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Ciprofloxacin and calcium carbonate should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of ciprofloxacin and reduce its effectiveness. If possible, it may be best to avoid taking calcium carbonate while your are being treated with ciprofloxacin. Otherwise, you should take ciprofloxacin either 2 to 4 hours before or 4 to 6 hours after the calcium carbonate dose.