6.0 EXTRUSION AND SPHERONIZING USING NICA SYSTEM 6.1 MIXING 6.1.1 Judging the Wet Mass 6.2 EXTRUSION in the NICA E140 6.2.1 Set-Up 6.2.2 Testing the Wet Mass 6.2.3 Reducing Extruder Load 6.2.4 Judging the Quality 6.2.5 6.2.6
“
Sharkskin
Screen
”
or
l
“
of Extrus ons
i
Sawtooth
”
Extrusions
i
se ect on
6.2.7 Optimization
of Extrus on
i
6.3 SPHERONIZATION 6.3.1 Principles Af f f ecting Pellet Quality 6.3.2 Operating the Spheronizer 6.3.3 The Mechanism
of Pe
llet
Formulation
6.4 OPTIMIZATION 6.4.1 Repeat Processing
7.0 INTEGRATED PRODUCTION PLANTS
TechPapers/NICA/09.02.2001-GB
Extrusion
d Spheronization
an
of
pharmaceuticals
us
™
ing NICA
System
-
Page 3
1.0 Introduction
The
production
of
pellets by Extrusion
d Spheronization involves
an
three essential
processes:
- Mixing of the dry powder components with a liquid to f orm a homogeneous and even
ly wetted
mass
- Extrusion of the wet mass into cylindrical
“
paghetti like
s
”
stran
ds and f inally
- Spheronization which f ragments the strands into short cylindrical lengths and roll-f orms them into spheres. Equipment f or an
d
a
ll
Extruders, in
three
processes are
number
a
quipment types available
e
of
ilable f rom
ava
dif f erent f orms.
This guide
the case of Mixers
manuf acturers an
d, in
l
severa
ill f irst describe and categorise the basic
w
an
d then give practical guidance
on the use of Aeromat c
i -Fielder
NICA System.
2.0 Mixers There
are three
etary,
High Shear
cho ce
i
general types
of m xer ty
i
d Continuous.
an
is non-critical
on sma
ll
or
All
of
pically used in pharmaceutical production
produce suitable wet
laboratory scale.
In
a
mass
production
lity of handling and f eeding materials f avour the High
