Methcathinone HCl FAQ v2.2 Contents: 1. What is methcathinone? 2. Theory and Concepts leading to this synthetic approach . !reparation " A simple and practical approach. #. Testing the prod$ct %rom a&ove synthesis '. Comentary on the dr$g itsel% (. Anecdotal reports o% $se ). *o$rces %or materials listed in the synthesis +. ,-tensions " chemically similar dr$gs amino/etones0 . ther 3ata " 4e%erences and copies o% 5o$rnal articles. 16. Q$estions 7 Ans8ers regarding this %ile. 11. Concl$sion " a&o$t the FAQ itsel% 999999999999999999999999999What is Methcathinone9999999999999999999999999999 the designer dr$g methcathinone HCl is also /no8n as Cat;
*3 Methamphetamine; on the other hand; is >,@A> 8ith a valid triplicate prescription. Chemically; Methcathinone is 2"methylaminopropiophenone. The name Methcathinone is derived %rom the name o% the dr$g cathinone; o&vio$sly; 8hich in t$rn is derived %rom BcathineB; an alternate name %or norpse$dephedrine; an isomer o% phenpropanolamine. The name B,phedroneB is o&vio$sly derived %rom the %act that B,phedroneB is the /etone o% the alcohol that is ,phedrine. D D D Contrast the molec$les %or in%ormational p$rposes only: D D Methcathinone: pse$d,phedrine: Methamphetamine: D D D D E H E H H E H H D D G "C""C""CH G "C""C""CH G "C""C""CH D D E D E H D E H D D D HI""CH HI""CH HI""CH D D D D pse$dephedrine and ephedrine di%%er only in the isomerism o% the H D D gro$p. They are in most 8ays identical as prec$rsors to either dr$g.D DD
99999999999999999999999999999999Theory99999999999999999999999999999999999999 The JMn# *ynthesis: Theory and Kac/gro$nd This synthesis $ses JMn#; a damn strong o-idiLer that $nder most conditions might not &e the ideal reactant %or this synthesis; &$t 8hen treated 8ith some degree o% respect; 8ill 8or/ e-tremely 8ell. This synthesis relies on t8o principles $nderstanda&le &y anyone 8hos had chemistry at the college level.. or any e-perience 8ith chemicals at all. ,ven &a/ing a ca/e. Theres t8o other synthesises ma/ing their 8ay a&o$t the net; that = am
a8are o%. The %irst $ses the less potent CH4MAT,* 8hich are more to-ic0 at room temperat$re; and the second $ses JMn# 8ith a variety o% other 8eird things and conditions " al&eit at room temperat$re. *ee/ing to avoid the chromates 8hile also avoiding $sing a lot o% more advanced techni$e and e$ipment; leaves only one option. *lo8ing JMn# do8n to a reasona&le rate. 1. The reaction in the FAQ is dill$ted considera&ly... 2. The reaction in the FAQ is done 8ay colder than any other cat synth. !resto; the t8o /ey elements to changing the rate o% a reaction. The end res$lt is $ite pleasing and economical; and the reaction is a&o$t as %ast as the chromate recipe. ther than that; the only commentary on the recipe is that its a standard alcohol to /etone o-idiLation proceed$re %or the most part. Nield; 8hen meas$red is li/ely to vary according d$e to a %e8 things: 1. The e%%iciency o% the pse$dephedrine e-traction employed. 2. Temperat$re o% the reaction " higher temperat$res are %ar more apt to yield side prod$ct deamination?0 8hich 8ill &e lost. . Care ta/en d$ring solvent B8ashB o% %inal prod$ct. #. 4ealiLe that JCl is a very li/ely to &e present in the %inal prod$ct. and ad5$st estimated yield %rom 8eight accordingly. 9999999999999999999999999999999!reparation9999999999999999999999999999999999 The o&5ective o% this proced$re is to prod$ce methcathinone in a reletively p$re %orm. This 8as accomplished as evidenced &y a resid$eE&$rn test; and $ite a %e8 testimonials %rom $sers. A secondary o&5ective 8as to not re$ire complicated la& proceed$res " avoiding even an acid"&ase e-traction and to stray a8ay %rom to-ic &yprod$cts. Opon completion; yo$r methcathinone sho$ld &e Bp$reB 8ith a small potassi$m s$pplement... The methcathinone prod$ced &y this proceed$re is no do$&t not as p$re as that 8hich may &e prod$ced $sing a typical acid"&ase solvent e-traction; &$t certainly rivals it nicely. And the conditions re$ired %or this method are %ar less demanding; as none o% the to-ic chromates are $sed. I,,3,3 F4 !4,!A4AT=I: Collander 8E reletively small holes *haved =ce !se$dephedrine ta&lets; 166 o% 6mg each. !otassi$m !ermaganate crystals; o% reasona&ly p$re origin no lead; other to-ic metals allo8ed.0 !