The Ultimate Science-Based Supplement Guide

The Ultimate Science-Based Supplement Guide | 1

FOREWORD

Americans spend more than $30 billion per year on nutritional supplements, vitamins, minerals, and meal replacements. Reasons for supplement use vary from person-to-person; almost half of users take them to “improve” overall health, about one third claim they just want to “maintain” health, and less l ess that one quarter use supplements s upplements because they were recommended by a health care provider (NIH Survey). Whatever Whatever your reason for taking supplements, you are probably interested in knowing: “what does this specific product do, how does it work, and how do I take it?”. Sometimes these questions are difficult, i f not impossible to answer! Unlike food and medications, the U.S. Food and Drug Administration does not have the authority to review dietary supplement products for safety and effectiveness before they are marketed to review the public. This leave the overwhelming task of determining the usefulness of these products to consumers. With hundreds of new supplements s upplements entering the market every year, year, who has the time to analyze the effectiveness and risk of each product? Even if you do have time, most people do n’t have the background knowledge in chemistry, pharmacology, and physiology to determine if a specific supplement is right for them. So, who do you trust to deliver valid information? Many consumers are becoming more reliant on sources such as websites, advertisements, friends, and “experts”. This creates opportunities for the spread of misinformation and false health claims. The best way to get accurate information is through reading peer-reviewed peer-reviewed scientific articles, as these must undergo a rigorous process to ensure the data is valid and reliable. Unfortunately,, these articles often require a paid subscription and can be full of Unfortunately o f jargon, making accessibly to the general public problematic. In this book, the authors dove into into this scientific literature to make this complex information more accessible for you! A growing body of research supports the connection between diet and performance, enticing many people to continue trying new supplements. While this book does not include an exhaustive list, it should be used as a starting point for those interested in learning more about common dietary supplements, vitamins, vitamins , and minerals. As you will see, sever several al common supplements are well understood and established while many others need further study. We hope this book will help you, the consumer, make the best decisions possible to meet your personal health and performance goals.

Jimmy Bagley, PhD

San Francisco, California


SUPPLEMENT: BETASUPPLEMENT: BETA-ALANI ALANINE NE

Mechanism(s): Beta-alanine combines with histidine to form carnosine, an

intracellular buffer (50). Under continuous muscle contraction, hydrogen ions can accumulate and ultimately hinder further contraction. Therefore, increased intramuscular carnosine levels assist in buffering out pesky hydrogen ions, allowing for continued work (4, 50).

Dosage: 3.2-6.4g/day (4, 50)

Directions: Beta-Alanine increases are not fully maximized in a short period and

the upper limits for saturation have not fully been discovered yet (27). However, a month of supplementation should yield yiel d noticeable performance changes (27). Supplementation is not time sensitive and slowly accumulates carnosine in the muscle. Therefore, maintaining a daily, consistent regimen is the best method to reaping the benefits of beta-alanine. There appears to be a positive linear relationship between beta-alanine supplementation and muscle carnosine concentrations, with 80% increased levels after 10 weeks. (14).

Notes: Most common gym-goers consume beta-alanine in pre-workout mixes.

Subsequently,, they feel a tingling sensation, like ants crawling Subsequently crawling on their skin. This is called acute paresthesia, and is an effect of beta-alanine supplementation that is non-related to its intended function (18). Beta-alanine is best suited for activities that are greater than 60-90 seconds (4). Therefore, those who perform long duration exercise, exer cise, resistance training under the context of supersets, or rep ranges of 20+ would be target populations of supplementation.

Recommended Brands: Optimum Nutrition’s

Beta-Alanine powder uses Carnosyn, a thirdparty manufacturer that controls for purity and quality.


SUPPLEMENT: CAFFEINE SUPPLEMENT: CAFFEINE

Mechanism(s): The most common supplemental uses for caffeine include

displacement of fatigue and “fat burning”. Caffeine binds to the same receptors as adenosine, a nucleotide that leads to the “sleepy” feeling. Therefore, preemptively blocking these receptors causes a lowered perception of fatigue when adenosine can’t bind instead (53). On a subtler level, caffeine can stimulate the central nervous system to increase levels of hormones that may increase fatty acid oxidation (38, 53).

Dosage: Effective doses ranging from 3-9mg/kg body weight (equivalent to 1.5-

3.5 cups of coffee) produce a significant performance improvement (4).

