MCU-FDTMF COLLOGE OF MEDICINE DEPARTMENT OF PHARMACOLOGY Board Questions
1. A patient came in because because of severe severe headache. headache. Before giving a drug, drug, the physician must know what the drug will do to the body. This is known as: A. Pharmacodyn Pharmacodynamic amic . !rug development B. Pharmacokinetic !. Adverse drug reaction "P#$ 1 %% 1&th 'd pp. (1 ). !istribu !istribution tion of drugs drugs to to tissu tissue: e: A. *s independent on blood flow to the organ B. *s independent of the solubility of the drug to the tissue . !epend on the unbound unbound drug concentrat concentration ion gradient gradient between between blood and the tissue !. *s increased for drugs that are strongly bound to plasma proteins "P# $ &.+ %% 1&th 'd pp.)& (. %iving a second drug in order order to enhance enhance the the action of a primary primary drug is a kind of drug interaction known as: A. potentiation potentiation . additive B. synergism !. antagonism "P#$ 1 %% 1&th 'd pp ) -. Two Two drugs have have said to have this this property property when they reached reached the same plasma concentration at the same rate after oral administration: A. Potency Potency . Bioavailability Bioavailability B. 'fficacy !. Bioeuivalence "P#$ &.+ %% 1&th 'd pp / +. 0hen the rate of elimination elimination is proportionate proportionate to to the concentrat concentration ion it is: A. ero order order kinetic kinetic . "aechelis "aechelis "enten "enten kinetics kinetics B. 2irst order kinetics !. none of the above "P#$ &.(( 3at4ung / th 'd pp (+ 5. 'ntero6h 'ntero6hepa epatic tic recyc recycling ling of of drugs drugs is: is: A. 7olume 7olume of distributio distribution n B. 8alf6life
. 2irst pass effect !. 2irst order kinetics "P#$ &.+ 3at4ung / th 'd pp +)
. 0hich of the the following following reactions reactions is most most effective effective for Phase Phase ** elimination elimination of hydrophobic drugs9 A. glucoronidation . oidation B. hydrolysis !. reduction "P#$ &.(( %% /th 'd pp1)
/. !rug oidation oidation freuently freuently involve involve all of the following following ';'PT ';'PT::
A. ytochrome p-+& en4ymes B.
. 'sterases !. "olecular oygen "P#$ &.)+ %% 1&th 'd pp1)
=. >ovita after recurrent sei4ure became comatose. Blood gas analysis showed severe metabolic acidosis. The antidote for >ovita is: A. 'ndophonium . Pyridoine B. Atropine sulfate !. Thiamine "P#$ &.+ %% /th 'd. Pp5 1&.A 1- year old was rushed to the '.?. because of poisoning. P.'. showed increased sweating and salivation with constricted pupils. The most likely substance ingested is: A. @alicylates .pioids B. Anticholinesterase drugs !.Antidepressants "P$ &.+ %% /th 'd. pp1/11. 0hich of the following will produce the most rapid induction of anesthesia9 A. 8alothane . "ethoyflurane B.
1+.?epeated eposure to which of the following anesthetic agents is most associated with liver damage:
A. *soflurane B. 8alothane
.
15.0hich of the following inhalation anesthetics is most likely to produce diffusional hypoia9 A. yclopropane .
)).The maor action involve in the antisei4ure activity of Phenytoin is: A. Block of sodium ion channel B. Block of calcium ion channel . 2acilitation of %ABA action on chloride ion !. *nhibition of %ABA transaminase "P#$ &.+ %% 1&th 'd pp +)= )(.A ( years old was brought to the '? because of recurrent attacks of blank stares lasting for few minutes. This child is best manage with this anti6sei4ure agent: A. Phenobarbital . #amotrigine B. 'thosuimide !. 7igabantrine "P#$ &.)+ %% 1&th 'd pp +(+ )-.Prolonged treatment with this anti6sei4ure agent is associated with gingival hyperplasia : A. 'thosuimide . 7alproate B. Phenobarbital !. Phenytoin "P#$ 1 %% 1&th 'd +(& )+.This is an inhibitory neurotransmitter: A. Acetylcholine B. %lutamic acid
. %lycine !. %ABA "P#$ 1 %% 1&th 'd pp (&-
)5.The best treatment for ParkinsonCs disease is: A. #evodopa . Amantadine B. @elegiline !. Pergolide "P#$ 1 %% 1&th 'd pp +++ ). This drug competitively inhibits the binding of aldosterone to mineralocorticoid receptors: A. amiloride . spirinolactone B. triamterene !. hydrochlorothia4ide "P#$ 1 %% 1&th 'd pp = )/. This drug potentiates the ototoic effect of loop diuretics: A. coumadin . digitalis B. lithium !. streptomycin "P#$ 1 %% 1&th 'd pp ( )=.A diuretic agent that inhibit
(&.A symphatomimetic agent that also acts as beta adrenergic agonist: A. dopamine . isoproterenol B. dobutamine !. norepinephrine "P#$ &.+ %% 1&th 'd pp ))/ (1. This drug acts by inhibiting renal systemic and tissue generation of angiotensin **: A. losartan . amrinone B. captopril !. hydrala4ine "P#$ 1 %% 1&th 'd. Pp=1& (). !opamine is used in the treatment of advanced left heart failure because it: A. causes vasoconstriction B. produces positive inotropic effect . reduces left ventricular afterload !. decreases cardiac output "P#$ 1 %% 1&th 'd pp =)+