$ri%ied 8ater TA! WAT,4 W=>> 9IT9 FOICT=I A3,QOAT,>N =I M*T CA*,*0 4e%ridgerator chilled to 5$st over 6c. T$r/ey Kaster or other method o% meas$ring 8ater in mililiter $antities. An area heated or chilled to Broom temperat$reB 4O@H>N 2'c or )'% =sopropanol %or $enching JMn#. ,thanol optional %or speeding drying process. Acetone %or the 8ashing o% crystals. Most /itchens do IT come e$ipped 8ith a scale capa&le o% meas$reing
individ$al grams; let alone miligrams. And in many states; possession o% s$ch a %inely t$ned instr$ment; 8hile not a crime; certainly is admissa&le as one o% many items o% evidence to &e $sed in a criminal investigation. 3e%initly something to &e avoided. Jeep all the ingredients and all the la&8are in its Beverday"$seB place; and theres no evidence to s$pport the e-istance o% a cat la&. And no need to man$%act$re the st$%% in the high desert regions either; since 8eird scents are %or the most part avoided. C>,AI=I@ TH, !*,O3,!H,34=I, TAK>,T* /$dos to !!eye %or his doc$ment B@etting the 4ed o$tB0 166 o% the 6mg generic pse$dephedrine ta&lets 8ere placed into a collander containing a&o$t the same Bvol$meB o% cr$shed ice. They 8ere s8irled aro$nd in this collander over a sin/ 8ith r$nning 8ater to 8ash the color do8n the drain $ntil all the ice had melted and 8ashed thr$. The ta&lets 8ere then rinsed once 8ith distilled 8ater; and removed to a glass 5ar %or e-tracting. 9 IT,: The r$nning 8ater /ept the drain clean; &$t 8asnt ever in contact 9 8ith the ta&lets themselves. This con%$sed a n$m&er o% people. &vio$sly; 9 its not necessary %or this... 5$st convienent = g$ess. 9 3o not 8ash the ta&lets OI3,4 WAT,4 8ith cr$shed ice. 4ather; place 9 them in the colander 8ith cr$shed ice; thats it; and stir them aro$nd;.. 9 The very cold ice does a minim$m o% disolving WH=>, its a&rasion removes 9 the coloring. M,A*O4=I@ OT 7 !4,!A4=I@ TH, JMn# F4 4,ACT=I: JMn# is sat$rated at 2'c in 8ater " 166ml o% sol$tion holds ).#g This time = 8ill &e $sing 5$st $nder g o% pse$dephedrine i% e-tract 8as per%ect 8o$ld &e e-actly g pse$dephedrine. Jeep in mind that 8hen preparing the sat$rated sol$tion yo$ need room temperat$re and time " yo$ need to let the crystals settlePPP ,-cess $ndisolved JMn# 8ill stay Bs8irled inB the sol$tion. >et it settle %or a 8hile at room temp; then meas$re the 1'm> or so... Fail$re to do this 8ill res$lt in a %ailed synthesis. =% yo$ are too impatient to do this; then yo$ sho$ld p$rchase a miligram"$antity scale. =n acid conditions; 1 mole o% JMn# 8ill o-idiLe ' hydrogens. =n &asic conditions; 1 mole o% JMn# 8ill o-idiLe hydrogens. We 8ont &e speci%ically $sing either; &eca$se JMn# also 8or/s nicely $nder ne$tral conditions. =t can &e reasona&ly anticipated that the !se$dephedrine HCl 8ill posess some8hat o% an acidic character; so 8e 8ill ass$me acidic conditions; 8hich also 8ill allo8 $s to avoid $sing T MOCH JMn#... small amo$nts o% pse$dephedrine 8ill go $nnoticed in the %inal prod$ct; &$t gooey messes 8ill not; %or o&vio$s reasons. The !se$dephedrineEJMn# ratio sho$ld &e 2.'Mole to 1Mole; according to previo$s calc$lations. g pse$dephedrine is 1+.1'mMole; there%ore ).2(mMole o% JMn#; or 1.1#+g 8ill &e needed %or the reaction. This means that 1'.#'m> o% concentrated sol$tion at room temperat$re 8ill &e needed. &vio$sly $s /itchen chemists cant &e that precise; so aim a little high; as previo$s margins 8ere set a&o$t 16 lo8... $se AT >,A*T 1'.#'m> prepared at AT >,A*T 2'c. This 1'.' or so m> o% sol$tion is then dil$ted 8ith 2'6m> H2; and is
