05 Solubility Distribution Phenomena Image

Pharmaceutics I (Pharm351) 05 Solubility & distribution phenomena

Introduction

Introduction

Definitions

Solubility expressions

Solubility expressions (Cont’d)

Solent!solute interactions

Solent!solute interactions 1. Polar solvents

Solent!solute interactions 1. Polar solvents (Cont’d)

Solent!solute interactions 1. Polar solvents (Cont’d)

Solent!solute interactions 2. Nonpolar solvents

Solent!solute interactions !. Semipolar solvents

Solubility of "ases in li#uids

Solubility of "ases in li#uids "ntrodu#tion

Solubility of "ases in li#uids $a#tors that a%%e#t the solubility o% ases in li'uids

Solubility of "ases in li#uids $a#tors that a%%e#t the solubility o% ases in li'uids (Cont’d)

Solubility of "ases in li#uids $a#tors that a%%e#t the solubility o% ases in li'uids (Cont’d)

Solubility of "ases in li#uids $a#tors that a%%e#t the solubility o% ases in li'uids (Cont’d)

Solubility of "ases in li#uids Solubility #al#ulations

$xample 1

$xample 1 (Cont’d)

Solubility of li#uids in li#uids

Introduction

Ideal s% real solutions

$xample &

$ffect of internal pressure on miscibility

Complete s% partial miscibility

Phase e#uilibria ' the phase (ibbs) rule

$xamples on phase rule

Sin"le component system (C1)

Phase rule* 1% Sin"le component system (Cont’d)

Phase rule* 1% Sin"le component system (Cont’d)

Phase rule* 1% Sin"le component system

+,o components system (C&)

+,o components system (C&)

Condensed systems

-ater!phenol partially miscible condensed system

-ater!phenol partially miscible condensed system (Cont’d)

$xample 3* -ater!phenol system

Example 4: Water-Phenol system

Factors that afect miscibility o two component liquid-liquid systems

.actors that affect miscibility* 1. emperature

miscible as a unction o temperature  They do not show neither upper nor lower critical temperature points



.actors that affect miscibility* 2. Presen#e o% %orein substan#es

+hree components system (C3)

Phase rule in three component system

/ules in dealin" ,ith trian"ular systems

/ules in dealin" ,ith trian"ular systems (Cont’d)

+ernary Systems ,ith 0ne Pair of Partially iscible %2i#uids

+ernary Systems ,ith 0ne Pair of Partially iscible 2i#uids (Cont’d)% %%e#t o% temperature

+ernary Systems ,ith +,o Pairs of Partially iscible %2i#uids