MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIK (From Academic Year 2010-11 & onwards)
Syllabus for MD (Ayurved) Final Examination
RASA SHASTRA LECTURES-400 PRACTICALS-150
PAPER-I Adharabhuta Siddhant, Rasa Chikitsa and Pharmacy Management 1.
History History and Chronolog Chronological ical evaluation evaluation of Rasa Rasa shastr shastra, a, Concep Conceptt of Rasesh Raseshwar war dars darsha han n
and and stud study y of Rasa Rasa gran granth thas as with spec specia iall emph emphas asis is on Rasa Rasarn rnav ava, a,
Rasahriday Rasahridaya a tantra, tantra, Rasa Ratna Samuccha Samucchaya, ya, Sharngadh Sharngadhara ara Samhita, Samhita, Rasendra Rasendra Chintamani, Rasa Ratnakar, Rasadhyaya, Rasa Kamdhenu, Anandkanda, Ayurveda Prakash, Bhavaprakash, Rasatarangini and Relevant portions of Brihatrayi 2. Concept of Rasamandapa and establishment of Rasashala in accordance with GMP.
3. Fundamental Principles of Rasashastra and Bhaisajya kalpana including principles principles of design designing ing differe different nt formula formulatio tions ns with with refere reference nce to Samsle Samslesha sha Vishle Vishleha ha and other other principles. 4. Study of ancient and metric systems of weights and measures including Kala mana with their correlation. 5. Technical terminologies (Paribhasha) used in Rasa shastra and Bhaishajya kalpana. 6. Concept of Kshetrikaran, Importance of association of Rasa with Loha and Rasaabhraka with loha (Rasyoga and Rasabhrayog), Study of Kramana(Anupana) yoga as described in Rasa Ratnakar, Rasayan Rasayan khanda and Ananda Ananda kand, Study of Ashuddha, Apakva, Avidhi sevita Rasa dravya sevana dosha and its management. Concept of lohajirna and Rasajirna. 7. Mana Manag gement ent
of
Pha Pharmac rmacy y,
Stor Store e
and
Inve Invent ntor ory y
Man Managem agemen ent, t,
Person rsonn nel
Management, Good Manufacturing Practices related to Ayurvedic Drug Industry. 8. Marketing Pharmaceutical Services 9. Product Release and Withdrawals 10.
Community Pharmacy
11.
Laws Governing Pharmacy a) Relevant regulatory provisions of Ayurvedic drugs in Drug and Cosmetic Act 1940 and Rules 1945
b) Laws pertaining to Drugs and Magic remedies (objectionable advertisement) Act1954. c) Prevention of Food Adulteration (PFA) act. d) Laws pertaining to Narcotics e) Factory and Pharmacy Acts f) Consumer Protection Act -1986 12.
Regulatory Affairs related to International Trade and Practices of Ayurvedic Drugs.
13.
Introduction to Ayurvedic Pharmacoepia of India, Ayurvedic Formulary of India.
14.
Introd Introduc uctio tion n to Indian Indian Pharma Pharmacoe coepia pia,, Britis British h and United United States States Pharma Pharmacoe coepia pia,, Pharamcoepial Codex.
15.
Introduction to Traditional Knowledge Digital Library
PAPER-II Aushadh Prasamsaskaran evam Rasa dravya Vigyan 1.
Deta Detail iled ed know knowled ledge ge of anci ancien entt
and and
cont contem empo pora rary ry Yant Yantro ropa paka karan rana a
and and
thei their r
access accessori ories es used used in Aushad Aushadhik hikara aran n and their their contem contempor porary ary modifi modificat cation ion such such as yantras yantras,, musha mushas, s, putas, putas, Koshth Koshthis, is, Bhras Bhrashtr htris, is, Muffle Muffle furnac furnaces es and other other heatin heating g appliances, ovens, driers etc. used in manufacturing of Rasaushadhis in small scale and large scale along with their applications. 2. Study Study of Sams Samska kara ra,, defi defini nitio tion, n, type types s and and its effe effect ct on Phys Physic icoo- chem chemic ical al and and Therapeutic
properties
of
Samskararha
dravya.
Role of Agni (Heat), Jala and other dravas (Water and other processing liquids), Kala (Time span), Patra (Container) and other processing materials and their significance in Aushadhikaran. 3. Deta Detail iled ed Know Knowle ledg dge e of Shod Shodha hana na with with spec specia iall emph emphas asis is on Shod Shodha han n drav dravya ya,, instrumentation and processing techniques in relation to Shodhya dravya. 4.
Study of Mardana and its significance in Aushadhikaran. Concept of Bhavana, of Bhavana, detailed knowledge of ancient and contemporary grinding and trituration techniques.