started chilling in a re%ridgerator; 8ith 5$st over 6c the goal. ,RT4ACT=I@ AI3 !4,!A4=I@ TH, !*,O3,!H,34=I, HCl F4 4,ACT=I: !lace the 5$st 8ashed and pro&a&ly slightly red pse$dephedrine ta&lets in a 5ar; and po$r 1'6m> o% 8ater over them. Io8 heat this in a micro8ave at lo8 po8er $ntil it gets BhotB &$t not &oiling. *tir the crap $ntil the ta&lets %all all to pieces; then let the po8dery F=>>,4 material settle; leaving pse$dephedrine in sol$tion all &y its lonesome; or at least mostly &y its lonesome. *lo8ly po$r this TH4O co%%ee %ilter into another 5ar. When this is done; scrapeEsha/eEget any po8der ca$ght in the %iller and stic/ it in the F=4*T 5ar; the one that might have some sl$dge at the &ottom still. Io8 add another 1'6m> o% 8ater; heat $ntil BhotB; stir; then let settle. !o$r this thr$ the co%%ee %ilter. @et the po8der st$c/ in the %ilter again &ac/ 8ith the sl$dge and add still another 1'6m> and heat $ntil BhotB. This time po$r thr$ the %ilter; and yo$r done. =t is 8orth noting that the %iller material clogs the %ilters and 8ill dramatically increase time %or %ilteration to ta/e place; li/e %rom 6 seconds to 6 min$tes. The enlightened 8ill at once realiLe that the easiest 8ay to avoid this is to decant the top layer thr$ the %ilter %irst; 8aiting $ntil necessary to d$mp the sl$dge onto the %ilter. !lace the pse$dephedrine sol$tion in the %ridge to chill; ne-t to the JMn# sol$tion. >a&el the 5ar so that in the event yo$ are raided d$ring the proceed$re more evidence 8ill e-ist to prosec$te yo$. 9 9 9 9 9 9 9 9 9
=t sho$ld &e noted at this point that m$ch %eed&ac/ has &een recieved %rom B%ailedB synthesis ca$sed entirely &y not letting the mi-t$re chill long eno$gh. =% yo$r impatient; place it in the %reeLer $ntil ice &egins to %orm then allo8 it to 8arm 5$st eno$gh to melt &e%ore mi-ing remem&er; the I>N reason this 8or/s at all is &eca$se the dil$tion and temperat$re are s$ch that the permaganate o-idiLes the alcohol to a /etone and then @,T* O*,3 O! &e%ore it can do anything else.
IW TH, FOI K,@=I* TH, 4,ACT=I: And %or the ne-t %e8 ho$rs; nothing happens. This is a good time to stop %or l$nch. A%ter a %e8 ho$rs; the t8o cold sol$tions are mi-ed together; stirred; and replaced in the %ridge overnight +"12 ho$rs. =n the morning; instead o% a !O4!>, color in the 5ar; there is a mostly clear layer; and a &ro8nish g$n/ on the &ottom; 8hich agitates easily. Keca$se its sa%er to err on the side o% ca$tion; 166m> o% )6 isopropyl alcohol is added and stirred. =% a p$rple color remains; odds are that an ,RC,** o% JMn# 8as $sed and the synthesis 8ill %ail; or that not eno$gh time 8as allo8ed %or the reaction to ta/e place. 3o not allo8 more than 12 ho$rs in any case; instead give the JMn# something else to che8 on the isopropyl alcohol0. This is the sole reason %or the addition o% isopropanol. ,thanol or methanol 8ere not $sed &eca$se they tend to o-idiLe %$rther to s$&stances
not so easily seperated %rom the prod$ct. Acetone %rom the isopropanol 8ill evaporate easily. >et the mi-t$re sit %or ro$ghtly 2 ho$rs on a shel%; and at the end o% this period it sho$ld &e aro$nd room temperat$re. Time to room temp 8ill vary 8ith dimentions and thic/ness o% the container; o% co$rse. This mi-t$re is %iltered thr$ t8o co%%ee %ilters stac/ed on top o% each other 8ith the intention o% catching all the little maganeese particles that have precipitated. =n an ideal 8orld; yo$ can do this on the %irst try and get a per%ectly clear li$id on the &ottom. =n a less than ideal 8orld; it 8as necessary to again 4,C> *>=@HT>N the %iltered mi-; and %ilter this thr$ another pair o% co%%ee %ilters. My h$nch is that the slight cooling in the %ridge; andEor the e-tra time allo8ed the rest o% the maganeese to cl$mp together into pieces too &ig to escape $n%iltered. 9 9 9 9
many have %o$nd t8o; three; or even %o$r re%iltrations to &e necessary apparently the choice in co%%ee %ilter places a dramatic role. The tr$ly patient chemist co$ld $se a !A!,4 %ilter; provided it is %ree o% anything that 8o$ld end $p in the mi-t$re coloring; etc0
