A Drug Study on Aztreonamm

 A Drug Study on Aztreonam Aztreonam

In Partial Fulfillment of the Requirements in Clinical Education 1

Submitted to: Mr. Lloyd Deocades Clinical Instructor

Submitted by: John-Francis B. Ycong Group 5

Date Submitted:

Brand Name: Azactam Generic Name: Aztreonam Classification: Antibiotic Mode of Action: Aztreonam is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis it is a monobactam antibiotic used primarily to treat infections caused by gram-negative bacteria Dosage:

Powder for Reconstitution: Oral inhalation (75 mg) >7 years: 75 mg 3x/day x 28 days Do not repeat for 28 days after completion Indications:  Aztreonam is an antibiotic that fights severe or life-threatening infection caused by bacteria. It is used to treat severe infections of the urinary tract, lower respiratory tract, skin, stomach, female reproductive organs, and other body systems. Contraindications: This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation. Side Effects:      

Cough mild stomach pain Nasal congestion sore throat Vomiting Pain at injection site

Adverse Effects: Cough Severe allergic reactions Increase in serum transaminases Neutropenia Diarrhea Nausea Vomiting  

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Drug Interaction:

BCG Vaccine aztreonam decreases effects of bcg vaccine live by pharmacodynamic antagonism. Cholera vaccine pharmacodynamic antagonism. Avoid coadministration of cholera vaccine with systemic antibiotics since these agents may be active against the vaccine strain. Typhoid vaccine live oral decreases effects of bcg vaccine live by pharmacodynamic antagonism. amoxicillin - increase effects of the other by pharmacodynamic synergism combination may be used synergistically against enterobacteriaceae aztreonam will increase the level of effect of digoxin by altering intestinal flora

RT Management: 

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In patients with impaired hepatic or renal function, appropriate monitoring is recommended during therapy . Patients should be counseled that antibacterial drugs including Aztreonam for injection should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). You should use a bronchodilator (eg, albuterol) before you use Aztreonam Inhalation. Contact your doctor for instructions on how and when to use a bronchodilator before using Aztreonam Inhalation.

Do not use Aztreonam Inhalation if it is cloudy, contains particles, or if it has been stored at room temperature for more than 28 days. To clear up your infection completely, use Aztreonam Inhalation for the full course of treatment. Keep using it even if you feel better in a few days.

Aztreonam Inhalation is usually used for 28 days on the medicine followed by at least 28 days off the medicine. Follow the dosing schedule given to you by your doctor carefully.

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If you miss a dose of Aztreonam Inhalation, use it as soon as possible. If it is less than 4 hours until your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.