5. Concept of Puta, definition, types and specifications of different Putas. Significance of different Putas in relation to Bhasmikaran and therapeutic efficacy of dravya under process. Bhasma pariksha vidhi and its significance in relation to contemporary testing procedures 6. Deta Detail iled ed
Kno Knowled ledge
of
Mara Marana na,,
with with
spec pecial ial
emp emphas hasis
on
Marak rak
dravy ravya, a,
Instrumentation, Processing technique in relation to Martya Dravya. 7. Detailed knowledge of Amritikaran and Lohitikaran and its significance in preparation of Bhasma with reference to dravya under process. 8. Detail Detailed ed knowle knowledge dge of Satvap Satvapata atan; n; Shodha Shodhan, n, Mriduka Mridukaran ran and Maran Maran of Satva, Satva, its significance, in relation to therapeutic efficacy of dravya under process.
9. Detailed knowledge of Druti, its processing and its significance in relation to therapeutic efficacy. 10.
Concept of Jarana, Moorcchana, Bandhan, Pakshaccheda and Maran in relation to Parad.
11. Detailed ancient and contemporary knowledge of Parada and its compounds with reference to Source, Occurrence, availability, Physico-chemical characterization, Grahya Agrahyatva, Shodhan maranadi vidhi, Therapeutic Properties and uses. 12.
Detailed
ancient
&
contemporary
knowledge
with
Geochemical/mineralogical/Biological identification, source, occurrence, availability, physico-chemical characterization, grahya-agrahyatva, Shodhan Maranadi Vidhi and Therapeutic properties and uses of dravyas included in Maharasa, Uparasa, Sadharana rasa, Dhatu, Upadhatu, Ratna, Uparatna, Visha, Upavisha, Sudha varga, Lavan varga, Kshar Varga and other varga used in Rasashastra. 1. Detailed
knowledge
of
Standard
Operating
Procedure
of
manufacturing,
Standardization, Quality control, Storage, therapeutic efficacy, Mechanism of action, Dose, Anupan and Method of administration of following Bhasma and pishti viz: Bhasma - Abhraka Bhasma, Vaikrant Bhasma, Svarnamakshika Bhasma, Kasis Bhasma, Svarna Bhasma, Rajat Bhasma, Tamra Bhasma, Loha Bhasma, Mandur Bhasma, Naga Bhasma, Vanga Bhasma,Yashad Bhasma, Trivanga Bhasma, Pittal, Kamsya and Varthaloha Bhasma, Shankha Bhasma, Shukti Bhasma, Kapardika Bhasma, Godanti Bhasma, Praval Bhasma, Mrigashringa Bhasma, Mayurpiccha Bhasma, Kukkutand twaka Bhasma, Hiraka Bhasma, Manikya Bhasma. Pishti - Praval pishti, Manikya Pishti, Mukta Pishti, Jahara mohara pishti, Trinakanta mani pishti. 2. Principles of Aushadhi Path Samyojan, Standard Operating Procedure of Preparation, Quality Control, Storage and Stability Kupipakwa and Pottali Kalpa.
of
Kharaliya, Parpati,
PAPER- III Aushadha Yoga Vigyan Rasa Yoga Vigyan Detailed knowledge of Aushadhi Patha Samyojan, Therapeutic efficacy, Mechanism of action, Dose, Anupan and Method of administration of following Aushadhi Yogas 1. Kharaliya Yoga Shwasakuthara Rasa, Tribhuvanakirti Rasa, Higuleshwara Rasa, Anandabhairava Rasa, MahaLakshmivilasa Rasa, Vasnathakusumakara chintamani
Rasa,
Laghusutashekhar Rasa,
Rasa, Vasantamalti Rasa, Bhrihatvata Sutashekhar
Rasa,
Ramban Rasa,
Chandrakala Rasa, Yogendra Rasa, Hridyarnava rasa, Grahanikapata Rasa, Garbhapala Rasa, Jalodarari Rasa, Mrityunjaya Rasa, Madhumalini vasanta Rasa, Arshakuthara Rasa, Krimimudgara Rasa, Suchikabharana Rasa, Trinetra Rasa, Smrutisagara Rasa, Vatagajankusha
Rasa,
Agnikumar
Rasa,
Ekangavir
Rasa,
Kamadudha
Rasa,
Purnachandrodaya Rasa, Prataplankeshwara Rasa, Mahavata vidhwansaka Rasa, Kasturibhairava Rasa, Ashwakanchuki Rasa, Gulmakuthara Rasa, Mahajwarankusha Rasa, Chandramrita Rasa, Kaphaketu Rasa, Prabhakara Vati, Pravala Panchamrita, Gandhaka Rasayana, Chaturbhuj rasa, Navajivan rasa, Shonitargal rasa, Raktapitta kulakandan rasa, Amavatari Rasa, Kravyada Rasa, Garbhachintamani Rasa, Chintamani Rasa,
Trilokyachintamani
Rasa,
Pradarantaka
Rasa,
Vangeshwara
Rasa,
Brihatvangeshwara Rasa, Shwasakasa Chintamani Rasa, Arogyavardhini Vati, Agnitundi vati, Shankha Vati, Kautajyadi Shilajeet. 2. Loha Kalpa Ayaskriti, Loha Rasayana, Amlapittantaka loha, Chandanadi loha, Dhatri loha, Navayasa loha, Putapakva vishamajwarantaka loha, Shilajatwadi loha, Tapyadi loha, Saptamrita loha, Punarnava Mandura, Amritasara Loha, Shankaramat loha, Pradarantaka loha, Rohitaka loha. 3. Kupipakva Yoga Rasa Sindura, Makaradhwaja, Sidhamakaradhwaja, Samirapannaga Swarnavanga, Malla sindura, Rasa karpura, Rasa pushpa, Manikya Rasa. 4. Parpati Yoga Rasa Parpati, Loha Parpati, Tamra Parpati, Suwarna Parpati, Gagana Parpati, Vijay Parpati, Panchamrit Parpati, Shwet Parpati, Bola Parpati . 5. Pottali Yoga Rasagarbhapottali, Hemagarbhapottali, Mallagarbha pottali, Shankagarbha pottali, Lokanatha rasa, Mriganka Pottali.
