Pathophysiology Laryngeal Cancer

Environmental damaging agent: Smoker and Alcoholic Drinker (nicotine and alcohol)

Normal cell

Alcohol suppresses DNA

DNA damage

Environmental Environmental damaging agent: Wood dust, paint fumes ccupation: !arpenter" E#posure to $ood dust, paint fumes

Failure of DNA repair utations in the genome of lar&ngeal

Activation Activation of gro$th" promoting oncogenes

Failure of genes to regulate apoptosis

+nactivation +nactivation of  cancer

E#pression of altered gene products and loss of regulator& regulator&

!lonal e#pansion

Additional mutations (progression)

'eterogeneit&

%ar&ngectom&

alignant neoplasm +ncreased metaolic needs

!hemotherap& Formation of mass at su ra lottic ar area

struction at the lar n# -. !

+nammation of the lar n# /nale to meet caloric re0uirements *ecurrent

lar&ngitis

1ainless palpale cervical l&mph

-A Accumulation of !hemotherap& 'oarseness of  Doceta#el, 2"uorouracil, inammator& cells in voice !aroplatin (si# c&cles) near& l&mph nodes

D&sphagia ." 1artial ostruction of  air in th the u er ai air$a

Decreased

&elosuppression Decreased o#&gen Dec3

Dec3 hemo loin Decreased perfusion " pale mucous memranes, pale nail eds

stomatitis Anemia

+nsertion of

pallor

+ne5ective 1eri heral 6issue

alasorp +nc3 *DW, tion of vit3 normal .78

*isk for +malanced Nutrition: %ess than ! - tracheostoma Air inhaled not humidi9ed

+ncreased insensile

*isk for De9cient uid volume

Dr& mucosal memranes of trachea