inco incorr rrec ectl tly y sto store red d or or ou out-of t-of-d -dat atee bl blood ood
ii.
inad inadv verte erten ntly tly froze rozen n bloo blood d
iii.
overheated bl blood
iv.
infected blood
v.
mechanical destruction
- infusion under pressure
Acute Haemolytic Transfusion Reactions 1.
incidence
~ 1:4000-14,000
2.
mortality
~ 1:100,000
3.
aetiology
~ 23% anti-Fya (mainly IgM) ~ 18% anti-A ~ 12% anti-D intravascular haemolysis * complement fixing with direct intravascular
4.
symptoms & signs
- fe fever & chills, na nausea, fl flushing - chest pain, dyspnoea, apprehension - bleeding diathesis§ § - hypotension § may be the only signs under GA § - haemoglobinuria haemoglobinuria
5.
complications
- an anaemia, th thrombocytopaenia, DI DIC - haemoglobinuria haemoglobinuria (? acid (? acid haematin precipitate - ARDS, MOSF