Microreactor
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Microreactor A microreactor or microstructured reactor or microchannel reactor is a device in which chemical reactions take place in a confinement with typical lateral dimensions below 1 mm; the most typical form of such confinement are microchannels.
[1]
Microreactors
are studied in the field of micro process engineering, together with other devices (such as micro heat exchangers) in which physical processes occur. The microreactor is usually a continuous flow reactor (contrast with/to a batch reactor). Microreactors offer many advantages over conventional scale reactors, including vast improvements in energy efficiency, reaction speed and yield, safety, reliability, scalability, on-site/on-demand production, and a much finer degree of
Microreactor technologies developed at LLNL use micromachining techniques to miniaturize the reactor design. Applications include fuel processors for generating hydrogen, chemical
process control.
synthesis, and bioreaction studies.
History Gas-phase microreactors have a long history but those involving liquids started to appear in the late 1990s.
[1]
One of
the first microreactors with embedded high performance heat exchangers were made in the early 1990s by the []
Central Experimentation Department ( Hauptabteilung Versuchstechnik , HVT) of Forschungszentrum Karlsruhe in Germany, using mechanical micromachining techniques that were a spinoff from the manufacture of separation nozzles for uranium enrichment.
[]
As research on nuclear technology was drastically reduced in Germany,
microstructured heat exchangers were investigated for their application in handling highly exothermic and dangerous chemical reactions. This new concept, known by names as microreaction technology or micro process engineering, was further developed by various research institutions. An early example from 1997 involved that of azo couplings in a pyrex reactor with channel dimensions 90 micrometres deep and 190 micrometres wide.
[1]
Benefits Using microreactors is somewhat different from using a glass vessel. These reactors may be a valuable tool in the hands of an experienced chemist or reaction engineer: • Microreacto Microreactors rs typically typically have heat exchang exchangee coefficients coefficients of at least least 1 megawatt per cubic cubic meter per kelvin, kelvin, up to 500 MW m
−3
−1
K
vs. a few kilowatts in conventional glassware glassware (1 l flask ~10 kW m
−3
−1
K )). Thus,
microreactors can remove heat much more efficiently than vessels and even critical reactions such as nitrations can be performed safely at high temperatures.
[2]
Hot spot temperatures as well as the duration of high temperature
exposition due to exothermicity decreases remarkably. Thus, microreactors may allow better kinetic investigations, because local temperature gradients affecting reaction rates are much smaller than in any batch vessel. Heating and cooling a microreactor is also much quicker and operating temperatures can be as low as −100 °C. As a result of the superior heat transfer, reaction temperatures may be much higher than in conventional
batch-reactors. Many low temperature reactions as organo-metal chemistry can be performed in microreactors at temperatures of −10 °C rather than −50 °C to −78 °C as in laboratory glassware equipment. • Microreacto Microreactors rs are normally normally operated continuou continuously. sly. This allows allows the subsequent subsequent processing processing of unstable unstable intermediates and avoids typical batch workup delays. Especially low temperature chemistry with reaction times in the millisecond to second range are no longer stored for hours until dosing of reagents is finished and the next reaction step may be performed. This rapid work up avoids decay of precious intermediates and often allows better selectivities.
[3]
Microreactor
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• Continuous operation and mixing causes a very different concentration profile when compared with a batch process. In a batch, reagent A is filled in and reagent B is slowly added. Thus, B encounters initially a high excess of A. In a microreactor, A and B are mixed nearly instantly and B won't be exposed to a large excess of A. This may be an advantage or disadvantage depending on the reaction mechanism - it is important to be aware of such different concentration profiles. • Although a bench-top microreactor can synthesize chemicals only in small quantities, scale-up to industrial volumes is simply a process of multiplying the number of microchannels. In contrast, batch processes too often perform well on R&D bench-top level but fail at batch pilot plant level.
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• Pressurisation of materials within microreactors (and associated components) is generally easier than with traditional batch reactors. This allows reactions to be increased in rate by raising the temperature beyond the boiling point of the solvent. This, although typical Arrhenius behaviour, is more easily facilitated in microreactors and should be considered a key advantage. Pressurisation may also allow dissolution of reactant gasses within the flow stream.
