Best way that I've found to learn the anemias. Use MCV to categorize them & get the big picture. Credit to Toby Steinberg for making these.
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This notes is prepared for the use of O'Level Commerce students of Cambridge University and London University.If you would like to get a copy of this document Please feel free to write to me at emm...
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Descripción: 1_Drag Reducing Agents in Multiphase Flow
USMP ArchivosDescripción completa
Top 10 AnemiasFull description
Rpg
anemia normocitica normocromica hipercromica
AG A GENTS US ED I N ANEMIAS & HEMATOPOIETIC GROWTH FACTORS
A.. Q . S a n g a l a n g , M D , F P O G S , R M T A FACULTY OF PHARMACY UNIVERSITY OF SANTO TOMAS
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A G E N T S U S E D I N A N E M I A S & AG HEMATOPOIETIC GROWTH FACTORS
Hematopoiesis
Production from undifferentiated stem cells of circulating erythrocytes, erythrocyt es, pl atelets, and leucocytes
Resides primarily in the bone marrow
Requires constant supply of 3 essential
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A G E N T S U S E D I N A N E M I A S & AG HEMATOPOIETIC GROWTH FACTORS
Hematopoiesis
Requires the presence of hematopoietic growth factors Proteins
that regulate the proliferation and
differentiation of hematopoietic cells/lineages of blood cells and regulate blood cell function
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A G E N T S U S E D I N A N E M I A S & AG HEMATOPOIETIC GROWTH FACTORS ESSENTIAL ROLES OF BLOOD CELLS Oxygenation of tissues Coagulation Protection against infectious agents Tissue repair Blood cell deficiency is a relativel y common occurrence that can have profound repercussions
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A G E N T S U S E D I N A N E M I A S & AG HEMATOPOIETIC GROWTH FACTORS A n e m i a An Deficiency in oxygen-carrying erythrocytes Most common and easily treated Insufficient supply of iron, vitamin B 1 2 , or folic acid erythroc yte deficiency or Most common cause of erythrocyte anemia
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A G E N T S U S E D I N A N E M I A S & AG HEMATOPOIETIC GROWTH FACTORS
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A G E N T S U S E D I N A N E M I A S & AG HEMATOPOIETIC GROWTH FACTORS BLOOD CELL DEFICIENCIES A.. Iron and Vitamin Deficiency Anemias A
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS BLOOD CELL DEFICIENCIES A.. Iron and Vitamin Deficiency Anemias A
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS BLOOD CELL DEFICIENCIES B . Other Blood Cell Deficiencies
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS BLOOD CELL DEFICIENCIES B . Other Blood Cell Deficiencies
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS IRON A.. Role of Iron A
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS IRON D . Toxicity of iron 1 . Signs and symptoms Chronic toxicity
Patients who receive frequent transfusions Sickle
cell anemia
Hemochromatosis
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS IRON D . Toxicity of iron 2 . Treatment of acute iron intoxication
Immediate treatment is necessary
Whole bowel irrigation
Removal of unabsorbed tablets from the gut
Correction of acid-base abnormalities
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS IRON D . Toxicity of iron 2 . Treatment of acute iron intoxication
Deferasirox
New oral iron chelator As e f fe fect ctii v e a s d e fe ferr o x a m i ne More convenient
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS IRON D . Toxicity of iron 3 . Treatment of chronic iron intoxication Treatment of hemochromatosis Intermittent One
phlebotomy
unit of blood is remove/week
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS VII T A M I N B 12 V A.. Role of vitamin B 12 A
Cobalamin
Cobalt-containing molecule
Sometimes called extrinsic factor
A l o n g w i t h f o l i c a c i d , i s a c o f a c t o r i n t h e Al transfer of 1-carbon units
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS VII T A M I N B 12 V A.. Role of vitamin B 12 A
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS VII T A M I N B 12 V B . Pharmacokinetics
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A 1 . Pharmacokinetics
Recombinant human erythropoeitin
Given IV
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A 1 . Pharmacokinetics
Erythrocyte Stimulating Agents (ESAs)
Darbopoietin alfa
Glycosylated form of erythropoietin
Twofold to threefold longer half-life
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A 2 . Pharmacodynamics
Stimulates the production of red cells
Interacts with specific erythropoietin receptors on red cell progenitors
Increases the release from the bone marrow
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A 2 . Pharmacodynamics
Hematocrit (hct) and hemoglobin (hgb) level and serum erythropoietin levels
Inverse relationship
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A 2 . Pharmacodynamics
Serum erythropoietin levels
Less than 20 iu/L in nonanemic individuals
Level rises exponentially as the hct and hgb fall
Except for anemia with chronic renal failure
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HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A
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HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS A.. Erythropoietin (Epoietin alfa) A
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AGENTS USED IN ANEMIAS & HEMATOPOIETIC GROWTH FACTORS HEMATOPOIETIC GROWTH FACTORS B . Myeloid Growth Factors
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