Directions: For athletic purposes, consuming around 160-260mg of caffeine 45

to 60 minutes before exercise may improve performance (38).

Notes: Caffeine can be found in many sources, ranging from coffee, to energy

drinks, and even chocolate (4). Furthermore, caffeine should be noted for its side effects. Even in the context of intelligent dosing, caffeine may still produce a diuretic effect. Also, daily, chronic use may result in an increased tolerance and dependency (4).

Recommended Brands: Common

supplemental forms of caffeine are in the various existing preworkout formulas, caffeine pills (typically 100mg), and in coffee (16oz contains 250-300mg) (38). For

a

quality

supplement,

pre-workout

consider

Citadel

Nutrition’s Tier 1 (100mg caffeine) / Tier 1+ (200mg caffeine). The Ultimate Science-Based Supplement Guide | 4

SUPPLEMENT: CITRULLINE SUPPLEMENT: CITRULLINE MALATE

Mechanism(s): The most common supplemental uses for caffeine include

displacement of fatigue and “fat burning”. Caffeine binds to the same receptors as adenosine, a nucleotide that leads to the “sleepy” feeling. Therefore, preemptively blocking these receptors causes a lowered perception of fatigue when adenosine can’t bind instead (53). On a subtler level, caffeine can stimulate the central nervous system to increase levels of hormones that may increase fatty acid oxidation (38, 53).

Dosage: 6000-8000mg citrulline malate before exercise (42, 51).

Directions: Citrulline Malate is sour in powdered form, therefore it may help if it

is taken with food. My anecdotal recommendation would be to mix it with other supplements in a shake, or simply add it to an already sour drink.

Notes: Citrulline Malate has shown effective in increasing cellular energy

efficiency (7), however there is not substantial evidence to support it as an athletic supplement currently for resistance training or aerobic endurance exercise exer cise (26, 42).

Recommended Brands: Primaforce Citrulline Malate


SUPPLEMENT: CR SUPPLEMENT: CREA EATINE TINE MONOHYDRATE MO NOHYDRATE

Mechanism(s): Creatine is found in all cells of the body, with the highest

concentration in the muscle (~95%) (43).

Creatine has the cellular cellular function

of maintaining stable energy status in the cell. Ultimately Ultimately,, it recycles ATP ATP,, our biological energy currency (11). Creatine is one of the most scientifically founded supplements, with a plethora of evidence to back its efficacy in athletic endeavors (11). More recent research has investigated creatine as a cognitive supplement with promising results (6, 36, 37 37,, 41, 54).

Dosage: Loading Phase: 4x5g (20g total split evenly throughout the day)/ 7

days (31) Maintenance Phase: 3-5g/daily (31)

Directions: If planning on intermittently using creatine for an athletic event or

time specific goal, a loading phase should be implemented. For long term term use without a time restraint, a maintenance dose over a 30-day span is equally as effective as the loading dose (11, 31). While time of supplementation is irrelev irrelevant, ant, there is some data to show that post workout ingestion may yield slightly greater benefits (2). Co-ingestion with carbohydrate and/or protein may also facilitate muscle creatine saturation in the loading phase (13, 48).

Notes: Creatine primarily benefits high intensity/short duration sports such as

sprinting, heavy resistance training, and perhaps the explosive aspects of sports like mixed martial arts. Many individuals are concerned with water retention in creatine supplementation, however howe ver water water is distributed evenly throughout the body (45). Other concerns, such as kidney dysfunction, are a non-issue if the individual has healthy kidney function (11).


Recommended Brands: Optimum Nutrition’s Nutritio n’s “Micronized Creatine Monohydrate”

or any supplier that uses Creapure brand creatine. Creapure is a third-party company that controls quality and purity of their creatine monohydrate.


SUPPLEMENT: FISH SUPPLEMENT: FISH OIL

Mechanism(s): Fish oil supplementation commonly targets two essential

Omega-3 fatty acids: EPA & DHA. These cannot be synthesized in human bodies, therefore we must get them from our diets. Fish oil supplementation assists in a plethora of beneficial effects, including increased HDL (“good cholesterol”, reduced triglycerides, and lowered LDL (“bad cholesterol”. Also, EPA EPA and DHA play play a role in the production of antiinflammatory markers, such as prostaglandins and leukotrienes (15, 20, 21).