Hiranyagarbha pottali,
Bhaishajya Yoga Vigyan Detailed knowledge of Aushadhi Path Samyojan, Therapeutic efficacy, Mechanism of action, Dose, Anupan and Method of administration of following Aushadhi Yogas: 6. Panchavidha Kashayas and their Upakalpa Ardraka swarasa, Tulasi swarasa, Vasa putapaka swarasa, Nimba kalka, Rasona kalka, Kulattha Kwath, Punarnavasthaka kwatha, Rasna saptaka kwatha, Dhanyak hima, Sarivadi hima, Panchakola phanta, Mustadi pramathya, Kharjuradi mantha, Shadanga paniya, Laksha rasa, Ajamoda arka, Yavanyadi arka, Chincha panaka, Candana panaka, Banapsha sharkara, Nimbu sarkara, Darvi rasakriya, Amrita satva, Ardraka satva, Arjuna kshirapaka, Rasona kshirapaka, 7.Pathya Kalpana Yavagu, (Krita and Akrita), Ashtaguna manda, Laja manda, Peya, Vilepi, Krishara, Yusha, Mudga yusha, Kulattha yusha, Saptamushtika yusha, Khad, Kambalika, Raga, Shadava Mamsarasa, Veshavara,
Takra, Udasvita, Katvar, Mathita, Chhacchika, Dadhi,
Tandulodaka, Neutraceuticals and Food Supplements 8.. Churna Sitopaladi Churna, Talisadi Churna, Triphala Churna, Hingvashtaka Churna, Yashtimadhu Churna, Avipattikara Churna, Swadishta Virechana Churna, Trimada Virechana Churna, Lavana Bhaskar Churna, Sudarshana Churna, MahaSudarshana Churna, Gandharva Haritaki Churna, Navayasa Churna, Pushyanuga Churna, Ajamodadi Churna, Hingvadi Churna, Eladi Churna, Dadimashtaka Churna, Trikatu Churna, Vaishwanara Churna 9. Gutika Chandraprabha vati, Chitrakadi Gutika,, Sanjivani Vati, Lasunadi vati, Lavangadi Vati, Vyoshadi vati, Khadiradi Vati,
Kankayan Vati, Abhayadi modak, Marichyadi gutika,
Amalakyadi gutika, Samshamini Vati, Kutaja Ghana vati 10. Guggulu Yogaraja Guggulu, Maha yogaraja Guggulu, Trayodashanga Guggulu, Kanchanara Guggulu, Rasnadi Guggulu, Triphala Guggulu, Simhanada Guggulu, Gokshuradi Guggulu, Kaishora Guggulu, Panchatikta Guggulu, Amritadi Guggulu, Vatari Guggulu, Lakshadi Guggulu, Abha Guggulu 11. Snehapaka Sneha Moorchhana - Ghrita Murchana, Taila Murchhana
Siddha Ghrita- Shatavari Ghrita, Jatyadi Ghrita, Phala Ghrita, Dadimadi Ghrita, Kshira Shatpala Ghrita, Triphala Ghrita, Dhanvantri Ghrita, Amritaprasha Ghrita, Kalyanaka Ghrita, Brahmi Ghrita, Changeri Ghrita, Panchatikta Ghrita, Sukumara Ghrita Siddha Taila - Maha Narayana Taila, Maha Masha Taila, Bala Taila, Nirgundi Taila, Shadbindu Taila, Vishagarbha Taila, Sahacharadi Taila, Jatyadi Taila, Apamarga Kshara Taila,Tuvaraka Taila, Kshirabala Taila, Lakshadi Taila, Anu Taila, KumKumadi Taila, Hingutriguna
Taila,
Kottumchukadi
Taila,
Prasarinyadi
Taila,
Dhanwantari
Taila,
Balashwagandhadi Taila, Balaguduchyadi Taila, Nilibhringyadi Taila, Brihadavadi Taila, Irimedadi Taila, Chandanadi Taila, Panchaguna taila, Arka taila 12. Avaleha Vasa Avaleha, Brahma rasayana, Chyavanprasha Avaleha, Kushmanda Avaleha, Vyagri Haritaki Avaleha, Dadima Avaleha, Bilvadi Avaleha, Kantakaryavaleha, Haridra Khanda, Narikela khanda, Saubhagya shunthi paka. 13.Sandhan Kalpa Shukta- Ikshu shukta, Tushambu, Kanjik, Sandaki Madya - Sura, Shidhu, Varuni Asava Arishta - Lodhrasava, Kumaryasava, Ushirasava, Chandanasava, Kanakasava, Sarivadyasava, Pippalyasava, Raktamitrarka, Sarasvatarishta,
Lohasava, Vasakasava, Kutajarishta,
Dashamularishta, Arjunarishta,
Abhayarishta,
Khadirarishta,
Amritarishta,
Ashwagandha
Arishta,
Draksharishta, Ashokarishta, Vidangarishta,
