FORMULASI “TABLET “TABLET EFERVESEN KOMBINASI VIT VI TAMIN A, C DAN E”
OLEH : KELAS
:A
KELOMPOK
: VI
ASISTEN
: RAHMAT MULYADI
NO
NAMA
NIM
1
MUH. RIDWAN ESI
O1A1 14 027
2
ISMAR WULAN
O1A1 14 017
3
NABILA SARASWATI HENDRA
O1A1 14 029
4
PUTRI CHANDRA SARI
O1A1 14 038
JURUSAN FARMASI FAKULTAS FARMASI UNIVERSITAS UNIVERSITAS HALU OLEO KENDARI 2016
TT
FORMULASI “TABLET EFERVESEN KOMBINASI VITAMIN A, C DAN E”
A. FORMULA ASLI
R/ Vit!i" A# C $" E
B. RANCANAN FORMULA
Ti% 1#& ' T()*t E++*,-**"t !*"'"$"' Vit!i" A 2& !' Vit!i" C
40 !'
Vit!i" E PVP
3
PE 8000 A! it,t
7#3&
A! t,t,t
14#7
)i! (i5,(6"t
2&
L5t6
A$ 100
C. MASTER FORMULA
1. N! P,6$5
E++*,*
2. !) P,6$5
3. T"'') :6,!)i 1& M,*t 2014 4. T"'') P,6$5i
1; M,*t 201;
&. N6.,*'it,i
DTL 1;80012311A1
;. N6.(t
D 1713101
U"t5 1#& ' T(*)t *+*,-**" -it!i" A# C $" E# !*"'"$"' N6. 1
N! B" Vit!i" A
:"'i <t 5ti+
P*, $6i
P*, (t
2 3 4
Vit!i" C Vit!i" E PVP
& ; 7 8 9
PE 8000 A! Sit,t A! T,t,t )i! (i5,(6"t L5t6
<t A5ti+ <t A5ti+ P*"'i5t L(,i5" S!(*, A! S!(*, A! S!(*, B P*"'ii
D. PATOFISIOLOI PENYAKIT
Vit!i" $) t =t *">? 56!%)*5 >"' "'t $i(t5" 6)* t( 5it >"' (*,+"'i "t5 !*!("t %*"'t," t %,6* 5*'it" t(. T"% -it!i" !"i# *?" $" !5)5 i$% )i""> ti$5 5" $%t !*)55" 5ti+it i$% $" 5*5,"'" -it!i" $%t !*">*((5" !*!%*,(*, %*)"' t*,5*" %*">5it %$ t( 5it. D*"'" $"> it*! %5, !5 5" $%t !*"'")i '*@)'*@) 5*5,"'" -it!i" %$ t( !"i *i"'' *'*, t*,t"'"i $*"'" *+*5ti+ $" *+ii*" <i"# 2012. Vit!i" A !*,%5" -it!i" >"' ),t $)! )*!5# $" !*,%5" -it!i" >"' **"i) "t5 %*!*)i," 5**t" $" 5*)"'"'" i$%. Vit!i" A $) t =t 'i=i >"' "'t %*"ti"' ('i !"i# 5,*" =t 'i=i i"i ti$5 $i(t 6)* t(# @$i , $i%*"i $,i ), t( (*,% !5"" >"' $i56"!i. Vit!i" C (*,'" "t5 !*"*' ,i?"# !*!*)i, 5**t" 'i'i $" 'i# *,t !*)i"$"'i $,i %*">5it )i" >"' $i*((5" 6)* 5*5,"'" -it!i" C H"$,i" $55# 2013. A"ti65i$" $i )*" $) -it!i" C# 6)* 5,*" (*,i+t ),t $)! i, !5 -it!i" i"i t*,$%t $)! 5$, 5% ti"''i $i !6, 6. B*(*,% %*"*)iti" !*""@55" -it!i" C !!% (*,5i )"'"' $*"'" %*,65i$# "i6"# i$,6'*" %*,65i$# i$,6'*" ,$i5) $" ,$i5) (*( )i">. Di !%i"' it -it!i" C $%t !*"i"'5t5" $" !*!%*,t"5" ')tti6" $" -it!i" E $)! tt t*,*$5i ', $%t (*5*,@ !*)i"$"'i )*" $,i ,$i5) (*( W>$i $" Ri">ti# 2012.
