Regarding acute inflammation a) Initial Initial vasoconstr vasoconstriction iction is the the result result of histamine histamine and and nitric oxide oxide b) Stasis occurs due to vasodilatation and the larger caliber of vessels c) Increased Increased permeability permeability leads to protein protein depleted depleted plasma plasma leaking leaking into into the tissue tissue d) Initial Initial formation formation of endothel endothelial ial gaps lasts lasts for only only !"#$ !"#$ minutes minutes e) Cytokines Cytokines %I&" %I&" and and '() '() are respon responsible sible for for the early early permeabil permeability ity
*istamine is involved in acute inflammatory responses and is released from mast cells+ ,hich of the follo-ing statements is incorrect. a) It is found found in blood blood basophils/ basophils/ platelet plateletss and mast cells cells b) It causes increased permeability of arterioles c) It may may be be release released d by physical physical trauma trauma d) It causes causes const constric rictio tion n of large large vess vessels els e) It acts acts on the micro microcirc circula ulatio tion n via * recep receptor torss
Complement a) 0roteins 0roteins are usually usually stored stored in an active active state state in lysosoma lysosomall molecules molecules b) 0ath-ay is inhibited by C# cleavage c) C# is the most most abundan abundantt protein protein in in the complement complement family family d) Activation Activation by the the classical classical path-ay path-ay involves involves microbi microbial al surface antigen antigenss e) Cobra Cobra venom venom acti activat vates es the lect lectin in path-a path-ay y Regarding mediators of inflammation a) '( is a chemokine chemokine -ith chemoattracta chemoattractant nt propert properties ies b) '( contributes to cachexia of disease c) '( and and I&" I&" are produced produced mainly mainly by activated activated leukocytes leukocytes d) 'he systemic systemic acute acute phase respon response se is induced induced by MI0" MI0" and RA('1S RA('1S chemokines e) 0A 0A causes causes vasodilat vasodilation ion -hen -hen expressed expressed at high high levels levels Chronic inflammation is characteri2ed by all of the belo- except a) 'issu issuee destr destruc ucti tion on b) Angiogenesis c) Infilt Infiltrati ration on -ith -ith neutro neutrophi phils ls d) ibrosis e) Increas Increased ed tissue tissue concentr concentrati ation on of lymphoc lymphocyt ytes es