Problems • Although there have been reactors made for handling particles, microreactors generally do not tolerate particulates well, often clogging. Clogging has been identified by a number of researchers as the biggest hurdle for microreactors being widely accepted as a beneficial alternative to batch reactors. So far, the so-called [5]
microjetreactor
is free of clogging by precipitating products. Gas evolved may also shorten the residence time
of reagents as volume is not constant during the reaction. This may be prevented by application of pressure. • Mechanical pumping may generate a pulsating flow which can be disadvantageous. Much work has been devoted to development of pumps with low pulsation. A continuous flow solution is electroosmotic flow (EOF). • Typically, reactions performing very well in a microreactor encounter many problems in vessels, especially when scaling up. Often, the high area to volume ratio and the uniform residence time cannot easily be scaled. • Corrosion imposes a bigger issue in microreactors because area to volume ratio is high. Degradation of few µm may go unnoticed in conventional vessels. As typical inner dimensions of channels are in the same order of magnitude, characteristics may be altered significantly.
T reactors One of the simplest forms of a microreactor i s a 'T' reactor. A 'T' shape is etched into a plate with a depth that may be 40 micrometres and a width of 100 micrometres: the etched path is turned into a tube by sealing a flat plate over the top of the etched groove. The cover plate has three holes that align to the top-left, top-right, and bottom of the 'T' so that fluids can be added and removed. A solution of reagent 'A' is pumped into the top left of the 'T' and solution 'B' is pumped into the top right of the 'T'. If the pumping rate is the same, the components meet at the top of the vertical part of the 'T' and begin to mix and react as they go down the trunk of the 'T'. A solution of product is removed at the base of the 'T'.
Microreactor
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Applications Synthesis Microreactors can be used to synthesise material more effectively than current batch techniques allow. The benefits here are primarily enabled by the mass transfer, thermodynamics, and high surface area to volume ratio environment as well as engineering advantages in handling unstable intermediates. Microreactors are applied in combination with photochemistry,
electrosynthesis,
multicomponent
reactions
and
polymerization (for example that of butyl acrylate). It can involve liquid-liquid systems but also solid-liquid systems with for example the channel walls coated with a heterogeneous catalyst. Synthesis is also combined with online purification of the product.
[1]
Following Green
Chemistry principles, microreactors can be used to synthesize and purify extremely reactive Organometallic Compounds for ALD and CVD applications, with improved safety in operations and higher [6][7]
purity products.
In one microreactor study a Knoevenagel condensation
[8]
was
performed with the channel coated with a zeolite catalyst layer which also serves to remove water generated in the reaction:
Glass Microreactors involve microfabricated structures to allow flow chemistry to be performed at a microscale. Applications include Compound Library Generation, Process Development and Compound Synthesis
A Suzuki reaction was examined in another study
[9]
with a palladium catalyst confined in a polymer network of
polyacrylamide and a triarylphosphine formed by interfacial polymerization:
The combustion of propane was demonstrated to occur at temperatures as low as 300°C in a microchannel setup filled up with an aluminum oxide lattice coated with a platinum / molybdenum catalyst:
[10]
Microreactor
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Analysis Microreactors can also enable experiments to be performed at a far lower scale and far higher experimental rates than currently possible in batch production, while not collecting the physical experimental output. The benefits here are primarily derived from the low operating scale, and the integration of the required sensor technologies to allow high quality understanding of an experiment. The integration of the required synthesis, purification and analytical capabilities is impractical when operating outside of a microfluidic context. NMR Researchers at the Radboud University Nijmegen and Twente University, the Netherlands, have developed a microfluidic high-resolution NMR flow probe. They have shown a model reaction being followed in real-time. The combination of the uncompromised (sub-Hz) resolution and a low sample volume can prove to be a valuable tool for [11]
flow chemistry.
Infrared Spectroscopy Mettler Toledo and Bruker Optics offer dedicated equipment for monitoring with attenuated total reflectance spectrometry (ATR spectrometry) in microreaction setups. The former has been demonstrated for reaction [12]
monitoring.
The latter has been successfully used for reaction monitoring
[14]
characteristics
[13]
and determing dispersion
of a microreactor.