This %inal sol$tion 8as %o$nd to &e &asic 8ith a pool test /it; no s$prise i% yo$ %ig$re that the HCl part o% the !%ed 8as $sed $p in the o-idation as acid. 4es$lts 8ill vary on the %inal pH. =% its already acidic; yo$ dont need to add any more acid heheh 9 most have %o$nd a pool test /it 8oe%$lly inade$ate; and have s$ggested 9 $sing pH paper. = almost 8onder i% the amate$r pH meter made %rom &oiling 9 red ca&&ages 8o$ldnt &e &etter; as it is also 8ider range. *ee &elo8. MAJ=I@ @>=TT,4=I@ WH=T, C4N*TA>*: =% not yet; d$ring this part o% the proceed$re yo$ 8ill de%initly smell the methcathinone. =t has a stronger odor than methamphetamine; KOT the odor o% methcathinone is pleasant; even to those 8ho have not e-perienced the dr$g some people >,A4I to li/e certain smells; &$t cat 5$st smells plain good. 9 The smell has &een most closely li/ened to pistacio ice cream; o% all 9 things. Will 8onders never cease... Considering the %act that theres either isopropanol or acetone in the a&ove mi-t$re; its pro&a&ly not a 8ise idea to 5$st load yo$r rig straight %rom it and shoot. And considering yo$ might 8ant to give some o% yo$r creation a8ay; itd s$re &e nice to have a transporta&le %orm. 9 IT,: A 9very small9 amo$nt o% conc. HCl is re$ired. Add it one drop 9 at a time 8ith stiring. Io8 to ma/e s$re the st$%% is indeed the HCl %orm... Add HCl 8ith stiring to ad5$st the pH to slightly acidic; i.e. 5$st $nder ) li/e ' " (.'. This 8ill ens$re that Methcathinone HCl is prod$ced; and not the %ree&ase; 8hich can decompose easily. While the original FAQ s$ggesting $sing a pool test /it to meas$re the change in pH across a very narro8 range; many people havent got this to 8or/; and instead a less sensitive agent pH paper?0 is reccomended. !erhaps even the classic Bred ca&&ageB pH tester 8ill 8or/... see any /ids chemistry &oo/ %or more details on this plant"&ased pH test... =n any case; i% its concentrated HCl; add it I, 34! AT A T=M, 8ith stiring and chec/ing o% the pH. =% yo$ add
too m$ch HCl; the crystals 8ont seem to dry o$t properly. Fear not; place them in a %reeLer or some s$ch; then ta/e them o$t let them tha8 7 dry more; they 8ill event$ally %reeLe 9a%ter9 the e-cess HCl moves into the atmosphere. !o$r the st$%% into a glass !N4,RP &ro8nie dish. !lace on a stove and heat gently %rom &elo8 8hile &lo8ing lightly 8ith a hair dryer avoid splashing " it 8astes dr$gs and leaves resid$e. ,vent$ally there 8ill start to &e a really really thic/ gooey mess. Adding methanol or ethanol to this thins it 8hile speeding the drying process " a de%inite pl$s. =n my case; ethanol 8as $sed; altho$gh methanol may &e pre%era&le. 3oing this is pro&a&ly a m$st to dry the crystals at a reasona&le temperat$re in a reasona&le amo$nt o% time; $nless yo$ happen to have a vacc$$m p$mp lying aro$nd.... 999 While it 8o$ld seem that adding li$id 8o$ld increase drying time; this is not the case &eca$se the alcohol helps remove 8ater %rom the crystals " almost dry crystals can &e heated very hot and still not dry. For &est res$lts do not add the e-tra alcohol $ntil the drying st$%% is /inda thic/; or the %irst crystals have started to %orm. Ke care%$l not to overheat the crystals. =% they M,>T; yo$ve almost de%initly scre8ed $p.... : Washing the crystals 8ith acetone is a possi&ility &$t can dramatically red$ce yields; as Methcathinone HCl is apparently pretty sol$a&le in the st$%%. <$st save the acetone and let it dry all alone; some8here; %or a prod$ct that is smo/a&le &$t too oily to chop 7 sni%%... Methcathinone is easily recovered %rom an acetone"8ash &y slo8 evaporation; and s$ch recovered glo&sEh$n/sEcrystalsEslimeEooLeE8hatever yo$ get sho$ld &e saved and 8ashed again; to recover any lost crystals. *trangely; certain solvents 8ill a%%ect the potency o% the end prod$ct. 3isol$tion o% the &ase in methanol 8ill res$lt in racemiLationP =% yo$ are especially disE pleased 8ith the res$lts o% a partic$lar &atch and cant %ig$re o$t 8hy; thin/ &ac/ to 8hat solvents 8ere $sed in drying andEor 8ashing. 