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1- Ondansteron HCl is used for : a-hypertension c-prophylaxis of migraine
b-angina pectoris d-anti-emetic
It is used as anti-emetic with with patients receiving cytotoxics due to its serotonin antagonism Ondansetron is ( Zofran 4 , 8 mg tab. & amp ) amp ) these are side effect of Chloramephenicol
2- All of except : a-irreversible aplastic anaemia b-optic neuritis c-peripheral neuritis d-iron deffeciency anaemia 3- Ticlopidine is used for : a-anticoagulant b-antibiotic c-anticholinergic d-antiplatelets 4- All these drugs are fibrinolytics except : a-dipyridamole b-streptokinase c-urikinase Anti-Coagulants : vit. K antagonists , heparin , warfarin Fibrinolytics : streptokinase : streptokinase , alteplase , reteplase Antiplatelets :aspirin,clopidogrel,tirofiban,eptifibatide, :aspirin,clopidogrel,tirofiban,eptifibatide, abciximab,dipyridamole
5- All these drugs can be used for parkinsonism parkinsonism except: a-seligiline HCl b-carbidopa c-pergolide d-nedocromil sod. Drugs used in Parkinson`s disease
Anticholinergic drugs : (Muscarinic Antagonists)
Benzatropine,trihexphenidyl,orphenadrine Benzatropine,trihexphenidyl,orphenadrine MAO B B inhibitors inhibitors : : Selegiline COMT inhibitors : : Entacapone Dopamenergic drugs : : *Dopamine precursor : levodopa : levodopa (+ carbidopa or Beserazide) *Releases dopamine : amantadine : amantadine *Dopamine agonists : bromocriptine,cabergoline,pergolide,ropinirole
6- All these cases not cure with thiazides except: a-hypernatrimia b-hyperglycemia c-hypokalaemia d-hyperuricaemia 7- Cardiac arrest could be managed by the following except : a-ephedrine b-lidocaine c-propranolol d-normal saline 8- Insulin which can be given I.V. is : a-regular type b- 30/70 type c- NPH type d-non of the above 9- Drug that used for leishmania is: a-sod. stiboglyconate b-mebendazole c-sod. cromoglyconate 10- All these drugs are antibacterial except: a-zalcitabine b-lomefloxacin c- cefopyrazone 11- All these are natural Estrogens except : a-mestronol b-oestrone c-oestriol d-oestradiol Natural Estrogens : Oestrone , Hydroxyoestrone , Oestradiol Oestr adiol , Oestriol Deriv. of nat. Estrogens : Ethenylestradiol , Mestronol Synth. Estrogens : Stilbesterol , Hexanosterol , Trianiselchlorethylene , Propanestriol , Clomifen
12- Co-Trimethoxazole contains : ( Trimethoprim + Sulphamethoxazole )
13- Which of the following has vasodilator effect ? a-nicotine b-cholestyramine c-urokinase d-vit. A 14- One of the following is not from Quinolone group : a-naldixic acid b-quinine c-eoxacin d-norfloxacin 15- One of the following is not for epilepsy : a-clorizepam b-phenytoin c-primidone d-imipramine (antidepressant)
16- All of these can be used for leprosy except : a-dapson b-rifampicin c- clofazinine d- INH 17- Sumatriptan is used for : a-hypertension b-treatment of migraine c-angina pectoris d-control of epilepsy ( 5-HT1 agonist )
18- Which is enzyme inducer ? a-rifampicin b-cimetidin c-vit. C d-chloramephenicol Enzyme Inducers: Phenobarbital,carbamazepine,ethanol,rifampicin,polycyclic Phenobarbital,carbamazepine,ethanol,rifa mpicin,polycyclic aromatic hydrocarbons in tobacco smokers Enzyme Inhibitors : Cimetidine ,erythromycin
19- All of the following for prophylaxis of asthma except : : a-ketotifen b-nedocromil sod. c-sod. cromoglycate d-salbutamol
