BioInformatics National Certification (BINC) Examination 2009 Instituted by: Department of Biotechnology, Government of India, New Delhi Coordinated by: Bioinformatics Centre, University of Pune Sample Questions for Paper I (Objective type) Answers are shown in bold type & are underlined
Subject: BIOINFORMATICS 1. What What is PROS PROSIT ITE? E? A. B. C. D.
A databa database se of prote protein in struct structure uress A databa database se of intera interactin cting g protei proteins ns A databa database se of of protei protein n motifs motifs A sea searc rch h too tooll
2. You have have two distantly distantly related related protein proteins. s. Which Which BLOSUM BLOSUM or PAM PAM matrix matrix would you you choose to compare them? A. B. C. D.
BLOSUM45 BLOSUM 45 or PAM250 PAM250 BLOS BLOSUM UM60 60 or PAM1 PAM1 BLOS BLOSUM UM80 80 or or PAM1 PAM120 20 BLOS BLOSUM UM80 80 or PAM1 PAM1
3. What What is the differ differenc encee between between RefSeq RefSeq and and GenBank GenBank?? A. B. C. D.
RefSeq includes includes publicly publicly availab available le DNA sequen sequences ces GenBank GenBank includ includes es nonredu nonredundant ndant curated curated data data GenBank GenBank sequen sequences ces are are derived derived from RefSeq RefSeq RefSeq sequenc sequences es are deriv derived ed from from GenBank GenBank
4. The two two main main features features of any any phyl phylogenet ogenetic ic tree are the the A. B. C. D.
clad clades es and and the the nod nodes es topology topology and the branch branch lengt lengths hs clad clades es and and the the root root alignm alignment ent and and the boot bootstr strap ap
5. The approach approach that that can be used used to predict predict the the 3D structure structure of a protein protein which which has has no detectable sequence similarity with the available templates is A. homo homolo logy gy mode modeli ling ng B. comp compar arati ative ve modeli modeling ng C. fold fold reco recogn gnit itio ion n D. ab initio modeling Sample questions for BINC examination: Paper I
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Subject: Biology 1. Phase of the cell cycle during which replication occurs is A. B. C. D.
G0 phase M phase G1/G2 phase S phase
2. Polycistronic mRNA refers to A. B. C. D.
mRNA which is transcribed by multiple RNA polymerases mRNAs that are simultaneously translated mRNA that is translated by many ribosomes simultaneously mRNA with multiple open reading frames
3. Total number of carbon atoms in lauric acid is A. B. C. D.
10 12 14 16
4. An enzyme was purified from liver extract. The total activity and total protein were estimated at each step of purification. During this process the A. B. C. D.
specific activity increases and total activity increases specific activity decreases and total activity increases specific activity increases and total activity decreases specific activity and total activity remain unchanged
5. Which pair of amino acids absorbs the most UV light at 280nm? A. B. C. D.
Thr and His Trp and Tyr Cys and Asp Phe and Pro
Sample questions for BINC examination: Paper I
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Subject: Physical and Chemical Sciences 1. Equilibrium constant, Kp, of a chemical reaction has A. B. C. D.
no unit. unit in the order of pressure. unit in the order of concentration. unit containing both concentration and pressure.
2. Which of the following statements is true? A.Tetrachloromethane is a polar solvent while chloroform is not. B.Chloroform is a polar solvent while tetrachloromethane is not. C.Both chloroform and tetrachloromethane are polar solvents D.Both chloroform and tetrachloromethane are non-polar solvents 3. In magnetic resonance imaging, one looks at A.proton signals of water B.proton signals of proteins C.nitrogen signals of proteins D.phosphorus signals of DNA or phospholipids
4. Distance between the point (2, -3, 4) and any point on the surface x2 + y2 + z2 – 4x + 6y –8z + 4 = 0 is A. B. C. D.
4 5 6 7
5. Mean and variance are equal for a distribution which is A.symmetric B.normal C.poisson D.skew
Sample questions for BINC examination: Paper I
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Subject: Information Technology 1. In which of the following systems, there is a stringent timing constraint? A. B. C. D.
Batch Online Real-time Offline
2. Which protocol is used by browsers to communicate between two machines? A. B. C. D.
ftp ssl tcp http
3. The relationship between the colour of the eyes and the colour of the skin in humans is an example of A. B. C. D.
