ple of days and had a few fun reagents lying around, so I though I'd try and make some 1-(4-methylphenyl)--methyla 1-(4-methylphenyl)--methyla uppose it would be commonly called! "ompleted within 4# hours, starting from toluene! $ach step is a first attempt only, again! %he first two steps work very nicely, but the yield killer is the final step, giving &4! owever, this still correspo overall+
ophenone
1
as added over * minutes to a solution of /*g (mmol) anhydrous aluminium chloride and 4.m (mmol, 40g) pro ernal ice bath! %he solution was allowed to stir for a further 1! hours at o", and was then carefully added to m st ted off, and the a2ueous layer etracted with m dichloroethane! %he combined etracts were washed with 1m te! %he solvent was removed, and the ketone vacuum distilled at 1*-1. o", to give 1-(4-methylphenyl)-propan-1-one 1-(4-methylphenyl)-propan-1-one
3a instead of 1m! simply because it is easier to remove under vacuum!
bromo-4’-methylpropiophenone
1,2
l, */g) 4-methylpropiphenone in 1m glacial acetic acid was added 1m 4# 8r followed by, over the course of an h miture, which changed to a nice pink colour during addition, was stirred for a further 1! hours, then slowly poured int on! %he cream-coloured precipitated product was taken up in m dichloroethane, and the a2ueous layer etracted wit with m cold water, then dried over magnesium sulfate! %he solvent was removed under vacuum, taking care to k romo-(49-methylphenyl)-propan-1-on romo-(49-methylphenyl)-propan-1-one, e, which solidified almost immediately on cooling, into sparkling way crystals!
mperature below * o" when removing the solvent : coloured crystals indicate some decomposition (above were a very l ent since it could be stripped off at a lower temperature, causing less decomposition!
none to 1-(4-methylphenyl)-2-methylaminopropanone hydrochloride
3
water water henone water
mmol) -bromo-49-methylpropiophenone in m toluene held at o" was added, over minutes, .!g methylamine i mol) sodium hydroide in m cold water to a cooled solution of 1*!g methylamine "l in 1m water)! %he miture oured into 1m ice-cold water! %he toluene layer was separated off, and the remaining freebase etracted with m ith *m water, and then acidified with 1m dilute "l! %he combined acidic etracts then washed twice with m off-white solid to form! m acetone was added and was heated to boiling, forming a homogenous solution, which was als were filtered and rinsed with around 1m ice cold acetone!
ours at o", which will inhibit pyra;ine formation! It may also lower the yield, but I'll see net time I try! It's doubtful (I p, because of the side reactions which can and do occur! n, but after concentration and re-filtering and washing of the 1m acetone washes, which provided a further 1g of pr maining pyra;ine, and can be done from acetone>methanol!
synthesis of a @yrovalerone analogue, 4-7@@, @yrovalerone with a heane chain instead of pentane! %hanks to our end ! is 2uite a powerful lachrymator, even when solid! %ake care with washing your glassware after the synthesis, and pleas thing with cold water first! (foxy2: "Methcathinone and ephedrine from propiophenone", Stimulants), although I never managed the /-/4 yields
be reduced in good yield to 4-methylephedrine, and then very easily made into (4-methyl)-methamphetamine! If you w e adding the methylamine! %his way, the methylamino group can be added under much more vigorous conditions, resulti round ., but I'm sure it could be increased!
o! I was a bit scared about what snorting mg might do, but since I've been almost constantly abusing the (badly synt ethcathinone with a butyl chain instead of the usual propyl), mg didn't do too much! I thought I'd wasted my time un it hit me! Intense rushes all over, lasting for well over * minutes! ?ince I have 2uite a high cathinone tolerance at the an hour or so after that! $ach time I could feel the rushes of energy coming across me, and after that, a fantastic sense my beloved ecstasy!
since I only completed the synthesis . hours ago, and began the bioassay an hour later ! It's a fun drug, and although l h), it's easy to make, and best of all, legalB opefully someone will find this of use, or at least of interest!!!