Takrarishta. 14.Miscellaneous - Phala varti, Chandrodaya varti, Arka lavana, Narikela lavana, Triphala masi, Apamarga kshara, Snuhi kshara, Ksharasutra, Atasi upanaha, Sarjarasa malahara, Gandhaka malahara,Sinduradi Malahar, Shatadhouta Ghrita, Sahasra Dhouta Ghrita, Sikta taila, Dashanga lepa, Doshaghna lepa, Bhallataka taila, Jyotishmati Taila, Bakuchi Taila, Dashanga dhupa, Arshoghna dhupa, Nishadi Netra bindu, Madhutailika Basti, Sneha Basti, Matra Basti, Piccha Basti, Yapana Basti.
PAPER -IV Pharmaceutical Science Pharmaceutical technology 1. Scope and Evolution of Pharmacy 2. Information Resources in Pharmacy and Pharmaceutical Science 3. Posology 4. Colloidal and Coarse dispersion and Pharmaceutical Rheology 5. Preformulation 6. Separation
7. Principles of Distillation, Methods of Extraction, Infusion, Decoction, Maceration, Percolation and Fusion. 8. Sterilization & Sterile products, Ophthalmic and Parenteral Preparations 9. Preservation and stabilization of pharmaceutical products 10. Drying, Open and Closed Air drying, Freeze drying, Vacuum drying and other drying methods 11.Pharmaceutical Excipients 12. Oral Solid Dosage Forms, Powder, Size reduction & size separations,
Principles of
mixing Micrometrics- Methods of determination of particle size, shape & Surface area, Methods of compression & Consolidation of powder solids, Tablets, Sustained release dosage forms, Suppositories & Pessaries, Capsules- Hard capsules & soft gelatin capsules & micro encapsulation 13. Semisolid Dosage Forms Emulsion, Suspensions and Extracts 14.Liquids - Solution, Solubility Phenomenon, Diffusion & Dissolution, pH, Buffers & Isotonic solutions, Clarification & Filtration: Techniques of filtration & Centrifugation, Syrup, Elixirs 15.Pharmaceutical aerosols 16.Topical drugs and Cosmetics 17.Packaging Materials and Labeling 18.Standardization of Raw material, In process Material and Finished Product
Pharmacology 19. Principles of Pharmacology Pharmcodynamics & Pharmacokinetics: Absorption, distribution, mechanism of action & Excretion, Dose response relationship, structure activity relationship 20.Routes of administration of drug 21.Factors modifying drug effect, Drug interactions, Adverse drug reaction and Drug toxicity 22.Detailed Knowledge of Pharmacovigilance – National and International Scenario. Pharmacovigillance of Ayurvedic Drugs Clinical pharmacology: Preclinical & clinical evaluation, Bioequivalence
Toxicology 23.Principles of Toxicology 24.Toxicology of Metallic, Mineral, Plant & Animal products General principles of Management of Acute and Chronic Toxicity
Bioavailability and
Scheme of Practicals
Duration: - 2 Years i)
Departmental Practicals :Student should prepare following drugs / perform practicals, (Any 100 out of 126) under supervision of Guide and record the same in Practical Journal. (Proforma of journal is attached herewith as Annexure A) 1) Hidgulotha Parad Nirman 2) Parad Shamanya Shodhan 3) Parad Swedan Sanskar 4) Parad Mardan Sanskar 5) Parad Murchan Sanskar 6) Parad Utthapan Sanskar 7) Parad Trividha Patan Sanskar 8) Parad Rodhan Sanskar 9) Parad Niyman Sanskar 10) Parad Dipan Sanskar 11) Gandhak Samanya Shodhan 12) Gandhak Vishesh Shodhan 13) Gandhak Drutri Nirman 14) Gandhak Rasayan Nirman 15) Kajjali Nirman 16) Rasaparpati Nirman 17) Rasasindur Nirman 18) Rasapottali Nirman 19) Abhrak Shodhan 20) Dhanyabhrak Nirman 21) Abhrak Maran 22) Abhrak Amrutikaran 23) Abhrak Lohitikaran 24) Abhrak Satwapatan 25) Suvarna makshik Samanya Shodhan 26) Suvarna makshik Vishesh Shodhan 27) Suvarna makshik Maran 28) Suvarna makshik Amrutikaran 29) Shilajatu Prapti Agnitapi 30) Shilajatu Prapti Suryatapi 31) Sasyak Shodhan 32) Sasyak Satvapatan 33) Sasyak Maran 34) Chapal (Bismuth) Shodhan 35) Gairik Shodhan 36) Gairik Satwapatan 37) Kasis Shodhan 38) Kasis Maran 39) Kankshi Shodhan 40) Hartal Samanya Shodhan 41) Hartal Vishesh Shodhan 42) Hartal Bhasm Nirman 43) Rasmanikya Nirman 44) Man Shila Shodhan 45) Rasanjan Nirman 46) Pushpanjan Nirman