Vit!i" E α-tokoferol !*,%5" "ti65i$" >"' ),t $)! )*!5 >"' $%t !*"'*"ti5" )i%i$ %*,65i$ !*!(," %)! *)! %,6* %*"$i"'i"". Vit!i" E !*!%">i 5*!!%" !*!t ,"ti ,*5i %*,65i$i t !*""'5% ,$i5) (*( $*"'" , (*,*5i *, )"'"' $*"'" (*,('i ,$i5) %*,65i 6,'"i5 *i"'' !*"*' t*,@$i"> ,*5i (*,"ti $" $%t !*"*5" t*,@$i"> 5*,5" %*,65i$ti+ B*( $55# 201;. E. ALASAN PEMILIHAN KADAR !AT AKTIF
Di'"5" 56"*"t,i ME-6># 2004. F.
ALASAN PEMILIHAN BENTUK SEDIAAN
B*"t5 *$i" >"' 5" $i(*,i5" $) T()*t *+*,-**". T()*t effervescent !*,%5" t()*t >"' $i'"5" "t5 !*!(t !i"!" ,i"'" *, %,5ti. *%,5ti""> $) t()*t $%t !*),t *"$i,i $*"'" $"> ' CO2 >"' !*!("t %,6* %*),t". B*"t5 *$i" *%*,ti i"i $%t !*"i"'5t5" ti"'5t 5*5" %,6$5 $" !*!%*"',i %*5 %i56)6'i 56"!*". Di!%i"' it# 5*""> *('i 6(t @' 5" (*,5,"' 5,*" ,"> >"' $%t !*"t%i , %it *i"'' $%t !*",i5 !i"t 56"!*" >"' ti$5 5 !*"'56"!i 6(t 6(t" 6)i$ $55# 2014.
. ALASAN PEMILIHAN !AT AKTIF <t 5ti+ >"' $i%i)i $)
H. ALASAN PEMILIHAN !AT TAMBAHAN 1. A! Sit,t $" A! T,t,t A! it,t $" ! t,tt !*,%5" (" %*"'! $)! +6,!)i *$i" i"i. D)! %*!(t" *$i" *++*,-**" i"i $i'"5" 56!(i"i 2 !! !# >it ! it,t $" ! t,t,t $,i%$ "> t @*"i ! @ 5,*" %*"''"" (" ! t"'') @ 5" !*"i!()5" 5*5," $)! %*!(*"t5" (i. A! it,t $i'"5" *('i (" t"'') 5" !*"'i)5" !%," >"' )*5t $" 5, !*"@$i *,(5. S*$"'5" %*"''"" ! t,t,t @# *,(5 >"' $ii)5" 5" !$ 5*i)"'"
5*5t""> $" 5" !*"''!%) S>!) $" S%6!6.# 2014. S*)i" it# 5 6!(i"i ! it,t $" ! t,t,t $) 56!(i"i >"' !! $i'"5" 5,*" $i"i)i )*(i *56"6!i $" !$ $i$%t $i("$i"'5" $*"'" !(*, ! $" *">? 5,(6"t )i"">. P*,("$i"'" ! it,t# ! t,t,t $" 5)i! (i5,(6"t >"' $i'"5" $) 123#4 D*?i $55.# 2014. 2. )i! Bi5,(6"t )i! (i5,(6"t !*,%5" (" ( $)! +6,!)i *$i" i"i.)i! (i5,(6"t *,i"' $i+6,!)i5" $*"'" ! it,t t ! t,t,t $)! *$i" *+*,-**". A%(i) 56"t5 $*"'" i,# CO2 $i)*% !*))i ,*5i 5i!i# $" (" t*,i"t*',i. *$i," 5)i! (i5,(6"t *"$i,i $%t 665 %$ +6,!)i i"i# 5,*" ,*5i ! )!