Enhancing borohydride’s reductive selectivity so that it may accomplish the conversion of amides to amines, alcohols or aldehydesFull description
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Growth in demand for chemicals in developing countries is high leading to substantial cross border investment in the chemical sector. In modern age chemical industries have permeated most ex…Descripción completa
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Guide on how to make a easy, fairly powerful, homemade gunpowder out of Sodium Chlorate. This gunpowder can be use in suitable pyrotechnic devices and firecracker.
synthesis of NaCN
Proposal Skripsi Sodium KloratFull description
Acetophenone Reduction by Sodium Borohydride
Procedure:
Weigh 1 g of of Acetophenone into a clean 250 mL round bottom flask. Add 14mL 14mL of MeOH and stir the solution using magnetic stirrer with the add of magnetic pellet. Keep the reaction mixture in a ice bath to attain the temperature zero degree. Now weigh around 0.35g of NaBH4 NaBH4 in a butter paper paper and add to the reaction mixture. Continue the stirring for 5-10 minutes. Monitor the progress of reaction using TLC. Spot both starting material as well as the reaction mixture parallelly. Elute the plate using ethyl acetate-Hexane eluent.(1:9) Visualize the reactant and product spot with the UV lamp and mark with with the dull pencil pencil and dip in 2,4-dinitrophenyl hydrazine (2,4-DNP) stain. The ketone will show a faint orange spot.
Note: NEVER look directly at the light of this UV lamp, or your eyes could be severely damaged. If you can see your sample on the plate using the UV light, you have enough.
Work up:
Remove the solvent using distillation set up. Add water to the mixture and extracted with the DCM (Dichloromethane) Finally dry the DCM layer using anhy. Sodium sulphate. Evaporate DCM layer.
Take the weight of the RBF.
Clean Up
The TLC solvent mixtures should should be placed in the organic waste bottles. Check the pH of the EtOH/aqueous mixture; neutralize as needed and flush down the drain.
QUESTIONS : 1) Write an equation for the hydrolysis of NaBH4. The products should be NaH2BO3 and H2 gas. 2) Under what circumstances would you expect to find unreacted acetophenone in the product in this experiment? 3) Which compound would you expect to undergo borohydride reduction more rapidly? Explain. (a) CH3CH2CHO or (b) CH3CH2COCH2CH3