Dosage: The American Heart Association recommends 1g of o f total EPA/DHA daily

(21), however however a 1.8g dose dos e spread out over the course of a day may contribute to reduced soreness (52).

Directions: Fish oil can be found in both

capsules and liquids. Avoid rancidity through

controlling

light exposure. exposure.

temperature

and

Store fish oil in a cool,

dark room to avoid rancidi rancidity ty.. Commonl Commonly y, antioxidants such as Vitamin E are added to prevent oxidation and preserve the oil (56).

Notes: Omega 3 fatty acids and Omega

6 fatty acids are both essential fatty acids. Our bodies need both to mediate mediate inflammation and anti-inflammation (21). Therefore, Therefor e, it is important not to throw the baby out with the bathwater, ensuring that you moderate both in your diet.

Recommended Brands: Nordic Naturals

or Carlson’s Fish Oil.


SUPPLEMENT: “GREEN” SUPPLEMENT: “GREEN” POWDER

Mechanism(s): “Green Powder” based supplements commonly place many

compounds into a proprietary blend that have a wide range of proposed benefits. While these green “superfood” powders are common, they are not homogenous and the ingredients wildly wi ldly vary. vary. Rather, Rather, here are some of the scientifically s cientifically backed compounds to look for if you choose choos e to buy such products. Garlic – Apart from tasting great on bread, garlic plays a role in improving blood

circulation and as an antioxidant (3, 40, 46). Spirulina-

This compound is an anti-inflammatory and an antioxidant. As an

ergogenic aid, spirulina can improve muscular endurance and potentially assist in power production (1, 34)! Curcumin – An active component of turmeric, a commonly used cooking spice.

Amongst many benefits, curcumin can relieve joint pain and symptoms of osteoarthritis (19, 33).

Dosage: Garlic should be supplemented between 300-1500mg (3, 46).

For athletic performance, ranges of 2-8g of spirulina have proven effective (1, 34). Curcumin is better absorbed when paired with other compounds, such as black pepper extract. Howe However ver,, you can commonly find curcumin with Meriva, which also enhances transit into the blood. With a co-ingested enhancer, a 500mg dose is sufficient (35).

Directions: Garlic can c an be purchased in supplemental s upplemental form; however however,, you can also

reap the benefits through food. The evidence on Spirulina is still relatively new, new, therefore overconsumption overconsumption may not be wise above the recommended daily dose. Also, since ingestion frequency hasn’t been fully parsed out, it would be pragmatic to start on the lower end before increasing daily dosage.


Notes: A huge issue surrounding powder supplements is proprietary blending.

The company will take several compounds and group them up together into one “superfood blend” with one lump sum of the constituents’ weight. The problem is that you can’t know how much of each individual ingredient there is that makes up a blend. Therefore, it would be practical to find the compounds that work, and individually supplement with them.

Recommended Brands: Now Garlic 5000: Odor Controlled

Now Organic Spirulina Powder


SOURCE NATURALS TURMERIC WITH MERIVA 500MG

Ebook Title | 11

SUPPLEMENT: L-CARNITINE SUPPLEMENT: L-CARNITINE

Mechanism(s): Carnitine is an amino acid responsible for the transfer of fatty

acids into the mitochondrial matrix, where they can be oxidized for fuel (21). Most commonly, L-Carnitine will be part of a fat burning proprietary blend, targeting those who are are seeking a “fat burner”. Unfortunately Unfortunately,, current evidence evidence does not support L-Carnitine for increased fat metabolism (4). There is some research that indicates L-Carnitine supplementation may enhance recovery recov ery and reduce muscle soreness (29, 30, 47).

Dosage: Up to 2-3g of L-Carnitine daily appear to be safe and effective (4, 28,

47).

Directions: L-Carnitine should be supplemented daily in the form of L-Carnitine

L-Tartrate capsules, the form commonly used in physical performance based trials (47). Supplementation is commonly split into a morning and lunch-time dose, with a 2-3g total (28, 47).

Notes: The existing evidence for L-Carnitine

supplementation

is

weak

in

healthy

populations. Ultimately, unless your daily protein intake is low, chances are that you are not deficient in carnitine and supplementation will not result in increased energy yield from fat (4).