((.The following are effects of cardiac glycosides ecept: A. inhibits
(.An acute attack of re6entrant supraventricular tachycardia will respond to: A. !igitalis . "agnesium sulfate B. 7erapamil !. Fuinidine "P#$ &.+ %% 1&th 'd pp =5+ (/.A 5& years old female patient complained of nystagmus after taking this antiarrythmic drug. The drug could be: A. !isopyramide . Procainamide B. #idocaine !. Fuinidine "P#$ 1 %% 1&th 'd pp =51 (=.The mechanism of action of gembfibro4il is: A. *ncrease ecretion of bile acid salts B. *ncrease epression of high affinity #!#6 receptor . *ncrease hydrolysis by lipoprotein lipase !. *nhibition of secretion of 7#!# by the liver "P#$ &.(( %% 1&th 'd ==( -&.This antihyperlipidemic agents reduces circulating cholesterol levels by binding to cholesterol in the %*T9 A. niacin . clofibrate B. cholestyramine !. gemfibro4il "P#$ &.(( %% $ 1& th 'd =/= -1.0hich of the following drugs is used as an emergency agent for hypertensive crisis9 A. "ethyldopa . 8ydrala4ine B. !iltia4em !.
-+.0hich among these antithombotic drugs inhibit the synthesis of thomboane by irreversible acetylation of the en4yme cyclooygenase9 A. Abciimab . *ntegrilin B. Aspirin !. Ticlodipine "P#$ &.+ %% 1&th 'd pp 1+(-5.An isoa4ole derivative of ethinyltestosterone that is used to suppress ovarian function: A. !ana4ol . ?aloifene B. lomiphene !. "ifepristone "P#$ &.(( 3at4ung / th 'd pp 5== -.A gn?8 analog which produces gonadal suppression: A. 2lutamide . 2inasteride B. #euprolide !. @pironolactone "P#$ &.)+ 3at4ung / th 'd pp =-) -/.A principal regulator of bone mineral homeostasis which needs to be metaboli4ed to gain biologic activity: A. 7itamin ! . %lucocorticoids B. Parathyroid hormone !. Adrenal androgens "P#$1 %% 1&th 'd pp 1)/ -=.0hich among the following is a long6acting glucocorticoids9 A. Betamethasone . Prednisone B. ortisone !. Triamcinolone "P#$ 1 %% 1&th 'd pp 15+ +&.Antineoplastic agent usually cause the following side effects ';'PT: A. loss of hair . nausea and vomiting B. liver damage !. bone marrow suppression "P#$ &.)+ %% 1&th ed pp 1(// +1.Busulfan, a useful drug in chronic myelocytic leukemia is: A. An antimetabolite . an alkylating agent B. An antibiotic !. a hormonal agent "P#$ &.+ %% 1&6th 'd pp 1(/( +).An immunopotentiating agent with an antihelminthic property: A. 8erceptin . *nterferon B. ?ituimab !. #evamisole "P#$ &.+ %% 1&th 'd pp 1-
+(.The most effective drug to use during acute attacks of gouty arthritis is: A. Allopurinol . olchicine B. Probenecid !. Phenylbuta4one "P#$ 1 %% 1&th 'd pp 1= +-.ne approach in the treatment of bronchial asthma is the use of mediator release inhibitors which would include: A. romolyn sodium . Terbutaline B. Theophylline !. 3etotifen "P#$ 1 %% 1&th 'd pp -) ++.0hich anti6asthmatic would be your choice if you want one with a less cardiac activity9 A. 'pinephrine . Terbutaline B. 'phedrine !. *soproterenol "P#$ 1 %% 1&th ed pp (5 +5. A long acting Beta6) selective agonist used for asthma prophylais: A. romolyn . "etaproterenol B. *patropium !. @almeterol "P#$ 1 %% 1&th ed pp ( +.The 8) antagonist with the highest bioavailability: A. imetidine . ?anitidine B. 2amotidine !.
. mepra4ole !. 2amotidine "P#$ &.+ %% 1&th 'd 1&&
+=.This drug is used in the treatment of PG! as a mucosal protective agent A. @ucralfate . magnesium 8 B. metronida4ole !. ocreotide "P#$ &.+ %% 1&th 'd pp 1&1) 5&.'thambutol is administered concurrently with other antituberculous drugs in the treatment of TB inorder to: A. ?educe the pain of inection B. 2acilitate penetration of the BBB . ?etard the development of organism resistance !. !elay ecretion of other anti TB drugs by the kidney "P#$ &.)+ %% 1&th 'd pp 1)/&
51.The mainstay drug in the treatment of all types of leprosy is: A. lofa4imine . *sonia4id B. !apsone !. ?ifampicin "P#$ 1 %% 1&th ed pp 1)// 5).7estibular and auditory dysfunction can follow the administration of: A. Tetracycline . lindamycin B. Amikacin !. arbenicillin "P#$ &.+ %% 1&th ed 1))61))/ 5(.A beta6lactamase inhibitor: A. efotaime B. Amoicillin
. @ulbactam !. Ticarcillin "P#$ &.+ %% 1&th 'd pp 1)1-
5-.A drug of choice in ?ickettsial infections: A. hloramphenicol . @ulfonamide B. Tetracycline !. Polymyin B "P#$ 1 %% 1&th 'd 1)-& 5+.An antimicrobial agent which inhibits bacterial cell wall synthesis: A.