20- All of the following is NSAH ( Non Sedating Anti-Histamine Anti-Histamine ) ) except : : a-loratadine b-cetrizine c-astimazole d-azotodin 21- All of the following are controlled drugs except : : a-rivotril b-epanutin c-sresolid d-diazepam 22- All these drugs are anti-viral except : a-amantadine b-zidovudine
c-acyclovir
d-aluerin ( it is antispasmodic )
23- Which one of these symptoms not occur with morphine ? a-diarrhea b-respiratory depression c-constipation d-vomiting 24- Which one of these drugs not used for acute pain ? a-naproxen b-colchicine c-codeine d-prednisolone 25- Which is drug of choice for myxodema ? (hypothyroidism) a-carbimazole b-iodine c-thyroxin sod. d-propyl thiouracil 26- Benzyl peroxide is a local treatment for Acne volgaris 27- Vit. A daily dose is 30`000 – 50`000 IU for the correction of deficiency and 100`000 – 200`000 IU for therapy 28- The drug of choice for treatment of amoebae : a-chloramephenicol b-tetracycline c-gentamycin d-metronidazole
29- To prevent more absorption of the toxic drug we use : a-water b-salt sol. c-saline d-charcoal 30- Hepatitis vaccine dose is : a-once/year b-twice/year c-three times/year 31- Which one is OTC drug : a-simple analgesic b-warfarin c- ciprofloxacin 32- Anticoagulant effect of warfarin is decreased by : a-rifampicin b-aspirin c-vit. K d-verapamil 33- One of the following is given once daily : a-amorphous insulin b-protamine zinc insulin(isophan) insulin(isophan) c-neutral insulin d-regular insulin 34- The steady state conc. Of drug in plasma depends on : a-dirct proportion to the rate of administration b-~~~~~~~~~~~~~~~~ b-~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~~~~~ elimination c-Indirect ~~~~~~~~~~~~~~~~~~~ ~~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~~~ d-~~~~~~~~~~~~~~~~~~~~ d-~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~ administration
35- All these are anticoagulants except : a-warfarin b-ancord c-heparin d- dipyridamol ( anti-platelet )
36- All these are anti-platelets except : a-dipyridamol b-aspirin c-streptokinase (antifibrinolytic) d-presantin e-ticlopidine 37- Ferrograde is : a-ferrous sulphate b- ferrous citrate c- ferrous gluconate d- ferrous fumarate ... .
38- Procainamide is : a-Na channel blocker c-lisinopril
...
b-nifedipine d-quinidine
39- Mechanism of action of vit. K ? Vit. K has an essential role in the synthesis of coagulation factors by hepatic cells.
40- Thiazide diuretics cause all the following except : a-hypokalaemia b-hypercalcemia c-hyperuricaemia d-hyponatremia e-hyperglycemia f-hypernatremia 41- Treatment with anti-arrhythmic drug depends on the on the following except : a-type of medication b-period of medication c-patient sex 42- Elimination of digoxin is mainly by : a-kidney b-liver c-both 43- Dobutamine is given I.V. because : a-it is not stable in the gastric gastr ic PH
d-non of them
b-it is needed needed in large quantities quantities in case case of oral route
c-it is eliminated very quickly 44- Amloride as trimetren causes :
a- CNS disturbance b-hyperkalaemia c-hypokalaemia d-not affect K ( potassium ) 45- What is the most drug can causes damage if it is given OTC ? a-captopril b-warfarin c-chlorothiazide d-rifampicin 46- Drug physical dependence is as same as drug abuse a-true b-false 47- Mention two thiazide diuretics ? a-chlorothiazide
b-hydrochlorothiazide
