DRUG DATA
CLASSIFICATION
GENERIC NAME:
THERAPEUTIC:
Erythromycin
Anti-infectives
TRADE NAME:
Akne-Mycin, Del-Mycin, A/T/S, E/Gel, Erycette, Erygel, Ery-Max, Erysol, ETS, Staticin, Theramycin Z, T-Stat CONTENTS:
Erythromycin MINIMUM DOSE:
MAXIMUM DOSE:
AVAILABILITY:
ROUTES OF ADMINISTRATION:
PO, IV
PHARMACOLOGIC:
macrolides PREGANANCY RISK CATEGORY:
B
MECHANISM OF ACTION
Suppresses protein synthesis at the level of the 50S bacterial ribosome. Therapeutic effects: bacteriostatic action against susceptible bacteria
INDICATION >
CONTRAINDICATION C on on tr tr ai ai nd nd ic ica te te d i n: n:
SIDE EF EFFECTS C NS NS : seizures
> > >
qtc prolongation, ventricular arrhythmias CV:
EENT: PHARMACOKINETICS :
Absorption: Variable absorption from the duodenum after oral administration (depending on salt form). Absorption of enteric-coated products is delayed. Minimal absorption may follow topical or ophthalmic use. Distribution: Widely distributed. Minimal CNS penetration. Crosses placenta; enters breast milk. Metabolism and Excretion: Partially metabolized by the liver, excreted mainly unchanged in the bile; small amounts excreted excreted unchanged in the urine. Half-life: Neonates:2.1 Neonates:2.1 hr; Adults:1.4-2 hr PHARMACODYNAMI CS: Onset:
PO – 1 hr IV – rapid Peak:
PO – 1-4 hr IV – end of infusion Duration:
PO – 6-12 hr IV – 6-12 hr
BEFORE:
Check brand name labels for administration route restriction >
> >
NURSING RESPONSIBILITES
ototoxicity
nausea, vomiting, abdominal pain, cramping, diarrhea, druginduced hepatitis, infantile hypertrophic pyloric stenosis, druginduced pancreatitis GI:
> > > >
DURING: > > > > >
AFTER: >
Derm:
rashes
Local:
phlebitis a IV
> >
site Misc: allergic reactions, superinfection
> >
SOURCE:
SOURCE:
SOURCE:
SOURCE:
SOURCE:
SOURCE:
SOURCE:
Davis’s Drug Guide for Nurses 11th Edition, p.498-499
Davis’s Drug Guide for Nurses 11th Edition, p.498-499
Davis’s Drug Guide for Nurses 11th Edition, p.498-499
Davis’s Drug Guide for Nurses 11th Edition, p.498-499
Davis’s Drug Guide for Nurses 11th Edition, p.498-499
Davis’s Drug Guide for Nurses 11th Edition, p.498-499
Davis’s Drug Guide for Nurses 11th Edition, p.498-499
