DOTES Microbiology

Microbiology  Basic Medical Science Time: 40 mins

DOTES Entry Level Exam Total Marks: 50 | Pass Marks: 30

DominusTestimonium Pleaseuseadarkpencil/pentocompl Pleaseuseadarkpencil/pentocompletethetest.Readtheinstruc etethetest.Readtheinstructionsatthe tionsatthe beginingcarefully.ThisisaSampleT beginingcarefully.ThisisaSampleTestPaperforDOTESEntryLe estPaperforDOTESEntryLevelExamination velExamination towardDOTESCert.LevelA.Thisseriesconta towardDOTESCert.Leve lA.ThisseriescontainsquestionsinMic insquestionsinMicrobiology.Thisis robiology.Thisis anentrylevelexaminationtobeeligible anentrylevelexaminationtobeeligibletoappearforDOTECertificatio toappearforDOTECertificationLevels. nLevels.

PleaseNote:ThereisaNegativeMarkingof(-1)foreachincorrectresponse. 1. Mycosisinfectionthatiscausedduetominortraumatotheskinfrom Mycosisinfectionthatiscausedduetominortraumatotheskinfromthornsor thornsor splinters:  A coccidioidomycosis

C blastomycosis

B actinomycetemcomitans

D chromoblastomycosis

2. Inclusionbodywh Inclusionbodywhichisdiagnos ichisdiagnosticof ticofG Granulom ranulomainguinale: ainguinale:  A Hansemanncells

C Medlerbodies

B Donovanbodies

D Russellbodies

3. Whichoft Whichofthefo hefollowingisnott llowingisnottruea rueabout boutOr Orthom thomyxovirus yxovirus? ?  A belongstofamilyofRNAvirus

C belongstofamilyofDNAvirus

B causativeagentofinfluenza

D picornavirus

4. Influenzaviru InfluenzavirusAst sAstrainth rainthatwas atwasresp responsiblefo onsibleforcau rcausing1968 sing1968-1969 -1969pande pandemic mic HongKongflu  A H3N2

C H2N2

B H1N1

D H3N8

5. Presenceof Presenceofwhichof whichofthe thefollowinginclusionbod followinginclusionbodiesisdiagnos iesisdiagnosticof ticofSarco Sarcoidosis? idosis?  A Schaumannbodies

C Michaelis-Gutmannbodies

B Mikulicz'scells

D Dutcherbodies

6. Matcht Matchthefo hefollowinginclusionbodieswith llowinginclusionbodieswiththeir theircharac characterist teristicdisease icdiseases/disor s/disorders: ders:  A.

Heinzbo Heinzbodies dies

A. measles measles

B.

Cabots ring

B. ad adenovirus

C.

acidophilic Cowdry Type A

C. herpes simplex virus

D.

basophilic Cowdry Type B

D. abnormal hemoglobin precipitation

E.

Warthin finkeldey bodies

E. megaloblastic anemia

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Microbiology  7. Mechanism Mechanismofa ofactiono ctionofer ferythr ythromy omycin: cin:  A blockingDNAbiosynthesis

C blockingproteinbiosynthesis30S ribosome

B blockingcellwallbiosynthesis

D blockingproteinbiosynthesis50S ribosome

8. Picktheincorr Picktheincorrect ectstat stateme ements ntsabout aboutOs Osteoca teocalcin lcin  A collagenousproteininbone

C dependsonVitaminD

B serumlevelsindicateosteoblast activities

D methodsofdetectionis immunoassay

9. Elevatedlevelsof Elevatedlevelsofalkalinephos alkalinephosphata phatase(AL se(ALP)isf P)isfoundin oundin  A viralhepatitis

C myocardialinfarction

B obstructivejaundice

D musculardystrophy

10. Elevatedlevelsof Elevatedlevelsofleukocy leukocytealka tealkalinephospha linephosphatase tase(LAP) (LAP)isfoun isfoundin din  A chroniclymphocyticleukaemia (CLL)

C paroxysmalnoctural hemoglobinuria(PNH)