48- What is the difference between Q.I.D & Q.6H ? Q.I.D = Q.I.D = 4 times /day Q.6H = every 6 hours 49- What is the difference between the following anti-fungal ? Miconazole = local & systemic Amphotericin = Amphotericin = parentral only Griseofulvin = Griseofulvin = oral
50- Give the indication of the following : a- gimfibrazole -------> for hyperlipidaemia b- cisapred ------------> cisapred ------------> for gastroesophegyl reflux c- fluexiten SSRI SSRI ( selective serotonin reuptake inhibitor ) ----------- Antidepressant d- carbimazole ---------> ---------> for for hyperthyroidism e- imipramine -----------> tricyclic antidepressant f- ibratrobium Br ----> Br ----> antimuscarinic antimuscarinic as bronchodilator
51- All are antimetabolites except : a-methotrexate b-flurouracil c- cytarabine d-azathioprine(Imuran) e-cyclophosphamide (alkylating agent)
52- Cefaclor is : a- 1st generation cephalosporin b- 2nd generation cephalosporin c- 3rd generation cephalosporin d- non of the above st
1 gen. : cefadroxil( Duricef ),cefazolin( Totacef Totacef ),cephalexin( Ceporex Ceporex ), cephalothin ,cephradine( Velocef Velocef ),cephapirin( Cefatrexyl Cefatrexyl )
nd
2 gen. : cefaclor,cefoxitin,cefotitan,cefuroxime( Zinnat ),cefprozil( Cefzil Cefzil ), loracarbef rd 3 gen. : cefotaxime( Claforan Claforan ),cefoperazone( Cefobid Cefobid ), cefotriaxone( Rocephin ),cifixime( Suprax Suprax ), ceftizoxime( Cefizox Cefizox ),proxetil,cefdinir, cefditoren,pivoxil,ceftazidime( Fortum ),ceftibuten,ceftizoxim ),ceftibuten,ceftizoximee th 4 gen. : cefepime( Maxipime ),cefpirome( Cefrom Cefrom ),cefpodoxime
53- Which aminoglycoside antibiotic can be taken orally a-gentamycin b-neomycin c-amikacin d-tobramycin 54- Teicoplanin antibiotic has similar effect on G+ve as a-vancomycin b-jamicacin c-gentamycin d-kanamycin 55- Which is not tetracycline ? a-minocyllin b-demeclocycline c-doxycycline d-clindamycin 56- Which is not Ca++ channel blocker ? a-verapamil b-deltiazem c-amlodipine d-cinnarizine 57 - Mesalazine is used for treatment treatment & maintainance of of remission remission of ulcerative colitis
58- Mention 4 lipid-soluble vitamins ? vit. A , D , E & K 59- Imipenam ( carbapenam )
It is the 1 st thiemamycin beta-lactam antibiotic
60- All these medications are used in ttt of TB except a-cyclosporin b-INH c- cycloserin d-rifampicin Treatment of TB : 1 line line or or primary primary drugs : drugs : Isoniazide(INH) & Rifampicin nd 2 line line or or secondary secondary drugs : Ethambutol , Streptomycin & Pyrazinamide. rd 3 line line or or tertiary drugs : drugs : Ethionamide , Cycloserine & Capreomycin st
61- All these drugs are anti-cholinergic except : a-ipratropium b-atropine sulphate c-benzatropine methylate d-dobutamine 62- All are antibiotics except : a-zalcitobin (ttt of AIDS) b-cefaprozil c-lomefloxacin d-cefopodoxin 63- There is one drug used for HIV : a-zalcitabin b-kinasterdin c-cefaprozil d-enoxocin 64- Which one is Suprax ? a-cefixime b-itraconazole 65- Which is Sporanox? a-cefixime b-itraconazole 66- All of these drugs can be used in ttt of leprosy except : a-dapson b-rifampicin c-clofazimin d- INH 67- One of these is not like others : a-timolol b-acebutalol c-labetolol d-betaxolol (selective B1 blocker)
68- Betahistine HCl :(betaserc) a-for mieniere`s disease b-antihistamine 69- Which one is not 5HT3 antagonist? a-tropisetron b-ondansetron c-domperidone d-gransetron 70- Which is not oral anti-coagulant? a-warfarin b-enoxaprine c-phenidione d-nicoumolone ...
..