100
47) Souviranjan Nirman 48) Kankushtha Shodhan 49) Kampillak Shodhan 50) Gouripashan Shodhan 51) Gouripashan Maran 52) Navsagar Shodhan(Urdhavpatan) 53) Kaparda Shodhan 54) Kaparda Maran 55) Agnijaar Collection 56) Girisindur Collection 57) Hingul Shodhan 58) Mugdh Ras Nirman 59) Raspushpa Nirman 60) Rasakarpur Nirman 61) Rashpushpa Malhar Nirman 62) Rasakarpur Malhar Nirman 63) Suvarna Samanya Shodhan 64) Suvarna Vishesh Shodhan 65) Suvarna Dhatu Pishti Nirman 66) Suvarna Maran 67) Makardhavaj Nirmanartha Kajjali Nirman 68) Makardhavaj Nirman 69) Raupya Samanya Shodhan 70) Raupya Vishesh Shodhan 71) Raupya Maran 72) Raupyasindur Nirman 73) Kantloh Samanya Shodhan 74) Kantloh Vishesha Shodhan 75) Kantloh Sthalipak 76) kantloh Bhanupak 77) Kantloh Putpak 78) Mandur Shodhan 79) Mandur Maran 80) Tamra Samanya Shodhan 81) Tamra Vishesh Shodhan 82) Tamra Dhatu Pishti Nirman 83) Tamra Sindur Nirman 84) Tamra Bhasm Nirman 85) Tamra Amrutikaran 86) Somnathi Tamra Basma Nirman 87) Vanga Samanya Shodhan 88) Vanga Vishesh Shodhan 89) Vanga Jaran 90) Vanga Basma Nirman 91) Suvarnavanga Nirman 92) Yashad Samanya Shodhan 93) Yashad Vishesh Shodhan 94) Yashad Jaran 95) Yashad Maran 96) Nag Samanya Shodhan 97) Nag Vishesh Shodhan 98) Nag Jaran 99) Nag Maran 100)Trivanga Bhasma Nirman 101)Kansyaloh Nirman
ii)
iii)
iv)
v)
vi)
102)Shankha Shodhan 103)Shankha Maran 104)Shukti Shodhan 105)Shukti Maran 106)Godanti Shodhan 107)Godanti Maran 108)Akik Pishti Nirman 109)Jaharmohara Pishti Nirman 110)Shwet Parpati Nirman 111)Tribhuvankirti Ras Nirman 112)Vatsanabh Shodhan 113)Dhattur Shodhan 114)Gunja Shodhan 115)Bhallatak Shodhan 116)Bhallatak Tail Patan 117)Kuchala Shodhan 118)Tankan Shodhan 119)Mayurpiccha Mashi Nirman 120)Kukkutanda tawk Bhasma Nirman 121)Ajasthi Bhasma Nirman 122)Shankha drava Nirman 123)Samirpannag Ras Nirman 124)Loknath Ras Nirman 125)Badarashama Shodhan 126)Badarashama Maran Research Project (other than Dissertation) : Student should work on a specific topic related to Rasa Shastra as allotted by Guide as per instructions and format provided in the P.G. Log Book Compilations : Student should prepare Compilations on a specific topic related to Rasa Shastra as allotted by Guide as per instructions provided in the P.G. Log Book Clinical Case Study : Student should study 15 cases and record the case in prescribed format (attached herewith as Annexure B) as per instructions provided in PG Log Book. Drug Testing and Drug Standardization Chromatographic separation T.L.C., H.P.T.L.C. or any other applicable tests – Any 18 Drugs a) Bhasmas - 6 b) Pottali - 2 c) Parpati - 3 d) Khalvi Rasayan - 3 e) Sindur - 2 f) Sudha Varga - 2 Educational Visits The brief report of each visit should be written by student in a journal (Duly signed by Guide and HOD) a) Visit to one Local Ayurvedic Pharmacy (GMP Approved) b) Visit to one State Ayurvedic Pharmacy (GMP Approved) c) Visit to one out of State Ayurvedic Pharmacy (GMP Approved) d) Visit to one R&D Centre of Modern Pharmacy (MNC) such as Glaxo, Pfizer, FDA Laboratory etc.