("' $%t !*">*((5" *+*,-**"i $" $ii"t*',i %,6$5 R6?* $55.# 2009. )i! (i5,(6"t $i'"5" *('i %*!(*"t5 ,*5i ( $" (*,ti"$5 $)! !*"*t,)ii, ! it,t $" ! t,t,t *,t $%t !*"'i)5" (i $" !*!(*(5" 5,(6" $i65i$ *,t ),t *!%," $)! i, S>!) $" S%6!6.# 2014. Di!(i) 56"*"t,i 2& 5,*" 5*),t" 6(t *"$*,"' )*(i *%t $*"'" *!5i" ti"''i"> 56"*"t,i 5)i! (i5,(6"t A",# 2010. ". L5t6
L5t6 $) (" %*"'ii >"' $i'"5" $)! +6,!)i i"i. )5t6 @' $%t $i'"5" *('i (" %*"'i5t R6?* $55.# 2009. P*"''"" )5t6 *('i (" %*"'ii 5,*" (*,i+t i"*,t ti$5 (*,*5i !%i, %$ *! (" 6(t. L5t6 t(i) *, 5i!i# +ii5# $" !i5,6(i6)6'i. U!!"> +6,!) $*"'" )5t6 *('i (" %*"'ii !*""@55" )@ %*)*%" 6(t >"' (i5. S*)i" it# ,' )5t6 )*(i !, $,i%$ (">5 (" %*"'ii )i""> S>!) $" S%6!6.# 2014. #. PVP
P6)i-i"i)%i,6)i$6" PVP *('i (" %*"'i5t >"' *,i"' $i'"5" $)! %*!(t" t()*t effervescent . H) i"i $i*((5" 5,*" 5*),t" PVP >"' (i5# ',")i >"' !*"''"5" it*! PVP)566) $%t $i%,6* $*"'" (i5# *%t 5*,i"' *,t i+t 5*!% >"' "'t (i5. Nt,i! (*"=6t $i'"5" *('i )(,i5" >"' ),t $)! i, (*,+"'i !*"',"'i '**5" "t, $i"$i"' )("' 5*!% $" %i"''i, t()*t 5*ti5 t()*t $i5*),5" $,i
)("' 5*!%. S5,i" $i'"5" *('i %*!"i "t5 !*"t%i 5,5t*,iti5 , >"' 5,"' *"5 6)i$ $55# 2014.
I.
URAIAN OBAT
J.
URAIAN BAHAN
1. A! Sit,t Dit@*" POM# 1979 &0 $" R6?* $55.# 2009 H) 181183 N! (" Si"6"i! B*,t !6)*5) R! 5i!i P*!*,i"
Ai$! Cit,i! A! Sit,t 210#14 C;H8O7.H2O : (), ti$5 (*,?,"# t *,(5 %ti# ti$5
*),t"
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=t %*"'! $)! ?$ t*,tt% (i5
A! T,t,t Dit@*" POM# 1979 ;&4 $" R6?* $55.# 2009 731731 N! ,*!i
T,t,i! i$!
N! )i"
A! t,t,t
RM
C4H4O;
BM
1&0#09
P*!*,i"
H(), ti$5 (*,?," t *,(5 %ti ti$5
(*,( , "'t !. *),t"
S"'t !$ ),t $)! i, !$ ),t $)! *t"6) 9& P 5, ),t $)! *t*, P
I"56!%(i)it
ti$5 56!%ti(*) $*"'" %*,5 $" (*,*5i $*"'"
)6'! 5,(6"t $" (i5,(6"t P*">i!%""
D)! ?$ t*,tt% (i5 $i t*!%t *@5 $"
5*,i"' /P
<t %*"'!