Academic research Microreactors, and more generally, micro process engineering, are the subject of worldwide academic research. A prominent recurring conference is IMRET, the International Conference on Microreaction Technology. Microreactors and micro process engineering have also been featured in dedicated sessions of other conferences, such as the Annual Meeting of the American Institute of Chemical Engineers (AIChE), or the International Symposia on Chemical Reaction Engineering (ISCRE). Research is now also conducted at various academic institutions around the world, e.g. at the Massachusetts Institute of Technology (MIT) in Cambridge/MA, University of Illinois Urbana-Champaign, Oregon State University in Corvallis/OR, at University of California, Berkeley in Berkeley/CA in the United States, at the EPFL in Lausanne, Switzerland, at Eindhoven University of Technology in Eindhoven, at Radboud University Nijmegen in Nijmegen, Netherlands and at the LIPHT [15] of Université de Strasbourg in Strasbourg and [16] of the University of Lyon, CPE Lyon, France.
Microreactor
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Market structure Depending on the application focus, there are various hardware suppliers and commercial development entities to service the evolving market. One view to technically segment market, offering and market clearing stems from the scientific and technological objective of market agents: a. Ready to Run (turnkey) systems are being used where the application environment stands to benefit from new chemical synthesis schemes, enhanced investigational throughput of up to approximately 10 - 100 experiments per day (depends on reaction time) and reaction subsystem, and actual synthesis conduct at scales
Glass Microreactor. The channels of the chip in the picture are 150 µm wide and 150 µm deep.
ranging from 10 milligrams per experiment to triple digit tons per year (continuous operation of a reactor battery). b. Modular (open) systems are serving the niche for investigations on continuous process engineering lay-outs, where a measurable process advantage over the use of standardized equipment is anticipated by chemical engineers. Multiple process lay-outs can be r apidly assembled and chemical process results obtained on a scale ranging from several grams per experiment up to approximately 100 kg at a moderate number of experiments per day (3-15). A secondary transfer of engineering findings in the context of a plant engineering exercise (scale-out) then provides target capacity of typically single product dedicated plants. This mimics the success of engineering contractors for the petro-chemical process industry. c. Dedicated developments. Manufacturer of microstructured components are mostly commercial development partners to scientists in search of novel synthesis technologies. Such development partners typically excel in the set-up of comprehensive investigation and supply schemes, to model a desired contacting pattern or spatial arrangement of matter. To do so they predominantly offer information from proprietary integrated modeling systems that combine computational fluid dynamics with thermokinetic modelling. Moreover, as a rule, such development partners establish the overall application analytics to the point where the critical initial hypothesis can be validated and further confined.
References [1] Recent advances in synthetic micro reaction technology Paul Watts and Charlotte Wiles Chem. Commun., 2007, 443 - 467, [2] D.Roberge, L.Ducry, N.Bieler, P.Cretton, B.Zimmermann, Chem. Eng. Tech. 28 (2005) No. 3, online available (http:/ / www.lonza.com/ group/ en/ company/ news/ publications_of_lonza.-ParSys-0002-ParSysdownloadlist-0001-DownloadFile.pdf/ 1_050510_Microreactor Technology A Revolution for the Fine Chemical and Pharmaceutical Industries.pdf) [3] T.Schwalbe, V.Autze, G.Wille: Chimica 2002, 56, p.636, see also Microflow Synthesis (http:/ / www.mrsp.net/ MRSP_Chimica_Oggi.pdf)
Example of a flow reactor system.