9999999999999999999999999999999999T,*T=I@99999999999999999999999999999999999 KO4I: A &$rn"test o% acetone"8ashed methcathinone le%t almost I resid$e. The methcathinone HCl 8as heated over methane %lame in a spoon. =t %irst melted; then &egan &oiling; and %inally literally KO4*T =IT F>AM,* and 8as gone e-cept %or a spot 8here the spoon 8as possi&ly corroded. A &$rn"test o% the oily methcathinone %rom the acetone 8ash 8hich evaporated and 8o$ld have &een lost had = not /ept the &yprod$ct o% the acetone 8ash per%ormed the same 8ayP =ts oily nat$re prevented clean chopping; &$t $pon 8ashing 8ith ethyl"ether good prod$ct 8as %ormed %rom this oily cat. A &$rn"test o% ether cleaned acetone"8ash e-tract le%t nothing &ehind &$t a slight discoloring o% the shiny part o% the spoon; pro&a&ly d$e again to reaction 8ith the HCl or reaction 8ith air catalysed &y the salt nat$re o% the crystals ? TA*T,: Kitter. Io evidence o% n$m&ing o% the to$nge or sin$ses 8as evidenced. *norting the prod$ct prod$ced intense &$rning %eelings in the nostrils; stronger than saline sol$tion or la$gha&ly; = did this once to prove a
point s$gar 8hich doesnt %eel at allP; a&o$t as m$ch sting as 8ith methamphetamine; and no 8here near as m$ch sting as 8as once o&tained %rom snorting diphenhydramine concentrated %rom &enedryl a very st$pid e-periment in nasal congestion... *M,>>: Typical o% a /etone " s8eet. nce report says it smells li/e Bpistaccio ice creamB 8hen 8et. The dry crystals dont smell all that m$ch; &$t it doesnt ta/e a geni$s to realiLe that once they get dogs trained %or this st$%% detection 8ill &e simple. melting point o% the HCl %orm is 1+2"1+#c according to listing &elo8. 999999999999999999999999999999999CMM,ITA4N999999999999999999999999999999999 Methcathinone 8as $sed as an antidepressant in the %ormer soviet $nion. This almost ma/es good sense; as even in a&$se doses the hangover is no8here near as severe as 8ith the amphetamines. =ndeed; &$propion; a close chemical relative; is $sed as an antidepressant in todays Onited *tates. Methcathinone 8as considered &y one company %or mar/eting in the Onited *tates as an antidepressant in the 1'6s; &$t 8as shelved d$e to Bsevere side e%%ectsB. =% yo$ve ever ta/en =mipramine or another TCA; or /no8 o% the pharmacology o% the MA= antidepressants; yo$ really 8onder a&o$t the tr$th o% this statement. The Bsevere side e%%ectB that shelved the pro5ect 8as no do$&t addiction and a&$se; not an act$al physiological side e%%ect... =% = had to characteriLe the dr$g; = 8o$ld say it ind$ces mania more so than methamphetamine; &$t psychosis m$ch less. The initial dose prod$ced some paranoia; &$t s$&se$ent doses did not ma/e this 8orse ? and in %act seemed to lessen it. This is de%initly a dr$g %or goo%ing o%%; $nli/e methamphetamine 8hich ma/es one serio$s. Methamphetamine may dramatically help certain peoples academic and or &$siness careers; &$t it doesnt appear li/ely that methcathinone 8o$ld do this; as it increases distracta&ility rather than decreases it. BThe dr$g didnt catch on in Ann Ar&or. it 8o$ld &e hard to go to classes on cat; Koyer theoriLedB ">.A. Times article on methcathinone a&$se crac/do8ns 999999999999999999999999AI,C3TA> 4,!4T* F O*,9999999999999999999999999999 Io dilation o% the p$pils 8as noticed at any level ?P?; ho8ever &oth p$lse rate and &lood press$re 8ere $p $ite a &it. Opon sni%%ing; mo$th instantly B8ateredB; and thr$ the e-perience my mo$th did not &ecome dry. *o SE"cholinergic side e%%ects appear a&sent; $nli/e either amphetamines or cocaine. When the dr$g 8ears o%%; sleep is m$ch easier to o&tain. The %irst night a%ter a day o% CATting = slept very 8ell; &$t a%ter the ne-t day o% the same = a8a/ened a%ter only 2 ho$rs o% sleep and had to ta/e diphenhydramine to ret$rn to sleep. Withdra8l is characteriLed &y sadness and %eelings o% despair; along 8ith a lac/ o% energy. thers have reported a physical 8ithdra8l; &$t these reports come %rom the high3ose michaganCatI$t cro8d. Alternately %elt hopeless or giddy and almost e$phoric. Ca%%eine appears to dramatically alleviate the depression.