B aplasticanemia

D acutemyelogenousleukaemia (AML)

11. Infections Infectionswhichcaus whichcauseleukem eleukemoidreac oidreaction tion  A Epstein-Barrvirusinfection

C psittacosis

B histoplasmosis

D systemiclupuserythematosus

12. Whatisno Whatisnottr ttrueof ueofstr strict(ob ict(obligate)an ligate)anaerob aerobes? es?  A lacksuperoxidedismutaseand catalase

C Escherichiacoliisanexampleof strictanaerobe

B peptococcusanaerobiusare intoleranttooxygen

D gatheratthebottomofatubeof thioglycollatebroth

13. Testtubes Testtubesandg andglasswares lasswaresare arester sterili ilizedb zedby y  A autoclave

C moistheatsterilization

B pressuresterilization

D hotairoven

14. Rheologicalproperties Rheologicalpropertiesoff offoodc oodconcer oncernswith nswith  A sterilizationoffood B consistency,textureandfluidityof food

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C preventinggrowthofbacteriaand fungiduringpreservationoffood D fortificationandenrichmentoffood

Microbiology  15. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsisn tsisnott ottruer rueregarding egardingreov reoviruses? iruses?  A includerotaviruseswhichcause gastroenteritisinhumans

C icosahedralsinglestrandedlinear RNA

B icosahedraldoublestranded linearRNA

D belongstoflavivirusfamilies whichcausedenguefever

16. Whatist Whatistruea rueabout boutrhabdo rhabdoviruses viruses? ?  A causativeagentofRatbitefever B β-adrenergicreceptorsactashost cellsurfaceproteinviralreceptor

C genomeislineardoublestranded positive-senseRNA D genomeislinearsinglestranded negative-senseRNA

17. Whatisno Whatisnottr ttrueabo ueaboutac utactinom tinomycet ycetes? es?  A fungithatcloselyresemble bacteria

C formbranchingfilamentsand hyphae

B havehighG+Ccontentintheir genome

D produceasexualsporesor conidiospores

18. Whichoft Whichofthefo hefollowingistrue llowingistrueregar regardingm dingmadura aduramy mycosis? cosis?  A granulomatousinfectionofthe skinthatinvolvesboneand muscles

C treatmentofactinomycetomais primarilysurgical

B maduramycosisduetobacteriais causedbyLeptosphaeria

D maduramycosisduetofungiis causedbyNocardia

19. Pathogenwhichis Pathogenwhichisanimp animporta ortantca ntcauseof useoftoxic toxicshock shocksynd syndrom rome: e:  A staphylococcussaprophyticus

C staphylococcusepidermidis

B staphylococcusaureus

D streptococcusviridans

20. Whichoft Whichofthefo hefollowingisacoagu llowingisacoagulasenega lasenegatives tivespecies? pecies?  A yersiniapestis

C staphylococcusepidermidis

B staphylococcusaureus

D staphylococcusintermedius

21. Picktheincorr Picktheincorrect ectstat stateme ements ntsabout aboutN.g N.gonorr onorrheae heae  A humanantibodiesIgMare directedagainstgonococcal antigenicsidechains

C unencapsulatedgram-negative non-motilediplococcus D encapsulatedgram-positive motilediplococcus

B characterizedby lipopolysaccharideOantigenic sidechains

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Microbiology  22. Whichoft Whichofthefo hefollowingorganism llowingorganismspro sproduces ducesam ametal-indep etal-independent endentIgAs IgAspecific pecific serineendopeptidase?  A Streptococcuspneumoniae

C Haemophilusinfluenzae

B Neisseriagonorrhoeae

D alloftheabove

23. Matcht Matchtheincuba heincubationper tionperiodswitht iodswiththeircor heircorrect rectdisease diseases: s:  A.

Mump Mumps s

A. 9-12 9-12da days ys

B.

Chicken pox

B. 9 - 21 days

C.

Measles

C. 14 - 18 days

D.

Pertussis (Whooping cough)

D. 7 - 14 days

E.