71- Which is correct for Diazepam? a-can cause muscle spasm b-it is taken IM only c-it is a derivative from morphine
d-it is not used for long term 72- Maximum dose of paracetamol is : 4gm / day 73- The duration of treatment of TB by CTC is : a-one week b-two months c-one month d-six months ( CTC = = Tuberculosis Committee Thoracic Society )
74- Metoclopramide is a is a dopamine antagonist acts centrally by blocking by blocking vomiting center and peripherally and peripherally acts on the on the chemo-receptor trigger zone (CTZ) to be used as antiemetic 75- Which one is contra-indicated in pregnancy ? a-sucralfate b-ethambutol c-chlorpheneramine d-ciprofloxacin 76- What is the definition of Bioavailability of drug? The quantity of the active constituent of the drug absorbed by the blood through the intestine or any other route in a certain period of time OR : The conc. of drug in blood in a certain time
77- Give ex. of a drug induces hepatotoxicity paracetamol,ketokonazole,rifampicin,quinolo paracetamol,ketokonazol e,rifampicin,quinolones nes
78- Give ex. of a drug induces nephrotoxicity Aminoglycosides( as gentamycin gentamycin )
79- What is the generic name of vit. B12 ? Cyanocobalamine
80- Zidvudine ( Zalacitabin ) is used for HIV ... ...
81- What is the meaning of poor patient compliance? T he he patient didn`t take the medication properly ( not properly dose , not proper time ) may be due to the the dose regimen is not easy or the dose is high , or the side effect is clear
82- Fluxetine ( Fluxetine ( Prozac Prozac ) ) is : Selective serotonin re-uptake inhibitor ( ( SSRI ) )
83- Omeprazole ( Omeprazole ( Losec ) is : Proton pump inhibitor inhibitor
84- Mention two diseases cause Edema? Renal failure
Congestive heart failure
85- Give examples of Drug-Drug interactions ? Warfarin--------- ---- Aspirin Warfarin-------- Insulin --------------- B-Blocker Heparin -------- ----- Aspirin & Ampicillin Warfarin -------- ----Vit. ---- Vit. K Warfarin ----------------------- Phenobarbital Phenobarbital Spironolactone --------- Digoxin Digoxin S --------------- K-Sparing diuretics ACEI S
86- Generic name of : Vit. B1 ------------- Thiamine Vit. B2 ----------------------- Riboflavin Riboflavin Vit. B6 ------------B6 ------------- Pyridoxin Pyridoxin Vit. B12 --------------------- Cyanocobalamine Cyanocobalamine
87- All of these are the components of calamine lotion B.P except: a- ZnO b-calamine c-sod. citrate d-bentonite e-sod. sulphate 88- Terbinafene is used topically for : a-eczema b-candida c-fungal infections 89- Which one is not contra-indicated in pregnancy ? a-captopril b-enalapril c-lisinopril d-methyldopa 90- PCP ( pneumocystis corin pneumonia ) a-virus b-bacteria c-parasite d-mycobacterium 91- Which of the following is not antibiotic ? a-erythromycin b-cifixim c- cefprozil d- finasteride ( anti-cancer ) )
92- Which one is used for benign prostatic hyperplasia (BPHP)
a-flumazenil b-cefprozil c-mivacurim d-finasteride 93- All of these are 3rd generatio generationn cephalosporin except: a-cifixime b-cefopodoxime c-cefotriaxone d-cefotaxime 94- Which of the following is not mucolytic? a-bromohexin b-carbocistene c-ambroxol d-guaphenesin e-dextromethorphan
95- Which one is anti-platelet? a-ticlopidine c-aldesleukin
b-desfluron d-atovouon
96- All of these are anti-neoplastic except? a-aldesleukin b-taniposide c-pentostatin d-amlodipine (Ca++ channel blocker)
97- Which is not benzodiazipne ? a-temazepam b-nitrozepam c-loprazepam d-clozapine 98- Potassium supplement must not be given with triametrin a-false b-true 99- MMR vaccine is ? M easleseasles- M M umpsumps- Rubella Rubella vaccine BCG= BCG = B Bacillus acillus C almette almette Guerin DTP = D Diphteria& iphteria&T T etanus etanus toxoids and P and P ertussis ertussis V. Td =T =T etanus etanus & d iphtheria iphtheria toxoids OPV =Oral ral P P oliovirus oliovirus V accine accine HIbV = H aemophilus I aemophilus I nfluenzae nfluenzae type b ,conjugated V irus irus HAV = H epatitis A epatitis A V irus irus