B= hadnt /no8n = 8as hoo/ed. = %elt li/e = had a temperat$re o% 1 million degrees. = co$ld hardly &reathe. My 8hole &ody achedB "@rimes on his e-perience in a detotan/ in the Mar$ette co$nty 5ail. 99999999999999999999999999999999*O4C,*9999999999999999999999999999999999999 !se$dephedrine " From the ta&lets; silly. HCl " Any hard8are store; as Bm$ratic acidB. JMn# " searsWater *o%tener *ection; to regenerate iron %ilters 8ater so%tener section o% Home 3epot (El&?. " %o$nd it at a %arm s$pply store. A&o$t .66 per ll&. " Osed to stain &acteriaE&iologicals %or slides i% going this ro$te; dont &$y a /ilogram o&vio$sly0 Acetone " Hard8are stores $sed as paint thinner; to clean grease o% o%% things; etc 9999999999999999999999999999999,RT,I*=I*99999999999999999999999999999999999 ,$imolar amo$nts o% phenpropanolamine; norephedrine or norpse$dephedrine may &e easily s$&stit$ted to prod$ce CATH=II, instead o% methcathinone. 3ata indicates this is a less potent dr$g; &$t this is easily remedied &y ta/ing more o&vio$sly and di%%erent people may or may not pre%er a slightly di%%erent side e%%ect pro%ile; etc etc etc. = notice all the generic phenpropanolamine =ve come across contains vitamin c. Wo$ld it &e necessary to e-tract that %irst to ma/e cathinone? Nes; yo$ m$st remove the vitamin C. There is little do$&t in my mind that s$ch a compo$nd co$ld ma/e a simple o-idation into a gooey hell. Anto-idant that it is; Uitamin C may &e in there to /eep the st$%% %rom o-idiLing on the shelves... some catHeads have noticed that gro$nd s$da%ed %rom K$rro$ghs Wellcome has a very mild methcathinone smell to it.... 8eird; no? What other Amino/etones are pop$lar E 8idely $sed; and can = ma/e them mysel%? 3iethylpropion " Ten$ate; a C"# O*A diet pill =% yo$ can prod$ce diethylphenpropanolamine; yo$ can $se it in the a&ove reaction to prod$ce 3iethylpropion; altho$gh the time involved ma/es it do$&t%$l that yo$d 8ant to " this dr$g is not all that potent or interesting. 3,!!A co$ld pro&a&ly &e prod$ced in decent yields via a controlled temperat$re reaction 8ith &ase; !!A and chloroethane; altho$gh = have no idea 8hat conditions 8o$ld &e ideal. ,-pected sideprod$cts 8o$ld &e $nchanged !!A; ,t!!A; and ,t!!AS ions... K$propion " Well&$trin; an $nsched$led O*A antidepressant Iope. meta"Chloro;I"tert"&$tyl"Cathinone; or &$propion; 8o$ld no do$&t &e pro&lematic d$e to the meta"chloro gro$ping " di%%ic$lt to prod$ce in a home environment; i% not damn near impossi≤ and pro&a&ly a point o% side reactions i% the ephedrine o% the compo$nd 8ere to &e o-idiLed. Additionally; a&$se potential %or K$propion is pro&a&ly lo8er than that o% even ca%%eine. Caged rhes$s mon/eys 8ill slam it; &$t thin/ a&o$t the condition o% their li%e: =n s$ch a misera&le state anything m$st &e a relie%. 999999999999999999999999999999999TH,4 3ATA999999999999999999999999999999999
9 Vingel; J.N.; 3ovens/y; W.; Crossman; A. and Allen; A.; B,phedrone: 2"Methylamino"1"!henylpropane"1"ne ,rlenmeyer %las/; e$ipped 8ith a magnetic stirring &ar; 8as charged 8ith methylene chloride 266 m>; acetic acid 16 m> 8ater 166 m>; potassi$m permanganate 2g and ephedrine hydrochloride 2g. The sol$tion 8as stirred at room temperat$re %or 6 min. This 8as %ollo8ed &y the addition o% s$%%icient sodi$m hydrogen s$l%ite to red$ce the precipitated manganese dio-ide. The a$eo$s phase 8as made &asic 8ith 'I sodi$m hydro-ide IaH and the methylene chloride 8as separated. The organic layer 8as e-tracted 8ith 6.'I s$l%$ric acid H2*#. =solation o% the acid layer %ollo8ed &y &asi%ication 8ith sodi$m &icar&onate and e-traction 8ith methylene chloride '6 m>; three times; removed the prod$ct into the organic phase. The solvent 8as concentrated &y rotary evaporation; %ollo8ed &y col$mn chromatography thro$gh ne$tral al$mina 8ith methylene chloride. *olvent removal thro$gh rotary evaporation prod$ced a colorless li$id 8hich 8as disolved in he-ane. @aseo$s hydrochloric acid 8as &$&&led into the he-ane to precipitate the amine hydrochloride to prod$ce a 1"g '6 yield o% 2"methylamino"1"phenylpropan"1"one hydrochloride. ,phedrone; li/e methamphetamine; processes one asymmetric center. 