Roseola

E. 5 - 15 days

24. Gonococc Gonococcihasde ihasdevelopedr velopedresistan esistanceaga ceagainstallof installofthe thefollowingdrugs followingdrugsexce except: pt:  A quinolones

C ceftriaxone

B penicillin

D spectinomycin

25. Mostco Mostcomm mmoncau oncauseof seofnonnon-gonococ gonococcaluret calurethritiswhich hritiswhichisnot isnotcause causedbyb dbybacte acteria ria  A chlamydiatrachomatis

C tichomonasvaginalis

B herpessimplexvirus

D ureaplasmaurealyticam

26. Typhoidfever Typhoidfeverischar ischaracter acterizedby izedbyallofth allofthefollowinglabor efollowinglaboratory atoryfindings findingsexcept except::  A serumALT:LDHratio>9:1

C leukopenia

B increasedESR

D serumALT:LDHratio<9:1

27. Incubationpe Incubationperiodof riodofdengu denguefev efeveris eris  A 5-15days

C 5-10days

B 3-14days

D 7-14days

28. Drugswh Drugswhich ichcan canca cause useleu leukop kopenia enia  A lithium

C corticosteroids

B clozapine

D clonazepam

29. Whatisno Whatisnottr ttrueabo ueaboutSm utSmallpox(v allpox(variola)? ariola)?  A belongstogenusorthopoxviridae B genomeislineardouble-stranded DNA

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C genomeislinearsingle-stranded DNA D presenceofGuarnieribodies

Microbiology  30. Whichoft Whichofthefo hefollowingisnott llowingisnottruea rueabout boutinclusionbodies inclusionbodies  A Levinthal-Coles-Lillieinclusion bodiespathognomicofpsittacosis

C Howell-Jollybodiescharacteristic ofMolluscumcontagiosum

B Torresbodiesarecharacteristicof Yellowfever

D representsitesofbacterialgrowth andmultiplication

31. Secondmos Secondmostco tcomm mmonm onmalignancyin alignancyinAIDSpat AIDSpatients ients  A Kaposi'ssarcoma

C Hodgkin'slymphoma

B Burkitt'slymphoma

D Non-Hodgkin'slymphoma

32. Whichcapsular Whichcapsularantigen antigencom component ponentof ofS.ent S.entericas ericaserot erotypeof ypeof S.typhireducesthe S.typhireducesthe expressionofneutrophilchemoattractantinhostcells?  A Piliantigen

C Flagellarantigen

B Viantigen

D K5capsularpolysaccharide

33. Daneparticleischa Daneparticleischaract racteristico eristicofwhich fwhichHepatitisv Hepatitisvirus? irus?  A HepatitisB

C Infectioushepatitis

B HepatitisC

D HepatitisD

34. Whatist Whatisthepr heprimary imaryreas reasonbeh onbehindscar indscarcityof cityofneut neutrophilsininte rophilsinintestines stinesofpa ofpatients tients withtyphoidfever?  A capsulemediatedstimulationof TLRdependentIL-10production

C enhancedIL-8productionin intestinalmucosa

B capsulemediatedreductionof TLRdependentIL-11production

D depressedIL-8productionin intestinalmucosa

35. Presenceof PresenceofantiHBe antiHBeantibodies antibodiesinpatient inpatientsindicate sindicates: s:  A patientshaverecoveredfrom hepatitisBinfection

C lateconvalescence D badprognosis

B highinfectivity

36. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsisn tsisnott ottrueab rueaboutSp outSphingom hingomyelin? yelin?  A containsceramide B phosphatidylethanolaminereacts withceramidetoform sphingomyelin

C canserveasaprecursorof glycolipids D essentialcomponentofmyelinof nervefibers

37. Treatmen Treatmentof tofchoice choicefor forhydat hydatidcyst idcystinliver inliver  A thiabendazole

C albendazole

B praziquantel

D alloftheabove

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Microbiology  38. Match atcht the hefo followin llowing: g:  A.