100- Oral re-hydrate solution(ORS) is one of the following :
a- sod. citrate,pot. chloride & glucose b- sod. citrate,pot. chloride & sod. chloride c- sod. chloride,pot. citrate, sod. citrate & glucose d- sod. chloride,pot. chloride, sod. bicarbonate &
citric acid 101- The major action of sodium chromoglycate is : a-mast cell stabilization b-bronchodilator c-prostaglandins modifier d-leukotrienes modifier non of the above 102-The action of histamine is :
e-
a-capillary constriction b-elevation of blood pressure c-stimulation of gastric secretion d-skeletal muscle paralysis e-slowing the heart rate
103-One of the following antibiotics is resistant to penicillinase : a-penicillin V b-penicillin G c-floxapen d-ampicillin e-amoxicillin Penicillinase Resistant Penicillins Penicillins : Dicloxacillin,Naficillin,Oxacillin Dicloxacillin,Nafic illin,Oxacillin
& )M.A.S.A(
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104- Inderal is : a-similar in action to ergotamine b-similar in action to tubocurarine c-used as an antihistamine d-pure -adrenergic receptor blocker e- and – adrenergic receptor blocker 105- Rifampicin is indicated for treatment of : a-impaired fat absorption b-pulmonary emboli c-tuberculosis d-neoplastic disorders e-psoriasis 106- Which of the following is selective 1 blocker ? a-labitolol b-terazosine c-cloridine d-captopril e-verapamil
Drugs acting on the sympathetic system
I-Sympathomimetics : *Indirectly acting : : ephedrine,amphetamine(tyramine),cocaine *Directly acting : : - Agonists: norepinephrine , epinephrine 2 : clonidine , -methylnorepinephrine : phenylephrine phenylephrine , methoxamine 1 : - Agonists : 1 / 2 : epinephrine,isoprenaline 2 : salbutamol,terbutaline : norepinephrine,dobutamine norepinephrine,dobutamine 1 :
II- Adrenergic neurone blockers : Reserpine, guanethidine,bethanidine III- Adrenoceptor antagonists : * - Blockers : : phenoxybenzamine,phentolamine phenoxybenzamine,phentolamine : : prazocin prazocin : * - Blockers : : propranolol,madolol,timolol, pindolol,oxprenolol,carvedilol (cardioselective) : atenolol,metoprolol,acebutolol
107- The latabbreviation for " After Meals " is is : a- a.c. b- a.a. c- p.c. d- i.c. e- c.c. 108- The latin abbreviation for " Four Times Daily " Daily " is : a- a.c. b- a.a. c- p.c. d- q.i.d. e- c.c. 109- The latin abbreviation for " Every Night " " is : a.c. b- o.n. c- p.c. d- i.c. e- c.c. 110- Erythroped A : a-is effective against G +ve Cocci b-is a macrolide antibiotic c-can increase g.i.t. motility d-could be used in pregnant women if need e-all of the above 111- For the treatment of anaphylactic shock use : a-salbutamol b-diphenhydramine c-acetazolamide d-epinephrine e-aminophylline
a-
112- Allopurinol is used as : a-analgesic agent b-uricosuric agent c-antiinflamatory agent d-antipyretic agent e-agent which increases renal tubular reabsorption 113- Which of the following is NOT betamethasone betametha sone side effect ? a-cataract b-hypoglycemia c-skeletal muscle weakness d-sodium retention e-lowered resistance to infections 114- A disease which is due to viral infection : a-poliomyelitis b-rabies c-chicken pox d-herpes e-all of the above 115- The mechanism of action of atropine is : a-muscarinic antagonist b-muscarinic agonist c-nicotinic antagonist d-nicotinic agonist
e-non of the above 116- Myocardial muscle tissue property to generate electrical is : a-inotropy b-chronotropy c-automaticity d-contractility e-non of the above 117- The heart`s dominant pacemaker is : a- AV node b- SA node c-pukinje fiber d-internodal pathways e-non of the above 118- Adenosine is used for : a-ventricular arrythmias b-atrial bradycardia c-supraventricular tachycardia d-supraventricular bradycardia e-non of the above 119- Adenosine P produces which of the following: a-facial flushing b-dyspnea c-marked tachycardia d- a and b e- a , b and c