3epending $pon the synthetic prec$rsor; l"ephedrine 14;2* or d"pse$doephedrine 1*;24; the prod$ct e-pected 8o$ld &e d"ephedrone 2* or l"ephedrone 24; respectively. Ho8ever; depending on the heat o% the reaction or harsh e-traction conditions the enoliLa&le /etone 8ill res$lt in a racemic d;l"ephedrone. 9 No$ng; 4. and 4.A. @lennon. BCocaine"*tim$l$s @eneraliLation to T8o Ie8 3esigner 3r$gs: Methcathinone and #"Methylaminore-B !harmacol. Kiochem. Kehav. #'1 22"21; 1 9 @lennon; 4.A.; No$si%; M.; Jali-; !. BMethcathinone: A ne8 and potent amphetamine"li/e agent.B !harmacol. Kiochem. Kehav. 2(:'#)"'#'1; 1+). 9 Kritish !atent; )(+;))2 1'#. This is the BclassicB recipe $sing the chromates as o-idiLers0 A sol$tion composed o% 6.g o% sodi$m dichromate and 1g o% concentrated s$l%$ric acid dissolved in #.#( cc o% 8ater is added slo8ly 8ith stirring to 1.('g o% l"ephedrine dissolved in #.) cc o% 8ater and 6.'' cc o% concentrated s$l%$ric acid at room temperat$re. The mi-t$re is stirred at room temperat$re %or an additional # to ( ho$rs and then made al/aline 8ith sodi$m hydro-ide solo$tion. the a$eo$s mi-t$re is e-tracted 8ith t8o vol$mes o% chloro%orm and then 8ith t8o vol$mes o% ether. The organic e-tracts containing the %ree &ase o% 1"a"methylaminoprophenone are com&ined; treated 8ith an e-cess o% dry hydrogen chloride and the solvents evaporated. The resid$al 1"a"methylaminopropiophenone hydrochloride is stirred 8ith petrole$m ether; collected and p$ri%ied &y dissolving in ethanol and reprecipitating 8ith ether. m.p. 1+2"1+# o C. 9 @oldstone; M.*.; BCat " Methcathinone " A Ie8 3r$g o% A&$seB
o% the American Medical Association v2( no 1 p2'6+ letter 1 This article &asically 8arns o% methcathinone appearing on the streets. Iota&le claims are that the typical dosage is .' to 1 gram a day PPP and that addicts descri&e long"lasting into-icating e%%ects o% $p to ( days = 8o$ld ass$me this is repeated administration.... The article also states that BcatB costs O*166 per gram P8hateverP; and goes on to reccomend &enLodiaLepines %or addicts yayP &$t antipsychotics %or those 8ho have overdone it and schiLd o$t &ooP. The article also indicates that tolerance develops and disapates rapidly; something that happens 8ith 5$st a&o$t any stim$lant; even ca%%eine... a&stract %ollo8s immiadetly &elo8ed; copied indirectly %rom M,3>=I,0 T= " Methcathinone: a ne8 and potent amphetamine"li/e agent. AK " The p$rpose o% the present investigation 8as to e-amine the e%%ect o% I"monomethylation o% phenylisopropylamine derivatives on amphetamine" li/e activity. =n tests o% stim$l$s generaliLation $sing rats trained to discriminate 1.6 mgE/g o% S"amphetamine %rom saline; the I" monomethyl derivatives o% 1"R"phenyl"2"aminopropane; 8here R 2;#" dimetho-y 2;#"3MA; ;#"dimetho-y ;#"3MA; 2;#;'"trimetho-y 2;#;';"TMA; and 2"metho-y"#;'"methylenedio-y MM3A"2; did not prod$ce amphetamine"appropriate responding at the doses eval$ated. Ho8ever; the I"monomethyl derivative o% cathinone i.e.; methcathinone; li/e cathinone; res$lted in stim$l$s generaliLation. F$rther st$dies 8ith this agent revealed that a in the amphetamine" trained animals; methcathinone ,3'6 6.) mgE/g is more potent than racemic cathinone or racemic amphetamine ,3'6 6.)1 mgE/g in &oth cases; & methcathinone is capa&le o% ind$cing release o% radioactivity %rom H0dopamine"prela&eled tiss$e o% rat ca$date n$cle$s in a manner similar to that o&served 8ith cathinone; amphetamine; and methamphetamine; and c methcathinone is more potent than cathinone as a locomotor stim$lant in mice as determined &y their e%%ect on spontaneo$s activity. The res$lts o% the present st$dy provide evidence %or a str$ct$ral analogy &et8een the prototypic psychostim$lants amphetamineEmethamphetamine and cathinoneEmethcathinone; and lend %$rther s$pport to the concept that amphetamine and cathinone correspond in their pharmacological e%%ects. 4egarding CATH=II, and the Jhat !lant: 9 Teri 4andall BJhat A&$se F$els *omali Con%lict; 3rains ,conomyB
99999999999999999999999999999999 QO,*T=I* 999999999999999999999999999999999 The %ollo8ing are some $estions = have recieved a&o$t this synthesis; They have &een paraphrased %or &revity. What &rand o% pse$dephedrine is &est???