1
8
15
18
5
e) Visit to any one Siddha Pharmacy
Annexure ‘A’
PROFORMA Departmental Practicals
Practical No: _____________________________________________ Date: ________________ Practical name: ___________________________________________ Time: ________________ Aim: __________________________________________________________________________ ______________________________________________________________________________ Reference: ____________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ Equipments: ___________________________________________________________________ ______________________________________________________________________________ Required Drugs: No
Drug Name
Qnty.
Cost
No
1
6
2
7
3
8
4
9
5
10
Drug Name
Qnty.
Cost
Method: ______________________________________________________________________ Procedure: ____________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ Diagram:
Observation: ___________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________
Precautions: ___________________________________________________________________ ______________________________________________________________________________
______________________________________________________________________________ ______________________________________________________________________________ Final Processed drug: Weight
Before ___________________ After ___________________ Loss ___________________ Gain ___________________
Change in weight due to _________________________________________________________ Examination of the processed drug: Shabda
: ______________________________________________________
Sparsha
: ______________________________________________________
Rupa
: ______________________________________________________
Rasa
: ______________________________________________________
Gandha
: ______________________________________________________
Drug Siddhi Lakshana
: ______________________________________________________
______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ Drug Standardization: ___________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ Properties of the finished drug: ___________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ ______________________________________________________________________________ Therapeutic indications: No Disease 1 2 3 4 5 Any other uses
Action
Anupan
Time
: ____________________________________________________________
Saviryatavadhi of the drug
: ______________________________________________________
Cost estimation: Item Raw material Fuel Labor charges
Dose
Label: Cost
Drug name Reference Dose Special note
Packaging charges
Mfg. Date Expiry date (if any)
Sign. of Student
Sign. of Guide
Date :-
Date :-
Annexure ‘B’
PROFORMA Clinical Case Study
STUDY TITLE
: Assessment of
& confirmation of mode of action
SUBJECT NO
: ______________________________________________________
SUBJECT NAME
: ______________________________________________________
AGE
: ______________________________________________________
SEX
: ______________________________________________________
OCCUPATION
: ______________________________________________________
ADDRESS
: ______________________________________________________ ___________________________________ TEL _______________
DATE OF FIRST VISIT : ______________________________________________________ INFORM CONSENT FORM
: ______________________________________________________
PAST HISTORY/POORVA ROOPA
: ________________________________________________
CHIEF COMPLAINTS/ROOPA:_____________________________________________________ INCLUSION CRITERIA : ______________________________________________________ EXCLUSION CRITERIA: ______________________________________________________ VISIT FIRST DATE OF VISIT
: ______________________________________________________ : ______________________________________________________
A) PHYSICAL EXAMINATION SR. No 1 2
Body system
ND
Normal
If Abnormal NCS
CS
Abnormality in brief
Skin Head, Eyes, Ears,
3
Nose, Throat Respiratory
4
Cardiovascular
5
Gastrointestinal
6
Neurological
7
Lymphatic
8
Musculoskeletal
9
Urogenital
10
Other (Specify)
ND: Not Done, NCS: Not Clinically Significant, CS: Clinically Significant (If abnormal CS, enter in medical History)
B) SCREENING VISIT VITAL SIGNS (in supine position after 3 min. rest) Sr.
Parameter
No. 1.
Blood pressure(mmHg)
2. 3.
Heart rate(bpm) Body temperature(ºF)
ND
Value
Normal
If abnormal NCS
CS
Abnormality in brief
Oral 4.
Axillary Respiration Rate(/min)
ND: Not Done, NCS: Not Clinically Significant, CS: Clinically Significant (If abnormal CS, enter in medical History)
VYADHI PRAKRITI
: ____________________________________________________________
RUGNAPRAKRITI
: ____________________________________________________________
DOSHA
: ____________________________________________________________
DUSHYA
: ____________________________________________________________
BALA
: ____________________________________________________________
KAAL
: ____________________________________________________________
VAYA
: ____________________________________________________________
AGNI
: ____________________________________________________________
PRAKRITI
: ____________________________________________________________
SAAR
: ____________________________________________________________
SATVA
: ____________________________________________________________
SATMYA
: ____________________________________________________________
AHARSHAKTI
: ____________________________________________________________
VYAYAMSHAKTI NIDAAN
: ____________________________________________________________
: ____________________________________________________________
AAHARJANYA : ____________________________________________________________ VIHARJAYNYA : ____________________________________________________________ VYASANJANYA : ____________________________________________________________ AUSHADHIJANYA
: ____________________________________________________________
VYADHIJANYA : ____________________________________________________________ KAALJANYA
: ____________________________________________________________
KULAJANYA
: ____________________________________________________________
C) 12 LEAD ECG
(in supine position after 5 min)
Date of examination Sr.