Recommended Brands: EverPure

L-Carnitine Tartrate


SUPPLEMENT: L-TYROSINE SUPPLEMENT: L-TYROSINE

Mechanism(s): Tyrosine is a precursor amino acid that is metabolized into

products such as dopamine, adrenaline, and norepinephrine. These chemical messengers are important for dealing with acute stressors in the environment (55). Supplementing with L-Tyrosine may provide protection against mental fatigue due to physical exertion and a subsequent decline in norepinephrine (5, 17).

Dosage: 100mg/kg bodyweight (~7g for an 150lb individual) 60 minutes before

acute stress, i.e. exercise (17)

Directions: The recommended dose should be taken 60 minutes before an acute

stressor. This could be any combination of exercise, heat exposure, and/or cold exposure (5, 17, 55).

Notes: Existing research does not heavily support the use of L-Tyrosine

supplementation for increased production of adrenaline, norepinephrine, nor dopamine. Howe However ver,, it can act as a buffer in times of acute, high stress situations, where norepinephrine may be depleted (55).

Recommended Brands: LiveLong Nutrition’s L-Tyrosine


SUPPLEMENT: MU SUPPLEMENT: MUL LTIV TIVIT ITAMI AMINS NS

Mechanism(s): “Multivitamin” is a blanket term to refer to a supplement that

contains multiple vitamins and or minerals. Also, a multivitamin may contain other bioactive compounds, such as antioxidants.

COMMON VITAMINS: (21) WATER SOLUBLE Vitamin B1 (Thiamin): Serves as a component of coenzymes for metabolism Vitamin B2 (Riboflavin): Serves as a component of coenzymes for metabolism

and vital for the transfer of electrons during energy metabolism Vitamin B3 (Niacin): Vital for the transfer of electrons during energy metabolism Vitamin B5 (Pantothenic Acid): Important as a component of cellular nutrient

metabolism Vitamin B6 (Pyridoxine): (P yridoxine): Serves to aid in cellular enzyme function Vitamin B12 (Cyanocobalamin): Important to ensure proper metabolism of

homocysteine, a “toxic” compound associated negatively with cardiovascular health. Also serves a role in the synthesis of compounds necessary for the creation of end products such as fatty acids. Vitamin C (Ascorbic Acid): Vital for production of collagen, carnitine, and

norepinephrine, as well as serving as an antioxidant. Commonly known for its role to enhance the immune imm une system Folic Acid: Important to ensure proper metabolism of homocysteine, a “toxic”

compound associated negatively with cardiovascular health Biotin: Serves to aid in cellular enzyme function functio n

FAT SOLUBLE Vitamin A: Responsible for compounds necessary for healthy vision, as well as

being involved in growth, cell differentiation, bone development, and immune function Vitamin K: Activates blood clotting factors and facilitates bone health Vitamin D: (see section “Vitamin D” below)


Vitamin E: Serves as an antioxidant and potentially in the prevention of eye

cataracts COMMON MINERALS: (21) Calcium: Maintains bone homeostasis and is a tightly regulated mineral for

cellular function Magnesium: Maintains bone homeostasis, has a role in nerve impulse transmission,

and serves as a cofactor for cellular reactions Phosphorous: Maintains bone homeostasis, plays a role in DNA/RNA structure,

and is important for energy storage and transfer Zinc: Plays a role in enzyme function, nutrient metabolism, collagen formation,

cell replication and growth Iron: Facilitates oxygen transport and use, serve an antioxidant function, and

assists in the synthesis of carnitine, collagen, and thyroid hormone Selenium: Serves as an antioxidant Chromium: May play a role in insulin signaling Sodium: Regulates water, water, pH, and electrolytes. Also assists in nerve transmission

and muscle contraction Potassium: Regulates water, pH, and electrolytes. Also assists in nerve

transmission and muscle contraction Chloride: Maintains pH balance, assists with enzyme activation, and serves as a

component of gastric acid for digestion. Iodine: Plays a large role in thyroid hormone synthesis Copper: Used in iron metabolism, serves as an antioxidant, and facilitates

collagen synthesis The primary rationale to supplement with a multivitamin would be as a prophylactic against deficiency disease. Those who are on specific diets, low calorie diets, or do not have access to nutrient dense foods may need to supplement with the appropriate vitamins and/or and/ or minerals. Examples include vegans who may lack iron, pregnant pregnant women who have higher requirements of folic acid, and very low income areas that do not have easy access to fresh produce (21).