H=IT: The smaller the pill; the less %iller material it has. No$r sa%est &et on this one is to %ind o$t %or yo$rsel%. Compared to 5$st a&o$t anything else in this 8orld; pse$dephedrine is cheap. !$rchase and %ind o$t. =s there any %aster or less la&or"intensive method o% drying a &atch? An in%ormed netter replies: No$ are a&sol$tely right. = B$nderstandB that placing the Bst$%%B into a glass casserole dish; then immersing in a do$&le &oiler set$p does the 5o& m$ch nicer; 8hile still &eing 8ell 8ithin the means o% the average /itchen. The main things to /eep in mind are the addition o% ethanol to thin the st$%% 8hile drying; and the $se o% a large s$r%ace area; to promote moving solvent into the air; &oth 8ater and ethanol. What o% =.U. $sage o% the dr$g prod$ced %rom this method? = 8o$ldnt reccomend it as this method avoids an acid"&ase e-traction. While certainly less to-ic than the chromates; in5ection o% BotherB material o$ght to &e avoided. This is the same method o% ma/ing cat that yo$ 8rote $p some time ago; &$t yo$ said that it the synthesis yo$ typed $p 8as crap. =s this synthesis the same as the one yo$ 8ere $sing? = never read yo$rs Iot the same &y any stretch o% the imagination. All the di%%erence in the 8orld res$lts %rom $sing e-act amo$nts o% JMn#; highly dil$ted; and in an e-tremely chilled condition. The FAQ said )6 isopropanol; can this &e varied? Nes; that is 5$st %ine esp. since its &eing added to a 8ater"containing sol$tion any8ays : The p$rpose is to provide Bsomething elseB another alcohol0 to &e o-idiLed so that the Methcathinone 8ont get che8ed $p i% any o-idiLer remains... 3o not s$&stit$e another alcohol %or this 9$nless9 it is a BsecondaryB alcohol. !rimary alcohols li/e ethanol and methanol can o-idiLe %$rther to s$&stances that 8ill not evaporate %rom the mi-t$re as easily. The isopropanol 8ill o-idiLe to acetone; 8hich evaporates easily. What dr$g"salts o% methcathinone are there? The HCl %orm is the easiest and pro&a&ly sa%est sni%%a&le %orm. =ts also pretty resistant to decomposition esp. compared to %ree&ase %orm0. &vio$sly other %orms co$ld &e easily made; &$t 8hy &other? Will BHard8are store HClB 8or/? Nes; in %act any ae$o$s sol$tion o% HCl alone 8ill 8or/. Concentration doesnt even really matter provided that pH is monitored " add the amo$nt needed to achieve the desired pH change.
When yo$r p$tting the 5ars in the %ridge do yo$ also p$t the lid on them or does it even matter? Onless the reagents are attac/ed &y drippingWeenie3ogs it sho$ldnt matter all that m$ch. Kest to place it sa%e and $se lids any8ays. What is B%iller materialB? The other crap in any medicine ta&let E pill E caps$le that holds it together. Were yo$r anti&iotics to come 8itho$t %iller material; they 8o$ld also arrive in a little plastic &aggie 5$st li/e the illegal dr$gs. =% yo$ 8ant to ma/e li%e easier %or /itchen chemists; a Bta&lespoonB is a&o$t 1'm> h. Cool. Than/s. Ievertheless; a ta&lespoon is $s$ally metalic; and there%or pro&a&ly not to cool to $se 8ith permaganate sol$tion :