120- Which of the following is responsible for buffering a-magnesium b-chloride c-bicarbonates d-potassium e-troponin 121- Respiratory acidosis is due to : a- O2 removal b- O2 retention c- CO2 removal d- CO2 retention e-non of the above 122- Which of the following is NOT colloid solution ? a-albumin 5% b-ringer`s solution c-dextran d-beta starch e-albumin 20%
Some examples of hydrophilic colloids used in pharmacy are acacia, methylcellulose, and proteins, such as gelatin and albumin. examples of substances which form hydrophobic colloids in water are silver iodide, hydrated ferric oxide, sulfur, and gold. arsenous sulfide, aluminum chloride magnesium chloride
123- The term shock signifies: a-hyperperfusion b-hypoperfusion c-tachycardia d-bradycardia e-non of the above 124- In treatment of shock , which of the following should be considered? a-airway control b-IV of crystalloid solution c-dopamine to support blood pressure d-monitor heart rhythm e-all of the above .... ....
125- Which of the following is released by bacterial infection?(…. by bacterial cell wall during there growth) a-endotoxin b-exotoxin c-antibiotics d-cytotoxin e-non of the above 126- the amount of water in adult male is about: a-25% b-60% c-80% d-10% e-17% 127- Which of the following are causes of oedema? a- hydrostatic pressure b- oncotic pressure c- capillary permeability d- a and b e- a , b and c 128- Patients prescribed non reversible monoamine oxidase inhibitor should be advised not to consume food containing tyramine because this combination causes: a-postural hypotension b-hallucinations
c-anaphylactic shock d-muscle weakness and tremor e-acute adrenergic crisis including sever hypertention
Effect :
Concurrent use of MAO inhibitors inhibitors (e.g. phenelzine) and anorexiants anorexiants (e.g. amphetamine) leads to increased amounts of norepinephrine, which increases sympathetic activity. Potential reactions include chest chest pain, cardiac arrhythmias, hypertensive crisis (headache, hyperpyrexia, and hypertension), seizures, cerebral hemorrhage, and death.
Tyramine-containing Tyramine-con taining foods: aged cheese, aged or spoiled meats, beer, red wine, yeast
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129- Concerning COX 2 inhibitors , which is NOT true? a-they have lower risk gastric adverse reactions b-good evidence about their effectivene effectiveness ss c-cardiac toxicity is a recent concern of this class d-they usually administrated twice daily e-combination with non selective agents give more effective action
130- In the treatment of osteoporosis which of the following is NOT true? a-alendronate should be taken 60 min. before breakfast b-Ca and vit. D are essential c-hormone replaceme replacement nt therapy should be considered d-outcome should be assessed with periodic bone density e-raloxifeno is selective oestrogen modulator
131- Which of the following is the first choice in acute gout? a-allopurinol b-indomethacin c-colchicine probencid e-sulfinylpyrazone
d-
132- Which of the following is NOT a risk r isk factor for osteoparalysis? a-minimal exercise b-low calcium intake c-male gender d-family history e-minimal exposure to sunlight 133- Early symptoms of aspirin poisoning are : a-lethergy & fatigue b-skin rash & headache c-throbbing headache & dizziness d-fluid retention hypotension e-ringing in the ears & blurred vision
134- Which of the following is NOT true about infiximab a-IL-1 blocker b-used for treatment of severe rheumatoid arthritis c-may increase risk of infections d-administered as IV infusion e-postadministration e-postadminis tration reactions include fever & chills
(M.A.S.A (
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