ملخص عن المضادات الحيوية.pdf

Mohamed Hossany Negm Senior Technical Support Specialist and Marketing Master’s Degree, Poultry Degree, Poultry Science TEL:00201123223874 Faculty of Agriculture Zagazig University

Antibiosis

         

1

Vuillemin 1945

 

Waksman 1889



   

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Pasteur and joubert





1899 Metchnikoff

1875 

    Lactobacillus 

   1940 Waksman

1910 Emmerich and low  P.aeruginos  a 

   

1939 Dubos

 

Bacillus

1928 Alexander fleming staphylococcus staphylococcus au res

  

  

 







) Penicillium notatum(







Gratia and Dath 1924



 

 

:        



Anti Antibody

 Antigen


















         

Antimicrobial

 Antibacterial Antifungal

 

Antiparasitic



  

 

Antiviral Antiseptic

 

Disinfectants

 )

(





 (

 )     : .  

Sanitizer

   Antibiotics














 

  Streptomycin

. .



   



.

 



antibiotic



:  



Antibiotic

    









Antibiotic

Microorganism

 -1 Bacitracin

Bacil Bac il lu s li che heni ni formi s

 (

-2












Streptomycin

-3 Penicillin

Peni Pe ni cill iu m nota notatum tum



         





   

 

Selective toxicity

:

    

 



   

  












:





    

)1    )2   )3   )4     )5  )6 normal flora   )7     )8



 

: 

   



 -1 -2














 



:
























Baceteriostatc Bacteriolytic

 

  Bacetriocidal

  

:

 Measuring Antibiotic activity







 












-

-

 -

: sensitivity test  :      plate   diffusion test : 

(MIC) Minimum Bacteriocid al concentrati : on

. MIC

 



 :  -1

serial dilution  MBC  : test . 37

  :



  24

 streak test 

- 2

Nephelometry



- 3

En zym Actity M ethod - 4 CO2 CO 2 

  

- 1

Turbidimetry

 -2 MIC

, 

 

 



: disc test







 -1

  .

 



I mpedance

- 5 














 -2

. MBC Agar dilution : test

         .














:  

MBC  MIC

. .)

 ( .

. ) pH  





  

     

(





: 

.

  The activity of antibiotic combination

)

 (

  



 ,














( synergy  .  

 ** : ) combination



.

  .

. .

 .  

. 

 

 

-1 -2 -3 -4 -5 -6 -7












Synergism



-4

.

 :

1

4



2



:

3























 Streptomycin Sisomicin Neomycins

Bactericidal

     ) Resting ( Penicillins   Bacitracin Proliferating 

Fosfomycin Tetracyclines Carbomycin Novobiocin

 

    














   

 

:  

)

(


















(  .











.

)        
















  .

  



 

                



 












-4












: 



 .



-5





 

   












  .



  

 : 



: :



 

 : 

























ملخص عن المضادات الحيوية.pdf

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