Parameter
No. 1.
Qtc(msec)
2.
QTcB(msec) Overall interpretation
3.
Value
Abnormality
If abnormal
Normal
NCS
CS
in brief
of ECG
ND: Not Done, NCS: Not Clinically Significant, CS: Clinically Significant (If abnormal CS, enter in medical History) D) CHEST X-RAY Date of investigation: Examination
ND
Normal
Abnormality
If abnormal NCS
CS
in brief
Chest X-ray ND: Not Done, NCS: Not Clinically Significant, CS: Clinically Significant (If abnormal CS, enter in medical History) E) HEMATOLOGY: Date of sample collection: Sr.
Parameter
No. 1.
WBC
2.
RBC
3.
Haemoglobin
4.
MCV
6.
MCH
7.
MCHC
8.
Platelate
9.
WBC differential count
9.a
Neutrophils
9.b
Lymphocytes
9.c
Monocytes
9.d
Eosinophils
9.e
Bosophils
ND
Normal
If abnormal NCS
CS
ND: Not Done, NCS: Not Clinically Significant, CS: Clinically Significant (If abnormal CS, enter in medical History)
F) URINE ANALYSIS: Date of urine sample collection: Sr.
Parameter
No. 1.
Protien
2.
Glucose
3.
Ketones
4.
Blood
5.
Bilirubin
6.
Urine Microscopy
6.a
Pus cells
6.b
RBC
6.c
Casts
ND
Normal
If abnormal NCS
CS
ND: Not Done, NCS: Not Clinically Significant, CS: Clinically Significant (If abnormal CS, enter in medical History) G) LIPID PROFILE Sr.
Parameter
No. 1.
Total cholesterol
2.
Triglycerides
3.
HDL
4.
LDL
5.
VLDL
ND
Normal
If abnormal NCS
CS
ND: Not Done, NCS: Not Clinically Significant, CS: Clinically Significant (If abnormal CS, enter in medical History)
DIAGNOSIS
: ______________________________________________________
MEDICATION DETAILS : ______________________________________________________ SOURCES INGREDIENTS
: ______________________________________________________ : ______________________________________________________
MANUFACTURING METHOD: _____________________________________________________ TEST DETAILS-Physical/Analytical : _______________________________________________ BATCH NO
: ______________________________________________________
H) MANUFACTURING DATE Sr.
Pharmaceutical
Ingredients
No. 1.
Mercury
2.
Sulphur
3.
Copper
4.
Iron
5.
Aluminium
6.
Zinc
7.
Arsenic
DRUG/KALPA
value
Therapeutic value
:______________________________________________________
ETIOPATHOGENESIS/HETU SAMPRAPTI : _________________________________________ BREAK UP OF ETIOPATHOGENESIS/Samprapti Vighatn : _____________________________ *ANCIENT POINT OF VIEW
: ______________________________________________________
*MODERN POINT OF VIEW
: ______________________________________________________
I) SR.N O
1.
2.
3.
4.
5.
6.
7.
ADVERSE DRUG REACTION IF ANY Mercury
Metallic Taste
Throat constriction Burning sensation from mouth to stomach Radiating painover Abd. Corrossion of mouth , tongue , faeces Mucous membrane appears grayish white
Nausea
Arsenic
Lead
Copper
Zinc
Iron
Calcium
Acute G.I disturbances
Same as of arsenic except diarrhea is replaced by constipation
Metallic Taste
G.I disturbance
Nausea
Reduce bone mass
Nausea
Dry throat
Salivation
Metallic taste
Vomiting
Osteoporo sis
Burning in G.I tract
Metallic astringent taste
Thirst
Gullet
Diarrhoea
Severe, continous and persisting vomiting
Thirst
Burning in stomach
Vomiting
Constipation
Diarrhoea
Nausea
Colicky abdominal pain
Diarrhoea
Iron overload with organ damage
Intense thirst
Colicy pain
Vomitting
Collapse
Diarrhoea
Destruction of mucus membran e of mouth
Cramps in legs
Vomiting
8.
9.
Vomiting with stringy mass of bloody white mucous Profuse bloody purging
Oligouria
Purging
Skin eruption in later stage
Offensive black faeces
Collapse
Liquid brown stool Inky appearance of urine
10.
Painful tenesmus
Cramps
11.
