Newer Drugs for USMLE step 2 CK:-

$ Newer Drugs :1. Anegrelide - PDE-3 inhibitor and also prevents prevents maturation of platelets. used for thrombocythemia in polycythemia and essential thrombocytosis. 2. Azacitadine - myelodysplastic myelodysplas tic syndrome, decreases transfusion dependence 3. Belimumab- newer drug that inhibits B cells, used to stop progression of SLE 4. bortezomib - best initial therapy for multiple myeloma. given along with dexamethasone and lenolidomide 5. Cevemiline - icrease ACH used to stimulate saliva production in sjogren 6. Conivaptan - ADH antagonist. 7. DenosumabDenosumab- RANK-L inhibitor that inhibits inhibits Osteoclast activity , that is used in rx of Osteoporosis 8. deferasirox , deferiprone - oral iron iron chelators , deferoxamine - iv iron chelator ; used in thalessemia , when iron overload occurs due to transfusion. 9. Eculizumab - c5 compliment inhibitor , used in PNH to prevent prevent lysis of cells thro complement overactivation. 10. Eflornithine - first line topical drug to remove unwanted facial hair, used in idiopathic hirsutism.

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Eltrombopag - synthetic thrombopoietin used in ITP refractory to steroids and splenectomy FIdaxomicin - alternate drug to oral vancomycin to treat pseudomembrane colitis. Glatiramer- immunomodulator used to prevent relapse and progression of Multiple sclerosis Ivacaftor- used in CF with 6551 D mutation Lenalidomide, Thalidoamide - TNF inhibitors which somehow increase bone marrow production ; a. used in good prognostic prognostic 5q deletion of myelodysplasia myelodysplas ia to decrease transfusion dependence. b. myelofibrosis c. in multiple myeloma along with dexamethasone w or wout bortezomib 16. Lubiprostone - Cl- channel activator that increases bowel movement frequency; used for constipation in irritable bowel syndrome. 17. Lucinactant - synthethic surfactant used for Rx of respiratory distress syndrome in new born. 18. Melphalan - nitrogen mustard alkylating agent, used in multiple myeloma in >70Y old fragile pts, who cannot tolerate adverse e!ects of other treatments. deals with amyloid protein. 19. Methysergide - formerly used ofr headaches , no longer used because it causes retroperitoneal fibrosis. 20. MidodrineMidodrine- alpha 1 agonist, causes vasoconstriction and is used to treat orthostatic orthostatic hypotension and HEPATORENAL HEPATORENAL SYNDROME. 21. Milnacipran - SSRI USED IN fibromyalgia fibromyalgia 22. Mycophenolate Mycophenolat e - immunosuppresant used along with steroids in SLE with nephritis 23. Nebivolol - B1 + B3 agonist. B3 causes vasodilation by produing NO in vasculature 24. Oprelevkin - IL-11 analog , causes maturation of megakaryocytes megakaryocy tes 25. Pentostatin Pentostat in - is a adenosine deaminase inhibitor , used in hairy cell leukemia , steroid refractory graft vs host disease, relapsed CLL 26. Pegvisomant - GH receptor antagonist, inhibits IGF release from liver. liver. one of the drugs used in Rx of Acromegaly. 27. Ranolazine - decreases Ca2+ in heart and decreases contractility; shifts ATP ATP production from fatty acids to O2 e"cient carbohydrates…. used in refractory angina 28. Rifaximin - blocks transcription of bacterial RNA polymerase and somehow treats HEPA HEPATIC ENCEPHALOPATHY and travellers diarrhea. 29. Romiplostim - synthetic thrombopoeitin used in ITP refractory to steroids and splenectomy. 30. Senokot- natural vegetable vegetable laxative. laxative. 31. Spiramycin - a macrolide antibiotic ie erythromycin class, used to prevent vertical transmission of toxoplasmosis 32. Tizanadine - CENTRALLY acting alpha agonist which is used to treat spasticity 33. tolvaptan - ADH antagonist 34. Trientine- copper chelating agent, can be used in wilson disease. 35.