol at very reasonable prices, in both an oral as well as injectable form. Unfortunately, production value differs vastly due to the varying size of the Stanozolol powder used to make the injectable version; the finer the powder, the smaller gauge needle it will fit through, and the easier the injection will be. Of course the opposite is also true& In any case, you should be paying under $100 for a 10ml bottle of 100mg/ml concentration, and roughly the same for 100 or so 10mg tablets. Winstrol Profile (Stanozolol) [17beta-Hydroxy-17-meth [17beta-Hydroxy-17-methyl-5alpha-andros yl-5alpha-androstano[3,2-c] tano[3,2-c]pyrazole] pyrazole] Molecular Weight: 344.5392 Molecular Formula: C22H36N2O Melting Point:N/A Manufacturer: (Originally) Sterling Release Date:1962 Effective Dose(men): 50-100mgs/day Effective Dose (women): 2.5-10mgs/day Active Life:8hours Detection Time:3 weeks (oral) to 9 weeks (injectable) Androgenic/Anabolic Ratio:30:320 Winstrol References: Trop Doct. 2004 Jul;34(3):149-52. J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200 JAMA. 1989 Feb 24;261(8):1165-8. J Steroid Biochem Mol Biol. 2005 Jan;93(1):43-8. Epub 2005 Jan 25. Di Yi Jun Yi Da Xue Xue Bao. 2003 Nov;23(11):1117-20. Can J Vet Res. 2000 Oct;64(4):246-8. Endocrinology. 1984 Jun;114(6):2100-6. J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22 Agents Actions. 1994 1994 Mar;41(1-2):37-43. Mar;41(1-2):37-43. Chemical Muscle Enhancement J Invest Dermatol. 1998 Dec;111(6):1193-7.



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Links of of In Interest

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Links of Interest

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Index -DDorsogluteal

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-VVentrogluteal

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Endnotes 2... (after index)


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