Cardiorespiratory arrest.
Headache drowsiness
Oligouria
Paraylsis
Severe headache
12. 13. 14. 15.
Encephalo pathy Sleeplessnes s HalluciNation
16.
Excitement
17.
Delerium
18.
Tremors of eyes ,mouth and fingers
Bloody purging
Dyspnoea Jaundice Muscle cramp Convulsio n Coma
WHO Scaling for ADR : ______________________________________________________ Temporal Relationship : ______________________________________________________ Concomittant Disease : ______________________________________________________ Concomittant Drug
: ______________________________________________________
Causative Dechallenge : ______________________________________________________ Causative Rechallenge : ______________________________________________________ Comments
: ______________________________________________________
Sign. of Student
Sign. of Guide
Date :-
Date :-
Format of Question Paper For All Four Papers Q.No. 1 2 3 4 5
Nature of Questions One Long Answer Question(LAQ) One Long Answer Question(LAQ) One Long Answer Question(LAQ) One Long Answer Question(LAQ) Five SAQ (Attempt Any Four)
Division of Marks 20 20 20 20 4x5
Total Marks 20 20 20 20 20 100
Format of Practical / Oral Examination a) Log book
b) All Practical Journals c) One Long experiment d) Two Short experiments (10x2) e) Drug testing practical (any one) f) Spotting on Instrument/ Equipment / Drugs (10 Spots x2) g) Viva-Voce/Oral by Four Examiners ----------------------------------------------------------------Total :-
-
20 10 20 20 10 20
-
100 Marks 200 Marks
Reference Books
1. Rasendra Chintamani 2. Rasakamadhenu 3. Rasaratna Samucchaya 4. Anand Kanda 5. Rasarnava 6. Bharatiya Rasashastra
- Vishvanath Dwivedi
7. Rasa – Bhaishajya Kalpana Vigyan
- Santosh Khandal
8. Modern texts related to Rasashastra 9. Rasahridaya tantra 10.
Rasa Ratnakar
11.
Arka Prakash
12.
Rasatarangini
13.
Rasajala Nidhi
14.
Kupipakwa Rasayana
15. Parad Vigyaneeyam
– Harisharananand – Vasudeva Moolashankar Dvivedi
16. Rasaadhyaya 17. Rasa Chandanshu 18. Chakradatta 19. Gada Nigraha
– Ratnaprabha commentary
20. Vangasena 21. Vaidyaka Paribhasha Pradeepa 22. Rsayoga Sagara 23. Bhasma Vigyan
– Harisharananand
24. Ratna Dhatu Vigyan
– Badrinarayana Shastri
25. Remington: Science and Practice of Pharmacy 26. Industrial Pharmacy
– Lackma
27. Text Book of Phrmacology
– Goodman and Gilman
28. Dana’s Text Book of Minerology 29. Quality Control of Ayurvedic Drugs
– PLIM, Gaziabad publication
30. Ayurvedic Pharmacopeia of India 31. Ayurvedic Formulary of India 32. Indian Pharmacopeia 33. British Pharmacopeia 34. United States Pharmacopeia 35. Pharmacopeia Codex 36. Current Good Manufacturing Practices 37. Drugs and Cosmetic Act 1940 and Rules 1945 38. Drugs and Magic remedies (Objectionable advertisement) Act-1954 39. Prevention of Food Adulteration (PFA) act 40. Laws pertaining to Narcotics 41. Factory and Pharmacy Acts 42. Consumer Protection Act -1986 43. History of Hindu Chemistry 44. Ayurvedeeya Shodhan Vidhi
– P. C. Roy –Dhootpapeswar Publication
45. Siddha Yoga Samgriha
–Yadavaji Trikamji Acharya
46. Rasamritam
- Yadavaji Trikamji Acharya
47. Dravyaguna Vijnan Pat-1 and 2 48. Dravyaguna
- Yadavji Trikamji Acharya – Chakradatta CCRAS Publication
49. Sahasrayoga 50. Rasa-tantra sara evam Siddha prayoga Sangriha
– Krishnagopal Kaleda
publication
51. Parad Yoga Chintamani – Vd. Ramesh C. Wavare 52. Charak Samhita 53. Sushrut Samhita 54. Ashtanga Sangraha 55. Ashtanga Hridaya 56. Ayurvediya Aushadhikaran - by Dhamankar / Puranik
57. Rasoushadhi Nirman - by S.D.Kulkarni 58. Parad Samhita 59. Bharat Bhaishajya Ratnakar Vol I to V 60. Aushadhi Gunadharma Shastra - by Gune Shastri 61. Rasashastra by Dr. Damodar Joshi 62. Rasaratna Samucchaya English translation by Dr. V.A.Dole
63. Rasashastra Dr.Dole Dr. Paranjape (Chaukhamba Publication, Varanasi) 64. Clinical Rasashastra by Dr. P.H.Khaparde