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)i! i$,6'*" 5,(6"t
N! )i"
5)i! (i5,(6"t
R! !6)*5)
HCO3
B*,t !6)*5)
100#11
P*!*,i"
P,i! !6"65)i" ti$5 (*,?,"# t,"%," t
*,(5 (*,(ti, %ti *),t"
L,t $)! 3 ('i" i, "'t 5, ),t $)!
*t"6) 9& P I"56!%(i)it
(*,*5i $*"'" ! $" ',! ! $*"'"
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$)! ?$ t*,tt% (i5 $i t*!%t *@5 $"
5*,i"' *'"" <t %*!( 4. L5t6 Dit@*" POM# 1979 338 $" R6?* $55# 2009 3;&3;9 N! ,*!i Lt6! N! )i" L5t6 S,! )ti R! !6)*5) C12H22O11.H2O B*,t !6)*5) 3;0#30 P*!*,i" *,(5 (), %ti ti$5 (*,( , '5 !"i
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K. PERHITUNAN BAHAN
. P*,it"'" B" $" P*"i!("'" B"
Ti% 1000 !' !*"'"$"' N%,6F*" 2&0 !' 7,35
. 1000 mg
G 73#& !'
. 1000 mg
G 147 !'
( A! it,t
A! t,t,t
$ )i! (i5,(6"t
* L5t6 2&0 !'
1000 !' 2&0 !' 73#&!' 147 !'
100 14,7 100 25 100
. 1000 mg
G 2&0 !'
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10 100
. 25000 mg
G 2&00 !'
2&000 !' 2&00 !' G 27&00 !' 73#& !' .100 G 73&0 !'
10 100
. 7350 mg
G 73& !'
73&0 !' 73&!' G808& !' 147 . 100 G 14700!'
10 100
. 14700 mg
G 1470 !'
14700!' 1470 !' G 1;170 !' 2&0 !' . 100 G 2&000 !'
10 100
. 25.000 mg
G 2.&00 !'
2&.000 !' 2.&00 !' G 27.&00 !' 279#& !' . 100 G 27.9&0!' 10
. 27.950 mg
P*"!(" 10
$i >"' $iti!("'
27.9&0!' 279& !' G 30.74& !'
100
G 2.79& !'
L. METODE PEMBUATAN
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M. RANCANAN KEMASAN PRIMER DAN SEKUNDER
R""'" *!" P,i!*,
NAPRIXA® Serbuk Efervesen
Tiap 1500 mg mengandung: Naproxen............................................................................500 mg Mengurangi rasa sakit bengkak dan kemera!an pada r!eumatoid artritis osteoartritis dan artritis gout akut #i!at di $rosur konstipasin%eri abdomina& d%spepsia diare munta! tukak
( R""'" *!" S*5"$*,
&ambung sakit kepa&a vertigo &eukopenia gaga& gin'a& !epatitis
No. (eg : "T# 1)*55001*+,1 No.bat-!:)01001 rod. "ate : 1) Mar *01) Ex . "ate : 1) Maret *01/
®
Tiap 1500 mg mengandung: Naproxen......500 mg
NAPRIXA
Mengurangi rasa sakit bengkak dan kemera!an
konstipasin%eri abdomina& d%spepsia diare munta! tu ka k & am bu ng s ak it kepa&a vertigo &eukopenia gaga& gin'a& !epatitis
pada r!eumatoid artritis osteoartritis dan artritis gout akut
"a&am 3ada! tertutup kedap ditempat se'uk dan 'aga dari -a!a%a
#i!at di $rosur
"iproduksi &e!: T. mi 2arma Kendari Indonesia
No. (eg :"T# 1)*55001*+,1 No.bat-!:)01001 rod. "ate : 1) Mar *01) Exp. "ate : 1) Maret *01/
®
NAPRIXA
N. RANCANAN BROSUR N%,iF
S*,(5
N%,iF
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N6. R*' DTL 1;2&&00123A1
N6. R*' DTL 1;2&&00123A1
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O. DAFTAR PUSTAKA
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