Dosage: Ranges depending on content.

Multivitamins come in various forms and dosages. Some target specific demographics (i.e. men, women, pregnant mothers, the elderly elderly,, etc.)


Directions: Most vitamins indicate on the label an intended intended dosage. Also, most

should be taken with food and/or liquid for improved absorption (21).

Notes: Certain vitamins and minerals are common deficiencies among the

American population. These include Vitamin D, Magnesium, Iron, Folic Acid, etc. It may be more pragmatic to individually supplement with these, as opposed to taking a singular umbrella pill. There is some weaker evidence that excess vitamin and mineral consumption could be detrimental (39, 49), however the consensus is that they are benign at worst (25, 32). When possible, nutrients should be consumed through whole, minimally processed foods. While there are exceptions, absorption of many vitamins and minerals are aided by the context of the food they are in. The various bioactive components work synergistically to impart greater health benefit (21).

Recommended Brands: Citadel Nutrition’s Athlete Vitamin (contains Vitamin D,

Vitamin K, Zinc, Calcium, and Magnesium).


NATURE MADE MULTI COMPLETE WITH IRON

Ebook Title | 17

SUPPLEMENT: VITAMIN SUPPLEMENT: VITAMIN D

Mechanism(s): Vitamin D is responsible for many functions, including action

as a regulator of bone mineral metabolism, bone calcium maintenance, cell differentiation, proliferation, and growth (21). Sufficient Vitamin D status in athletes also provides protection against stress fractures and illness (22). Vitamin D is also the only vitamin that can be obtained through exposure to sunlight (21). It should also be noted that men who are deficient in vitamin D may have lowered lowered testosterone, testoster one, and can potentially benefit from supplementation (44).

Dosage: The RDA recommends 600 IU of Vitamin D (21), ( 21), however however more current

research suggests that a more optimal dose of 800IU/day, and up to even 5000IU/day 5000IU/ day for fast metabolizers (8, 23).

Directions: Vitamin D is a fat-soluble vitamin, therefore

transport and absorption are facilitated through a small amount of fat. It may be pragmatic to consume your Vitamin D with a daily fish oil supplement, killing two birds with one stone (16). The optimal supplementation form of Vitamin D is D3, or cholecalciferol (21).

Notes: While

supplementation of Vitamin D is

practical for the American population, getting it through natural sources should be prioritized. prioriti zed. Apart from sunlight exposure, one can find Vitamin D in the diet through fatty fish, fortified orange juice, and even small amounts in eggs (21).

Recommended Brands: Nature Made (3rd party

verified) Vitamin D3 1000 IU soft gels are a good choice.


SUPPLEMENT: WHEY SUPPLEMENT: WHEY PROTEIN

Mechanism(s): Whey protein is one of the constituents of milk, along with casein.

Whey is a high biological value protein, containing all essential amino acids. It also has a high amount of the branched-chain amino acids, of which leucine, in particular,, is measured as a proxy for muscle protein synthesis (9). particular Ultimately, whey protein is supplemented to augment recovery and enhance muscle growth after training (38).

Dosage: 20-30g, depending on total protein content relative to proprietary add-

ins, form, etc. (38).

Directions: The media would have you slamming a protein shake before, during,

and within two nanoseconds of your your training period. The evidence base is much less definitive (24). Without too much context, a general guideline would be to consume your whey protein within relative proximity proximity of your training bout. The closeness in timing of the post-workout shake becomes more important if your training session spans over two two hours, if you did not have a small amount of protein in your pre-workout meal, or a combination of the two factors (24). A key characteristic of quality protein supplements i s the presence or availability of an amino acid list. Companies that do not list their individual amino acid totals per serving may be hiding shady practices, in which cheap, low quality amino acids are added to the powder to boost total protein content.

Notes: There are as many options for purchasing whey protein as there are

choices for picking an outfit of the day. day. Three primary forms of whey protein exist on the market. Whey protein isolate is standard 90% protein, while concentrate is between 35-80% protein by weight (12). Whey protein hydrolysate hydrolysate refers to a process that refines the particles into even smaller fragments, eliciting a faster rate of absorption and even a greater capacity to reduce soreness (10). These benefits will be most desirable to those who train multiple times per day. Keep in mind, however, that hydrolysate has a steeper price tag.