stron strongylo gyloides idesst sterc ercora oralis lis

A. urinary urinarysc schist histoso osom miasis

B.

schistosoma haematobium

B. biliary obstruction and cholangitis

C.

schistosoma mansoni

C. hyperinfection syndrome

D.

clonorchis sinensis

D. intestinal schistosomiasis

39. Organwhich Organwhichismo ismostc stcomm ommonlyth onlythesite esiteofhy ofhydatidc datidcyst ystinfect infection: ion:  A peritoneum

C brain

B lungs

D liver

40. Whichoft Whichofthefo hefollowingisatre llowingisatreponem ponemalbloodte albloodtest? st?  A TPHA

C USRtest

B RPR

D VDRL

41. Helminthicautoinf Helminthicautoinfections ectionsinhum inhumansiss ansisseenwith eenwith  A Schistosomamansoni

C Strongyloidesstercoralis

B Enterobiusvermicularis 42. Virussh Virusshedd eddingd ingdoes oesno noto toccu ccurin rin  A herpeszoster(VZV)infection

C herpessimplexviralinfection

B rabiesinfection

D poliomyelitisinfection

43. Themost Themostfreq frequentlyu uentlyuseda sedapproac pproachfo hforth rthelaborat elaboratoryd orydiagnosisof iagnosisofsyph syphili ilis: s:  A Wassermantest

C VDRL

B MHA-TPtest

D FTA-ABS

44. Drugthatc Drugthatcanbe anbeusedf usedfort ortreat reatmen mentof tofmo molluscum lluscumconta contagiosum giosum::  A artemesinin

C salvinorinA

B calaminelotion

D cantharidin

45. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsis/ tsis/areinco areincorrec rrectabo taboutc utchickenp hickenpoxvirus oxvirus? ?  A alsocalledherpessimplexvirus type1

C aspirincanbeusedtoreduce feverinchickenpox

B alsocalledherpesvirustype3 (HHV-3)

D genomeislineardsRNAduplex

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Microbiology  46. Matcht Matchthefo hefollowingpathoge llowingpathogens(v ns(viruses) iruses)witht withthediseas hediseasest estheyc heycause: ause:  A.

Human Humanher herpes pesvir virus ustyp type1 e1 (HHV-1)

 A. infect infectious iousmo monon nonucleo ucleosis sis

B.

Varicella zoster virus (VZV)

B. herpes gladiatorum

C.

Human pappiloma virus (HPV)

C. genital herpes

D.

Human herpes viru irus type 2 (HHV-2)

D. shing ingles les

E.

Human herpes viru irus type 4 (HHV-4)

E. genit genital alwa wart rts s

47. Anontrepone Anontreponemals malscreen creeningtes ingtestfo tforsy rsyphilis philis  A Wassermantest

C VDRL

B Kahntest

D TPparticleagglutinationassay (TPPA)

48. Whichoft Whichofthefo hefollowingstate llowingstatemen mentsab tsabout outmyc mycobact obacterium eriumisnot isnottrue? true?  A anaerobic,motile, nonencapsulated,nonsporing

C acidfastduetopresenceof mycolicacid

B aerobic,nonmotile, nonencapsulated,nonsporing

D catalase-positivetestisusedto differentiatetuberclebacillifrom atypicalmycobacteria

49. Whichoft Whichofthefo hefollowingparasites llowingparasitesdono donothav thaveanint eaninterm ermediateh ediatehost( ost(IH)? IH)?  A onchocercavolvulus

C ancyclostomaduodenale

 Ascarislum lumbric bricoides oides B  Ascaris

D Trichinellaspiralis

50. Matcht Matchthepar heparasiticdisea asiticdiseaseswith seswiththeir theirmod modeof eoftran transm smission: ission:  A.

Onchoce nchocercia rciasis sis

A. uncook uncooked edfish fish

B.

Strongyloidiasis

B. uncooked pork

C.

Opisthorchiasis

C. uncooked beef  

D.

Taenia saginata

D. through skin

E.

Taenia solium

E. bite of black fly Simulium

Basic Medical Sciences

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