[4] T.Schwalbe, V.Autze, M. Hohmann, W. Stirner: Org.Proc.Res.Dev 8 (2004) p. 440ff, see also Continuous process research and implementation from laboratory to manufacture (http:/ / www.mrsp.net/ MRSP_lo-res.pdf) [5] and literature cited therein [6] Method of Preparing Organometallic Compounds Using Microchannel Devices, 2009, Francis Joseph Lipiecki, Stephen G. Maroldo, Deodatta Vinayak Shenai-Khatkhate, and Robert A. Ware, US 20090023940 (http:/ / www.freepatentsonline.com/ y2009/ 0023940.html) [7] Purification Process Using Microchannel Devices, 2009, Francis Joseph Lipiecki, Stephen G. Maroldo, Deodatta Vinayak Shenai-Khatkhate, and Robert A. Ware, US 20090020010 (http:/ / www.freepatentsonline.com/ y2009/ 0020010.html) [8] Knoevenagel condensation reaction in a membrane microreactor Sau Man Lai, Rosa Martin-Aranda and King Lun Yeung Chem. Commun., 2003, 218 - 219,
Microreactor
[9] Instantaneous Carbon-Carbon Bond Formation Using a Microchan nel Reactor with a Catalytic Membrane Yasuhiro Uozumi, Yoichi M. A. Yamada, Tomohiko Beppu, Naoshi Fukuyama, Masaharu Ueno, and Takehiko Kitamori J. Am. Chem. Soc.; 2006; 128(50) pp 15994 - 15995; (Communication) [10] Low temperature catalytic combustion of propane over Pt-based catalyst with inverse opal microstructure in a microchannel reactor Guoqing Guan, Ralf Zapf, Gunther Kolb, Yong Men, Volker Hessel, Holger Loewe, Jianhui Ye and Rudolf Zentel Chem. Commun., 2007, 260 - 262, [11] A Microfluidic High-Resolution NMR Flow Probe Jacob Bart†, Ard J. Kolkman, Anna Jo Oosthoek-de Vries, Kaspar Koch, Pieter J. Nieuwland, Hans (J. W. G.) Janssen, Jan (P. J. M.) van Bentum, Kirsten A. M. Ampt, Floris P. J. T. Rutjes, Sybren S. Wijmenga, Han (J. G. E.) Gardeniers and Arno P. M. KentgensJ. Am. Chem. Soc.; 2009; 131(14) pp 5014 - 5015; [15] http:/ / www-lipht.u-strasbg.fr/ Interface/ index.php [16] http:/ / www.lgpc.fr/ Objets|LGPC
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Article Sources and Contributors
Article Sources and Contributors Microreactor Source: http://en.wikipedia.org/w/index.php?oldid=547482866 Contributors: A Doon, Anna6, Calvero JP, Cubic Hour, Daniele Pugliesi, Dekisugi, Deli nk, Demericdebellefon, Dougher, DrTorstenHenning, Editore99, Flowsynthesis, Gaius Cornelius, Gene Nygaard, Gilligan mark, Goonybananas, Gurch, IX2007, Jim Douglas, Joolshoops, Junkers42, Kasparkoch, Khalid hassani, LGreiner, LilHelpa, M stone, Mark Arsten, Microreacteur, Mikeblas, Mindmatrix, MissMarpel, NHSavage, Patricksears, Penth, Peripitus, RSStockdale, Rifleman 82, Rjwilmsi, SimonP, Siroxo, Sixsnowflakes, Squids and Chips, Strongbow501, Twisp, V8rik, Wsv131, 113 anonymous edits
Image Sources, Licenses and Contributors Image:LLNL-microreactor.jpg Source: http://en.wikipedia.org/w/index.php?title=File:LLNL-microreactor.jpg License: Public Domain Contributors: Lawrence Livermore National Laboratory (LLNL). Image:Syrris Chip.jpg Source: http://en.wikipedia.org/w/index.php?title=File:Syrris_Chip.jpg License: Public Domain Contributors: Gilligan_mark (talk) (Uploads) Image:Knoevenagelmicroreactor.png Source: http://en.wikipedia.org/w/index.php?title=File:Knoevenagelmicroreactor.png License: Creative Commons Attribution-ShareAlike 3.0 Unported Contributors: Original uploader was V8rik at en.wikipedia Image:Suzukimicroreactorreaction.png Source: http://en.wikipedia.org/w/index.php?title=File:Suzukimicroreactorreaction.png License: GNU Free Documentation License Contributors: User:Ronhjones Image:PropaneCombustionInmicrochannelreactor.png Source: http://en.wikipedia.org/w/index.php?title=File:PropaneCombustionInmicrochannelreactor.png License: GNU Free Documentation License Contributors: Image:Glass-microreactor-chip-micronit.jpg Source: http://en.wikipedia.org/w/index.php?title=File:Glass-microreactor-chip-micronit.jpg License: Public Domain Contributors: Micronit File:FlowStart CloseUp.jpg Source: http://en.wikipedia.org/w/index.php?title=File:FlowStart_CloseUp.jpg License: Creative Commons Attribution-Sharealike 3.0 Contributors: Kasparkoch
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