Recommended Brands: Optimum Nutrition’s “Gold Standard 100% Whey”


REFERENCE

1.

Ali A, Jha P, Sandhu KS, and Raghuram N. Spirulina nitrate-assimilating enzymes (NR, NiR, GS) have higher specific activities and are more stable than those of rice. Physiol Mol Biol Plants 14: 179-182, 2008.

2.

Antonio J and Ciccone Ciccone V. V. The effects of pre versus post workout workout supplementation supplementation of creatine monohydrate on body composition and strength. J Int Soc Sports Nutr 10: 10: 36, 2013.

3.

Ashraf R, Khan RA, Ashraf Ashraf I, and Qureshi Qureshi AA. Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci 26: 26: 859-863, 2013.

4.

Baechle Baechl e T, R. and Earle R, W. Essentials of Strength Training and Conditioning. Champaign, IL: Human Kinetics, 2008.

5.

Banderet LE and Lieberman HR. Treatment with tyrosine, tyrosine, a neurotransmitter precursor precursor,, reduces environmental stress in humans. Brain Res Bull 22: 22: 759-762, 1989.

6.

Beal MF MF.. Neuroprote Neuroprotective ctive effects of creatine. Amino Acids 40: 1305-1313, 2011.

7.

Bendahan D, D, Mattei Mattei JP, JP, Ghattas B, Confort-Gouny Confort-Gouny S, Le Guern ME, and Cozzone PJ. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med 36: 36: 282-289, 2002.

8.

Bischoff-Ferrari HA, Dawson-Hughes Dawson-Hughes B, B, Staehelin HB, Orav JE, Stuck Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP DP,, and Henschkowski Hensc hkowski J. Fall prevention prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339: 339: b3692, 2009.

9.

Blomstrand E, Eliasson J, Karlsson HK, and Kohnke Kohnke R. Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr 136: 269S-273S, 2006.

10. Buckley JD, Thomson RL, Coates AM, Howe Howe PR, DeNichilo MO, and Rowney Rowney MK.

Supplementation with a whey protein hydrolysate enhances recovery of muscle force-generating capacity following eccentric exercise. J Sci Med Sport 13: 178-181, 2010. 11.

Buford TW, TW, Kreider RB, RB, Stout JR, JR, Greenwood Greenwood M, Campbell B, Spano M, Ziegenfuss T, T, Lopez H, Landis J, and Antonio J. International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr 4: 4: 6, 2007.


12. Carunchia Whetstine ME, Croissant AE, and Drake MA. Characterization Characterization of dried dried whey

protein concentrate and isolate flavor. J Dairy Sci 88: 88: 3826-3839, 2005. 13. Cooper R, Naclerio F, F, Allgrove Allgrove J, and Jimenez A. Creatine Creatine supplementation with

specific view to exercise/sports exercise/sports performance: an update. J Int Soc Sports Nutr 9: 9: 33, 2012. 14. Culbertson JY, JY, Kreider RB, Greenwood Greenwood M, and Cooke M. Effects of beta-alanine

on muscle carnosine and exercise performance: a review of the current literature. Nutrients 2: 75-98, 2010. 15. Davidson MH, Stein EA, Bays Bays HE, Maki KC, KC, Doyle RT, RT, Shalwitz RA, Ballantyne CM,

Ginsberg HN, and Investigators COopO-wS. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/ g/d d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther 29: 1354-1367, 2007. 2007. 16. Dawson-Hughes B, Harris SS, Palermo NJ, Ceglia L, and Rasmussen H. Meal

conditions affect the absorption of supplemental vitamin D3 but not the plasma 25-hydroxyvitamin D response to supplementation. J Bone Miner Res 28: 1778-1783, 2013. 17.. 17

Deijen Deije n JB, Wientjes CJ, Vullin Vullinghs ghs HF, HF, Cloin PA, PA, and Langefel Langefeld d JJ. JJ. Tyrosine Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull 48: 48: 203-209, 1999.

18. del Favero Favero S, Roschel H, Solis MY, MY, Hayashi AP, AP, Artioli GG, Otaduy MC, Benatti FB, Harris

RC, Wise JA, Leite CC, Pereira Pereira RM, de Sa-Pinto AL, Lancha-Junior AH, and Gualano B. Beta-alanine (Carnosyn) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity capaci ty.. Amino Acids 43: 49-56, 2012. 19. Di Pierro F, F, Rapacioli G, Di Maio EA, E A, Appendino G, Franceschi F, F, and Togni Togni S.