5=.Antimicrobial agent with greatest @2 penetration: A. hloramphenicol . Tetracycline B. Penicillin !. 'rythromycin "P#$ 1 %% 1&th 'd 1)- &.The most absorbable of all the oral erythromycin salt is: A. #actobromate . 'stolate B. @uccinate !. @tearate "P#$ &. + %% 1&th 'd pp 1)+) 1. This drug, with less side effects, is effective against ascaris and hookworms A. "ebenda4ole . Pyrantel pamoate B. Pipera4ine !.
. ephalosporin !. arbenicillin "P#$&.+ %% 1&th 'd1)1-
.0hich of the chemical structure of Beta6lactams is the site of action of Penicillinase9 A. Beta6lactam ring . ?6side chain B. Thia4olidine ring !. !ihydrothia4ine ring "P#$ 1 %% 11=& /.The Penicillin with the longest half life D)-6)/ days E is: A. Phenoymethylpenicillin . Ben4athine penicillin B. Procaine penicillin !. Ben4yl penicillin "P#$ &.+ %% 11= =. Antibiotic that is <T recommended for use in children or during pregnancy because of its potential to cause arthropathy: A. @ulfonamides . Aminoglycosides B. "acrolides !. Fuinolones "P#$ 1 %% 1&th 'd pp11/) /&."ost nephrotoic of the aminoglycosides: A. @treptomycin . %entamicin B.
/+.@erotonin antagonist not derived from a fungus that is useful for the treatment of migraine headache is: A.@umapitran . Bromocriptine B.'rgotamine !. 3etanserin "P#$ &.)+ %% 1&th 'd pp )/ /5.larithromycin and erythromycin have very similar spectrum of antimicrobial activity. The maor advantage of larithromycin is that: A. 'radicate mycoplasmal infection in a single dose B. Active against strains of streptococci that are resistant to erythromycin . "ore active against "ycobacterium avium comple !. Acts on methicillin resistant staphylococci "P#$ &.)+ %% 1&th ave.pp 1)+& /.The primary mechanism underlying the resistance of gram positive organism to macrolide antibiotics is: A. "ethylation of binding site on the +&@ ribosomal subunits B. 2ormation of esterases that hydroly4ed the lactone ring . 2ormation of drug6 inactivating acetyltransferase !. !ecrease drug permeability of the cytoplasmic membrane "P#$ &.)+ %% 1&T8 '! PP1)+& //.0eeping lesion is best treated with: A, 0et dressing B. %els
. intment !. Aerosol "P#$ 1 %% 1&T8 'd pp1=5
/=.8ost factors affecting the use of antimicrobial agents isJare: A. Age of patient . %enetic factor B. @ite of infection !. All of the above "P#$ 1 %% 11-=&.The mechanism of action of micona4ole is best described as: A. Binding to /& @ ribosomes B. *nhibition of sterol synthesis . Blockade of tetrahydrofolate reductase !. !
=).Antiarrhythmic drug that predominantly block the slow calcium channels :
A. 7erapamil B. Amiodarone
. #idocaine !. "etoprolol "P#$&)+ %% 1&th 'd pp =-/
=(.Antiarrythmic drug that predominantly block potassium channels and prolongs repolari4ation: A. lass * . lass ** B. lass *** !. lass *7 "P#$ &.)+ %% 1&th 'd pp =-= =-.?ecommended drug therapy for angina in patients with hyperthyroidism: A. !ihydroperidine alcium hannel blockers B. Beta6Adrinergic ?eceptor Blocker .
. Pork !. 8orse "P#$ 1 %% 1&th 'd pp 15=)
=.Preparation of choice for replacement and suppression therapy of the thyroid hormone A. levothyroine . liothyronine B. triiodothyronine !. tyrosine "P#$&.+ %% 1&th 'd pp 1+ =/.Anemia with neurologic abnormalities occur most often in deficiencies of: A. vitamin B1) . iron B. folic acid !. biotin "P#$ 1 %% 1&th 'd pp 1+&
==.0hich of the following has the highest elemental iron9
A. 2errous gluconate B. 8ydrated ferrous sulfate
. 2errous fumarate !. !esiccated ferrous sulfate "P#$ &.)+ %% 1&th 'd pp 1-=5
1&&. A direct acting cholinomimetic that is lipid soluble and often used in the treatment of glaucoma9 A. Acetycholine . Pilocarpine B. Bethanecol !. Physostigmine "P#$ 1 %% 1&th 'd pp151