Comparative Comparativ e evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva((R))), nimesulide, and acetaminophen. J Pain Res 6: 201-205, 2013. 20. Eslick GD, Howe PR, Smith C, Priest R, and Bensoussan A. Benefits of fish oil

supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J 136: 4-16, 2009. Cardiol 136: 21. Gropper SS and Smith J, L. Advan Advanced ced Nutrition Nutrition and Human Metabolism. Metabolism. Belmont, Ca:

Cengage Learning, 2013. 22. Halliday TM, Peterson NJ, Thomas JJ, JJ, Kleppinger K, Hollis BW, BW, and Larson-Meyer DE.

Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Med Sci Sports Exerc 43: 335-343, 2011.


23. Heaney RP, Davies KM, Chen TC, Holick MF, and Barger-Lux MJ. Human serum

25-hydroxycholecalcifer 25-hydr oxycholecalciferol ol response to extended oral dosing with cholecalciferol. Am 77: 204-210, 2003. J Clin Nutr 77: 24. Helms ER, Aragon AA, and Fitschen PJ. PJ. Evidence-based recommendations recommendations for natural

bodybuilding contest preparation: nutrition and supplementation. J Int Soc Sports Nutr 11: 11: 20, 2014. 25. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook Cook NR, Belanger C,

LaMotte F, F, Gaziano JM, Ridker PM, Willett W, and Peto R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular cardiov ascular disease. N Engl J Med 334: 334: 1145-1149, 1996. 26. Hickner RC, Tanner Tanner CJ, Evans CA, Clark PD, Haddock A, Fortune C, Geddis H, Waugh Waugh

W, and McCammon M. L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sports Exerc 38: 660-666, 2006. 27.. Hill CA, Harris RC, Kim HJ, Harris BD, 27 BD, Sale C, Boobis LH, Kim CK, and Wise JA. JA. Influence

of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity capacity.. Amino Acids 32: 225-233, 2007. 28. Ho JY, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, Coday M,

Hakkinen K, and Maresh CM. l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism 59: 1190-1199, 2010. 29. Hulsmann WC and Dubelaar ML. Aspects of fatty acid metabolism in vascular

endothelial cells. Biochimie 70: 681-686, 1988. 30. Hulsmann WC and Dubelaar ML. Carnitine requirement requirement of vascular endothelial and

smooth muscle cells in imminent ischemia. Mol Cell Biochem 116: 125-129, 1992. 31. Hultman E, Soderlund K, Timmons JA, JA, Cederblad G, and Greenhaff PL. Muscle creatine creatine

loading in men. J Appl Physiol Physiol (1985) 81: 232-237, 1996. 32. Jacobs EJ, Connell Connell CJ, McCullough ML, Chao A, Jonas CR, Rodriguez Rodriguez C, Calle EE, and

Thun MJ. Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer Prevention Prevention Study II cohort. Cancer Epidemiol Biomarkers Prev 11: 35-41, 2002. 33. Kuptnirats Kuptniratsaikul aikul V, V, Thanakhumtorn S, Chinswangwatanakul Chinswangwatanak ul P, P, Wattanam Wattanamongkons ongkonsil il L,

and Thamlikitkul V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement 15: 891-897, 2009. Complement Med 15: 34. Lu HK, Hsieh CC, Hsu JJ, Yang YK, and Chou HN. Preventive effects of Spirulina

platensis on skeletal muscle damage under exercise-induced oxidative stress. Eur J Appl Physiol Physiol 98: 98: 220-226, 2006.


35. Marczyl Marczylo o TH, Verschoyl Verschoyle e RD, Cooke DN, Morazzoni P, Steward WP, WP, and Gescher AJ.

Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 60: 60: 171-177, 2007. 36. McMorris T, Harris RC, Howard AN, Langridge G, Hall B, Corbett J, Dicks M, and

Hodgson C. Creatine supplementation, sleep deprivation, cortisol, melatonin and behavior. Physiol Behav 90: 90: 21-28, 2007. 37.. McMorris T, 37 T, Harris RC, Swain Swain J, Corbett J, J, Collard K, Dyson Dyson RJ, Dye L, Hodgson C, and

Draper N. Effect of creatine supplementation and sleep deprivation, with mild mi ld exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmac Psychopharmacology ology (Berl) 185: 93-103, 2006. 38. Murray B and Kenney L, W. A Practical Guide to Exercise Physiology Physiology.. Champaign, IL:

Human Kinetics, 2016. 39. Mursu J, Robien K, Harnack LJ, LJ, Park K, and Jacobs DR, Jr. Jr. Dietary supplements and

mortality rate in older o lder women: the Iowa Women’s Women’s Health Study. Arch Intern Med 171: 171: 1625-1633, 2011. 40. Nantz MP, Rowe CA, Muller CE, Creasy RA, Stanilka JM, and Percival SS.

Supplementation with aged garlic extract improves both NK and gammadelta-T cell function and reduces the severity of cold and flu symptoms: a randomized, doubleblind, placebo-controlled nutrition intervention. Clin Nutr 31: 31: 337-344, 2012. 41. Pan JW and Takahashi Takahashi K. Cerebral Cerebral energetic effects of creatine supplementation in

humans. Am J Physiol Regul 292: R1745-1750, 2007. 2007. Regul Integr Comp Physiol Physiol 292: 42. Perez-Guisado J and Jakeman PM. Citrulline malate enhances athletic anaerobic

performance and relieves muscle soreness. J Strength Cond Res 24: 1215-1222, 2010. 43. Persky AM and Brazeau GA. Clinical pharmacology of the dietary supplement creatine creatine

monohydrate. Pharmacol Rev 53: 53: 161-176, 2001. 44. Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, and

Zittermann A. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res 43: 223-225, 2011. 45. Powers ME, Arnold BL, Weltman AL, Perrin DH, Mistry D, Kahler DM, Kraemer W,

and Volek J. Creatine Supplementation Increases Total Body Water Without Altering Train 38: 44-50, 2003. Fluid Distribution. J Athl Train 46. Ried K, Frank OR, and Stocks NP. Aged garlic extract reduces blood pressure in

hypertensives: hypertensiv es: a dose-response trial. Eur J Clin Nutr 67: 67: 64-70, 2013. 47.. Spiering BA, Kraemer WJ, 47 WJ, Vingren JL, Hatfield DL, Fragala MS, Ho JY, JY, Maresh CM,

Anderson JM, and Volek JS. Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. L-tartrate. J Strength Cond Res 21: 259-264, 2007.


48. Steenge GR, Lambourne J, Casey A, Macdonald IA, and Greenhaff PL. Stimulatory

effect of insulin on creatine accumulation in human skeletal muscle. Am J Physiol 275: E974-979, 1998. 49. Stev Stevens ens VL, McCullough ML, Diver WR, Rodriguez C, Jacobs EJ, EJ, Thun MJ, and Calle

EE. Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes Control 16: 16: 643-650, 2005. 50. Stout JR, Cramer JT, Zoeller RF, RF, Torok Torok D, Costa P, P, Hoffman JR, Harris Harr is RC, and O’Kroy

J. Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids 32: 381-386, 2007. 51. Sureda A, Cordova Cordova A, Ferrer MD, MD, Perez G, Tur Tur JA, and Pons A. L-citrulline-malate

influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol 110: 110: 341-351, 2010. 52. Tartibian B, Maleki BH, and Abbasi A. The effects of ingestion of omega-3 fatty

acids on perceived pain and external symptoms of delayed onset muscle soreness in untrained men. Clin J Sport Med 19: 19: 115-119, 2009. 53. Trexler ET, ET, Smith-Ryan AE, Roelofs EJ, Hirsch KR, and Mock MG. Effects of coffee and

caffeine anhydrous on strength and sprint performance. Eur J Sport Sci 16: 16: 702-710, 2016. 54. Watanabe A, Kato N, and Kato T. T. Effects of creatine on mental fatigue and cerebral

hemoglobin oxygenation. Neurosci Res 42: 279-285, 2002. 55. Young SN. L-tyrosine to alleviate the effects of stress? J Psychiatry Neurosci 32: 32: 224,

2007. 56. Zou L and Akoh CC. Antioxidant activities of annatto and palm tocotrienol-rich

fractions in fish oil and structured lipid-based infant formula emulsion. Food Chem 168: 504-511, 2015.


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